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The map label for this gene is aroE

Identifier: 220931440

GI number: 220931440

Start: 647961

End: 648830

Strand: Direct

Name: aroE

Synonym: Hore_05960

Alternate gene names: 220931440

Gene position: 647961-648830 (Clockwise)

Preceding gene: 220931439

Following gene: 220931441

Centisome position: 25.13

GC content: 42.53

Gene sequence:

>870_bases
ATGTTTGATAATAGTACACAGGTGGTTGGATTGATGGGATACCCCCTGGGTCATTCAATGTCCCCGGCCATGCATAACCG
GGCCTATAAAGACCTTGGGATTAATTATGTTTATCTTCCGCTGGAAATAAAGCCTGACTTTCTCAAAGAAGGGATAGAGG
GATTAAGAGCATTTAATTTCCGGGGGGTTAATGTGACCATACCCTATAAGGAAAAAGTTATCCCCTATCTGGATGAAATT
GATAGGCTGGCCGGGGAAATCGGGGCTGTCAATACAATAGTTAATAATGGTGGAAAATTAAAGGGTTATAATACTGACGC
CCTGGGCTTTAAAAAAATGCTTGAAGATGACTGTAGTTTTGAAATTAAGGGAACAAAAGCGGTAATTATCGGAGCAGGAG
GGGCCAGCCGGGCAGTCGGGGCAGTCCTGGCCAGGGAAGGGGCCAGTGAAATCTTTCTCTTAAACAGAACCCTGAAAAAA
GCAGCAAAACTGGTCGGTATCTGGAATAAGACTTATCCCGGTATAAAAACTGTTGCTCTACCTTTAGATGAAGATAAATA
TCTACCTGTTGTTAAAAGATGTGATGTAATCATTGATACAACACCGGTGGGCATGGCTCCTGGTATTAAAGGAGGGCCTG
TAATTGCTAAAGAAGCTATAACCAGGGATACTCTTGTAGTCGATCTGGTATATAATCCACCTGAAACTACATTAATAAAA
GCCGGAAGGCAGGTCGGGGCCAGAACTATGAATGGTTTTCCTATGCTTATTTATCAGGCGGCTTATGCATTTAAACTGTG
GACGGGGATAAAACCTGAACTATTTATAAAACCGGTCCGGGAGGCAATTTCACCAGATTTTTTTGCATAA

Upstream 100 bases:

>100_bases
TTAATACTGGGAGAAGTTATGGGATTTACCGGTTTGTTCGGTGGATTACTGATAGTGACCGGTATGTTGATTACAGAAGT
GAAAGCTGAGGGGGTCTAGA

Downstream 100 bases:

>100_bases
AATAATTATTAAATAAAATATACATTAATACCTGGCTTTGCCAGGTATTTTTTTTATTTGACTGAAAATAATGGTGTAAA
ATTGAAGGACTTTTGTTTCA

Product: shikimate 5-dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 289; Mature: 289

Protein sequence:

>289_residues
MFDNSTQVVGLMGYPLGHSMSPAMHNRAYKDLGINYVYLPLEIKPDFLKEGIEGLRAFNFRGVNVTIPYKEKVIPYLDEI
DRLAGEIGAVNTIVNNGGKLKGYNTDALGFKKMLEDDCSFEIKGTKAVIIGAGGASRAVGAVLAREGASEIFLLNRTLKK
AAKLVGIWNKTYPGIKTVALPLDEDKYLPVVKRCDVIIDTTPVGMAPGIKGGPVIAKEAITRDTLVVDLVYNPPETTLIK
AGRQVGARTMNGFPMLIYQAAYAFKLWTGIKPELFIKPVREAISPDFFA

Sequences:

>Translated_289_residues
MFDNSTQVVGLMGYPLGHSMSPAMHNRAYKDLGINYVYLPLEIKPDFLKEGIEGLRAFNFRGVNVTIPYKEKVIPYLDEI
DRLAGEIGAVNTIVNNGGKLKGYNTDALGFKKMLEDDCSFEIKGTKAVIIGAGGASRAVGAVLAREGASEIFLLNRTLKK
AAKLVGIWNKTYPGIKTVALPLDEDKYLPVVKRCDVIIDTTPVGMAPGIKGGPVIAKEAITRDTLVVDLVYNPPETTLIK
AGRQVGARTMNGFPMLIYQAAYAFKLWTGIKPELFIKPVREAISPDFFA
>Mature_289_residues
MFDNSTQVVGLMGYPLGHSMSPAMHNRAYKDLGINYVYLPLEIKPDFLKEGIEGLRAFNFRGVNVTIPYKEKVIPYLDEI
DRLAGEIGAVNTIVNNGGKLKGYNTDALGFKKMLEDDCSFEIKGTKAVIIGAGGASRAVGAVLAREGASEIFLLNRTLKK
AAKLVGIWNKTYPGIKTVALPLDEDKYLPVVKRCDVIIDTTPVGMAPGIKGGPVIAKEAITRDTLVVDLVYNPPETTLIK
AGRQVGARTMNGFPMLIYQAAYAFKLWTGIKPELFIKPVREAISPDFFA

Specific function: Aromatic amino acids biosynthesis; shikimate pathway; fourth step. [C]

COG id: COG0169

COG function: function code E; Shikimate 5-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the shikimate dehydrogenase family

Homologues:

Organism=Escherichia coli, GI1787983, Length=284, Percent_Identity=36.9718309859155, Blast_Score=186, Evalue=1e-48,
Organism=Escherichia coli, GI1789675, Length=285, Percent_Identity=32.6315789473684, Blast_Score=113, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6320332, Length=286, Percent_Identity=30.0699300699301, Blast_Score=101, Evalue=1e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): AROE_HALOH (B8D2C6)

Other databases:

- EMBL:   CP001098
- RefSeq:   YP_002508348.1
- ProteinModelPortal:   B8D2C6
- SMR:   B8D2C6
- GeneID:   7314501
- GenomeReviews:   CP001098_GR
- KEGG:   hor:Hore_05960
- HOGENOM:   HBG553408
- OMA:   RTEANAQ
- GO:   GO:0005737
- HAMAP:   MF_00222
- InterPro:   IPR016040
- InterPro:   IPR011342
- InterPro:   IPR013708
- InterPro:   IPR022893
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- TIGRFAMs:   TIGR00507

Pfam domain/function: PF01488 Shikimate_DH; PF08501 Shikimate_dh_N

EC number: =1.1.1.25

Molecular weight: Translated: 31542; Mature: 31542

Theoretical pI: Translated: 9.46; Mature: 9.46

Prosite motif: NA

Important sites: ACT_SITE 70-70

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDNSTQVVGLMGYPLGHSMSPAMHNRAYKDLGINYVYLPLEIKPDFLKEGIEGLRAFNF
CCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEEEEECHHHHHHHHHHHHHHEE
RGVNVTIPYKEKVIPYLDEIDRLAGEIGAVNTIVNNGGKLKGYNTDALGFKKMLEDDCSF
CCEEEEECCHHCCCHHHHHHHHHHHHHHHHHHEECCCCEEECCCCCHHHHHHHHCCCCCE
EIKGTKAVIIGAGGASRAVGAVLAREGASEIFLLNRTLKKAAKLVGIWNKTYPGIKTVAL
EECCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCEEEEE
PLDEDKYLPVVKRCDVIIDTTPVGMAPGIKGGPVIAKEAITRDTLVVDLVYNPPETTLIK
ECCCCCCCCHHHHCCEEEECCCCCCCCCCCCCCEEHHHHHCCCEEEEEEEECCCCHHHHH
AGRQVGARTMNGFPMLIYQAAYAFKLWTGIKPELFIKPVREAISPDFFA
CCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
>Mature Secondary Structure
MFDNSTQVVGLMGYPLGHSMSPAMHNRAYKDLGINYVYLPLEIKPDFLKEGIEGLRAFNF
CCCCCCEEEEEECCCCCCCCCHHHHHHHHHHCCCEEEEEEEEECHHHHHHHHHHHHHHEE
RGVNVTIPYKEKVIPYLDEIDRLAGEIGAVNTIVNNGGKLKGYNTDALGFKKMLEDDCSF
CCEEEEECCHHCCCHHHHHHHHHHHHHHHHHHEECCCCEEECCCCCHHHHHHHHCCCCCE
EIKGTKAVIIGAGGASRAVGAVLAREGASEIFLLNRTLKKAAKLVGIWNKTYPGIKTVAL
EECCCEEEEEECCCCHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHHCCCCCCCCCEEEEE
PLDEDKYLPVVKRCDVIIDTTPVGMAPGIKGGPVIAKEAITRDTLVVDLVYNPPETTLIK
ECCCCCCCCHHHHCCEEEECCCCCCCCCCCCCCEEHHHHHCCCEEEEEEEECCCCHHHHH
AGRQVGARTMNGFPMLIYQAAYAFKLWTGIKPELFIKPVREAISPDFFA
CCHHHCCCCCCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA