Click here to switch to the map view.

The map label for this gene is pdp [H]

Identifier: 220931541

GI number: 220931541

Start: 756186

End: 757490

Strand: Direct

Name: pdp [H]

Synonym: Hore_06970

Alternate gene names: 220931541

Gene position: 756186-757490 (Clockwise)

Preceding gene: 220931540

Following gene: 220931542

Centisome position: 29.33

GC content: 40.31

Gene sequence:

>1305_bases
ATGAGAGCATATGATATCATTTATAAAAAAAGGGAAGGTTTTAAATTATCAAAAGAGGAAATAGATTTTTTAATTCAGGA
ATATACCCGTGGTCAAATACCAGACTATCAAATGTCAGCCTGGGCTATGGCTGTTTTCTTCAAAGGTATGGATTCTGAAG
AAACTTCACACCTGACAATGGCTATGGCTAAATCCGGGGATATTATTGATTTGAGTGAAATTCGTGGAATAAAAGTAGAT
AAACATAGTAGTGGTGGTGTTGGTGATACGACTACTCTGGTTCTGGCGCCGCTGGTTGCTGCTGCCGGAATTCCTGTTGC
CAAGATGTCCGGGCGGGGTCTGGGTCATACCGGAGGTACTATTGATAAACTGGAATCTATTCCTGGATTTAAAACAGAGC
TTGATCGTCGAGATTTTATAAATATCGTTAATTCTACTGGTGTTGCTGTGGCCGGTCAAACCGGTAATCTGACTCCTGCT
GACAAAAAGCTATACAGTTTAAGGGATGTAACAGCAACAGTTGATTCTATACCCCTGATAGCCAGCAGTATAATGAGTAA
GAAGATTGCCGGAGGGGCCGATGGTATTGTCCTTGATGTTAAAACAGGCCGTGGTGCCTTTATGGAAAACCTGGAAGATG
CCAGGAAACTGGCCCGGGCTATGGTTGAAATAGGGAGACAGGTCCAGAGAAAAACTATAGCAGTGATAACAGATATGAAT
CAGCCTCTGGGATATGCCGTAGGTAATGCCCTTGAAGTGAAAGAGGCTATTGACACCCTTGGGGGACATGGGCCTGAGGA
TTTAGAGGAATTATGCCTGACCCTGGGGGCTAATATGCTTGTAATTGGTGAAAAGGCCACTGATTTTGAAGAAGGGTATA
ATAAATTAAAGGACCTGATTGAGACCGGTAAAGCCCTTGAAAAGTTTAAAGAGTTTATAAAGGCTCAAAAAGGAAATCCT
GATGTAGTTGATAATAAAGAACTATTACCCCGGGCCAATAATATAATAGCTGTTAAAGCCAATAATGATGGCTATGTCCA
GCAGATAGATGCCAGAGAGATTGGACTAACTGTTATGTCTTTAGGTGGAGGACGGGAGAAAAAAGGTGACCGGATCGATC
CTGCTGTTGGTATTGTTCTGAAGAAAAAAATGGGTGATAAGGTGAATAAAGATGAACTACTTGCAGAAATACATATTAAT
GATACTACAAACAGTGAAGAAGTAAAAGAAAGAGTTCAAAAAGCTATAATTATAGGCCAGGAAAAGAATAAAAGAAACAA
GTTAATTTATGAGATAATCGAATAA

Upstream 100 bases:

>100_bases
CCTCTCTCTCATGATGATGTTATGGAGATTTCAAGTAAGGTTAAACCTAAATTTATAAACCTGGTTAGAGGGATATTAGA
AGAAATGTAGGGGGGGTATC

Downstream 100 bases:

>100_bases
TTACTTTAAAACAATACCTGTCCCTCCTGCATAAACCCCGAGATTAGGTAATAAATATCTACTATAAGGGTAAAGGAGGG
ACTATATATATGTTTTGCAG

Product: thymidine phosphorylase

Products: NA

Alternate protein names: PYNP [H]

Number of amino acids: Translated: 434; Mature: 434

Protein sequence:

>434_residues
MRAYDIIYKKREGFKLSKEEIDFLIQEYTRGQIPDYQMSAWAMAVFFKGMDSEETSHLTMAMAKSGDIIDLSEIRGIKVD
KHSSGGVGDTTTLVLAPLVAAAGIPVAKMSGRGLGHTGGTIDKLESIPGFKTELDRRDFINIVNSTGVAVAGQTGNLTPA
DKKLYSLRDVTATVDSIPLIASSIMSKKIAGGADGIVLDVKTGRGAFMENLEDARKLARAMVEIGRQVQRKTIAVITDMN
QPLGYAVGNALEVKEAIDTLGGHGPEDLEELCLTLGANMLVIGEKATDFEEGYNKLKDLIETGKALEKFKEFIKAQKGNP
DVVDNKELLPRANNIIAVKANNDGYVQQIDAREIGLTVMSLGGGREKKGDRIDPAVGIVLKKKMGDKVNKDELLAEIHIN
DTTNSEEVKERVQKAIIIGQEKNKRNKLIYEIIE

Sequences:

>Translated_434_residues
MRAYDIIYKKREGFKLSKEEIDFLIQEYTRGQIPDYQMSAWAMAVFFKGMDSEETSHLTMAMAKSGDIIDLSEIRGIKVD
KHSSGGVGDTTTLVLAPLVAAAGIPVAKMSGRGLGHTGGTIDKLESIPGFKTELDRRDFINIVNSTGVAVAGQTGNLTPA
DKKLYSLRDVTATVDSIPLIASSIMSKKIAGGADGIVLDVKTGRGAFMENLEDARKLARAMVEIGRQVQRKTIAVITDMN
QPLGYAVGNALEVKEAIDTLGGHGPEDLEELCLTLGANMLVIGEKATDFEEGYNKLKDLIETGKALEKFKEFIKAQKGNP
DVVDNKELLPRANNIIAVKANNDGYVQQIDAREIGLTVMSLGGGREKKGDRIDPAVGIVLKKKMGDKVNKDELLAEIHIN
DTTNSEEVKERVQKAIIIGQEKNKRNKLIYEIIE
>Mature_434_residues
MRAYDIIYKKREGFKLSKEEIDFLIQEYTRGQIPDYQMSAWAMAVFFKGMDSEETSHLTMAMAKSGDIIDLSEIRGIKVD
KHSSGGVGDTTTLVLAPLVAAAGIPVAKMSGRGLGHTGGTIDKLESIPGFKTELDRRDFINIVNSTGVAVAGQTGNLTPA
DKKLYSLRDVTATVDSIPLIASSIMSKKIAGGADGIVLDVKTGRGAFMENLEDARKLARAMVEIGRQVQRKTIAVITDMN
QPLGYAVGNALEVKEAIDTLGGHGPEDLEELCLTLGANMLVIGEKATDFEEGYNKLKDLIETGKALEKFKEFIKAQKGNP
DVVDNKELLPRANNIIAVKANNDGYVQQIDAREIGLTVMSLGGGREKKGDRIDPAVGIVLKKKMGDKVNKDELLAEIHIN
DTTNSEEVKERVQKAIIIGQEKNKRNKLIYEIIE

Specific function: The Enzymes Which Catalyze The Reversible Phosphorolysis Of Pyrimidine Nucleosides Are Involved In The Degradation Of These Compounds And In Their Utilization As Carbon And Energy Sources, Or In The Rescue Of Pyrimidine Bases For Nucleotide Synthesis. [C

COG id: COG0213

COG function: function code F; Thymidine phosphorylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family [H]

Homologues:

Organism=Homo sapiens, GI166158925, Length=424, Percent_Identity=38.6792452830189, Blast_Score=281, Evalue=6e-76,
Organism=Homo sapiens, GI4503445, Length=424, Percent_Identity=38.6792452830189, Blast_Score=281, Evalue=6e-76,
Organism=Homo sapiens, GI166158922, Length=424, Percent_Identity=38.6792452830189, Blast_Score=281, Evalue=6e-76,
Organism=Escherichia coli, GI1790842, Length=409, Percent_Identity=45.9657701711491, Blast_Score=339, Evalue=2e-94,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000312
- InterPro:   IPR017459
- InterPro:   IPR020072
- InterPro:   IPR013102
- InterPro:   IPR018090
- InterPro:   IPR000053
- InterPro:   IPR017872 [H]

Pfam domain/function: PF02885 Glycos_trans_3N; PF00591 Glycos_transf_3; PF07831 PYNP_C [H]

EC number: =2.4.2.2 [H]

Molecular weight: Translated: 47277; Mature: 47277

Theoretical pI: Translated: 5.86; Mature: 5.86

Prosite motif: PS00647 THYMID_PHOSPHORYLASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAYDIIYKKREGFKLSKEEIDFLIQEYTRGQIPDYQMSAWAMAVFFKGMDSEETSHLTM
CCCHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHEEE
AMAKSGDIIDLSEIRGIKVDKHSSGGVGDTTTLVLAPLVAAAGIPVAKMSGRGLGHTGGT
EECCCCCEEEHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCC
IDKLESIPGFKTELDRRDFINIVNSTGVAVAGQTGNLTPADKKLYSLRDVTATVDSIPLI
HHHHHCCCCCHHHCCHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ASSIMSKKIAGGADGIVLDVKTGRGAFMENLEDARKLARAMVEIGRQVQRKTIAVITDMN
HHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCC
QPLGYAVGNALEVKEAIDTLGGHGPEDLEELCLTLGANMLVIGEKATDFEEGYNKLKDLI
CCCHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHH
ETGKALEKFKEFIKAQKGNPDVVDNKELLPRANNIIAVKANNDGYVQQIDAREIGLTVMS
HHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCEEEEEECCCCCEEEECHHHHCEEEEE
LGGGREKKGDRIDPAVGIVLKKKMGDKVNKDELLAEIHINDTTNSEEVKERVQKAIIIGQ
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHEEECC
EKNKRNKLIYEIIE
CCCCCHHHHHHCCC
>Mature Secondary Structure
MRAYDIIYKKREGFKLSKEEIDFLIQEYTRGQIPDYQMSAWAMAVFFKGMDSEETSHLTM
CCCHHHHEECCCCCCCCHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCCHHEEE
AMAKSGDIIDLSEIRGIKVDKHSSGGVGDTTTLVLAPLVAAAGIPVAKMSGRGLGHTGGT
EECCCCCEEEHHHCCCEEEECCCCCCCCCHHHHHHHHHHHHCCCCEEECCCCCCCCCCCC
IDKLESIPGFKTELDRRDFINIVNSTGVAVAGQTGNLTPADKKLYSLRDVTATVDSIPLI
HHHHHCCCCCHHHCCHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ASSIMSKKIAGGADGIVLDVKTGRGAFMENLEDARKLARAMVEIGRQVQRKTIAVITDMN
HHHHHHHHHCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEECCC
QPLGYAVGNALEVKEAIDTLGGHGPEDLEELCLTLGANMLVIGEKATDFEEGYNKLKDLI
CCCHHHHCCHHHHHHHHHHHCCCCHHHHHHHHHHHCCCEEEECCCCCCHHHHHHHHHHHH
ETGKALEKFKEFIKAQKGNPDVVDNKELLPRANNIIAVKANNDGYVQQIDAREIGLTVMS
HHHHHHHHHHHHHHHCCCCCCCCCCHHHCCCCCCEEEEEECCCCCEEEECHHHHCEEEEE
LGGGREKKGDRIDPAVGIVLKKKMGDKVNKDELLAEIHINDTTNSEEVKERVQKAIIIGQ
CCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHEEECC
EKNKRNKLIYEIIE
CCCCCHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8987664; 9817849 [H]