Click here to switch to the map view.

The map label for this gene is cymR [H]

Identifier: 220931730

GI number: 220931730

Start: 955560

End: 956015

Strand: Direct

Name: cymR [H]

Synonym: Hore_08870

Alternate gene names: 220931730

Gene position: 955560-956015 (Clockwise)

Preceding gene: 220931729

Following gene: 220931731

Centisome position: 37.06

GC content: 41.23

Gene sequence:

>456_bases
ATGAAAATATCCACCAGGGGTAGATATGGACTAAGAGCAATGGTTGACCTTGCCATCCACCAGGATTCGGGTGCAATTCC
CTTAAGGGAAATTGCGGAGAGACAACAGATATCTGAGCAGTATCTGGAACAACTTTTCGCCAATTTACGTAAAGCAGGGC
TTGTTAAGAGTGTGAGAGGGGCCCATGGCGGTTATTTGTTAAATCGTGATGCTGATGAAATTACTGCTGGAGATGTACTT
CGAACCCTCGAGGGTCCTATTGCACCGACCGACTGTGTTCTCGATAATGACGAAGATGTCTGTAGTTTAATAGATAAATG
TGTTACCCATGAATTGTGGGTAAAATTACAGAAACAGGTAAGTGAAATCCTTGACTCGGTTACTTTAAGAGACTTACAGG
AAAGGGCAAAAGAACTAATACGTAATAAAAATAAAGGTTTGATGTATCATATCTGA

Upstream 100 bases:

>100_bases
ACGTACTGGTGCTGAATATATATGTTGACAGTAACAATGGGTTGTGTTAAAATAATCATATAAAGTTGATAAAATTAATC
AGGATTAGTGGGGTGAAAAC

Downstream 100 bases:

>100_bases
ATATTTTAAGGGGTGTTTTTATATGAAGAATATCTATTTAGATAATGCTGCAACCACACCGGTTGCACCTGAAGTTATTA
AAGTTATGGAACCCTATTTT

Product: BadM/Rrf2 family transcriptional regulator

Products: NA

Alternate protein names: Cysteine metabolism repressor [H]

Number of amino acids: Translated: 151; Mature: 151

Protein sequence:

>151_residues
MKISTRGRYGLRAMVDLAIHQDSGAIPLREIAERQQISEQYLEQLFANLRKAGLVKSVRGAHGGYLLNRDADEITAGDVL
RTLEGPIAPTDCVLDNDEDVCSLIDKCVTHELWVKLQKQVSEILDSVTLRDLQERAKELIRNKNKGLMYHI

Sequences:

>Translated_151_residues
MKISTRGRYGLRAMVDLAIHQDSGAIPLREIAERQQISEQYLEQLFANLRKAGLVKSVRGAHGGYLLNRDADEITAGDVL
RTLEGPIAPTDCVLDNDEDVCSLIDKCVTHELWVKLQKQVSEILDSVTLRDLQERAKELIRNKNKGLMYHI
>Mature_151_residues
MKISTRGRYGLRAMVDLAIHQDSGAIPLREIAERQQISEQYLEQLFANLRKAGLVKSVRGAHGGYLLNRDADEITAGDVL
RTLEGPIAPTDCVLDNDEDVCSLIDKCVTHELWVKLQKQVSEILDSVTLRDLQERAKELIRNKNKGLMYHI

Specific function: Master repressor of cysteine metabolism in B.subtilis. Controls the expression of genes involved either in cysteine synthesis from sulfide (cysK), sulfonates (ssu), or methionine (mccAB) or in cystine uptake (tcyP). Activity of CymR is positively regulate

COG id: COG1959

COG function: function code K; Predicted transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH rrf2-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1788880, Length=132, Percent_Identity=43.1818181818182, Blast_Score=111, Evalue=2e-26,
Organism=Escherichia coli, GI1790621, Length=141, Percent_Identity=28.3687943262411, Blast_Score=65, Evalue=2e-12,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000944 [H]

Pfam domain/function: PF02082 Rrf2 [H]

EC number: NA

Molecular weight: Translated: 17040; Mature: 17040

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: PS01332 UPF0074

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKISTRGRYGLRAMVDLAIHQDSGAIPLREIAERQQISEQYLEQLFANLRKAGLVKSVRG
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AHGGYLLNRDADEITAGDVLRTLEGPIAPTDCVLDNDEDVCSLIDKCVTHELWVKLQKQV
CCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHH
SEILDSVTLRDLQERAKELIRNKNKGLMYHI
HHHHHHHHHHHHHHHHHHHHHCCCCCCEECC
>Mature Secondary Structure
MKISTRGRYGLRAMVDLAIHQDSGAIPLREIAERQQISEQYLEQLFANLRKAGLVKSVRG
CCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
AHGGYLLNRDADEITAGDVLRTLEGPIAPTDCVLDNDEDVCSLIDKCVTHELWVKLQKQV
CCCCEEECCCHHHHHHHHHHHHHCCCCCCCCCEECCCHHHHHHHHHHHHHHHHHHHHHHH
SEILDSVTLRDLQERAKELIRNKNKGLMYHI
HHHHHHHHHHHHHHHHHHHHHCCCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]