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The map label for this gene is lysA [H]

Identifier: 220931558

GI number: 220931558

Start: 772043

End: 773389

Strand: Direct

Name: lysA [H]

Synonym: Hore_07140

Alternate gene names: 220931558

Gene position: 772043-773389 (Clockwise)

Preceding gene: 220931557

Following gene: 220931559

Centisome position: 29.95

GC content: 39.79

Gene sequence:

>1347_bases
TTGAGGTTGTATGGAACCATGGAAATTAGTAATTCAGGGGTACTTCATATCGGAGGTATTAGTACAGTAGACCTTGTTGA
AAAATATGGGACTCCCCTCCTTGTTTTTGATGAGTGGGAGATCCGTAAAAAGGCCCGTGAATATGTAAAAGCCTTTAATA
AATATTACCCCAACTCCAGGACAGTCTATGCCAGTAAGGCTTTTTTAAACCAGGCTTTATGTTATATTATTGAAGAAGAA
GGACTGGGGTTAGATGTAGTTTCAGGGGGTGAGTTATATATTGCCCTCAAAGCAGGATTTCCACCTGAAAAAATCTTTTT
CCATGGTAATAATAAGTCAAATGCTGAAATTAAAATGGCAGTTGAGGCCGGTATAGGACGTTTTATGCTGGATAATTTAA
AAGAAGCCAGATATATTAATAAAGTGGCCGGTAGACTGGAGAAAAGTATCAAGGCCATTTTACGGGTTACCCCGGGAATT
GAGGCCCATACCCATGAATTTATCCAGACCGGTCAGATAGATTCAAAGTTTGGAGTAAGTGTTTACCGGGATCAGGCTTT
AAAAGCAATTGAAGAGATAATAAGAATGGATAATATAGAACTGACGGGAGTTCATGTTCACATTGGTTCACAGATTTTTA
ATTTAACTTCCTTTAGCAGGACTATAGATGTTATGTTTGAATTTATGAATAATGTCAGGGATAAAACCGGGTATATCTTA
AAAGAACTGGATCTGGGAGGAGGTCTGGGTATACCATATACTGAGGATGAACCTGATCCCGGTATTGATGAATATGCCAG
ACTGGTTTCAGAGAAAGTCAGAGAAAAAAGTCATGAATTTGATTATCCACTCCCGGTAATTATTAACGAACCCGGCAGAT
CTATAATCGGTACAGCCGGAACTACTTTATATACGGTAGGGACGGTAAAGGAGATACCCTTTATCCGGAAATACCTCGCT
GTAGATGGAGGTATGACCGATAATATTAGACCAGCCCTTTATGGGGCAGAATATGATGCTATTTTAGCCAACCGGGCCGA
TGATGAACGGGAAGAGATTGTTTCCATTGCCGGTAAATGCTGTGAATCAGGTGATATTCTTATTCATGATATTAAAATGC
CGGAAGCCAGGGAAGGAGACATTATAGCAATTCCCTGTACAGGGGCCTACACTTATGCCATGTCAAGTAACTATAATGGA
TTAAGGAGACCGGCAGTGGTTCTTGTCAATGATGGGAATGCAGACCTGATAATTAAGCGAGAATCCTATGAGGATCTGAT
AAAAAATGATATAGTCCCGGCTCGATTGCGAAAAATAAAACTAAAAAAAGTTGTTTCCCATGGCTAG

Upstream 100 bases:

>100_bases
ATATACGGTTTGACTTTTGAATATAAATATGTTATGCTGGTAAAAATTAATTCAGTCAGGTAACTTATATGGTATTTATT
AGAGAAGGGAGCTGAGTAGG

Downstream 100 bases:

>100_bases
AAATTTATCGGACCACCGGTTTTTACCGGTGGTTTTTTTATGTTTTTTATGAATAAATATACATAATCGGGGATTTAAAG
TATGGTATAATAATGGTGGA

Product: diaminopimelate decarboxylase

Products: NA

Alternate protein names: DAP decarboxylase [H]

Number of amino acids: Translated: 448; Mature: 448

Protein sequence:

>448_residues
MRLYGTMEISNSGVLHIGGISTVDLVEKYGTPLLVFDEWEIRKKAREYVKAFNKYYPNSRTVYASKAFLNQALCYIIEEE
GLGLDVVSGGELYIALKAGFPPEKIFFHGNNKSNAEIKMAVEAGIGRFMLDNLKEARYINKVAGRLEKSIKAILRVTPGI
EAHTHEFIQTGQIDSKFGVSVYRDQALKAIEEIIRMDNIELTGVHVHIGSQIFNLTSFSRTIDVMFEFMNNVRDKTGYIL
KELDLGGGLGIPYTEDEPDPGIDEYARLVSEKVREKSHEFDYPLPVIINEPGRSIIGTAGTTLYTVGTVKEIPFIRKYLA
VDGGMTDNIRPALYGAEYDAILANRADDEREEIVSIAGKCCESGDILIHDIKMPEAREGDIIAIPCTGAYTYAMSSNYNG
LRRPAVVLVNDGNADLIIKRESYEDLIKNDIVPARLRKIKLKKVVSHG

Sequences:

>Translated_448_residues
MRLYGTMEISNSGVLHIGGISTVDLVEKYGTPLLVFDEWEIRKKAREYVKAFNKYYPNSRTVYASKAFLNQALCYIIEEE
GLGLDVVSGGELYIALKAGFPPEKIFFHGNNKSNAEIKMAVEAGIGRFMLDNLKEARYINKVAGRLEKSIKAILRVTPGI
EAHTHEFIQTGQIDSKFGVSVYRDQALKAIEEIIRMDNIELTGVHVHIGSQIFNLTSFSRTIDVMFEFMNNVRDKTGYIL
KELDLGGGLGIPYTEDEPDPGIDEYARLVSEKVREKSHEFDYPLPVIINEPGRSIIGTAGTTLYTVGTVKEIPFIRKYLA
VDGGMTDNIRPALYGAEYDAILANRADDEREEIVSIAGKCCESGDILIHDIKMPEAREGDIIAIPCTGAYTYAMSSNYNG
LRRPAVVLVNDGNADLIIKRESYEDLIKNDIVPARLRKIKLKKVVSHG
>Mature_448_residues
MRLYGTMEISNSGVLHIGGISTVDLVEKYGTPLLVFDEWEIRKKAREYVKAFNKYYPNSRTVYASKAFLNQALCYIIEEE
GLGLDVVSGGELYIALKAGFPPEKIFFHGNNKSNAEIKMAVEAGIGRFMLDNLKEARYINKVAGRLEKSIKAILRVTPGI
EAHTHEFIQTGQIDSKFGVSVYRDQALKAIEEIIRMDNIELTGVHVHIGSQIFNLTSFSRTIDVMFEFMNNVRDKTGYIL
KELDLGGGLGIPYTEDEPDPGIDEYARLVSEKVREKSHEFDYPLPVIINEPGRSIIGTAGTTLYTVGTVKEIPFIRKYLA
VDGGMTDNIRPALYGAEYDAILANRADDEREEIVSIAGKCCESGDILIHDIKMPEAREGDIIAIPCTGAYTYAMSSNYNG
LRRPAVVLVNDGNADLIIKRESYEDLIKNDIVPARLRKIKLKKVVSHG

Specific function: Lysine biosynthesis; last step. [C]

COG id: COG0019

COG function: function code E; Diaminopimelate decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-II family [H]

Homologues:

Organism=Homo sapiens, GI4505489, Length=420, Percent_Identity=25.7142857142857, Blast_Score=96, Evalue=6e-20,
Organism=Homo sapiens, GI16506287, Length=378, Percent_Identity=23.5449735449735, Blast_Score=66, Evalue=7e-11,
Organism=Escherichia coli, GI1789203, Length=422, Percent_Identity=30.0947867298578, Blast_Score=147, Evalue=1e-36,
Organism=Drosophila melanogaster, GI24586472, Length=375, Percent_Identity=22.6666666666667, Blast_Score=75, Evalue=7e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009006
- InterPro:   IPR002986
- InterPro:   IPR022643
- InterPro:   IPR022657
- InterPro:   IPR022644
- InterPro:   IPR022653
- InterPro:   IPR000183 [H]

Pfam domain/function: PF02784 Orn_Arg_deC_N; PF00278 Orn_DAP_Arg_deC [H]

EC number: =4.1.1.20 [H]

Molecular weight: Translated: 49988; Mature: 49988

Theoretical pI: Translated: 5.72; Mature: 5.72

Prosite motif: PS00879 ODR_DC_2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLYGTMEISNSGVLHIGGISTVDLVEKYGTPLLVFDEWEIRKKAREYVKAFNKYYPNSR
CCEEEEEEECCCCEEEECCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCC
TVYASKAFLNQALCYIIEEEGLGLDVVSGGELYIALKAGFPPEKIFFHGNNKSNAEIKMA
EEEEHHHHHHHHEEEEECCCCCCEEEECCCEEEEEEECCCCCCEEEEECCCCCCCEEEEE
VEAGIGRFMLDNLKEARYINKVAGRLEKSIKAILRVTPGIEAHTHEFIQTGQIDSKFGVS
EHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHH
VYRDQALKAIEEIIRMDNIELTGVHVHIGSQIFNLTSFSRTIDVMFEFMNNVRDKTGYIL
HHHHHHHHHHHHHHHHCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
KELDLGGGLGIPYTEDEPDPGIDEYARLVSEKVREKSHEFDYPLPVIINEPGRSIIGTAG
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEECCC
TTLYTVGTVKEIPFIRKYLAVDGGMTDNIRPALYGAEYDAILANRADDEREEIVSIAGKC
CEEEEECCHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHCCCCCCHHHHHHHHHHHHH
CESGDILIHDIKMPEAREGDIIAIPCTGAYTYAMSSNYNGLRRPAVVLVNDGNADLIIKR
CCCCCEEEEEECCCCCCCCCEEEEECCCEEEEEEECCCCCCCCCEEEEEECCCCEEEEEC
ESYEDLIKNDIVPARLRKIKLKKVVSHG
CCHHHHHHCCCCHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRLYGTMEISNSGVLHIGGISTVDLVEKYGTPLLVFDEWEIRKKAREYVKAFNKYYPNSR
CCEEEEEEECCCCEEEECCCCHHHHHHHHCCCEEEECCHHHHHHHHHHHHHHHHHCCCCC
TVYASKAFLNQALCYIIEEEGLGLDVVSGGELYIALKAGFPPEKIFFHGNNKSNAEIKMA
EEEEHHHHHHHHEEEEECCCCCCEEEECCCEEEEEEECCCCCCEEEEECCCCCCCEEEEE
VEAGIGRFMLDNLKEARYINKVAGRLEKSIKAILRVTPGIEAHTHEFIQTGQIDSKFGVS
EHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHH
VYRDQALKAIEEIIRMDNIELTGVHVHIGSQIFNLTSFSRTIDVMFEFMNNVRDKTGYIL
HHHHHHHHHHHHHHHHCCEEEEEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHCCCEE
KELDLGGGLGIPYTEDEPDPGIDEYARLVSEKVREKSHEFDYPLPVIINEPGRSIIGTAG
EEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCEEECCCCCEEEECCC
TTLYTVGTVKEIPFIRKYLAVDGGMTDNIRPALYGAEYDAILANRADDEREEIVSIAGKC
CEEEEECCHHHHHHHHHHHHHCCCCCCCCCCEEECCCHHHHCCCCCCHHHHHHHHHHHHH
CESGDILIHDIKMPEAREGDIIAIPCTGAYTYAMSSNYNGLRRPAVVLVNDGNADLIIKR
CCCCCEEEEEECCCCCCCCCEEEEECCCEEEEEEECCCCCCCCCEEEEEECCCCEEEEEC
ESYEDLIKNDIVPARLRKIKLKKVVSHG
CCHHHHHHCCCCHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2513554; 7934829; 1368705; 8969508; 9384377 [H]