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The map label for this gene is coaE [H]

Identifier: 220931334

GI number: 220931334

Start: 529858

End: 530811

Strand: Direct

Name: coaE [H]

Synonym: Hore_04890

Alternate gene names: 220931334

Gene position: 529858-530811 (Clockwise)

Preceding gene: 220931333

Following gene: 220931335

Centisome position: 20.55

GC content: 38.99

Gene sequence:

>954_bases
TTGATAATTGGGCTAACCGGGGGAATTGCCTCTGGTAAAAGTACAGTAAGTAATATTTTGAAGGAACTGGGTGCCTGTAT
TATTGATGCTGACAGGATTGCTCATAAAATATTAAAAAAAGGCCAACCTGGTTGGAGAGGTGTTGTCGGTTACTTTGGTA
CAGATATTATTGATGATAAAGGTGAAATAGATAGAAAAAAACTTGGTAAACTGGTTTTTAATAAACCTGAAGAAAGAAAA
AAACTGGAAAAAATAACCCATCCAATAATTATCTCACAAATTAAAGATGAAATAGTTTCTCTCAAAAATAAATGCAATTT
AATTATTCTTGATGCCCCACTTTTATTTGAAGCCAACCTGGACAGGCTGGTGGACCGGGTCTGGGTGGTTTATGTTGATC
GGGACATACAGCTTAGACGTTTACAGGAACGGGATGGGCTTAGCCGGGAAGAAGCCATTTTGAGGATAGAAACCCAGATG
CCGCTTAAAGAAAAGGCCAGACTGGCTGATATTGTTATAGATAATAATGGGAGTATTAAAAAACTAAAAAAACAGGTAAT
AAAACACTGGAGGGAGTTAAAGATGAAGAGGATAGCTTTGATTGCTCATGATGAAAAAAAAGATGATATAATTGAGTTTG
CCAGAAAACATTATGACCTTTTAAAGAAATGTAAACTTATTGCAACCGGGACTACCGGGAAAATGATTATTGATAAGGTT
GGCCTTGAGGTTGAGAGAATGCTCTCTGGACCACTGGGTGGCGACCAGATGATTGGCTCCAGGGTAGCTCAGGAGAAACT
GGATGGTGTAATCTTTTTACGGGATCCCCTTACAGCCCAGCCTCATGAACCTGATATTACAGCCCTGTTAAGGGTCTGTG
ATGTTCATAATGTACCCCTGGCTACTAACCTGGCAACAGCTGATTTGATTTTGCACAAACTACTGGAAGAATAA

Upstream 100 bases:

>100_bases
GCCTGCTTGATGGTATGTTACCGGGTAAGCTTGAGGTGATGCCCGGCCTTGTTATCATGTTTCTAGGTTTTTTAAGATTT
TTTTGAAGGAGGATTGAGCC

Downstream 100 bases:

>100_bases
CTGATATTGAATTTTAGATCTTTAAAATTGATTTATGGAATAAAACTGATAAATGTTAGTTTTTTCACTTATAAATATAA
AAATTTTGTGACCTTGACGG

Product: Dephospho-CoA kinase

Products: NA

Alternate protein names: Dephosphocoenzyme A kinase [H]

Number of amino acids: Translated: 317; Mature: 317

Protein sequence:

>317_residues
MIIGLTGGIASGKSTVSNILKELGACIIDADRIAHKILKKGQPGWRGVVGYFGTDIIDDKGEIDRKKLGKLVFNKPEERK
KLEKITHPIIISQIKDEIVSLKNKCNLIILDAPLLFEANLDRLVDRVWVVYVDRDIQLRRLQERDGLSREEAILRIETQM
PLKEKARLADIVIDNNGSIKKLKKQVIKHWRELKMKRIALIAHDEKKDDIIEFARKHYDLLKKCKLIATGTTGKMIIDKV
GLEVERMLSGPLGGDQMIGSRVAQEKLDGVIFLRDPLTAQPHEPDITALLRVCDVHNVPLATNLATADLILHKLLEE

Sequences:

>Translated_317_residues
MIIGLTGGIASGKSTVSNILKELGACIIDADRIAHKILKKGQPGWRGVVGYFGTDIIDDKGEIDRKKLGKLVFNKPEERK
KLEKITHPIIISQIKDEIVSLKNKCNLIILDAPLLFEANLDRLVDRVWVVYVDRDIQLRRLQERDGLSREEAILRIETQM
PLKEKARLADIVIDNNGSIKKLKKQVIKHWRELKMKRIALIAHDEKKDDIIEFARKHYDLLKKCKLIATGTTGKMIIDKV
GLEVERMLSGPLGGDQMIGSRVAQEKLDGVIFLRDPLTAQPHEPDITALLRVCDVHNVPLATNLATADLILHKLLEE
>Mature_317_residues
MIIGLTGGIASGKSTVSNILKELGACIIDADRIAHKILKKGQPGWRGVVGYFGTDIIDDKGEIDRKKLGKLVFNKPEERK
KLEKITHPIIISQIKDEIVSLKNKCNLIILDAPLLFEANLDRLVDRVWVVYVDRDIQLRRLQERDGLSREEAILRIETQM
PLKEKARLADIVIDNNGSIKKLKKQVIKHWRELKMKRIALIAHDEKKDDIIEFARKHYDLLKKCKLIATGTTGKMIIDKV
GLEVERMLSGPLGGDQMIGSRVAQEKLDGVIFLRDPLTAQPHEPDITALLRVCDVHNVPLATNLATADLILHKLLEE

Specific function: Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A [H]

COG id: COG0237

COG function: function code H; Dephospho-CoA kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DPCK (dephospho-CoA kinase) domain [H]

Homologues:

Organism=Homo sapiens, GI191252797, Length=196, Percent_Identity=43.3673469387755, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI191252795, Length=196, Percent_Identity=43.3673469387755, Blast_Score=159, Evalue=4e-39,
Organism=Homo sapiens, GI110227605, Length=199, Percent_Identity=36.1809045226131, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI110227603, Length=199, Percent_Identity=36.1809045226131, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI110227601, Length=199, Percent_Identity=36.1809045226131, Blast_Score=118, Evalue=8e-27,
Organism=Homo sapiens, GI205277394, Length=199, Percent_Identity=36.1809045226131, Blast_Score=118, Evalue=9e-27,
Organism=Homo sapiens, GI110227607, Length=198, Percent_Identity=36.3636363636364, Blast_Score=117, Evalue=2e-26,
Organism=Escherichia coli, GI87081809, Length=118, Percent_Identity=49.1525423728814, Blast_Score=126, Evalue=1e-30,
Organism=Escherichia coli, GI1786292, Length=201, Percent_Identity=33.8308457711443, Blast_Score=118, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17554944, Length=192, Percent_Identity=40.625, Blast_Score=145, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI25143409, Length=200, Percent_Identity=31, Blast_Score=82, Evalue=5e-16,
Organism=Saccharomyces cerevisiae, GI6320402, Length=192, Percent_Identity=37.5, Blast_Score=117, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24644728, Length=214, Percent_Identity=38.785046728972, Blast_Score=142, Evalue=4e-34,
Organism=Drosophila melanogaster, GI24658602, Length=196, Percent_Identity=34.6938775510204, Blast_Score=124, Evalue=9e-29,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001977 [H]

Pfam domain/function: PF01121 CoaE [H]

EC number: =2.7.1.24 [H]

Molecular weight: Translated: 35764; Mature: 35764

Theoretical pI: Translated: 9.68; Mature: 9.68

Prosite motif: PS01294 COAE ; PS01335 METHYLGLYOXAL_SYNTH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIIGLTGGIASGKSTVSNILKELGACIIDADRIAHKILKKGQPGWRGVVGYFGTDIIDDK
CEEEECCCCCCCHHHHHHHHHHHHHHEECHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCC
GEIDRKKLGKLVFNKPEERKKLEKITHPIIISQIKDEIVSLKNKCNLIILDAPLLFEANL
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCH
DRLVDRVWVVYVDRDIQLRRLQERDGLSREEAILRIETQMPLKEKARLADIVIDNNGSIK
HHHHHHHEEEEECCCHHHHHHHHHCCCCHHHHEEEEECCCCHHHHHHEEEEEECCCCCHH
KLKKQVIKHWRELKMKRIALIAHDEKKDDIIEFARKHYDLLKKCKLIATGTTGKMIIDKV
HHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHH
GLEVERMLSGPLGGDQMIGSRVAQEKLDGVIFLRDPLTAQPHEPDITALLRVCDVHNVPL
CHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCC
ATNLATADLILHKLLEE
CCHHHHHHHHHHHHHHC
>Mature Secondary Structure
MIIGLTGGIASGKSTVSNILKELGACIIDADRIAHKILKKGQPGWRGVVGYFGTDIIDDK
CEEEECCCCCCCHHHHHHHHHHHHHHEECHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCC
GEIDRKKLGKLVFNKPEERKKLEKITHPIIISQIKDEIVSLKNKCNLIILDAPLLFEANL
CCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCHHHHCCH
DRLVDRVWVVYVDRDIQLRRLQERDGLSREEAILRIETQMPLKEKARLADIVIDNNGSIK
HHHHHHHEEEEECCCHHHHHHHHHCCCCHHHHEEEEECCCCHHHHHHEEEEEECCCCCHH
KLKKQVIKHWRELKMKRIALIAHDEKKDDIIEFARKHYDLLKKCKLIATGTTGKMIIDKV
HHHHHHHHHHHHHHHHHHHEEECCCCHHHHHHHHHHHHHHHHHCEEEEECCCCHHHHHHH
GLEVERMLSGPLGGDQMIGSRVAQEKLDGVIFLRDPLTAQPHEPDITALLRVCDVHNVPL
CHHHHHHHCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCCCHHHHHHHHHCCCCCC
ATNLATADLILHKLLEE
CCHHHHHHHHHHHHHHC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA