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The map label for this gene is disA [H]

Identifier: 220930937

GI number: 220930937

Start: 108091

End: 109170

Strand: Direct

Name: disA [H]

Synonym: Hore_00890

Alternate gene names: 220930937

Gene position: 108091-109170 (Clockwise)

Preceding gene: 220930936

Following gene: 220930938

Centisome position: 4.19

GC content: 43.89

Gene sequence:

>1080_bases
ATGGATGGAAAAAAGGTGAGCTGGGGTGAAGTACTAAAAATTCTGGCTCCGGGAACCCTGCTCAGGGAAGGGCTTGAAAA
TGTGTTACGTGCTAAAACCGGGGCCCTGATTGTTATCGGTGATAGTGAAGAAGTTTTGGGTATTGTGGATGGAGGGTTTA
ATATAAATGCAGAACTTACTCCAGCCCGGTTGTATGAATTGGCCAAAATGGATGGAGCCATGGTATTAAACTCAAGTGCG
GATAGAATTCTATGTGCCAATGCCCAGCTTATTCCGGACCCAACTATACCATCCTCGGAGACAGGGACACGTCACAGAAC
TGCCGAACGGGTTGCCAAGCAGACCAACCAGCTGGTTATAGCTATTTCCCAGAGAAGGGATATTATCTCACTTTATAAGG
GTGATTCCAAGCATGTTCTGGAGGATATAAGGATAGTCCTGGCCAAGGCCAACCAGGCTGTTCAGACTCTGGAGAAATAT
CGTTCTGTCCTTGATCAGGCCCTGATTAATTTAAGTGCCCTTGAGTTTGAAGACCTGGTAACCATTGCTGATGTGGTAAC
CGTTATTCAGAGGACAGAGATGGTATTGAAGATCCAGAAAGAAATAGAAAAGTATATTAGTGAGCTCGGAAGCGAAGGCC
GGTTAATTAAGATGCAGCTTGAAGAGCTTATTACCGATGTCAGGGAAGAAGGAGTCTTATTGATAAAAGATTATATTGAA
GAGAATGAAGAGGGAGAAATTCCTGATGCTAAGGAATTACTCGATGAGTTGATAGACTGGACAACAGATGAAATGCTCTC
ATTAAATACAATCAGTAAAGCCCTTGGTCACGGTGGGGGTATTAACTCCATGGATTTATCTGTAGAACCCAGAGGTTACC
GTATTTTGCGTAAAATTCCAAGGCTTCCCATGCCTGTTATCGATAACCTGGTAGGGCATTTTGGTTCCCTGCAAAAAGTT
TTAAATGCTTTCCCTGATGAACTTGACGATGTTGATGGTGTTGGCGAAGTCAGGGCCAAGGCCATAAAAGATGGTCTGAG
GCGTCTTCGGGATCAGGTATTACTGGATAGACATATATAA

Upstream 100 bases:

>100_bases
GGCAATATATCTGGTCTGGACTTTGACCCGGATATTAATATAGTTGAAGTTAAAAATGTTAATGATCTCATGAAGATATT
GTTTAACAGGAGGTGATGTA

Downstream 100 bases:

>100_bases
AAGTAATATTATTTGTCAGGAAAACCTCGTTATTGGAAGTTAATAATAGTTTATTACAGATATAACCGAGAAATTGCCTT
AATTGACAGTTGCCCCGGGA

Product: DNA integrity scanning protein DisA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 359; Mature: 359

Protein sequence:

>359_residues
MDGKKVSWGEVLKILAPGTLLREGLENVLRAKTGALIVIGDSEEVLGIVDGGFNINAELTPARLYELAKMDGAMVLNSSA
DRILCANAQLIPDPTIPSSETGTRHRTAERVAKQTNQLVIAISQRRDIISLYKGDSKHVLEDIRIVLAKANQAVQTLEKY
RSVLDQALINLSALEFEDLVTIADVVTVIQRTEMVLKIQKEIEKYISELGSEGRLIKMQLEELITDVREEGVLLIKDYIE
ENEEGEIPDAKELLDELIDWTTDEMLSLNTISKALGHGGGINSMDLSVEPRGYRILRKIPRLPMPVIDNLVGHFGSLQKV
LNAFPDELDDVDGVGEVRAKAIKDGLRRLRDQVLLDRHI

Sequences:

>Translated_359_residues
MDGKKVSWGEVLKILAPGTLLREGLENVLRAKTGALIVIGDSEEVLGIVDGGFNINAELTPARLYELAKMDGAMVLNSSA
DRILCANAQLIPDPTIPSSETGTRHRTAERVAKQTNQLVIAISQRRDIISLYKGDSKHVLEDIRIVLAKANQAVQTLEKY
RSVLDQALINLSALEFEDLVTIADVVTVIQRTEMVLKIQKEIEKYISELGSEGRLIKMQLEELITDVREEGVLLIKDYIE
ENEEGEIPDAKELLDELIDWTTDEMLSLNTISKALGHGGGINSMDLSVEPRGYRILRKIPRLPMPVIDNLVGHFGSLQKV
LNAFPDELDDVDGVGEVRAKAIKDGLRRLRDQVLLDRHI
>Mature_359_residues
MDGKKVSWGEVLKILAPGTLLREGLENVLRAKTGALIVIGDSEEVLGIVDGGFNINAELTPARLYELAKMDGAMVLNSSA
DRILCANAQLIPDPTIPSSETGTRHRTAERVAKQTNQLVIAISQRRDIISLYKGDSKHVLEDIRIVLAKANQAVQTLEKY
RSVLDQALINLSALEFEDLVTIADVVTVIQRTEMVLKIQKEIEKYISELGSEGRLIKMQLEELITDVREEGVLLIKDYIE
ENEEGEIPDAKELLDELIDWTTDEMLSLNTISKALGHGGGINSMDLSVEPRGYRILRKIPRLPMPVIDNLVGHFGSLQKV
LNAFPDELDDVDGVGEVRAKAIKDGLRRLRDQVLLDRHI

Specific function: Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions [H]

COG id: COG1623

COG function: function code R; Predicted nucleic-acid-binding protein (contains the HHH domain)

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the disA family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018906
- InterPro:   IPR003390
- InterPro:   IPR000445
- InterPro:   IPR003583
- InterPro:   IPR010994 [H]

Pfam domain/function: PF10635 DisA-linker; PF02457 DisA_N; PF00633 HHH [H]

EC number: NA

Molecular weight: Translated: 39855; Mature: 39855

Theoretical pI: Translated: 4.67; Mature: 4.67

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDGKKVSWGEVLKILAPGTLLREGLENVLRAKTGALIVIGDSEEVLGIVDGGFNINAELT
CCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCEECCCCCC
PARLYELAKMDGAMVLNSSADRILCANAQLIPDPTIPSSETGTRHRTAERVAKQTNQLVI
HHHHHHHHHCCCCEEECCCCCEEEECCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEE
AISQRRDIISLYKGDSKHVLEDIRIVLAKANQAVQTLEKYRSVLDQALINLSALEFEDLV
EECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIADVVTVIQRTEMVLKIQKEIEKYISELGSEGRLIKMQLEELITDVREEGVLLIKDYIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCEEEEHHHHC
ENEEGEIPDAKELLDELIDWTTDEMLSLNTISKALGHGGGINSMDLSVEPRGYRILRKIP
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHCC
RLPMPVIDNLVGHFGSLQKVLNAFPDELDDVDGVGEVRAKAIKDGLRRLRDQVLLDRHI
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MDGKKVSWGEVLKILAPGTLLREGLENVLRAKTGALIVIGDSEEVLGIVDGGFNINAELT
CCCCCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEEEECCCCEEEEEECCEECCCCCC
PARLYELAKMDGAMVLNSSADRILCANAQLIPDPTIPSSETGTRHRTAERVAKQTNQLVI
HHHHHHHHHCCCCEEECCCCCEEEECCCEECCCCCCCCCCCCCHHHHHHHHHHHCCCEEE
AISQRRDIISLYKGDSKHVLEDIRIVLAKANQAVQTLEKYRSVLDQALINLSALEFEDLV
EECCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TIADVVTVIQRTEMVLKIQKEIEKYISELGSEGRLIKMQLEELITDVREEGVLLIKDYIE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEHHHHHHHHHHHHHCCEEEEHHHHC
ENEEGEIPDAKELLDELIDWTTDEMLSLNTISKALGHGGGINSMDLSVEPRGYRILRKIP
CCCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCCEEEECCCHHHHHHHCC
RLPMPVIDNLVGHFGSLQKVLNAFPDELDDVDGVGEVRAKAIKDGLRRLRDQVLLDRHI
CCCHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA