| Definition | Halothermothrix orenii H 168 chromosome, complete genome. |
|---|---|
| Accession | NC_011899 |
| Length | 2,578,146 |
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The map label for this gene is pbpC [H]
Identifier: 220931810
GI number: 220931810
Start: 1050628
End: 1052940
Strand: Direct
Name: pbpC [H]
Synonym: Hore_09670
Alternate gene names: 220931810
Gene position: 1050628-1052940 (Clockwise)
Preceding gene: 220931809
Following gene: 220931811
Centisome position: 40.75
GC content: 39.69
Gene sequence:
>2313_bases ATGAACCACAGATTTAAAAAACCTTTGTTTAAAATATCAGTAATAGTTATTGTAACTTTTGTACTTCTTGAAGCCCTGAT CTTTATTATCCCTTTTCCAGAAGAAAAATTAAAAAGGTCCCAGTCAACCCTTGTCTATTCTAAGGAAGGTAAGGTTTTGC GGGCCTTTATATCGAAGGATGGAAAGTGGCGGATCTGGACTCCTCTTGAGGATATATCTCCCCATTTGATTAAATTTGTT GTTAATTACGAAGACCGGTTTTTTTACTATCACCCCGGGGTTAATCCCCTGGCAATAATGAGAGCATTCTGGCAAAATAT AAGGACCAGGGAGATTGTTTCAGGTGGTTCTACTATTACCATGCAGGTTAGCCGCCTAATGGAACCCAAAAAAAGGACTT TAAAAAATAAGATAATTGAGGCCTTCAGGGCCCTCCAGCTGGAGCATTTTTATACAAAGAATGAAATTCTTGAAATGTAT CTTAATCTGGCCCCATATGGAGGTAATATAGAGGGAGTTGAAGCAGCCAGCTATTTATATTTTGGAAAAGCTCCCTCGCA ACTTAGTTATGCTGAAGCAGCTTTAATAACATCATTACCACAATCACCGACCATATTAAGGCCTGATTATAACCCTGATG GGGCACGCAAAGCCAGAAATAAAGTTCTTAAAAGGATGTTGAGGTCTGGTGTAATTGATAAAGATAGTTATTTAGAAGCT ATGGAGGAACCTGTTCCTGCTTCCAGAAGGGAATGGCCTTTTATTGCCCCTCATTTATGCCGGGAGCTCCATCTTGAGAA TAATGATAGGTCCAGAATTTATGCAACAATTGATAGTGACATACAACTAATGACAAAAAGGATGCTGGTTAACCATCTCC GGGCCTTTAAGAGCAAAGGCATAACCAATGGGTCTGTAGTAGTTATAGATAATAAAACCCATGAAATAAAGGCCATGGTT GGTTCTGTCAGCTTTTTTGATGAAGATAATAATGGCCAGGTAAATGGGGCCCTGGCCCTGCGTTCTCCGGGCTCTACTCT GAAGCCTTTTATATATGGACTGGGTATTTGTCAGGGAATAATAACACCTGGTCATTATTTAGAAGATGTACCAATTGACT ATGGTGGCTATTCACCTGAAAATTATGATAGAACATATAATGGTATAGTATCAGCTGAAGAAGCATTGAAACGTTCTTTA AATGTTCCTGCTGTAAACCTTAATGCAAGACTTAATGAAGGTACTGATCTTTACAGATTACTGAAAAAAGCCGGGATTAG TTCTATCAGGAATTTAGATAATTATGGACTGGCTATCGCCCTCGGTGGTTGTGAAATTAATTTGCTTGAGCTTACGTCTT TATATTCTTCCATGGCCTGTGGTGGTTACTATTATGAGCCAATATTAACAGAAAACAAGAAGACAACATCGGTAAAATTA TTTGATGAGGGAACCAGTTTTATAATAACAGAAATACTGACAGAATTAAGGAGGCCTGATCTTCCTGCAGCCTGGCAGTT TACTGATTTGCCCCGGATAGCCTGGAAAACAGGCACCTCATATGGGCACCGCGATGCCTGGAGTATAGGTTATAACCCCC GTTATACTGTCGGGGTCTGGCTGGGGAATTTTGATGGCAGGGGATCTCCTAATCTTGTTGGAGCCAGGGCTGCGGCTCCA TTATTATTTGATATATTTAATGTCTTGAATAAAAATAATCCGACTGGATGGTTTGAAAGGCCTGATACTGTTGGAATAAG GAAAGTCTGCAGTCTCAGTGGTCAGCTTCCCAATAAATATTGCCCTGCTACTGTTGAGGAGTATTATTTAAAAGACCGTT CTCCAACTGTAAAGTGTCAGTTTCACCGTATTGTATATCTTAATGAAGAAGGTTACCGGGTTCCTAAAAGCATAAAAAAA GATTTTAACCTGGAAAGAAAAATATATATTCACTGGCCCCCCAGGATCGCCAGCTGGAGGACCAGCCATGGTTACCCAGT CTACCAGCTACCAGAATTACAACCTGATTTTCAGCATCAGCTTTCAGGTAAACCTCCGGTAATTGAATCACCGGTTGAGG GTGTTATCTATGATTTGCGGCAGGGTGTATCTGATAAATATCAAAAAATTGCTTTCACAGCTTCTGTCTCCAATGATGTT AGCCATATTTACTGGTTTGTTGATGGTAGTTTGATTGGGACAGTAAAACCTGGAGAAAAGCTTTTTTATCTGCCTGAACC CGGTGAACATGAGGTAGTTTGCCAGGATGATATGGGGCGTTTGAATAAAATTAATATAATTATTAAAAAATAA
Upstream 100 bases:
>100_bases AAGGGTCTGCCCCTGTCAGACCCTTCAATGTAATACCTGTATTTTTTATCTGGATAACATGAAGTATATGTAAAGGAGAG GGACGGTGAAGAACAGACTG
Downstream 100 bases:
>100_bases AGCAAGAGTAAAAAATAAAACAAGTGACATTTATCTAATAAACAGAGGGTGATTGAATTGGGTGTACGGTTTAAACGTGA TTATGATGAAATAGTACAAG
Product: penicillin-binding protein 1C
Products: NA
Alternate protein names: PBP-1c; PBP1c; Penicillin-insensitive transglycosylase; Peptidoglycan TGase; Transpeptidase-like module [H]
Number of amino acids: Translated: 770; Mature: 770
Protein sequence:
>770_residues MNHRFKKPLFKISVIVIVTFVLLEALIFIIPFPEEKLKRSQSTLVYSKEGKVLRAFISKDGKWRIWTPLEDISPHLIKFV VNYEDRFFYYHPGVNPLAIMRAFWQNIRTREIVSGGSTITMQVSRLMEPKKRTLKNKIIEAFRALQLEHFYTKNEILEMY LNLAPYGGNIEGVEAASYLYFGKAPSQLSYAEAALITSLPQSPTILRPDYNPDGARKARNKVLKRMLRSGVIDKDSYLEA MEEPVPASRREWPFIAPHLCRELHLENNDRSRIYATIDSDIQLMTKRMLVNHLRAFKSKGITNGSVVVIDNKTHEIKAMV GSVSFFDEDNNGQVNGALALRSPGSTLKPFIYGLGICQGIITPGHYLEDVPIDYGGYSPENYDRTYNGIVSAEEALKRSL NVPAVNLNARLNEGTDLYRLLKKAGISSIRNLDNYGLAIALGGCEINLLELTSLYSSMACGGYYYEPILTENKKTTSVKL FDEGTSFIITEILTELRRPDLPAAWQFTDLPRIAWKTGTSYGHRDAWSIGYNPRYTVGVWLGNFDGRGSPNLVGARAAAP LLFDIFNVLNKNNPTGWFERPDTVGIRKVCSLSGQLPNKYCPATVEEYYLKDRSPTVKCQFHRIVYLNEEGYRVPKSIKK DFNLERKIYIHWPPRIASWRTSHGYPVYQLPELQPDFQHQLSGKPPVIESPVEGVIYDLRQGVSDKYQKIAFTASVSNDV SHIYWFVDGSLIGTVKPGEKLFYLPEPGEHEVVCQDDMGRLNKINIIIKK
Sequences:
>Translated_770_residues MNHRFKKPLFKISVIVIVTFVLLEALIFIIPFPEEKLKRSQSTLVYSKEGKVLRAFISKDGKWRIWTPLEDISPHLIKFV VNYEDRFFYYHPGVNPLAIMRAFWQNIRTREIVSGGSTITMQVSRLMEPKKRTLKNKIIEAFRALQLEHFYTKNEILEMY LNLAPYGGNIEGVEAASYLYFGKAPSQLSYAEAALITSLPQSPTILRPDYNPDGARKARNKVLKRMLRSGVIDKDSYLEA MEEPVPASRREWPFIAPHLCRELHLENNDRSRIYATIDSDIQLMTKRMLVNHLRAFKSKGITNGSVVVIDNKTHEIKAMV GSVSFFDEDNNGQVNGALALRSPGSTLKPFIYGLGICQGIITPGHYLEDVPIDYGGYSPENYDRTYNGIVSAEEALKRSL NVPAVNLNARLNEGTDLYRLLKKAGISSIRNLDNYGLAIALGGCEINLLELTSLYSSMACGGYYYEPILTENKKTTSVKL FDEGTSFIITEILTELRRPDLPAAWQFTDLPRIAWKTGTSYGHRDAWSIGYNPRYTVGVWLGNFDGRGSPNLVGARAAAP LLFDIFNVLNKNNPTGWFERPDTVGIRKVCSLSGQLPNKYCPATVEEYYLKDRSPTVKCQFHRIVYLNEEGYRVPKSIKK DFNLERKIYIHWPPRIASWRTSHGYPVYQLPELQPDFQHQLSGKPPVIESPVEGVIYDLRQGVSDKYQKIAFTASVSNDV SHIYWFVDGSLIGTVKPGEKLFYLPEPGEHEVVCQDDMGRLNKINIIIKK >Mature_770_residues MNHRFKKPLFKISVIVIVTFVLLEALIFIIPFPEEKLKRSQSTLVYSKEGKVLRAFISKDGKWRIWTPLEDISPHLIKFV VNYEDRFFYYHPGVNPLAIMRAFWQNIRTREIVSGGSTITMQVSRLMEPKKRTLKNKIIEAFRALQLEHFYTKNEILEMY LNLAPYGGNIEGVEAASYLYFGKAPSQLSYAEAALITSLPQSPTILRPDYNPDGARKARNKVLKRMLRSGVIDKDSYLEA MEEPVPASRREWPFIAPHLCRELHLENNDRSRIYATIDSDIQLMTKRMLVNHLRAFKSKGITNGSVVVIDNKTHEIKAMV GSVSFFDEDNNGQVNGALALRSPGSTLKPFIYGLGICQGIITPGHYLEDVPIDYGGYSPENYDRTYNGIVSAEEALKRSL NVPAVNLNARLNEGTDLYRLLKKAGISSIRNLDNYGLAIALGGCEINLLELTSLYSSMACGGYYYEPILTENKKTTSVKL FDEGTSFIITEILTELRRPDLPAAWQFTDLPRIAWKTGTSYGHRDAWSIGYNPRYTVGVWLGNFDGRGSPNLVGARAAAP LLFDIFNVLNKNNPTGWFERPDTVGIRKVCSLSGQLPNKYCPATVEEYYLKDRSPTVKCQFHRIVYLNEEGYRVPKSIKK DFNLERKIYIHWPPRIASWRTSHGYPVYQLPELQPDFQHQLSGKPPVIESPVEGVIYDLRQGVSDKYQKIAFTASVSNDV SHIYWFVDGSLIGTVKPGEKLFYLPEPGEHEVVCQDDMGRLNKINIIIKK
Specific function: Cell wall formation. The enzyme has a penicillin- insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a transpeptidase C-terminal domain which may not be functional [H]
COG id: COG4953
COG function: function code M; Membrane carboxypeptidase/penicillin-binding protein PbpC
Gene ontology:
Cell location: Cell inner membrane; Single-pass type II membrane protein [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: In the C-terminal section; belongs to the transpeptidase family [H]
Homologues:
Organism=Escherichia coli, GI1788867, Length=789, Percent_Identity=32.6996197718631, Blast_Score=399, Evalue=1e-112, Organism=Escherichia coli, GI87082258, Length=262, Percent_Identity=35.4961832061069, Blast_Score=141, Evalue=2e-34, Organism=Escherichia coli, GI1786343, Length=549, Percent_Identity=26.775956284153, Blast_Score=129, Evalue=8e-31, Organism=Escherichia coli, GI1789601, Length=167, Percent_Identity=32.9341317365269, Blast_Score=86, Evalue=1e-17,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR012338 - InterPro: IPR001264 - InterPro: IPR011815 - InterPro: IPR009647 - InterPro: IPR001460 [H]
Pfam domain/function: PF06832 BiPBP_C; PF00912 Transgly; PF00905 Transpeptidase [H]
EC number: 2.4.2.-
Molecular weight: Translated: 87498; Mature: 87498
Theoretical pI: Translated: 9.25; Mature: 9.25
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.0 %Cys (Translated Protein) 1.6 %Met (Translated Protein) 2.6 %Cys+Met (Translated Protein) 1.0 %Cys (Mature Protein) 1.6 %Met (Mature Protein) 2.6 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MNHRFKKPLFKISVIVIVTFVLLEALIFIIPFPEEKLKRSQSTLVYSKEGKVLRAFISKD CCCCHHCHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHCCCCEEEEECCCCEEEHHHCCC GKWRIWTPLEDISPHLIKFVVNYEDRFFYYHPGVNPLAIMRAFWQNIRTREIVSGGSTIT CCEEEECCHHHCCHHHEEEEEECCCEEEEECCCCCHHHHHHHHHHCCCHHHHHCCCCEEE MQVSRLMEPKKRTLKNKIIEAFRALQLEHFYTKNEILEMYLNLAPYGGNIEGVEAASYLY EEHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE FGKAPSQLSYAEAALITSLPQSPTILRPDYNPDGARKARNKVLKRMLRSGVIDKDSYLEA ECCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH MEEPVPASRREWPFIAPHLCRELHLENNDRSRIYATIDSDIQLMTKRMLVNHLRAFKSKG HHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCC ITNGSVVVIDNKTHEIKAMVGSVSFFDEDNNGQVNGALALRSPGSTLKPFIYGLGICQGI CCCCEEEEEECCCCEEHHHHHCEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHH ITPGHYLEDVPIDYGGYSPENYDRTYNGIVSAEEALKRSLNVPAVNLNARLNEGTDLYRL CCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHH LKKAGISSIRNLDNYGLAIALGGCEINLLELTSLYSSMACGGYYYEPILTENKKTTSVKL HHHHCHHHHHCCCCCCEEEEECCCEEEHHHHHHHHHHHHCCCEEECCEECCCCCCEEEEE FDEGTSFIITEILTELRRPDLPAAWQFTDLPRIAWKTGTSYGHRDAWSIGYNPRYTVGVW EECCCHHHHHHHHHHHCCCCCCCCEECCCCCCCEEECCCCCCCCCCEECCCCCCEEEEEE LGNFDGRGSPNLVGARAAAPLLFDIFNVLNKNNPTGWFERPDTVGIRKVCSLSGQLPNKY EECCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC CPATVEEYYLKDRSPTVKCQFHRIVYLNEEGYRVPKSIKKDFNLERKIYIHWPPRIASWR CCCCHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCC TSHGYPVYQLPELQPDFQHQLSGKPPVIESPVEGVIYDLRQGVSDKYQKIAFTASVSNDV CCCCCCEEECCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHCHHHHHHEEEEEEECCCCC SHIYWFVDGSLIGTVKPGEKLFYLPEPGEHEVVCQDDMGRLNKINIIIKK EEEEEEECCEEEEEECCCCEEEECCCCCCCCEEECCCCCCCEEEEEEEEC >Mature Secondary Structure MNHRFKKPLFKISVIVIVTFVLLEALIFIIPFPEEKLKRSQSTLVYSKEGKVLRAFISKD CCCCHHCHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHCCCCEEEEECCCCEEEHHHCCC GKWRIWTPLEDISPHLIKFVVNYEDRFFYYHPGVNPLAIMRAFWQNIRTREIVSGGSTIT CCEEEECCHHHCCHHHEEEEEECCCEEEEECCCCCHHHHHHHHHHCCCHHHHHCCCCEEE MQVSRLMEPKKRTLKNKIIEAFRALQLEHFYTKNEILEMYLNLAPYGGNIEGVEAASYLY EEHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEE FGKAPSQLSYAEAALITSLPQSPTILRPDYNPDGARKARNKVLKRMLRSGVIDKDSYLEA ECCCCCCCHHHHHHHHHCCCCCCCEECCCCCCCHHHHHHHHHHHHHHHCCCCCCHHHHHH MEEPVPASRREWPFIAPHLCRELHLENNDRSRIYATIDSDIQLMTKRMLVNHLRAFKSKG HHCCCCCCCCCCCCCCHHHHHHHCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHCC ITNGSVVVIDNKTHEIKAMVGSVSFFDEDNNGQVNGALALRSPGSTLKPFIYGLGICQGI CCCCEEEEEECCCCEEHHHHHCEEEEECCCCCEEEEEEEECCCCCCHHHHHHHHHHHHHH ITPGHYLEDVPIDYGGYSPENYDRTYNGIVSAEEALKRSLNVPAVNLNARLNEGTDLYRL CCCCCCCCCCCCCCCCCCCCCCCCHHHCCHHHHHHHHHCCCCCEEEECCCCCCCHHHHHH LKKAGISSIRNLDNYGLAIALGGCEINLLELTSLYSSMACGGYYYEPILTENKKTTSVKL HHHHCHHHHHCCCCCCEEEEECCCEEEHHHHHHHHHHHHCCCEEECCEECCCCCCEEEEE FDEGTSFIITEILTELRRPDLPAAWQFTDLPRIAWKTGTSYGHRDAWSIGYNPRYTVGVW EECCCHHHHHHHHHHHCCCCCCCCEECCCCCCCEEECCCCCCCCCCEECCCCCCEEEEEE LGNFDGRGSPNLVGARAAAPLLFDIFNVLNKNNPTGWFERPDTVGIRKVCSLSGQLPNKY EECCCCCCCCCEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCC CPATVEEYYLKDRSPTVKCQFHRIVYLNEEGYRVPKSIKKDFNLERKIYIHWPPRIASWR CCCCHHHHHHCCCCCEEEEEEEEEEEECCCCCCCCHHHHHCCCCCEEEEEECCCCCCCCC TSHGYPVYQLPELQPDFQHQLSGKPPVIESPVEGVIYDLRQGVSDKYQKIAFTASVSNDV CCCCCCEEECCCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHCHHHHHHEEEEEEECCCCC SHIYWFVDGSLIGTVKPGEKLFYLPEPGEHEVVCQDDMGRLNKINIIIKK EEEEEEECCEEEEEECCCCEEEECCCCCCCCEEECCCCCCCEEEEEEEEC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 6.0
TargetDB status: NA
Availability: NA
References: 10542235; 9205837; 9278503; 9841666 [H]