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The map label for this gene is dxs

Identifier: 220931497

GI number: 220931497

Start: 707818

End: 709728

Strand: Direct

Name: dxs

Synonym: Hore_06530

Alternate gene names: 220931497

Gene position: 707818-709728 (Clockwise)

Preceding gene: 220931496

Following gene: 220931498

Centisome position: 27.45

GC content: 39.72

Gene sequence:

>1911_bases
ATGGGCAATATATTTGATAAAGTTAATTCCCCTGAGGATTTGAAATCCTTAAATATTGAGGACCTCAACAGTCTTGCCCA
GGAAGTTAGAAAGTTTATTATTGAAACAGTGGCAGATACAGGGGGCCATCTTGCTTCCAACCTTGGTGTTGTTGAACTGA
CGCTGGCTCTGCATTATCATTTGAACAGTCCCAAGGATAAAATAATCTGGGATGTCGGTCACCAGTCTTATACCCATAAA
ATACTGACCGGTCGCAAAAAAAAATTTCATACTATAAGACAGTATAAGGGACTAAGTGGTTTTCCAAAGTATAGTGAAAG
TATTCATGACGTTATAGAGACAGGTCATAGTAGCACATCGATATCTGCAGCCCTGGGTCTGGCCCTGGCCAGGGATTTAA
AGAACAGAAATGACAGGATATATGCAGTAATTGGTGATGGTGCTCTGACGGGTGGAATGGCCTTTGAAGCCCTCAACCAT
GCCGGGCACCTGGGAACGGATATTAAGGTTGTATTGAATGATAATGCAATGTCTATATCTAAAAATGTAGGTGCCCTTTC
TCATTATTTATCCCGGATTAGAACAGATCCGACTCTGAGTAAATTTAAAGATGATGTTGAGGTTTTATTGAGCCGCATTC
CTAAAATTGGTAATACTGTTTCCCGGAGTGTGGAAAGAGTAAAGGATGGATTAAAGTATTTATTCCTATCCGGGGTGCTC
TTTGAGGAAATGGGCTTTACTTATATGGGGCCCCTTGATGGCCATAATATACAGGAATTAATTACAAACTTCAAGAATGC
AGACAACATTAAGGGACCGGTTTTAATACATGTTAATACCAAAAAAGGTAAAGGGTATAAACCTGCTGAAAGTCAGCCAA
GTAAGTTTCATGGGGTAAGCCCTTTCAAAATTGATAATGGTGAAAGTAAGCGGAAAAAAAGTAATTTCACCTATAGTCAG
GTATTTGGACAGACCATGGTTAAACTGGGTAATAAAGATAAAAAAATAGTTGGCATTACTGCAGCTATGCCTGAAGGAAC
GGGTTTAAGTTACTTCAAAAAAGAATTTCCTGATAGATTTTTTGATGTTGGCATCGCTGAACAGCATGCGGTGACCCTGG
CCACTGGAATGGCCCGGGCGGGTATGAAACCGGTTGTGGCCATATATTCTACCTTTTTGCAAAGGGCATATGATCAGGTT
ATACATGATGCCTGTATTCAAAATTTACCTGTTACTTTTGCCATTGACAGGGCGGGAATAGTTGGTGCTGATGGGGAAAC
CCACCATGGCCTGTTTGATTTATCATTTCTTAGAGCAATTCCAAATATTATAATTATGGCTCCGAAAAATGAAAATGAAC
TACAGCATATGATCTATACAGCTATAAATAATGACCAACCGGTAGCTATCAGATATCCACGGGGTGAAGGCTATGGAGTA
GAACTTGATAATGATTTTTCAACTATACCGATTGGCAAAGGTGAGCTCCTATGTGATGGAAAAGATGTTTTAATTATTGC
AGTAGGCTCACGGGTTTATCCGGCTATGGAAGCAGCCAGAGTGTTGAGCCAACAGGGAATAAAGGCAGCTGTTATAAACG
CCAGATTTATAAAACCTCTGGATAAAAATTTAATATTAAACAAAATAAATGAATGTAAAAAGGTTATTACAGTCGAAGAG
CATGCTTTAAAAGGAGGATTTGGTTCAGCCATCCTTGAATTTATTAATGAAAATGACCTGAGAGGAATAAAGGTCAAGAG
ATTGGGATTGCCTGACCGCTTTTTGCCCCATGGACCTACCGGCCATCTCCAGACAATTTATCATATAGACAAAAATGCGA
TTATAGAATCTGCCTTAAAGTTAGTTGACGAAAGGGTGGAATTAGGTCTATGGCCCGGAAAAAACGCCTAG

Upstream 100 bases:

>100_bases
TAAAGAAGGCCGATGAGATTATTTTTTTTGTAGGTAAGATACTGGCAGGTTTAAGTCTTGTGAAACGAAGGGTCATTAAC
AAAATAAGAGGTGACTTATA

Downstream 100 bases:

>100_bases
ATATTTTATTAACAGATAAGGGTTTTTTTGAAACAAGAAGCCGGGCTAAAAGGGCAATAATGGCCGGAGATGTATTGGTT
AATGGTCAGCTGGAAACAAA

Product: deoxyxylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS

Number of amino acids: Translated: 636; Mature: 635

Protein sequence:

>636_residues
MGNIFDKVNSPEDLKSLNIEDLNSLAQEVRKFIIETVADTGGHLASNLGVVELTLALHYHLNSPKDKIIWDVGHQSYTHK
ILTGRKKKFHTIRQYKGLSGFPKYSESIHDVIETGHSSTSISAALGLALARDLKNRNDRIYAVIGDGALTGGMAFEALNH
AGHLGTDIKVVLNDNAMSISKNVGALSHYLSRIRTDPTLSKFKDDVEVLLSRIPKIGNTVSRSVERVKDGLKYLFLSGVL
FEEMGFTYMGPLDGHNIQELITNFKNADNIKGPVLIHVNTKKGKGYKPAESQPSKFHGVSPFKIDNGESKRKKSNFTYSQ
VFGQTMVKLGNKDKKIVGITAAMPEGTGLSYFKKEFPDRFFDVGIAEQHAVTLATGMARAGMKPVVAIYSTFLQRAYDQV
IHDACIQNLPVTFAIDRAGIVGADGETHHGLFDLSFLRAIPNIIIMAPKNENELQHMIYTAINNDQPVAIRYPRGEGYGV
ELDNDFSTIPIGKGELLCDGKDVLIIAVGSRVYPAMEAARVLSQQGIKAAVINARFIKPLDKNLILNKINECKKVITVEE
HALKGGFGSAILEFINENDLRGIKVKRLGLPDRFLPHGPTGHLQTIYHIDKNAIIESALKLVDERVELGLWPGKNA

Sequences:

>Translated_636_residues
MGNIFDKVNSPEDLKSLNIEDLNSLAQEVRKFIIETVADTGGHLASNLGVVELTLALHYHLNSPKDKIIWDVGHQSYTHK
ILTGRKKKFHTIRQYKGLSGFPKYSESIHDVIETGHSSTSISAALGLALARDLKNRNDRIYAVIGDGALTGGMAFEALNH
AGHLGTDIKVVLNDNAMSISKNVGALSHYLSRIRTDPTLSKFKDDVEVLLSRIPKIGNTVSRSVERVKDGLKYLFLSGVL
FEEMGFTYMGPLDGHNIQELITNFKNADNIKGPVLIHVNTKKGKGYKPAESQPSKFHGVSPFKIDNGESKRKKSNFTYSQ
VFGQTMVKLGNKDKKIVGITAAMPEGTGLSYFKKEFPDRFFDVGIAEQHAVTLATGMARAGMKPVVAIYSTFLQRAYDQV
IHDACIQNLPVTFAIDRAGIVGADGETHHGLFDLSFLRAIPNIIIMAPKNENELQHMIYTAINNDQPVAIRYPRGEGYGV
ELDNDFSTIPIGKGELLCDGKDVLIIAVGSRVYPAMEAARVLSQQGIKAAVINARFIKPLDKNLILNKINECKKVITVEE
HALKGGFGSAILEFINENDLRGIKVKRLGLPDRFLPHGPTGHLQTIYHIDKNAIIESALKLVDERVELGLWPGKNA
>Mature_635_residues
GNIFDKVNSPEDLKSLNIEDLNSLAQEVRKFIIETVADTGGHLASNLGVVELTLALHYHLNSPKDKIIWDVGHQSYTHKI
LTGRKKKFHTIRQYKGLSGFPKYSESIHDVIETGHSSTSISAALGLALARDLKNRNDRIYAVIGDGALTGGMAFEALNHA
GHLGTDIKVVLNDNAMSISKNVGALSHYLSRIRTDPTLSKFKDDVEVLLSRIPKIGNTVSRSVERVKDGLKYLFLSGVLF
EEMGFTYMGPLDGHNIQELITNFKNADNIKGPVLIHVNTKKGKGYKPAESQPSKFHGVSPFKIDNGESKRKKSNFTYSQV
FGQTMVKLGNKDKKIVGITAAMPEGTGLSYFKKEFPDRFFDVGIAEQHAVTLATGMARAGMKPVVAIYSTFLQRAYDQVI
HDACIQNLPVTFAIDRAGIVGADGETHHGLFDLSFLRAIPNIIIMAPKNENELQHMIYTAINNDQPVAIRYPRGEGYGVE
LDNDFSTIPIGKGELLCDGKDVLIIAVGSRVYPAMEAARVLSQQGIKAAVINARFIKPLDKNLILNKINECKKVITVEEH
ALKGGFGSAILEFINENDLRGIKVKRLGLPDRFLPHGPTGHLQTIYHIDKNAIIESALKLVDERVELGLWPGKNA

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP)

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily

Homologues:

Organism=Homo sapiens, GI205277463, Length=639, Percent_Identity=24.7261345852895, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI4507521, Length=639, Percent_Identity=24.7261345852895, Blast_Score=146, Evalue=6e-35,
Organism=Homo sapiens, GI133778974, Length=667, Percent_Identity=23.2383808095952, Blast_Score=124, Evalue=3e-28,
Organism=Homo sapiens, GI225637461, Length=419, Percent_Identity=26.2529832935561, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI225637459, Length=419, Percent_Identity=26.2529832935561, Blast_Score=108, Evalue=2e-23,
Organism=Homo sapiens, GI225637463, Length=419, Percent_Identity=26.2529832935561, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI156564403, Length=242, Percent_Identity=28.099173553719, Blast_Score=85, Evalue=2e-16,
Organism=Homo sapiens, GI291084858, Length=234, Percent_Identity=27.3504273504274, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI4557353, Length=280, Percent_Identity=22.5, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI34101272, Length=280, Percent_Identity=22.5, Blast_Score=76, Evalue=9e-14,
Organism=Escherichia coli, GI1786622, Length=615, Percent_Identity=47.9674796747967, Blast_Score=577, Evalue=1e-166,
Organism=Caenorhabditis elegans, GI17539652, Length=658, Percent_Identity=24.3161094224924, Blast_Score=120, Evalue=3e-27,
Organism=Caenorhabditis elegans, GI17538422, Length=291, Percent_Identity=25.4295532646048, Blast_Score=83, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6319698, Length=286, Percent_Identity=25.8741258741259, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI24666278, Length=641, Percent_Identity=25.585023400936, Blast_Score=144, Evalue=3e-34,
Organism=Drosophila melanogaster, GI45551847, Length=663, Percent_Identity=24.5852187028658, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI45550715, Length=663, Percent_Identity=24.5852187028658, Blast_Score=126, Evalue=4e-29,
Organism=Drosophila melanogaster, GI24645119, Length=568, Percent_Identity=24.8239436619718, Blast_Score=117, Evalue=2e-26,
Organism=Drosophila melanogaster, GI21358145, Length=293, Percent_Identity=25.938566552901, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI24650940, Length=293, Percent_Identity=25.938566552901, Blast_Score=86, Evalue=7e-17,
Organism=Drosophila melanogaster, GI160714832, Length=281, Percent_Identity=23.8434163701068, Blast_Score=75, Evalue=1e-13,
Organism=Drosophila melanogaster, GI160714828, Length=281, Percent_Identity=23.8434163701068, Blast_Score=75, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DXS_HALOH (B8D2I3)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002508405.1
- GeneID:   7314559
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_06530
- HOGENOM:   HBG571647
- OMA:   VSNTGGH
- ProtClustDB:   CLSK2806258
- HAMAP:   MF_00315
- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474
- Gene3D:   G3DSA:3.40.50.920
- SMART:   SM00861
- TIGRFAMs:   TIGR00204

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N; SSF52922 Transketo_C_like

EC number: =2.2.1.7

Molecular weight: Translated: 70038; Mature: 69906

Theoretical pI: Translated: 9.35; Mature: 9.35

Prosite motif: PS00801 TRANSKETOLASE_1; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGNIFDKVNSPEDLKSLNIEDLNSLAQEVRKFIIETVADTGGHLASNLGVVELTLALHYH
CCCHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEEEEE
LNSPKDKIIWDVGHQSYTHKILTGRKKKFHTIRQYKGLSGFPKYSESIHDVIETGHSSTS
CCCCCCCEEEECCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCH
ISAALGLALARDLKNRNDRIYAVIGDGALTGGMAFEALNHAGHLGTDIKVVLNDNAMSIS
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHH
KNVGALSHYLSRIRTDPTLSKFKDDVEVLLSRIPKIGNTVSRSVERVKDGLKYLFLSGVL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FEEMGFTYMGPLDGHNIQELITNFKNADNIKGPVLIHVNTKKGKGYKPAESQPSKFHGVS
HHHCCCEEECCCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
PFKIDNGESKRKKSNFTYSQVFGQTMVKLGNKDKKIVGITAAMPEGTGLSYFKKEFPDRF
CEEECCCCHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHCCHHH
FDVGIAEQHAVTLATGMARAGMKPVVAIYSTFLQRAYDQVIHDACIQNLPVTFAIDRAGI
HHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCE
VGADGETHHGLFDLSFLRAIPNIIIMAPKNENELQHMIYTAINNDQPVAIRYPRGEGYGV
ECCCCCCCCCHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCEE
ELDNDFSTIPIGKGELLCDGKDVLIIAVGSRVYPAMEAARVLSQQGIKAAVINARFIKPL
EECCCCCCCCCCCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEECHHHHCCC
DKNLILNKINECKKVITVEEHALKGGFGSAILEFINENDLRGIKVKRLGLPDRFLPHGPT
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCC
GHLQTIYHIDKNAIIESALKLVDERVELGLWPGKNA
CCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
GNIFDKVNSPEDLKSLNIEDLNSLAQEVRKFIIETVADTGGHLASNLGVVELTLALHYH
CCHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCEEEEEEEEEE
LNSPKDKIIWDVGHQSYTHKILTGRKKKFHTIRQYKGLSGFPKYSESIHDVIETGHSSTS
CCCCCCCEEEECCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCH
ISAALGLALARDLKNRNDRIYAVIGDGALTGGMAFEALNHAGHLGTDIKVVLNDNAMSIS
HHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHCCCCCCCEEEEECCCCHHHH
KNVGALSHYLSRIRTDPTLSKFKDDVEVLLSRIPKIGNTVSRSVERVKDGLKYLFLSGVL
HHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHH
FEEMGFTYMGPLDGHNIQELITNFKNADNIKGPVLIHVNTKKGKGYKPAESQPSKFHGVS
HHHCCCEEECCCCCCCHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCC
PFKIDNGESKRKKSNFTYSQVFGQTMVKLGNKDKKIVGITAAMPEGTGLSYFKKEFPDRF
CEEECCCCHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCCHHHHHHHCCHHH
FDVGIAEQHAVTLATGMARAGMKPVVAIYSTFLQRAYDQVIHDACIQNLPVTFAIDRAGI
HHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCE
VGADGETHHGLFDLSFLRAIPNIIIMAPKNENELQHMIYTAINNDQPVAIRYPRGEGYGV
ECCCCCCCCCHHHHHHHHHCCCEEEECCCCCHHHHHHHHHHCCCCCCEEEECCCCCCCEE
ELDNDFSTIPIGKGELLCDGKDVLIIAVGSRVYPAMEAARVLSQQGIKAAVINARFIKPL
EECCCCCCCCCCCCCEEECCCCEEEEEECCCHHHHHHHHHHHHHCCCEEEEECHHHHCCC
DKNLILNKINECKKVITVEEHALKGGFGSAILEFINENDLRGIKVKRLGLPDRFLPHGPT
HHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCC
GHLQTIYHIDKNAIIESALKLVDERVELGLWPGKNA
CCCEEEEEECHHHHHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA