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The map label for this gene is nuoE [H]

Identifier: 220931475

GI number: 220931475

Start: 680107

End: 680595

Strand: Direct

Name: nuoE [H]

Synonym: Hore_06310

Alternate gene names: 220931475

Gene position: 680107-680595 (Clockwise)

Preceding gene: 220931474

Following gene: 220931476

Centisome position: 26.38

GC content: 39.06

Gene sequence:

>489_bases
ATGGCTGTTAAGGAATTTGAAAATTGTAAAGACAGGTATTTAAAAAAGCTTGATGAGATTATATTGAAGTATAAGGATAA
GCCCGGTCCTTTGATTCCGGTTTTACATGAAGCCCAGGAGCTTTATGGTTACCTTCCTGAAGAGGTTCAGAGTTATATAG
CTGAAGGCCTGGGAGTCCCTGTAAGTAAAGTTTCAGGCGTTGTTAGTTTCTACTCATTCTTTACAACAAAACCCAAGGGC
GAGCATACTATCAACGTATGTATGGGTACTGCCTGTTATGTTAAGGGTGCTGAAGAAATTCTTAACAGGTTAAAAGAAGA
ACTCGGTATTGAAGAGGGAGAAACCAGTGAAGATGGTAAGTTTACGATGGTAGGTATGAGATGTCTTGGTGCCTGTAGTT
TAGCCCCGGTTGTAACAATTGATGACAAGGTTTATGGAAAAGTAACGCCCGAAAAAATGATGGAGATTATTGAATCCTAT
CGTAAATAA

Upstream 100 bases:

>100_bases
AATGGTGCCTGTAGGAGGCTGAAAGAAGAAGATTCTGTTAGTAGTATTTTTATTTTTAATTAGTTGTGTGAAATAATTCA
CTTCAAAGGGGGAATTTATA

Downstream 100 bases:

>100_bases
TATATTTTTTGATGTGATAAATATATCTTTCACAAACTTAATAATATCTGTTTTTAAGGAGGAAAATCGATGAAGAAATA
TACGATATGCGTCTGTGGGG

Product: NADH dehydrogenase (ubiquinone) 24 kDa subunit

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 162; Mature: 161

Protein sequence:

>162_residues
MAVKEFENCKDRYLKKLDEIILKYKDKPGPLIPVLHEAQELYGYLPEEVQSYIAEGLGVPVSKVSGVVSFYSFFTTKPKG
EHTINVCMGTACYVKGAEEILNRLKEELGIEEGETSEDGKFTMVGMRCLGACSLAPVVTIDDKVYGKVTPEKMMEIIESY
RK

Sequences:

>Translated_162_residues
MAVKEFENCKDRYLKKLDEIILKYKDKPGPLIPVLHEAQELYGYLPEEVQSYIAEGLGVPVSKVSGVVSFYSFFTTKPKG
EHTINVCMGTACYVKGAEEILNRLKEELGIEEGETSEDGKFTMVGMRCLGACSLAPVVTIDDKVYGKVTPEKMMEIIESY
RK
>Mature_161_residues
AVKEFENCKDRYLKKLDEIILKYKDKPGPLIPVLHEAQELYGYLPEEVQSYIAEGLGVPVSKVSGVVSFYSFFTTKPKGE
HTINVCMGTACYVKGAEEILNRLKEELGIEEGETSEDGKFTMVGMRCLGACSLAPVVTIDDKVYGKVTPEKMMEIIESYR
K

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=158, Percent_Identity=36.0759493670886, Blast_Score=107, Evalue=5e-24,
Organism=Escherichia coli, GI1788621, Length=138, Percent_Identity=35.5072463768116, Blast_Score=102, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17561328, Length=135, Percent_Identity=38.5185185185185, Blast_Score=110, Evalue=3e-25,
Organism=Drosophila melanogaster, GI18859877, Length=149, Percent_Identity=38.9261744966443, Blast_Score=116, Evalue=7e-27,
Organism=Drosophila melanogaster, GI21355353, Length=133, Percent_Identity=31.5789473684211, Blast_Score=91, Evalue=4e-19,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 18143; Mature: 18012

Theoretical pI: Translated: 4.94; Mature: 4.94

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
6.8 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAVKEFENCKDRYLKKLDEIILKYKDKPGPLIPVLHEAQELYGYLPEEVQSYIAEGLGVP
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCC
VSKVSGVVSFYSFFTTKPKGEHTINVCMGTACYVKGAEEILNRLKEELGIEEGETSEDGK
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCC
FTMVGMRCLGACSLAPVVTIDDKVYGKVTPEKMMEIIESYRK
EEEHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHCC
>Mature Secondary Structure 
AVKEFENCKDRYLKKLDEIILKYKDKPGPLIPVLHEAQELYGYLPEEVQSYIAEGLGVP
CCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCC
VSKVSGVVSFYSFFTTKPKGEHTINVCMGTACYVKGAEEILNRLKEELGIEEGETSEDGK
HHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCC
FTMVGMRCLGACSLAPVVTIDDKVYGKVTPEKMMEIIESYRK
EEEHHHHHHHHHCCCCEEEECCCCCCCCCHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA