Click here to switch to the map view.

The map label for this gene is lysC [H]

Identifier: 220931648

GI number: 220931648

Start: 863797

End: 865080

Strand: Direct

Name: lysC [H]

Synonym: Hore_08040

Alternate gene names: 220931648

Gene position: 863797-865080 (Clockwise)

Preceding gene: 220931647

Following gene: 220931649

Centisome position: 33.5

GC content: 39.56

Gene sequence:

>1284_bases
TTGAGAAAATGGGAACATGGTAGTAATACAGCGAATGGAGTTGGTATTATGGCTTTAATAGTACAAAAATACGGTGGTAC
ATCGGTGGGAACTATTGAAAGGATTAAAAATGTTGCCGACCGTGTCATTAAAGAATATAAAAGTGGTAACAAACTGGTTG
TAGTTGTTTCAGCAATGGGTGATACCACTGATAAGCTAATCAAGCTCATGAAAGGGGTTACAAGTGACCCCGATCCACGG
GAAGCGGATATGCTATTAACAACAGGAGAACAGGTTTCAATTGCGCTTCTCACAATGGCTATCCAGGAAAGAGGTTATCC
CGCTATTTCCCTGACTGGAAGTCAGGTCCAGATCAAGACCAATGACCATCATAATAAAGCTGAAATACTAGGTGTTGATA
ATAACCGGCTTATTGAGGAACTGGATCAGGGTAAAATTGTAGTGGTAGCAGGTTTTCAGGGGATTAACAGTAATAATGAT
TTTACAACACTGGGGCGTGGTGGTTCTGATACAACTGCCGTTGCTCTGGCAGCATCCCTGGGGGCAGAAAGGTGTGAAAT
ATATTCAGATGTTGAAGGGATCTATACTACCGATCCCAGGGTTGTACCTGAAGCGGTAAAGCTTGATTATATATCGTATA
ATGAAATGCTGGAGCTAGCCCATCTAGGGGCTAAAGTCCTTCATCCCCGTTCTGTGGAACTGGCCAAAGCCTATAATTTA
AAACTATATATAGCCTCAAGTTTTAATTATAAACCAGGTACGGTAGTAAAGGGGGTTGATGACATGGAGAAGAGGAGAAG
TGTTACCGGGGTAACCTGTGAAAAAGATGAGGTAAAAGTAACTGTACAAAAAGTACCTGATAGACCAGGTGTTGCCGGGA
AAATTTTTAAAGAACTGGCCAGATATAATATAAACGTTGATATGATTATCCAGAACCTGCAGTATGATAACCGAAATGAT
ATTACTTTTACCATAAATAAAGAAGATTTAATTAAATGTAAAAAGGTTATTTACCGGATTGCAGAAGAATTAAATGCCGG
TGGTGTTGAAATCGATACCAGGGTAGCCAAAGTATCAATAGTGGGAGCTGGAATGATATCAACACCCGGTATAGCCGGAA
AAATGTTTGAAATAATGGGGAATGAAAATATTAACATTCAGATGATTACTACATCTGATATAAAGATCTCCTGTTTAATA
AGGGAAAACCAGGCTGAAAAAGCCCTTAAAACCCTTCACAGACAATTTGAACTGGGGAATATTACTCAGAAACAGGCTCG
ATAA

Upstream 100 bases:

>100_bases
GTTGTGGCTGTCTTAACCGGTCACGGGCTTAAAGACCCAACCACTGCAATTGATACCATCAAAAAACCAGAACCTGTTTC
CGCAGAGGTAGAGGCGGTTC

Downstream 100 bases:

>100_bases
ACCAAAGTGTGGTTTGATACTTTATTTGACTAAAGGTTTTTGATAATGTATAATAATAAGCAGCCAAAATTAACTAACTT
TTGTATAAAAGATTAAAAGG

Product: aspartate kinase

Products: NA

Alternate protein names: Aspartate kinase [H]

Number of amino acids: Translated: 427; Mature: 427

Protein sequence:

>427_residues
MRKWEHGSNTANGVGIMALIVQKYGGTSVGTIERIKNVADRVIKEYKSGNKLVVVVSAMGDTTDKLIKLMKGVTSDPDPR
EADMLLTTGEQVSIALLTMAIQERGYPAISLTGSQVQIKTNDHHNKAEILGVDNNRLIEELDQGKIVVVAGFQGINSNND
FTTLGRGGSDTTAVALAASLGAERCEIYSDVEGIYTTDPRVVPEAVKLDYISYNEMLELAHLGAKVLHPRSVELAKAYNL
KLYIASSFNYKPGTVVKGVDDMEKRRSVTGVTCEKDEVKVTVQKVPDRPGVAGKIFKELARYNINVDMIIQNLQYDNRND
ITFTINKEDLIKCKKVIYRIAEELNAGGVEIDTRVAKVSIVGAGMISTPGIAGKMFEIMGNENINIQMITTSDIKISCLI
RENQAEKALKTLHRQFELGNITQKQAR

Sequences:

>Translated_427_residues
MRKWEHGSNTANGVGIMALIVQKYGGTSVGTIERIKNVADRVIKEYKSGNKLVVVVSAMGDTTDKLIKLMKGVTSDPDPR
EADMLLTTGEQVSIALLTMAIQERGYPAISLTGSQVQIKTNDHHNKAEILGVDNNRLIEELDQGKIVVVAGFQGINSNND
FTTLGRGGSDTTAVALAASLGAERCEIYSDVEGIYTTDPRVVPEAVKLDYISYNEMLELAHLGAKVLHPRSVELAKAYNL
KLYIASSFNYKPGTVVKGVDDMEKRRSVTGVTCEKDEVKVTVQKVPDRPGVAGKIFKELARYNINVDMIIQNLQYDNRND
ITFTINKEDLIKCKKVIYRIAEELNAGGVEIDTRVAKVSIVGAGMISTPGIAGKMFEIMGNENINIQMITTSDIKISCLI
RENQAEKALKTLHRQFELGNITQKQAR
>Mature_427_residues
MRKWEHGSNTANGVGIMALIVQKYGGTSVGTIERIKNVADRVIKEYKSGNKLVVVVSAMGDTTDKLIKLMKGVTSDPDPR
EADMLLTTGEQVSIALLTMAIQERGYPAISLTGSQVQIKTNDHHNKAEILGVDNNRLIEELDQGKIVVVAGFQGINSNND
FTTLGRGGSDTTAVALAASLGAERCEIYSDVEGIYTTDPRVVPEAVKLDYISYNEMLELAHLGAKVLHPRSVELAKAYNL
KLYIASSFNYKPGTVVKGVDDMEKRRSVTGVTCEKDEVKVTVQKVPDRPGVAGKIFKELARYNINVDMIIQNLQYDNRND
ITFTINKEDLIKCKKVIYRIAEELNAGGVEIDTRVAKVSIVGAGMISTPGIAGKMFEIMGNENINIQMITTSDIKISCLI
RENQAEKALKTLHRQFELGNITQKQAR

Specific function: Catalyzes 2 nonconsecutive reactions in the common biosynthetic pathway leading from Asp to diaminopimelate and Lys, to Met, and to Thr and Ile. [C]

COG id: COG0527

COG function: function code E; Aspartokinases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 ACT domains [H]

Homologues:

Organism=Escherichia coli, GI1786183, Length=463, Percent_Identity=26.7818574514039, Blast_Score=156, Evalue=2e-39,
Organism=Escherichia coli, GI1790455, Length=453, Percent_Identity=27.5938189845475, Blast_Score=122, Evalue=4e-29,
Organism=Escherichia coli, GI1790376, Length=453, Percent_Identity=24.0618101545254, Blast_Score=99, Evalue=5e-22,
Organism=Saccharomyces cerevisiae, GI6320893, Length=424, Percent_Identity=28.7735849056604, Blast_Score=119, Evalue=1e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR001048
- InterPro:   IPR005260
- InterPro:   IPR001341
- InterPro:   IPR018042 [H]

Pfam domain/function: PF00696 AA_kinase; PF01842 ACT [H]

EC number: =2.7.2.4 [H]

Molecular weight: Translated: 46894; Mature: 46894

Theoretical pI: Translated: 7.95; Mature: 7.95

Prosite motif: PS00324 ASPARTOKINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRKWEHGSNTANGVGIMALIVQKYGGTSVGTIERIKNVADRVIKEYKSGNKLVVVVSAMG
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECC
DTTDKLIKLMKGVTSDPDPREADMLLTTGEQVSIALLTMAIQERGYPAISLTGSQVQIKT
CCHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCEEEEECCEEEEEE
NDHHNKAEILGVDNNRLIEELDQGKIVVVAGFQGINSNNDFTTLGRGGSDTTAVALAASL
CCCCCCEEEEECCCCHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHC
GAERCEIYSDVEGIYTTDPRVVPEAVKLDYISYNEMLELAHLGAKVLHPRSVELAKAYNL
CHHHHHHHHCCCCEEECCCCCCCHHHEEEEECHHHHHHHHHHCHHHCCCCCEEEEEEEEE
KLYIASSFNYKPGTVVKGVDDMEKRRSVTGVTCEKDEVKVTVQKVPDRPGVAGKIFKELA
EEEEEECCCCCCCCEECCCHHHHHHCCCCCEEECCCCEEEEEEECCCCCCCHHHHHHHHH
RYNINVDMIIQNLQYDNRNDITFTINKEDLIKCKKVIYRIAEELNAGGVEIDTRVAKVSI
HHCCCHHEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEECEEEEEEE
VGAGMISTPGIAGKMFEIMGNENINIQMITTSDIKISCLIRENQAEKALKTLHRQFELGN
EECCCCCCCCCCHHHHHEECCCCEEEEEEEECCEEEEEEEECCHHHHHHHHHHHHHHCCC
ITQKQAR
CCHHHCC
>Mature Secondary Structure
MRKWEHGSNTANGVGIMALIVQKYGGTSVGTIERIKNVADRVIKEYKSGNKLVVVVSAMG
CCCCCCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEEEECC
DTTDKLIKLMKGVTSDPDPREADMLLTTGEQVSIALLTMAIQERGYPAISLTGSQVQIKT
CCHHHHHHHHHCCCCCCCCCCCCEEEECCCCHHHHHHHHHHHHCCCCEEEEECCEEEEEE
NDHHNKAEILGVDNNRLIEELDQGKIVVVAGFQGINSNNDFTTLGRGGSDTTAVALAASL
CCCCCCEEEEECCCCHHHHHHCCCCEEEEEECCCCCCCCCEEEECCCCCCHHHHHHHHHC
GAERCEIYSDVEGIYTTDPRVVPEAVKLDYISYNEMLELAHLGAKVLHPRSVELAKAYNL
CHHHHHHHHCCCCEEECCCCCCCHHHEEEEECHHHHHHHHHHCHHHCCCCCEEEEEEEEE
KLYIASSFNYKPGTVVKGVDDMEKRRSVTGVTCEKDEVKVTVQKVPDRPGVAGKIFKELA
EEEEEECCCCCCCCEECCCHHHHHHCCCCCEEECCCCEEEEEEECCCCCCCHHHHHHHHH
RYNINVDMIIQNLQYDNRNDITFTINKEDLIKCKKVIYRIAEELNAGGVEIDTRVAKVSI
HHCCCHHEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHHHHHHCCCCEEEECEEEEEEE
VGAGMISTPGIAGKMFEIMGNENINIQMITTSDIKISCLIRENQAEKALKTLHRQFELGN
EECCCCCCCCCCHHHHHEECCCCEEEEEEEECCEEEEEEEECCHHHHHHHHHHHHHHCCC
ITQKQAR
CCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]