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The map label for this gene is ycbM [H]

Identifier: 220931317

GI number: 220931317

Start: 505930

End: 506925

Strand: Direct

Name: ycbM [H]

Synonym: Hore_04720

Alternate gene names: 220931317

Gene position: 505930-506925 (Clockwise)

Preceding gene: 220931316

Following gene: 220931318

Centisome position: 19.62

GC content: 39.86

Gene sequence:

>996_bases
ATGACTGAGAAACGGTTTCTGGCCATGACAGGGTTGGTATTGATCCTGGCTTTATTCTTGCTGGATTCAAACCATGTCAC
GAGACAGATAATACTCATATTAACCGTGGTAATATGGTTATTCTTTATCCTTAAGAGCAGGCATGAGGAGAGGATAGTTG
ATATTGTAAATGAACAGCTTTCAGATGTCCTGAATGGGAATCTCAACCGGAGAATCCTTGTAGATAGCAAGGGTAAATAT
TCCGATTTCGTGGTCAGGGTAAATGAATTGATAGATAAACTTCAGGATGAAGCCATTAAAAATAAACAATATGAGGCAAG
TTTTAAAAGGGTTATGTCCAATATATCTCATGATATCAGGACCCCTCTGACATCCATTCTGGGTTATGCCGAGGCCTTAA
AGGATGGTTTAGCTGAAGATGATGAGGAAAGAGAAAAGTACCGGGAAATAATGGTCATGAAAGCCAGGAGGTTAAAAAAA
CTGGTTGATAAATTATTCTTTCTGGCCCGGCTTGAGGCCGGGGAAGAAGAGCTGGACTTTAAGGTTTATGACCTGGCTGA
AGTGACCAGGGAGTGTATAATAGACTTCTTGCCCCGGATAAATAAAGAAGATTTAGAATTAAAGACCGAAATACCGGAAC
AAGAATGCCTTATTTATGCCGATCACCTGGCCCTTGAACGGATGATAGATAATCTTATCAGTAATTCGATTAATTATGGT
AAAGAGGGAGGAATTATCGGGGTTAAACTTTTTCGACAGGAACAGAAATATGTCTTGCAGGTCTGGGATAAAGGGCCGGG
GATAACAGAAGATAAACTCCCCCACATATTTAATCGTCTTTATGTTGGAGATAAATCAGTTGAAAGACAAATATCCGGGA
GTGGACTGGGACTTGCTATAACCAGAAGGCTTATCGAAAAACATAATGGCAGGATTACGGTAGATAGTAAACCATATGAA
AAAACCATATTTTCCCTCCATTTTCCGGCCATATAA

Upstream 100 bases:

>100_bases
CATATAAGAAGATTGAGAACTAAAATAGAAGATGATCCCAAAAATCCTGAATTTATCGAGACTGTCTGGGGGATTGGTTA
CAGGTTTGCCGGTGATGAAA

Downstream 100 bases:

>100_bases
CCCTTTTTTACTAATTTAATCATTAATAATAAAACTTATAACATACTGGCTGGAGATAATACCATATGAAAGAAAATTAA
GATAATCTTAAGAATTTGTT

Product: integral membrane sensor signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 331; Mature: 330

Protein sequence:

>331_residues
MTEKRFLAMTGLVLILALFLLDSNHVTRQIILILTVVIWLFFILKSRHEERIVDIVNEQLSDVLNGNLNRRILVDSKGKY
SDFVVRVNELIDKLQDEAIKNKQYEASFKRVMSNISHDIRTPLTSILGYAEALKDGLAEDDEEREKYREIMVMKARRLKK
LVDKLFFLARLEAGEEELDFKVYDLAEVTRECIIDFLPRINKEDLELKTEIPEQECLIYADHLALERMIDNLISNSINYG
KEGGIIGVKLFRQEQKYVLQVWDKGPGITEDKLPHIFNRLYVGDKSVERQISGSGLGLAITRRLIEKHNGRITVDSKPYE
KTIFSLHFPAI

Sequences:

>Translated_331_residues
MTEKRFLAMTGLVLILALFLLDSNHVTRQIILILTVVIWLFFILKSRHEERIVDIVNEQLSDVLNGNLNRRILVDSKGKY
SDFVVRVNELIDKLQDEAIKNKQYEASFKRVMSNISHDIRTPLTSILGYAEALKDGLAEDDEEREKYREIMVMKARRLKK
LVDKLFFLARLEAGEEELDFKVYDLAEVTRECIIDFLPRINKEDLELKTEIPEQECLIYADHLALERMIDNLISNSINYG
KEGGIIGVKLFRQEQKYVLQVWDKGPGITEDKLPHIFNRLYVGDKSVERQISGSGLGLAITRRLIEKHNGRITVDSKPYE
KTIFSLHFPAI
>Mature_330_residues
TEKRFLAMTGLVLILALFLLDSNHVTRQIILILTVVIWLFFILKSRHEERIVDIVNEQLSDVLNGNLNRRILVDSKGKYS
DFVVRVNELIDKLQDEAIKNKQYEASFKRVMSNISHDIRTPLTSILGYAEALKDGLAEDDEEREKYREIMVMKARRLKKL
VDKLFFLARLEAGEEELDFKVYDLAEVTRECIIDFLPRINKEDLELKTEIPEQECLIYADHLALERMIDNLISNSINYGK
EGGIIGVKLFRQEQKYVLQVWDKGPGITEDKLPHIFNRLYVGDKSVERQISGSGLGLAITRRLIEKHNGRITVDSKPYEK
TIFSLHFPAI

Specific function: Member of the two-component regulatory system ycbM/ycbL. Probably activates ycbL by phosphorylation [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Single-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1788393, Length=264, Percent_Identity=28.7878787878788, Blast_Score=111, Evalue=7e-26,
Organism=Escherichia coli, GI1786912, Length=269, Percent_Identity=27.8810408921933, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1786600, Length=227, Percent_Identity=30.3964757709251, Blast_Score=104, Evalue=9e-24,
Organism=Escherichia coli, GI1786783, Length=310, Percent_Identity=28.0645161290323, Blast_Score=102, Evalue=3e-23,
Organism=Escherichia coli, GI145693157, Length=301, Percent_Identity=25.5813953488372, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788713, Length=254, Percent_Identity=25.9842519685039, Blast_Score=92, Evalue=7e-20,
Organism=Escherichia coli, GI48994928, Length=244, Percent_Identity=28.2786885245902, Blast_Score=88, Evalue=9e-19,
Organism=Escherichia coli, GI1787894, Length=265, Percent_Identity=27.5471698113208, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1789149, Length=243, Percent_Identity=28.3950617283951, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87081816, Length=239, Percent_Identity=30.5439330543933, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI1790436, Length=236, Percent_Identity=27.1186440677966, Blast_Score=84, Evalue=9e-18,
Organism=Escherichia coli, GI1789808, Length=295, Percent_Identity=27.1186440677966, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1790346, Length=227, Percent_Identity=25.1101321585903, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI87082128, Length=231, Percent_Identity=25.1082251082251, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1790861, Length=200, Percent_Identity=27, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788279, Length=228, Percent_Identity=25.8771929824561, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1790300, Length=252, Percent_Identity=26.5873015873016, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788549, Length=225, Percent_Identity=22.6666666666667, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1789403, Length=202, Percent_Identity=24.7524752475248, Blast_Score=66, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 38350; Mature: 38219

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTEKRFLAMTGLVLILALFLLDSNHVTRQIILILTVVIWLFFILKSRHEERIVDIVNEQL
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SDVLNGNLNRRILVDSKGKYSDFVVRVNELIDKLQDEAIKNKQYEASFKRVMSNISHDIR
HHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
TPLTSILGYAEALKDGLAEDDEEREKYREIMVMKARRLKKLVDKLFFLARLEAGEEELDF
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCC
KVYDLAEVTRECIIDFLPRINKEDLELKTEIPEQECLIYADHLALERMIDNLISNSINYG
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KEGGIIGVKLFRQEQKYVLQVWDKGPGITEDKLPHIFNRLYVGDKSVERQISGSGLGLAI
CCCCEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHH
TRRLIEKHNGRITVDSKPYEKTIFSLHFPAI
HHHHHHHCCCEEEECCCCHHHHHHHEECCCC
>Mature Secondary Structure 
TEKRFLAMTGLVLILALFLLDSNHVTRQIILILTVVIWLFFILKSRHEERIVDIVNEQL
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHH
SDVLNGNLNRRILVDSKGKYSDFVVRVNELIDKLQDEAIKNKQYEASFKRVMSNISHDIR
HHHHCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
TPLTSILGYAEALKDGLAEDDEEREKYREIMVMKARRLKKLVDKLFFLARLEAGEEELDF
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHCC
KVYDLAEVTRECIIDFLPRINKEDLELKTEIPEQECLIYADHLALERMIDNLISNSINYG
HHHHHHHHHHHHHHHHHCCCCCCCCHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCC
KEGGIIGVKLFRQEQKYVLQVWDKGPGITEDKLPHIFNRLYVGDKSVERQISGSGLGLAI
CCCCEEHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCHHHHHHHCCCCCHHHH
TRRLIEKHNGRITVDSKPYEKTIFSLHFPAI
HHHHHHHCCCEEEECCCCHHHHHHHEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 7704254; 9384377 [H]