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The map label for this gene is yoeA [H]

Identifier: 220931364

GI number: 220931364

Start: 566905

End: 568269

Strand: Direct

Name: yoeA [H]

Synonym: Hore_05190

Alternate gene names: 220931364

Gene position: 566905-568269 (Clockwise)

Preceding gene: 220931363

Following gene: 220931365

Centisome position: 21.99

GC content: 41.32

Gene sequence:

>1365_bases
GTGGAACATAAGAAAAGAGATAAATTCAGTTACATAACCGAAGGGCCAATACTGGGGTCTTTAGTTAAACTGGCTTTACC
TATTATGTTAAGCCAGTTGATGCAGACATTATATAACCCGGTAGATACTATCTGGGTTGGCAGGGTAGGAGCCAACGCAG
TGGCTGCTATTTCTATAAGTTTTCCGGTGGTAATGCTTATGGTGGCTCTCGGAGCCGGATTAACCATAGCCGGAACCGCA
TTAATAGCCCAGCATAAAGGAGCCGGTAACCAACAGGAAATAAACAAAATACTGGGTCAGCTTTTTAGTTTTATTGGGTC
CTTTTCAGTTATAATTGCCATTGTAGGGTATCTTTTATCCAGAAAAATGGTTGTCTGGATGGGGGCAGATCCTTCAATAG
TAAATGATGCTGCTCAATATTTAAAAATAATATTTTCTGGTATTCCCTTTATGTTTGGATTTTTTATCTTTTCTTCAACC
CTGAGGGGGATAGGGGATACGCTAACACCCGCAGTTATGATGTTTTCTTCGGTTATTTTAAATATGGTATTAGACCCTCT
TTTTATCTTTGGAATCTGGATTTTTCCTGAATTAGGGGTGGGGGGTGCTGCACTGGCAACCATTTTATCCAGGGGAATTG
TGGCTATCTGGGCTCTTTTTATGTTGCTTGGAGGTAATAAAGGCCTCAAACTGATAAAAGTTAATATGATTCCTGATTTT
AGCATAATAAAAAAGATAATTAAGATAGGAATACCGTCTTCTGTGGAACAATCCATGATATCTCTGGGACAGCTATTTAT
GACAAAACTGGTTGCTTCTTTTGGGACTATGACGCTGGCTGCTTATGGTATCGTAAACAGGGTTGTAAGCCTACCGGTAA
TTCTGGCCTTCGGTGTAGCAGCGGCTGCAACTACCATGGTTGGGCAGAATGTGGGGGCTGAAAAAAAGGAGCGAGCTGAG
AAAACAGCTCTGGTCAGTAATCTAACCATTTTCATCAGTTTAACGGTAATTGGATTTTTAATGATGGTTAAACCTGCACT
GGTTATCAGTGTTTTTAATAAAGCCCCGGAGGTTTTAAAATACGGAAGTGACTATTTGAATATTATCGCCCTTACCTTTG
GATTTACTGGAATTATGATTGTCTCCAATGGTATTTTTAAAGGTGCCGGGCGGACAGTCCCGCCAATGGTCATTTCAATT
ATATCACAATGGGGTTTTAGACTATGGCTTGGCTTTTATCTATCCCGGGACCTGGGCCTGGAGCAGGCTGGTTTATGGTG
GGCCATTGCCATAGCCAATATAGGGGGTGCCGTTATAGGTGTTACCTGGTTAAAATTAACTGACTGGAGTACCGGGCGTT
ATTAA

Upstream 100 bases:

>100_bases
ACAGAGTGGTTAAATAAAAACTAAGATATAATATGGTAATGGAAACATACCAGTAACATATATGATAAAATAATTAAACC
AGGATGGGAGATGAATATGA

Downstream 100 bases:

>100_bases
AGATGATAACCTTGAGCTGGAATTGAATGAGGCCTGAGGTTTTTATCTTGTGATTTGTAATTTATGTTAATGTTGTTAAA
TAAAGGGTAGGGGTGGTAAA

Product: MATE efflux family protein

Products: Proton [Cytoplasm]; multidrug [Periplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 454; Mature: 454

Protein sequence:

>454_residues
MEHKKRDKFSYITEGPILGSLVKLALPIMLSQLMQTLYNPVDTIWVGRVGANAVAAISISFPVVMLMVALGAGLTIAGTA
LIAQHKGAGNQQEINKILGQLFSFIGSFSVIIAIVGYLLSRKMVVWMGADPSIVNDAAQYLKIIFSGIPFMFGFFIFSST
LRGIGDTLTPAVMMFSSVILNMVLDPLFIFGIWIFPELGVGGAALATILSRGIVAIWALFMLLGGNKGLKLIKVNMIPDF
SIIKKIIKIGIPSSVEQSMISLGQLFMTKLVASFGTMTLAAYGIVNRVVSLPVILAFGVAAAATTMVGQNVGAEKKERAE
KTALVSNLTIFISLTVIGFLMMVKPALVISVFNKAPEVLKYGSDYLNIIALTFGFTGIMIVSNGIFKGAGRTVPPMVISI
ISQWGFRLWLGFYLSRDLGLEQAGLWWAIAIANIGGAVIGVTWLKLTDWSTGRY

Sequences:

>Translated_454_residues
MEHKKRDKFSYITEGPILGSLVKLALPIMLSQLMQTLYNPVDTIWVGRVGANAVAAISISFPVVMLMVALGAGLTIAGTA
LIAQHKGAGNQQEINKILGQLFSFIGSFSVIIAIVGYLLSRKMVVWMGADPSIVNDAAQYLKIIFSGIPFMFGFFIFSST
LRGIGDTLTPAVMMFSSVILNMVLDPLFIFGIWIFPELGVGGAALATILSRGIVAIWALFMLLGGNKGLKLIKVNMIPDF
SIIKKIIKIGIPSSVEQSMISLGQLFMTKLVASFGTMTLAAYGIVNRVVSLPVILAFGVAAAATTMVGQNVGAEKKERAE
KTALVSNLTIFISLTVIGFLMMVKPALVISVFNKAPEVLKYGSDYLNIIALTFGFTGIMIVSNGIFKGAGRTVPPMVISI
ISQWGFRLWLGFYLSRDLGLEQAGLWWAIAIANIGGAVIGVTWLKLTDWSTGRY
>Mature_454_residues
MEHKKRDKFSYITEGPILGSLVKLALPIMLSQLMQTLYNPVDTIWVGRVGANAVAAISISFPVVMLMVALGAGLTIAGTA
LIAQHKGAGNQQEINKILGQLFSFIGSFSVIIAIVGYLLSRKMVVWMGADPSIVNDAAQYLKIIFSGIPFMFGFFIFSST
LRGIGDTLTPAVMMFSSVILNMVLDPLFIFGIWIFPELGVGGAALATILSRGIVAIWALFMLLGGNKGLKLIKVNMIPDF
SIIKKIIKIGIPSSVEQSMISLGQLFMTKLVASFGTMTLAAYGIVNRVVSLPVILAFGVAAAATTMVGQNVGAEKKERAE
KTALVSNLTIFISLTVIGFLMMVKPALVISVFNKAPEVLKYGSDYLNIIALTFGFTGIMIVSNGIFKGAGRTVPPMVISI
ISQWGFRLWLGFYLSRDLGLEQAGLWWAIAIANIGGAVIGVTWLKLTDWSTGRY

Specific function: Unknown

COG id: COG0534

COG function: function code V; Na+-driven multidrug efflux pump

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family [H]

Homologues:

Organism=Homo sapiens, GI22907060, Length=443, Percent_Identity=23.4762979683973, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI153792564, Length=416, Percent_Identity=22.3557692307692, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI48994890, Length=437, Percent_Identity=27.0022883295195, Blast_Score=113, Evalue=2e-26,
Organism=Escherichia coli, GI226510954, Length=429, Percent_Identity=25.8741258741259, Blast_Score=108, Evalue=9e-25,
Organism=Saccharomyces cerevisiae, GI6321821, Length=381, Percent_Identity=23.3595800524934, Blast_Score=64, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002528
- InterPro:   IPR015522 [H]

Pfam domain/function: PF01554 MatE [H]

EC number: NA

Molecular weight: Translated: 48866; Mature: 48866

Theoretical pI: Translated: 10.42; Mature: 10.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.6 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.6 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEHKKRDKFSYITEGPILGSLVKLALPIMLSQLMQTLYNPVDTIWVGRVGANAVAAISIS
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEECCCCCCHHEEEEHH
FPVVMLMVALGAGLTIAGTALIAQHKGAGNQQEINKILGQLFSFIGSFSVIIAIVGYLLS
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RKMVVWMGADPSIVNDAAQYLKIIFSGIPFMFGFFIFSSTLRGIGDTLTPAVMMFSSVIL
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
NMVLDPLFIFGIWIFPELGVGGAALATILSRGIVAIWALFMLLGGNKGLKLIKVNMIPDF
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCH
SIIKKIIKIGIPSSVEQSMISLGQLFMTKLVASFGTMTLAAYGIVNRVVSLPVILAFGVA
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAATTMVGQNVGAEKKERAEKTALVSNLTIFISLTVIGFLMMVKPALVISVFNKAPEVLK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
YGSDYLNIIALTFGFTGIMIVSNGIFKGAGRTVPPMVISIISQWGFRLWLGFYLSRDLGL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
EQAGLWWAIAIANIGGAVIGVTWLKLTDWSTGRY
CCCCHHHHHHHHHCCCHHHHEEEEEEECCCCCCC
>Mature Secondary Structure
MEHKKRDKFSYITEGPILGSLVKLALPIMLSQLMQTLYNPVDTIWVGRVGANAVAAISIS
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHEECCCCCCHHEEEEHH
FPVVMLMVALGAGLTIAGTALIAQHKGAGNQQEINKILGQLFSFIGSFSVIIAIVGYLLS
HHHHHHHHHHCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
RKMVVWMGADPSIVNDAAQYLKIIFSGIPFMFGFFIFSSTLRGIGDTLTPAVMMFSSVIL
CCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHH
NMVLDPLFIFGIWIFPELGVGGAALATILSRGIVAIWALFMLLGGNKGLKLIKVNMIPDF
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCH
SIIKKIIKIGIPSSVEQSMISLGQLFMTKLVASFGTMTLAAYGIVNRVVSLPVILAFGVA
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AAATTMVGQNVGAEKKERAEKTALVSNLTIFISLTVIGFLMMVKPALVISVFNKAPEVLK
HHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
YGSDYLNIIALTFGFTGIMIVSNGIFKGAGRTVPPMVISIISQWGFRLWLGFYLSRDLGL
CCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCC
EQAGLWWAIAIANIGGAVIGVTWLKLTDWSTGRY
CCCCHHHHHHHHHCCCHHHHEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; multidrug [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + multidrug [Cytoplasm] = Proton [Cytoplasm] + multidrug [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]