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The map label for this gene is comC [H]

Identifier: 220931445

GI number: 220931445

Start: 653764

End: 654504

Strand: Direct

Name: comC [H]

Synonym: Hore_06010

Alternate gene names: 220931445

Gene position: 653764-654504 (Clockwise)

Preceding gene: 220931444

Following gene: 220931446

Centisome position: 25.36

GC content: 39.54

Gene sequence:

>741_bases
ATGAAATTATTTGTGTTTATCATGGGATTATTATTTGGAAGCTTCTTTAATGTAATTATCCTGAGGGTGCCCCGGAAAGA
ATCAATAATCTGGCCCCGTTCTCATTGCCCTCACTGTCAGACTACTCTGAAATGGTATGAGCTGATACCGGTTTTGAGTT
TTATATTTCTTAAGGGGAAATGCCGTTACTGCGGCTACAGGATTAGCTGGCAGTACCCGCTGGTTGAAGTCATGACTGGA
CTTATATACTTACTATTATACTATCATTTTGGTTTAACTATGGTCTTTCTTATTTATATAATTTTAATATCATTGTTGAT
TATCTCTTCAGTAATTGATATCAGGGAGAAGATTATCCCCAATGTTATTACTTTTCCGGGAATGGTGACCGGGCTTATAA
GTTCAATTATTTTAAAACACATTGGTTTCTGGAACTCTCTTCTGGGGATTTTAATTCCGGGAATATTTCTCTTCATAATC
GCCCTCATCTTTAAGGGAGGGCTGGGGATGGGTGATGTCAAGCTGGTAGCCATGATCGGGGCCTTTACGGGGGTTAGATG
GGCTTTAATGGCTTTATTCACCGGGGCTTTTCTCGGGGCCATAACCGGAATAATATTAATTGTTTCCGGGGTTTTGGACC
GAAAAAAACCTGTTCCCTTTGGACCGTTTATCAGTATTGGCGGGCTTGTATCCATTCTCTGGGGATATGAGATCTGGATT
TATATAATTAATCTTTATTAG

Upstream 100 bases:

>100_bases
TGGTGATATTGAAGTGAAATAATAATTTTACAACAAGAACTTTATTAAGTGGCCCGGCTTTTGCCGGGTCACATCCAGAT
TAAGATAAAGTGGTGGTTAT

Downstream 100 bases:

>100_bases
TCGATTTTTAAAATTAATTCTTCTGATTTAAAAACCGGGGGTATAACAAATTTATTTTAATAAGTAAATTTTAATTACTT
GCCTGAATTACTCTTGGATT

Product: Prepilin peptidase

Products: NA

Alternate protein names: Late competence protein ComC; Leader peptidase; Prepilin peptidase; N-methyltransferase [H]

Number of amino acids: Translated: 246; Mature: 246

Protein sequence:

>246_residues
MKLFVFIMGLLFGSFFNVIILRVPRKESIIWPRSHCPHCQTTLKWYELIPVLSFIFLKGKCRYCGYRISWQYPLVEVMTG
LIYLLLYYHFGLTMVFLIYIILISLLIISSVIDIREKIIPNVITFPGMVTGLISSIILKHIGFWNSLLGILIPGIFLFII
ALIFKGGLGMGDVKLVAMIGAFTGVRWALMALFTGAFLGAITGIILIVSGVLDRKKPVPFGPFISIGGLVSILWGYEIWI
YIINLY

Sequences:

>Translated_246_residues
MKLFVFIMGLLFGSFFNVIILRVPRKESIIWPRSHCPHCQTTLKWYELIPVLSFIFLKGKCRYCGYRISWQYPLVEVMTG
LIYLLLYYHFGLTMVFLIYIILISLLIISSVIDIREKIIPNVITFPGMVTGLISSIILKHIGFWNSLLGILIPGIFLFII
ALIFKGGLGMGDVKLVAMIGAFTGVRWALMALFTGAFLGAITGIILIVSGVLDRKKPVPFGPFISIGGLVSILWGYEIWI
YIINLY
>Mature_246_residues
MKLFVFIMGLLFGSFFNVIILRVPRKESIIWPRSHCPHCQTTLKWYELIPVLSFIFLKGKCRYCGYRISWQYPLVEVMTG
LIYLLLYYHFGLTMVFLIYIILISLLIISSVIDIREKIIPNVITFPGMVTGLISSIILKHIGFWNSLLGILIPGIFLFII
ALIFKGGLGMGDVKLVAMIGAFTGVRWALMALFTGAFLGAITGIILIVSGVLDRKKPVPFGPFISIGGLVSILWGYEIWI
YIINLY

Specific function: Cleaves type-4 fimbrial leader sequence and methylates the N-terminal (generally Phe) residue [H]

COG id: COG1989

COG function: function code NOU; Type II secretory pathway, prepilin signal peptidase PulO and related peptidases

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase A24 family [H]

Homologues:

Organism=Escherichia coli, GI87082194, Length=257, Percent_Identity=33.852140077821, Blast_Score=115, Evalue=3e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR010627
- InterPro:   IPR000045 [H]

Pfam domain/function: PF06750 DiS_P_DiS; PF01478 Peptidase_A24 [H]

EC number: =3.4.23.43 [H]

Molecular weight: Translated: 27807; Mature: 27807

Theoretical pI: Translated: 9.98; Mature: 9.98

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLFVFIMGLLFGSFFNVIILRVPRKESIIWPRSHCPHCQTTLKWYELIPVLSFIFLKGK
CHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCC
CRYCGYRISWQYPLVEVMTGLIYLLLYYHFGLTMVFLIYIILISLLIISSVIDIREKIIP
HHHCCEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
NVITFPGMVTGLISSIILKHIGFWNSLLGILIPGIFLFIIALIFKGGLGMGDVKLVAMIG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHH
AFTGVRWALMALFTGAFLGAITGIILIVSGVLDRKKPVPFGPFISIGGLVSILWGYEIWI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHH
YIINLY
HEEECC
>Mature Secondary Structure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HEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 2553669; 9384377; 8419299 [H]