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The map label for this gene is panF [H]

Identifier: 220931386

GI number: 220931386

Start: 587398

End: 589026

Strand: Reverse

Name: panF [H]

Synonym: Hore_05410

Alternate gene names: 220931386

Gene position: 589026-587398 (Counterclockwise)

Preceding gene: 220931387

Following gene: 220931384

Centisome position: 22.85

GC content: 38.0

Gene sequence:

>1629_bases
ATGGAATGGTACTATCTTATTCCGTTAGTCTATTTATTTTTACTACTGGTTGTTGGTTTTGTTATAGCTAAAAGACAGGA
AACCCGGTCAGATTTTTATGTTGCCTCAAATAAAATGGATGGATCAGTCCTCTTTGCTACAGTTATGTCCACAGTGGTTG
GCGCAAATACATATATGGGTTTTAGTGGCTTGATTTATAATGGTGGACTTCATTTTATGTGGATGCTCAGTGGTGCCGGT
CTTGCTTATTTTATCCTCTTCTTTATATCAGGTAAAATAAGGAAAATAGCCACAAAATACGAAGTATTCACTCTTCCTGA
CCTGGTAGAGCTTAGATATTCTAATCCTGTTGCCCTACTAACTACTTTCTTTTCCCTTATTGGGCTAGTTGGAGGTATCG
GAGGTGGTCTTCTCGGTTTAGGAGTTATACTTAATTCTTTACTGGGAATACCCACCACTACTGCTATAATTGTTACTTCC
ATTATTACTATCATTTATACCTGTCTTGGAGGTTTATGGGGAGTATCCCTGACAGACTGGATTCAATCTATTATTATGAT
TGCTGGTGTAGCAGTCTGTATAGTATTTGGGATAACCTCTGTAACACCGGGACAATCATTTGTCAATGGTGCCTTCGAAA
TAGTAAATGTATTAAAACAACAATTAGGAACAGAACTGGTTAGCCCCTTTGCCGGTTTAACCTTTTTTATGGCTCTGGCC
TGGACCATTACCTTTATGCCCCTTAATACTATCTCTCAGACCCAGATCCAGAGGGTTTATGCAGCAAAAAATGTAAAGAC
TATTCGTGGTGTCAGTTTACTAATGATTATTTTTGTAGCTATGGTCCTCACTTTCGGTTTAGCCTTTATCGGAATTCTTG
GAAGAGTTGCTTTACCCGGTTTAAAAAATGCTGAGGCAGTCTTCCCCCAGATGAGCATGAAAGTTATCAACCCTGCATTA
GGTATTTTAATTGTAACGGGAATTATGGGAGCTGCTATGTCTACAGTAGATTCAAACCTTCTCGGTTCCGCCATGCATGT
CACCCGTGACCTATATGAACGGTACATGAGATATAAGAATAAGTCTGTTGATGAAAAGCGTATTTTATTTATCAGTCGGG
TAACCATTGTTATTATTGGTGTAATTAGTACTATAGCTGCTCTATTCACTCCTTCTATAATGAGCCTACTACTGATAACA
ATGAAGATATTTGCCGGAGCTACTTTTGCCCCTGTACTTATCGGTCTTTACTGGAAAAGAGCCAATGCTTTCGGGGCTTT
ACTGGGTGAAATTCTTGGAGGTATGGCTGTTGTTATTAATATTATTCACCCCGTTGTCAACCTGGATCCTGTCATATTTG
GAATTATTATGGCAGTTTTAGGAACGATAACTGGCAGCTTATTTACCAAAGAAAATACAGAAAAAGGCAGTATTTTTTCT
TTTGCTAATGATATTTCATCAAAAGGATGGCTCGCAGTTATAGCTATTGCTCTTCTCTATTTTGGATGGGTTATAAGTAT
GAACAACTACGCCATGTGGCCGTATTTCATTATAACTACTGTAGTATTACTGGTTTTATCAGTTGTCTTCCTTATTTATA
GTTTTATCACTGAAAGAACCGGCAATTAA

Upstream 100 bases:

>100_bases
TCTATTGACGATACTGTAAAGGCTATTGAGTTAATTTATCGATATATTAAACATATAAATGATGAAATATAACATGAGAA
TCTAGGAGGGAGAATCTTTT

Downstream 100 bases:

>100_bases
ATTTATAATGTACCAGGTAACAAACATACACATATATATTCAAAAAAAGGGACAGCTTAAACAGCTGTCCCTTAAATATA
TGGTTATATTTAAATTTATA

Product: Sodium:solute symporter

Products: Na (I) [Cytoplasm]; pantothenate [Cytoplasm] [C]

Alternate protein names: Pantothenate permease [H]

Number of amino acids: Translated: 542; Mature: 542

Protein sequence:

>542_residues
MEWYYLIPLVYLFLLLVVGFVIAKRQETRSDFYVASNKMDGSVLFATVMSTVVGANTYMGFSGLIYNGGLHFMWMLSGAG
LAYFILFFISGKIRKIATKYEVFTLPDLVELRYSNPVALLTTFFSLIGLVGGIGGGLLGLGVILNSLLGIPTTTAIIVTS
IITIIYTCLGGLWGVSLTDWIQSIIMIAGVAVCIVFGITSVTPGQSFVNGAFEIVNVLKQQLGTELVSPFAGLTFFMALA
WTITFMPLNTISQTQIQRVYAAKNVKTIRGVSLLMIIFVAMVLTFGLAFIGILGRVALPGLKNAEAVFPQMSMKVINPAL
GILIVTGIMGAAMSTVDSNLLGSAMHVTRDLYERYMRYKNKSVDEKRILFISRVTIVIIGVISTIAALFTPSIMSLLLIT
MKIFAGATFAPVLIGLYWKRANAFGALLGEILGGMAVVINIIHPVVNLDPVIFGIIMAVLGTITGSLFTKENTEKGSIFS
FANDISSKGWLAVIAIALLYFGWVISMNNYAMWPYFIITTVVLLVLSVVFLIYSFITERTGN

Sequences:

>Translated_542_residues
MEWYYLIPLVYLFLLLVVGFVIAKRQETRSDFYVASNKMDGSVLFATVMSTVVGANTYMGFSGLIYNGGLHFMWMLSGAG
LAYFILFFISGKIRKIATKYEVFTLPDLVELRYSNPVALLTTFFSLIGLVGGIGGGLLGLGVILNSLLGIPTTTAIIVTS
IITIIYTCLGGLWGVSLTDWIQSIIMIAGVAVCIVFGITSVTPGQSFVNGAFEIVNVLKQQLGTELVSPFAGLTFFMALA
WTITFMPLNTISQTQIQRVYAAKNVKTIRGVSLLMIIFVAMVLTFGLAFIGILGRVALPGLKNAEAVFPQMSMKVINPAL
GILIVTGIMGAAMSTVDSNLLGSAMHVTRDLYERYMRYKNKSVDEKRILFISRVTIVIIGVISTIAALFTPSIMSLLLIT
MKIFAGATFAPVLIGLYWKRANAFGALLGEILGGMAVVINIIHPVVNLDPVIFGIIMAVLGTITGSLFTKENTEKGSIFS
FANDISSKGWLAVIAIALLYFGWVISMNNYAMWPYFIITTVVLLVLSVVFLIYSFITERTGN
>Mature_542_residues
MEWYYLIPLVYLFLLLVVGFVIAKRQETRSDFYVASNKMDGSVLFATVMSTVVGANTYMGFSGLIYNGGLHFMWMLSGAG
LAYFILFFISGKIRKIATKYEVFTLPDLVELRYSNPVALLTTFFSLIGLVGGIGGGLLGLGVILNSLLGIPTTTAIIVTS
IITIIYTCLGGLWGVSLTDWIQSIIMIAGVAVCIVFGITSVTPGQSFVNGAFEIVNVLKQQLGTELVSPFAGLTFFMALA
WTITFMPLNTISQTQIQRVYAAKNVKTIRGVSLLMIIFVAMVLTFGLAFIGILGRVALPGLKNAEAVFPQMSMKVINPAL
GILIVTGIMGAAMSTVDSNLLGSAMHVTRDLYERYMRYKNKSVDEKRILFISRVTIVIIGVISTIAALFTPSIMSLLLIT
MKIFAGATFAPVLIGLYWKRANAFGALLGEILGGMAVVINIIHPVVNLDPVIFGIIMAVLGTITGSLFTKENTEKGSIFS
FANDISSKGWLAVIAIALLYFGWVISMNNYAMWPYFIITTVVLLVLSVVFLIYSFITERTGN

Specific function: Catalyzes the sodium-dependent uptake of extracellular pantothenate [H]

COG id: COG0591

COG function: function code ER; Na+/proline symporter

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family [H]

Homologues:

Organism=Homo sapiens, GI310128183, Length=506, Percent_Identity=25.4940711462451, Blast_Score=106, Evalue=5e-23,
Organism=Homo sapiens, GI11141885, Length=331, Percent_Identity=22.6586102719033, Blast_Score=71, Evalue=2e-12,
Organism=Escherichia coli, GI87082237, Length=469, Percent_Identity=27.5053304904051, Blast_Score=122, Evalue=6e-29,
Organism=Escherichia coli, GI1787251, Length=487, Percent_Identity=27.9260780287474, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI1790503, Length=489, Percent_Identity=22.4948875255624, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790113, Length=437, Percent_Identity=21.5102974828375, Blast_Score=63, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI17539284, Length=486, Percent_Identity=23.0452674897119, Blast_Score=78, Evalue=9e-15,
Organism=Drosophila melanogaster, GI28573698, Length=429, Percent_Identity=23.3100233100233, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24648033, Length=465, Percent_Identity=24.0860215053763, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI21356865, Length=465, Percent_Identity=24.0860215053763, Blast_Score=72, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011849
- InterPro:   IPR001734
- InterPro:   IPR018212
- InterPro:   IPR019900 [H]

Pfam domain/function: PF00474 SSF [H]

EC number: NA

Molecular weight: Translated: 58925; Mature: 58925

Theoretical pI: Translated: 9.73; Mature: 9.73

Prosite motif: PS00962 RIBOSOMAL_S2_1 ; PS50283 NA_SOLUT_SYMP_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CC
>Mature Secondary Structure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CC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Na (I) [Periplasm]; pantothenate [Periplasm] [C]

Specific reaction: Na (I) [Periplasm] + pantothenate [Periplasm] = Na (I) [Cytoplasm] + pantothenate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2193919; 9278503; 8226664 [H]