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The map label for this gene is nuoE [H]

Identifier: 220931028

GI number: 220931028

Start: 185134

End: 185637

Strand: Direct

Name: nuoE [H]

Synonym: Hore_01790

Alternate gene names: 220931028

Gene position: 185134-185637 (Clockwise)

Preceding gene: 220931027

Following gene: 220931029

Centisome position: 7.18

GC content: 41.67

Gene sequence:

>504_bases
ATGGCCGATAAAGAAGCAGCCCGGCATAATTTCACCCGGGTAAATGAAATTATTGAAAAGCATGGTAAGGATCAGAGCAA
ACTTATACCGATCTTGCAGGAAGTTCAGAAGGAGTACAGATACTTACCGGAGGAAATATTAACCTATATTGCTACTGTAA
TGGACCTTTCTCCGGCAACAGTTTATGGTGTAGCAACCTTTTATGCCCAGTTTTCCCTTGATCCCAAAGGAAAATATGTA
ATTAATGTCTGTGATGGTACTGCCTGTCATGTTAGCGGGTCACTACCGGTATTAAATGCTATCAGGAAAAAGCTCAACCT
GGAAGATGGTAAGTTTACCACTGATGACCTGATGTTTACTGTGGAAACAGTATCCTGTCTGGGTGCCTGTGGTCTGGCCC
CTGTAGTGACAATAAATGGTAAGGTTTATGGAAAAATGACTCCTGAAGCCATTGAGGTAATTATAGATGAACTTATGGGG
AGGGATACAGATGATCAAGAGTAA

Upstream 100 bases:

>100_bases
TGGCAACAGGTGTAAAAGAACATCTAATAAATAAAATTGCCTCTATTCTGCAGAGGCAGGGGAAAAGGGTTAATATCAAA
TATTTTTAGGAGGGATAATA

Downstream 100 bases:

>100_bases
GACTGATTTAGAAGAGGCAATTAAAAAAGCTAAAGATAAGCTGCAGGAAGAAGGGTTAAGGATTCTTGTCTGTGCCGGAA
CCGGATGTGTGGCCGGAGGT

Product: NADH dehydrogenase I subunit E

Products: NA

Alternate protein names: NADH dehydrogenase I subunit E; NDH-1 subunit E [H]

Number of amino acids: Translated: 167; Mature: 166

Protein sequence:

>167_residues
MADKEAARHNFTRVNEIIEKHGKDQSKLIPILQEVQKEYRYLPEEILTYIATVMDLSPATVYGVATFYAQFSLDPKGKYV
INVCDGTACHVSGSLPVLNAIRKKLNLEDGKFTTDDLMFTVETVSCLGACGLAPVVTINGKVYGKMTPEAIEVIIDELMG
RDTDDQE

Sequences:

>Translated_167_residues
MADKEAARHNFTRVNEIIEKHGKDQSKLIPILQEVQKEYRYLPEEILTYIATVMDLSPATVYGVATFYAQFSLDPKGKYV
INVCDGTACHVSGSLPVLNAIRKKLNLEDGKFTTDDLMFTVETVSCLGACGLAPVVTINGKVYGKMTPEAIEVIIDELMG
RDTDDQE
>Mature_166_residues
ADKEAARHNFTRVNEIIEKHGKDQSKLIPILQEVQKEYRYLPEEILTYIATVMDLSPATVYGVATFYAQFSLDPKGKYVI
NVCDGTACHVSGSLPVLNAIRKKLNLEDGKFTTDDLMFTVETVSCLGACGLAPVVTINGKVYGKMTPEAIEVIIDELMGR
DTDDQE

Specific function: NDH-1 shuttles electrons from NADH, via FMN and iron- sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cyto

COG id: COG1905

COG function: function code C; NADH:ubiquinone oxidoreductase 24 kD subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the complex I 24 kDa subunit family [H]

Homologues:

Organism=Homo sapiens, GI222080062, Length=151, Percent_Identity=40.3973509933775, Blast_Score=110, Evalue=4e-25,
Organism=Escherichia coli, GI1788621, Length=156, Percent_Identity=34.6153846153846, Blast_Score=93, Evalue=8e-21,
Organism=Caenorhabditis elegans, GI17561328, Length=151, Percent_Identity=35.0993377483444, Blast_Score=101, Evalue=2e-22,
Organism=Drosophila melanogaster, GI18859877, Length=156, Percent_Identity=37.8205128205128, Blast_Score=101, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21355353, Length=156, Percent_Identity=31.4102564102564, Blast_Score=95, Evalue=2e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002023
- InterPro:   IPR012336
- InterPro:   IPR012335 [H]

Pfam domain/function: PF01257 Complex1_24kDa [H]

EC number: =1.6.99.5 [H]

Molecular weight: Translated: 18506; Mature: 18375

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS01099 COMPLEX1_24K

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADKEAARHNFTRVNEIIEKHGKDQSKLIPILQEVQKEYRYLPEEILTYIATVMDLSPAT
CCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHH
VYGVATFYAQFSLDPKGKYVINVCDGTACHVSGSLPVLNAIRKKLNLEDGKFTTDDLMFT
HHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHH
VETVSCLGACGLAPVVTINGKVYGKMTPEAIEVIIDELMGRDTDDQE
HHHHHHHHHCCCCEEEEECCEEEECCCHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ADKEAARHNFTRVNEIIEKHGKDQSKLIPILQEVQKEYRYLPEEILTYIATVMDLSPAT
CCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCHH
VYGVATFYAQFSLDPKGKYVINVCDGTACHVSGSLPVLNAIRKKLNLEDGKFTTDDLMFT
HHHHHHHHHHHCCCCCCCEEEEECCCCEEEECCCCHHHHHHHHHCCCCCCCCCHHHHHHH
VETVSCLGACGLAPVVTINGKVYGKMTPEAIEVIIDELMGRDTDDQE
HHHHHHHHHCCCCEEEEECCEEEECCCHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA