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The map label for this gene is htrA [H]

Identifier: 220930913

GI number: 220930913

Start: 76101

End: 77303

Strand: Reverse

Name: htrA [H]

Synonym: Hore_00650

Alternate gene names: 220930913

Gene position: 77303-76101 (Counterclockwise)

Preceding gene: 220930918

Following gene: 220930894

Centisome position: 3.0

GC content: 40.57

Gene sequence:

>1203_bases
ATGTCCCGGAGCAAAAGGAAAATAATGTTATTTGCTATAATTCTGGCTGTTGTTTTTACAACTGGTATCTTTGTCGGTTC
ACATTATGAATTAACCCCTACCAAAATTTATGCAGACCAGGAAAATGGCAGTTTAGTTGAAAACAATGAAGAAAATCCTG
CTGATCAGGATAAGATTGTTATAACTGATACCAATATTTTCGCCGATATAGCGGCCAAAGTTGATGCCGGAGTTGTTAAA
GTAACTTCATATACTAAAGTTCAGGGTGGGCAGTATTCAGACCCCTTTTTTAATGATCCTTTTTTCCGCTACTTCTTTGG
TGATCAATTGCCTTATCCCGAGCAACAACCGCGACTTGAAGAAGGCTTTGGTACCGGATTTATTGTATCAAAAGATGGTT
ATATTGTTACCAATGAACATGTAATCCATGGAGCCGAAAAGATAGAAGTTACTATAAAGGGTTTCGATAAACCCGTGCCT
GCAGAAATAGCCTGGTCTGACTTTAGCCTCGACCTGGCGGTTTTAAAGGTTAATGTAGATAGGGATTTAACCCCGATTAA
ACTTGGTGATTCAGATAAGATAAGGCCAGGTGACTGGGTTATTGCCATCGGTAATCCGTTCGGGTTTGAACACACCGTAA
CCATTGGTGTAGTCAGTGCCCTGGGTCGCCCCATTCAGATTCCAACCCAGGATGGGCAGGTAAGAACCTATCGGAATCTG
ATCCAGACCGATGCTGCTATTAACCCCGGTAACAGTGGTGGTCCTCTCCTGAATATAGACGGAGAAGTTATTGGAATCAA
CACTGCTGTAAGTGCCCAGGGCCAGGGTATTGGTTTTGCCATTCCGGCCAATGAGGTTAAGGAAATAGTAAATGACCTTA
AAACCAAAGGGGAAGTTATCAGACCCTGGATTGGGATTTATATGAATAAAATAACACCAGATGTTAAAGAATACTTCAAC
CTTGATAACACAGAAGGAGCTATAATTGTCGGTGTTGTTGAAAATAGTCCGGCTGCTGAAGCAGGGATAAAACCATATGA
CATTATTAAAGAAATTGACCGCAAACCCGTTAATACCCCGGAAGATGTTGTTAATATAGTTAAAAACAAAAAAGTAGGAG
ATAAAGTCCTCCTCAAAATCTTAAGGAATGGGGACCCGAGATTAATCTTTGTTGAAATTGGTAAAAGGCCAAATCAATTT
TAG

Upstream 100 bases:

>100_bases
TTAGAAATTTTGAGTATGTATAAGTATGTAATGTACTTATTGGTTAGATACCATATCCAGAAATTTATATTACAAATCAG
TAAAGGAAAGGTGGTATATT

Downstream 100 bases:

>100_bases
ATAAATATACCTCTGAATATTACCACCTCAATACTATCATACAATACCATATAAATAATCTTTACCATATAAATAATCCT
TTTAAAAAGCAAACCCCCTG

Product: 2-alkenal reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MSRSKRKIMLFAIILAVVFTTGIFVGSHYELTPTKIYADQENGSLVENNEENPADQDKIVITDTNIFADIAAKVDAGVVK
VTSYTKVQGGQYSDPFFNDPFFRYFFGDQLPYPEQQPRLEEGFGTGFIVSKDGYIVTNEHVIHGAEKIEVTIKGFDKPVP
AEIAWSDFSLDLAVLKVNVDRDLTPIKLGDSDKIRPGDWVIAIGNPFGFEHTVTIGVVSALGRPIQIPTQDGQVRTYRNL
IQTDAAINPGNSGGPLLNIDGEVIGINTAVSAQGQGIGFAIPANEVKEIVNDLKTKGEVIRPWIGIYMNKITPDVKEYFN
LDNTEGAIIVGVVENSPAAEAGIKPYDIIKEIDRKPVNTPEDVVNIVKNKKVGDKVLLKILRNGDPRLIFVEIGKRPNQF

Sequences:

>Translated_400_residues
MSRSKRKIMLFAIILAVVFTTGIFVGSHYELTPTKIYADQENGSLVENNEENPADQDKIVITDTNIFADIAAKVDAGVVK
VTSYTKVQGGQYSDPFFNDPFFRYFFGDQLPYPEQQPRLEEGFGTGFIVSKDGYIVTNEHVIHGAEKIEVTIKGFDKPVP
AEIAWSDFSLDLAVLKVNVDRDLTPIKLGDSDKIRPGDWVIAIGNPFGFEHTVTIGVVSALGRPIQIPTQDGQVRTYRNL
IQTDAAINPGNSGGPLLNIDGEVIGINTAVSAQGQGIGFAIPANEVKEIVNDLKTKGEVIRPWIGIYMNKITPDVKEYFN
LDNTEGAIIVGVVENSPAAEAGIKPYDIIKEIDRKPVNTPEDVVNIVKNKKVGDKVLLKILRNGDPRLIFVEIGKRPNQF
>Mature_399_residues
SRSKRKIMLFAIILAVVFTTGIFVGSHYELTPTKIYADQENGSLVENNEENPADQDKIVITDTNIFADIAAKVDAGVVKV
TSYTKVQGGQYSDPFFNDPFFRYFFGDQLPYPEQQPRLEEGFGTGFIVSKDGYIVTNEHVIHGAEKIEVTIKGFDKPVPA
EIAWSDFSLDLAVLKVNVDRDLTPIKLGDSDKIRPGDWVIAIGNPFGFEHTVTIGVVSALGRPIQIPTQDGQVRTYRNLI
QTDAAINPGNSGGPLLNIDGEVIGINTAVSAQGQGIGFAIPANEVKEIVNDLKTKGEVIRPWIGIYMNKITPDVKEYFNL
DNTEGAIIVGVVENSPAAEAGIKPYDIIKEIDRKPVNTPEDVVNIVKNKKVGDKVLLKILRNGDPRLIFVEIGKRPNQF

Specific function: A putative protease, its function overlaps that of the related putative proteases HhoA and HhoB [H]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Cell inner membrane; Single-pass membrane protein (Potential). Cell outer membrane (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PDZ (DHR) domain [H]

Homologues:

Organism=Homo sapiens, GI4506141, Length=301, Percent_Identity=36.8770764119601, Blast_Score=155, Evalue=5e-38,
Organism=Homo sapiens, GI24308541, Length=279, Percent_Identity=34.4086021505376, Blast_Score=153, Evalue=2e-37,
Organism=Homo sapiens, GI22129776, Length=347, Percent_Identity=32.8530259365994, Blast_Score=145, Evalue=6e-35,
Organism=Homo sapiens, GI7019477, Length=281, Percent_Identity=35.2313167259786, Blast_Score=144, Evalue=2e-34,
Organism=Escherichia coli, GI1789629, Length=292, Percent_Identity=42.8082191780822, Blast_Score=215, Evalue=3e-57,
Organism=Escherichia coli, GI1786356, Length=319, Percent_Identity=37.3040752351097, Blast_Score=195, Evalue=5e-51,
Organism=Escherichia coli, GI1789630, Length=281, Percent_Identity=36.6548042704626, Blast_Score=147, Evalue=9e-37,
Organism=Drosophila melanogaster, GI24646839, Length=338, Percent_Identity=34.3195266272189, Blast_Score=156, Evalue=3e-38,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 43969; Mature: 43837

Theoretical pI: Translated: 4.81; Mature: 4.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
0.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRSKRKIMLFAIILAVVFTTGIFVGSHYELTPTKIYADQENGSLVENNEENPADQDKIV
CCCCHHHHHHHHHHHHHHHHHHEEECCCEEECCEEEEEECCCCCEECCCCCCCCCCCEEE
ITDTNIFADIAAKVDAGVVKVTSYTKVQGGQYSDPFFNDPFFRYFFGDQLPYPEQQPRLE
EEECCHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHH
EGFGTGFIVSKDGYIVTNEHVIHGAEKIEVTIKGFDKPVPAEIAWSDFSLDLAVLKVNVD
HCCCCEEEEECCCEEEECCEEEECCEEEEEEEECCCCCCCCEEEECCCEEEEEEEEEECC
RDLTPIKLGDSDKIRPGDWVIAIGNPFGFEHTVTIGVVSALGRPIQIPTQDGQVRTYRNL
CCCCEEEECCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHCCCCEECCCCCCCHHHHHHH
IQTDAAINPGNSGGPLLNIDGEVIGINTAVSAQGQGIGFAIPANEVKEIVNDLKTKGEVI
HHHCCCCCCCCCCCCEEEECCEEEEEEEEEECCCCCEEEEECHHHHHHHHHHHHHCCCHH
RPWIGIYMNKITPDVKEYFNLDNTEGAIIVGVVENSPAAEAGIKPYDIIKEIDRKPVNTP
HHHHHHHHHHCCCCHHHHHCCCCCCCEEEEEEECCCCCHHCCCCHHHHHHHHCCCCCCCH
EDVVNIVKNKKVGDKVLLKILRNGDPRLIFVEIGKRPNQF
HHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCC
>Mature Secondary Structure 
SRSKRKIMLFAIILAVVFTTGIFVGSHYELTPTKIYADQENGSLVENNEENPADQDKIV
CCCHHHHHHHHHHHHHHHHHHEEECCCEEECCEEEEEECCCCCEECCCCCCCCCCCEEE
ITDTNIFADIAAKVDAGVVKVTSYTKVQGGQYSDPFFNDPFFRYFFGDQLPYPEQQPRLE
EEECCHHHHHHHHCCCCEEEEEEEEEECCCCCCCCCCCCCEEEEECCCCCCCCCCCCCHH
EGFGTGFIVSKDGYIVTNEHVIHGAEKIEVTIKGFDKPVPAEIAWSDFSLDLAVLKVNVD
HCCCCEEEEECCCEEEECCEEEECCEEEEEEEECCCCCCCCEEEECCCEEEEEEEEEECC
RDLTPIKLGDSDKIRPGDWVIAIGNPFGFEHTVTIGVVSALGRPIQIPTQDGQVRTYRNL
CCCCEEEECCCCCCCCCCEEEEECCCCCCCEEEHHHHHHHCCCCEECCCCCCCHHHHHHH
IQTDAAINPGNSGGPLLNIDGEVIGINTAVSAQGQGIGFAIPANEVKEIVNDLKTKGEVI
HHHCCCCCCCCCCCCEEEECCEEEEEEEEEECCCCCEEEEECHHHHHHHHHHHHHCCCHH
RPWIGIYMNKITPDVKEYFNLDNTEGAIIVGVVENSPAAEAGIKPYDIIKEIDRKPVNTP
HHHHHHHHHHCCCCHHHHHCCCCCCCEEEEEEECCCCCHHCCCCHHHHHHHHCCCCCCCH
EDVVNIVKNKKVGDKVLLKILRNGDPRLIFVEIGKRPNQF
HHHHHHHHCCCCCHHHHHHHHHCCCCEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905231 [H]