Click here to switch to the map view.

The map label for this gene is murC [H]

Identifier: 220931753

GI number: 220931753

Start: 983571

End: 984950

Strand: Direct

Name: murC [H]

Synonym: Hore_09100

Alternate gene names: 220931753

Gene position: 983571-984950 (Clockwise)

Preceding gene: 220931752

Following gene: 220931754

Centisome position: 38.15

GC content: 38.12

Gene sequence:

>1380_bases
TTGGCCTCAAAAAAACATGTTCATCTGATTGGTATTGGTGGTATTTCAATGAGTGGAATTGCCCAGATGTTATTAAAAAG
AGGCTATAAGGTTAGTGGATCTGATTTAAAGGATTCACCTTTACTCGATAGATTACGACGGTCAGGAGCCAATGTTTATA
TTGGTCATTCCCCTGAAAATATAAAAGGGGCCGATATGATAGTAATTTCAACAGCAATTCCTGAGGATAATAGTGAACTT
CAGGCTGCCAGAAAAGCAGGACTACCTGTTTACGGTAGGGCACAGATGATTGCAAAACTTATGGAAGACAAGAAAACAAT
AGCTATTTCAGGTACCCATGGAAAAACCACTACTACATCAATGGTAGCTACTATTTTAAAAGAAAACAAAATGGATCCTA
CAGTTATGGTTGGTGGTGTTTTGAATAACATTGGTGGTAATGTTTATCTGGGGAAAGGTGAATATTTTGTTACAGAAGCT
GATGAGAGTGATGGTTCATTGCTGTATTTTGATCCTAGCGGGGTTGTAGTTACTAATATAGAATTTGACCATCATGATTA
CTATGATAGCAAAGAAAAGCTCTTAAATACATTTAAAGAATTTGTCAATAAAATTCCTAAAGATGGTAAGGCAATTGTTT
ATGCTGAAGATGATAACATAAGAAAAATATTAGACAATGAGGACCGCAGGGTTTTAACTTACGGAATTAATGCTGGAAAG
CTAAAGGCCATAAACATAAATACCCTCCCCTTTGGAAGCTATTATAACCTGGTATATGGGGAGCGAGTCCTGGGAGAAAT
CAGGTTACAGGTTCCTGGAGTTCACAATGTATTAAATTCCCTGGCTGCAGTGGCAGTGGGAATGTATGTTGGCCTTAGTT
TTACCGATATTCAGGAGTCACTGGGCAAATTCTATGGTGTTCACCGGCGTTTTGAGAAAAAGGGGTTAATTGATAGTATC
CTTATTATTGATGATTATGCTCACCATCCTACTGAAATAAAAGCTACCTTAAAAGCTGCCAGGAATACAGGTTATGAAAG
AATAATTGCTATTTTCCAACCACATCGGTATTCCCGTACCAGGCACTTTATGGAGGAGTTTGCTAAATGTTTCGACGATG
TAGACCATCTTATAGTAACAGATATTTATAGTGCCAGTGAAAAACCGATACCGGGAGTTACTGCTGAAAAGCTGGCCTTG
AAGATTGATAATTGTAACGGTCCTGATGTGGATTATATTCCTGAACTTGAAGAGGTCGTAGACTATGTTGAAAAAATAAT
TAAACCCCGGGACCTGGTTATTACAATTGGAGCAGGGAATGTTTACAAAGTTGGAGACCGACTTGTCAATAGATTAAGGG
AAAAGCGGGAGATGGCATAA

Upstream 100 bases:

>100_bases
ATTTAATTGAAGATACTGCAAAGGGTAGTTGAAACAGGGGTACATTATAGAGTTAAAAAATGCATATACTGAGATGTGAT
AGATAAAAGGGGGGAGTATT

Downstream 100 bases:

>100_bases
ACCAGGGGGAGTGGCCAAGGTGACAAAGCCGCAAAACTACTATATTTATATACTTGTTTTGATAAGTGTAATAGCTCTGG
TTTCATTTTTATCATCCCCT

Product: UDP-N-acetylmuramate--alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 459; Mature: 458

Protein sequence:

>459_residues
MASKKHVHLIGIGGISMSGIAQMLLKRGYKVSGSDLKDSPLLDRLRRSGANVYIGHSPENIKGADMIVISTAIPEDNSEL
QAARKAGLPVYGRAQMIAKLMEDKKTIAISGTHGKTTTTSMVATILKENKMDPTVMVGGVLNNIGGNVYLGKGEYFVTEA
DESDGSLLYFDPSGVVVTNIEFDHHDYYDSKEKLLNTFKEFVNKIPKDGKAIVYAEDDNIRKILDNEDRRVLTYGINAGK
LKAININTLPFGSYYNLVYGERVLGEIRLQVPGVHNVLNSLAAVAVGMYVGLSFTDIQESLGKFYGVHRRFEKKGLIDSI
LIIDDYAHHPTEIKATLKAARNTGYERIIAIFQPHRYSRTRHFMEEFAKCFDDVDHLIVTDIYSASEKPIPGVTAEKLAL
KIDNCNGPDVDYIPELEEVVDYVEKIIKPRDLVITIGAGNVYKVGDRLVNRLREKREMA

Sequences:

>Translated_459_residues
MASKKHVHLIGIGGISMSGIAQMLLKRGYKVSGSDLKDSPLLDRLRRSGANVYIGHSPENIKGADMIVISTAIPEDNSEL
QAARKAGLPVYGRAQMIAKLMEDKKTIAISGTHGKTTTTSMVATILKENKMDPTVMVGGVLNNIGGNVYLGKGEYFVTEA
DESDGSLLYFDPSGVVVTNIEFDHHDYYDSKEKLLNTFKEFVNKIPKDGKAIVYAEDDNIRKILDNEDRRVLTYGINAGK
LKAININTLPFGSYYNLVYGERVLGEIRLQVPGVHNVLNSLAAVAVGMYVGLSFTDIQESLGKFYGVHRRFEKKGLIDSI
LIIDDYAHHPTEIKATLKAARNTGYERIIAIFQPHRYSRTRHFMEEFAKCFDDVDHLIVTDIYSASEKPIPGVTAEKLAL
KIDNCNGPDVDYIPELEEVVDYVEKIIKPRDLVITIGAGNVYKVGDRLVNRLREKREMA
>Mature_458_residues
ASKKHVHLIGIGGISMSGIAQMLLKRGYKVSGSDLKDSPLLDRLRRSGANVYIGHSPENIKGADMIVISTAIPEDNSELQ
AARKAGLPVYGRAQMIAKLMEDKKTIAISGTHGKTTTTSMVATILKENKMDPTVMVGGVLNNIGGNVYLGKGEYFVTEAD
ESDGSLLYFDPSGVVVTNIEFDHHDYYDSKEKLLNTFKEFVNKIPKDGKAIVYAEDDNIRKILDNEDRRVLTYGINAGKL
KAININTLPFGSYYNLVYGERVLGEIRLQVPGVHNVLNSLAAVAVGMYVGLSFTDIQESLGKFYGVHRRFEKKGLIDSIL
IIDDYAHHPTEIKATLKAARNTGYERIIAIFQPHRYSRTRHFMEEFAKCFDDVDHLIVTDIYSASEKPIPGVTAEKLALK
IDNCNGPDVDYIPELEEVVDYVEKIIKPRDLVITIGAGNVYKVGDRLVNRLREKREMA

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=462, Percent_Identity=38.3116883116883, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1790680, Length=467, Percent_Identity=28.051391862955, Blast_Score=196, Evalue=2e-51,
Organism=Escherichia coli, GI1786276, Length=320, Percent_Identity=27.1875, Blast_Score=73, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 51016; Mature: 50885

Theoretical pI: Translated: 7.21; Mature: 7.21

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASKKHVHLIGIGGISMSGIAQMLLKRGYKVSGSDLKDSPLLDRLRRSGANVYIGHSPEN
CCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCC
IKGADMIVISTAIPEDNSELQAARKAGLPVYGRAQMIAKLMEDKKTIAISGTHGKTTTTS
CCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHH
MVATILKENKMDPTVMVGGVLNNIGGNVYLGKGEYFVTEADESDGSLLYFDPSGVVVTNI
HHHHHHHHCCCCCEEEECHHHHHCCCEEEEECCCEEEEECCCCCCCEEEECCCCEEEEEE
EFDHHDYYDSKEKLLNTFKEFVNKIPKDGKAIVYAEDDNIRKILDNEDRRVLTYGINAGK
EECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHCCCCCEEEEEECCCCE
LKAININTLPFGSYYNLVYGERVLGEIRLQVPGVHNVLNSLAAVAVGMYVGLSFTDIQES
EEEEEEECCCCCCHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
LGKFYGVHRRFEKKGLIDSILIIDDYAHHPTEIKATLKAARNTGYERIIAIFQPHRYSRT
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHHEEEEECCCHHHHH
RHFMEEFAKCFDDVDHLIVTDIYSASEKPIPGVTAEKLALKIDNCNGPDVDYIPELEEVV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHEEEEEEECCCCCCCCCCCCHHHHH
DYVEKIIKPRDLVITIGAGNVYKVGDRLVNRLREKREMA
HHHHHHCCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
ASKKHVHLIGIGGISMSGIAQMLLKRGYKVSGSDLKDSPLLDRLRRSGANVYIGHSPEN
CCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCCEEECCCCCC
IKGADMIVISTAIPEDNSELQAARKAGLPVYGRAQMIAKLMEDKKTIAISGTHGKTTTTS
CCCCCEEEEEECCCCCCHHHHHHHHCCCCCCCHHHHHHHHHCCCCEEEEECCCCCCHHHH
MVATILKENKMDPTVMVGGVLNNIGGNVYLGKGEYFVTEADESDGSLLYFDPSGVVVTNI
HHHHHHHHCCCCCEEEECHHHHHCCCEEEEECCCEEEEECCCCCCCEEEECCCCEEEEEE
EFDHHDYYDSKEKLLNTFKEFVNKIPKDGKAIVYAEDDNIRKILDNEDRRVLTYGINAGK
EECCCCCCCHHHHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHCCCCCEEEEEECCCCE
LKAININTLPFGSYYNLVYGERVLGEIRLQVPGVHNVLNSLAAVAVGMYVGLSFTDIQES
EEEEEEECCCCCCHHHHHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHCCCHHHHHHH
LGKFYGVHRRFEKKGLIDSILIIDDYAHHPTEIKATLKAARNTGYERIIAIFQPHRYSRT
HHHHHHHHHHHHHCCCCEEEEEEECCCCCCHHHHHHHHHHHCCCHHHEEEEECCCHHHHH
RHFMEEFAKCFDDVDHLIVTDIYSASEKPIPGVTAEKLALKIDNCNGPDVDYIPELEEVV
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHEEEEEEECCCCCCCCCCCCHHHHH
DYVEKIIKPRDLVITIGAGNVYKVGDRLVNRLREKREMA
HHHHHHCCCCEEEEEECCCCEEHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA