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The map label for this gene is accC [H]

Identifier: 220931470

GI number: 220931470

Start: 676725

End: 678080

Strand: Direct

Name: accC [H]

Synonym: Hore_06260

Alternate gene names: 220931470

Gene position: 676725-678080 (Clockwise)

Preceding gene: 220931469

Following gene: 220931471

Centisome position: 26.25

GC content: 40.49

Gene sequence:

>1356_bases
ATGGCAATGTTTAATAAAGTATTAATAGCAAACAGGGGAGAAATTGCTGTCAGGATTATCAGAGCCCTTAAAGAATTACA
GATACCGTCTGTTGCAGTTTATTCTGAAGCTGATCGTGAATCCTTACATGTAAAACTGGCAGATGAGGCCTATTGTATTG
GGCCCGCCAGTTCAAGTGAAAGTTATCTGAATATACCGAGCATCATGAGTGTAGCTGAAGTAACAGGGGCTGATGCTATT
CACCCCGGTTATGGATTTTTATCAGAAAATGCCCATTTTGCTGAGGTTTGTGAAAGCAGTGGTATTAAGTTTATTGGACC
AAATTCCGGTGTGATCAGTTTAATGGGTGATAAGGCCAAAGCCAGGGAAACAATGAAAAAGGCAGGAGTGCCTGTAGTAC
CGGGCACAGAAGATGGGCTTGACAATGTTGATAAAACCCTTGAGGTTGCGGAGGAAATAGGTTATCCTGTAATTATAAAA
GCTGCTGCAGGTGGTGGTGGAAAGGGGATGCGGATTGCTCAAAATCCCCGTGATTTAAAGAAATCTATTCAGACCGCCCA
GAGTGAAGCCAGAGCTGCTTTCGGAGATGCAACAGTTTACCTGGAAAAATATGTTGAAGAACCGAGGCATATTGAATTTC
AGATACTGGCTGATGAGCATGGTAATGTAATTCATCTGGGAGAAAGGGACTGTTCTATTCAGAGAAGACACCAGAAAATA
CTGGAGGAAGCCCCGTCTCCTGTTCTTTCTGGAGAACTCAGGCAGAAGATAGGTGAGGCTGCAGTTAAAGCAGCCCGGGC
TGTAAACTATACCAATGCTGGAACTGTAGAATTTTTACTGGATAAATATAATAATTTTTATTTTATTGAAATGAATACCA
GAATCCAGGTCGAACATCCTATTACTGAACTTGTAACGGGTATTGACCTTATAAAAGAACAGATATTAATTGCAGCCGGG
AGAGAACTGGAATATAAACAGGATGAGATAACAATTACAGGTTCAGCAATTGAATGCAGGATAAATGCTGAAGACCCGGA
TTATAATTTTAGACCTTCACCAGGCAAAGTGGAAACTTATATTGTTCCGGGTGGACCTGGAGTTAGGCTTGATAGTGGGG
TATACCCCGGGTATTATATTACACCTTTTTATGACTCTATGGTCGCCAAATTAATTGTCTGGGATGAAAACAGGGAAGAG
GCCATTAAAAGGATGGAAAGGGCCTTAAAGGAGTTTACAGTTGAAGGTGTTAAAACAACAATACCATTCCACTTAAAAAT
TTTAAATAATGCCTTTTTCCGTAAAGGTGAGTATTATACAAACTTTATTCAGAGAAGAATCTTATCAGAAGGGTAG

Upstream 100 bases:

>100_bases
AAAAGGGGCGTATTGTTGATATTTTAGTTGAAAATGGGAAACCTGTTGAATATGGTCAGCCCCTTTTCCTGGTTGAGCCT
GTATAAAGATAGGAGTGGTT

Downstream 100 bases:

>100_bases
GAGGGGTAAAAAATGGTTGAGAAAGAAAGTTTGGGTTCAATTAAAATTGCCAATGAAGTGGTAGCAATTATTGCTGGTCT
GGCTGCGACTGAAGTTGATG

Product: acetyl-CoA carboxylase, biotin carboxylase

Products: NA

Alternate protein names: Acetyl-CoA carboxylase subunit A; ACC [H]

Number of amino acids: Translated: 451; Mature: 450

Protein sequence:

>451_residues
MAMFNKVLIANRGEIAVRIIRALKELQIPSVAVYSEADRESLHVKLADEAYCIGPASSSESYLNIPSIMSVAEVTGADAI
HPGYGFLSENAHFAEVCESSGIKFIGPNSGVISLMGDKAKARETMKKAGVPVVPGTEDGLDNVDKTLEVAEEIGYPVIIK
AAAGGGGKGMRIAQNPRDLKKSIQTAQSEARAAFGDATVYLEKYVEEPRHIEFQILADEHGNVIHLGERDCSIQRRHQKI
LEEAPSPVLSGELRQKIGEAAVKAARAVNYTNAGTVEFLLDKYNNFYFIEMNTRIQVEHPITELVTGIDLIKEQILIAAG
RELEYKQDEITITGSAIECRINAEDPDYNFRPSPGKVETYIVPGGPGVRLDSGVYPGYYITPFYDSMVAKLIVWDENREE
AIKRMERALKEFTVEGVKTTIPFHLKILNNAFFRKGEYYTNFIQRRILSEG

Sequences:

>Translated_451_residues
MAMFNKVLIANRGEIAVRIIRALKELQIPSVAVYSEADRESLHVKLADEAYCIGPASSSESYLNIPSIMSVAEVTGADAI
HPGYGFLSENAHFAEVCESSGIKFIGPNSGVISLMGDKAKARETMKKAGVPVVPGTEDGLDNVDKTLEVAEEIGYPVIIK
AAAGGGGKGMRIAQNPRDLKKSIQTAQSEARAAFGDATVYLEKYVEEPRHIEFQILADEHGNVIHLGERDCSIQRRHQKI
LEEAPSPVLSGELRQKIGEAAVKAARAVNYTNAGTVEFLLDKYNNFYFIEMNTRIQVEHPITELVTGIDLIKEQILIAAG
RELEYKQDEITITGSAIECRINAEDPDYNFRPSPGKVETYIVPGGPGVRLDSGVYPGYYITPFYDSMVAKLIVWDENREE
AIKRMERALKEFTVEGVKTTIPFHLKILNNAFFRKGEYYTNFIQRRILSEG
>Mature_450_residues
AMFNKVLIANRGEIAVRIIRALKELQIPSVAVYSEADRESLHVKLADEAYCIGPASSSESYLNIPSIMSVAEVTGADAIH
PGYGFLSENAHFAEVCESSGIKFIGPNSGVISLMGDKAKARETMKKAGVPVVPGTEDGLDNVDKTLEVAEEIGYPVIIKA
AAGGGGKGMRIAQNPRDLKKSIQTAQSEARAAFGDATVYLEKYVEEPRHIEFQILADEHGNVIHLGERDCSIQRRHQKIL
EEAPSPVLSGELRQKIGEAAVKAARAVNYTNAGTVEFLLDKYNNFYFIEMNTRIQVEHPITELVTGIDLIKEQILIAAGR
ELEYKQDEITITGSAIECRINAEDPDYNFRPSPGKVETYIVPGGPGVRLDSGVYPGYYITPFYDSMVAKLIVWDENREEA
IKRMERALKEFTVEGVKTTIPFHLKILNNAFFRKGEYYTNFIQRRILSEG

Specific function: This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA [H]

COG id: COG0439

COG function: function code I; Biotin carboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 biotin carboxylation domain [H]

Homologues:

Organism=Homo sapiens, GI116805327, Length=442, Percent_Identity=50.6787330316742, Blast_Score=467, Evalue=1e-131,
Organism=Homo sapiens, GI189095269, Length=445, Percent_Identity=49.438202247191, Blast_Score=447, Evalue=1e-126,
Organism=Homo sapiens, GI295821183, Length=442, Percent_Identity=49.7737556561086, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI65506442, Length=442, Percent_Identity=49.7737556561086, Blast_Score=446, Evalue=1e-125,
Organism=Homo sapiens, GI106049528, Length=443, Percent_Identity=48.3069977426637, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI106049295, Length=443, Percent_Identity=48.3069977426637, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI106049292, Length=443, Percent_Identity=48.3069977426637, Blast_Score=419, Evalue=1e-117,
Organism=Homo sapiens, GI38679960, Length=510, Percent_Identity=33.1372549019608, Blast_Score=267, Evalue=1e-71,
Organism=Homo sapiens, GI38679974, Length=510, Percent_Identity=33.1372549019608, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI38679971, Length=510, Percent_Identity=33.1372549019608, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI38679977, Length=510, Percent_Identity=33.1372549019608, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI38679967, Length=510, Percent_Identity=33.1372549019608, Blast_Score=267, Evalue=2e-71,
Organism=Homo sapiens, GI134142062, Length=506, Percent_Identity=32.0158102766798, Blast_Score=251, Evalue=7e-67,
Organism=Escherichia coli, GI1789654, Length=446, Percent_Identity=56.7264573991031, Blast_Score=504, Evalue=1e-144,
Organism=Escherichia coli, GI1786216, Length=245, Percent_Identity=25.3061224489796, Blast_Score=67, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17567343, Length=442, Percent_Identity=47.737556561086, Blast_Score=427, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17562816, Length=445, Percent_Identity=49.2134831460674, Blast_Score=423, Evalue=1e-118,
Organism=Caenorhabditis elegans, GI71987519, Length=450, Percent_Identity=48.2222222222222, Blast_Score=416, Evalue=1e-116,
Organism=Caenorhabditis elegans, GI133931226, Length=490, Percent_Identity=30.8163265306122, Blast_Score=237, Evalue=1e-62,
Organism=Caenorhabditis elegans, GI71997168, Length=506, Percent_Identity=29.8418972332016, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI71997163, Length=506, Percent_Identity=29.8418972332016, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI193204318, Length=248, Percent_Identity=22.9838709677419, Blast_Score=65, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6319695, Length=446, Percent_Identity=50.4484304932735, Blast_Score=418, Evalue=1e-118,
Organism=Saccharomyces cerevisiae, GI6321376, Length=446, Percent_Identity=51.5695067264574, Blast_Score=411, Evalue=1e-115,
Organism=Saccharomyces cerevisiae, GI6319685, Length=443, Percent_Identity=44.4695259593679, Blast_Score=381, Evalue=1e-107,
Organism=Saccharomyces cerevisiae, GI6324343, Length=521, Percent_Identity=31.0940499040307, Blast_Score=236, Evalue=6e-63,
Organism=Saccharomyces cerevisiae, GI6323863, Length=481, Percent_Identity=32.8482328482328, Blast_Score=236, Evalue=7e-63,
Organism=Drosophila melanogaster, GI24651757, Length=442, Percent_Identity=49.5475113122172, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI24652212, Length=442, Percent_Identity=50.9049773755656, Blast_Score=430, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652210, Length=442, Percent_Identity=50.9049773755656, Blast_Score=430, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652214, Length=442, Percent_Identity=50.9049773755656, Blast_Score=430, Evalue=1e-121,
Organism=Drosophila melanogaster, GI19921944, Length=442, Percent_Identity=50.9049773755656, Blast_Score=430, Evalue=1e-121,
Organism=Drosophila melanogaster, GI24652216, Length=442, Percent_Identity=50.9049773755656, Blast_Score=430, Evalue=1e-121,
Organism=Drosophila melanogaster, GI281363050, Length=442, Percent_Identity=50.9049773755656, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652224, Length=442, Percent_Identity=50.9049773755656, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652222, Length=442, Percent_Identity=50.9049773755656, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652220, Length=442, Percent_Identity=50.9049773755656, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24652218, Length=442, Percent_Identity=50.9049773755656, Blast_Score=430, Evalue=1e-120,
Organism=Drosophila melanogaster, GI24651759, Length=409, Percent_Identity=48.8997555012225, Blast_Score=402, Evalue=1e-112,
Organism=Drosophila melanogaster, GI161076409, Length=515, Percent_Identity=31.0679611650485, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI24586458, Length=515, Percent_Identity=31.0679611650485, Blast_Score=239, Evalue=3e-63,
Organism=Drosophila melanogaster, GI161076407, Length=515, Percent_Identity=31.0679611650485, Blast_Score=239, Evalue=4e-63,
Organism=Drosophila melanogaster, GI24586460, Length=515, Percent_Identity=31.0679611650485, Blast_Score=239, Evalue=4e-63,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004549
- InterPro:   IPR011761
- InterPro:   IPR013815
- InterPro:   IPR013816
- InterPro:   IPR011764
- InterPro:   IPR005482
- InterPro:   IPR005479
- InterPro:   IPR005481
- InterPro:   IPR013817
- InterPro:   IPR016185
- InterPro:   IPR011054 [H]

Pfam domain/function: PF02785 Biotin_carb_C; PF00289 CPSase_L_chain; PF02786 CPSase_L_D2 [H]

EC number: =6.3.4.14; =6.4.1.2 [H]

Molecular weight: Translated: 49922; Mature: 49791

Theoretical pI: Translated: 5.29; Mature: 5.29

Prosite motif: PS50975 ATP_GRASP ; PS00866 CPSASE_1 ; PS00867 CPSASE_2 ; PS50979 BC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAMFNKVLIANRGEIAVRIIRALKELQIPSVAVYSEADRESLHVKLADEAYCIGPASSSE
CCCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEECCCEEEECCCCCCC
SYLNIPSIMSVAEVTGADAIHPGYGFLSENAHFAEVCESSGIKFIGPNSGVISLMGDKAK
CEECCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCEEEEECCHHH
ARETMKKAGVPVVPGTEDGLDNVDKTLEVAEEIGYPVIIKAAAGGGGKGMRIAQNPRDLK
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCHHHHH
KSIQTAQSEARAAFGDATVYLEKYVEEPRHIEFQILADEHGNVIHLGERDCSIQRRHQKI
HHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHH
LEEAPSPVLSGELRQKIGEAAVKAARAVNYTNAGTVEFLLDKYNNFYFIEMNTRIQVEHP
HHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEECCEEEECCC
ITELVTGIDLIKEQILIAAGRELEYKQDEITITGSAIECRINAEDPDYNFRPSPGKVETY
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEEEECCCCCCCCCCCCCCCEEEE
IVPGGPGVRLDSGVYPGYYITPFYDSMVAKLIVWDENREEAIKRMERALKEFTVEGVKTT
EECCCCCCEECCCCCCCEEECHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEE
IPFHLKILNNAFFRKGEYYTNFIQRRILSEG
CCEEEEEHHHHHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
AMFNKVLIANRGEIAVRIIRALKELQIPSVAVYSEADRESLHVKLADEAYCIGPASSSE
CCCCEEEEECCCHHHHHHHHHHHHCCCCCEEEECCCCCCEEEEEECCCEEEECCCCCCC
SYLNIPSIMSVAEVTGADAIHPGYGFLSENAHFAEVCESSGIKFIGPNSGVISLMGDKAK
CEECCHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEECCCCCEEEEECCHHH
ARETMKKAGVPVVPGTEDGLDNVDKTLEVAEEIGYPVIIKAAAGGGGKGMRIAQNPRDLK
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCCCCEECCCHHHHH
KSIQTAQSEARAAFGDATVYLEKYVEEPRHIEFQILADEHGNVIHLGERDCSIQRRHQKI
HHHHHHHHHHHHHHCHHHHHHHHHHCCCCCEEEEEEECCCCCEEEECCCCCHHHHHHHHH
LEEAPSPVLSGELRQKIGEAAVKAARAVNYTNAGTVEFLLDKYNNFYFIEMNTRIQVEHP
HHHCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHCCCEEEEEECCEEEECCC
ITELVTGIDLIKEQILIAAGRELEYKQDEITITGSAIECRINAEDPDYNFRPSPGKVETY
HHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEECCEEEEEECCCCCCCCCCCCCCCEEEE
IVPGGPGVRLDSGVYPGYYITPFYDSMVAKLIVWDENREEAIKRMERALKEFTVEGVKTT
EECCCCCCEECCCCCCCEEECHHHHHHHEEEEEECCCHHHHHHHHHHHHHHHHHCCCEEE
IPFHLKILNNAFFRKGEYYTNFIQRRILSEG
CCEEEEEHHHHHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8102363; 11759840 [H]