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The map label for this gene is dnaA [H]

Identifier: 220930851

GI number: 220930851

Start: 593

End: 1984

Strand: Direct

Name: dnaA [H]

Synonym: Hore_00010

Alternate gene names: 220930851

Gene position: 593-1984 (Clockwise)

Preceding gene: NA

Following gene: 220930852

Centisome position: 0.02

GC content: 38.79

Gene sequence:

>1392_bases
ATGTCTTTTTCACAGGATGAACTAAACCATATATGGCAGGAGACCTTATCCAAAATTAAAGAAAAATTAAGTAATCCCAG
CTTTAGAACCTGGTTTTCGGATACTGAAGCCCATTCCCTGGTTAATAATCAGCTAATCGTTAAGGTACCCAATGATTTCA
TAAAGGACTGGCTGGAATCTAGATATTTAGAACTAATTGAAGAGGTTATTAAAAATTTAACCAATAGCAACTGGAAGATT
GTACTTATGTCACCGGAAGAACTGGATGAACTTGACAATAAGGACAGGGCAAGGGTTGAAACCAGGGATAAAGTTAAAAG
CAAAAATAACAAAAAGAATAGTAATATAGAAATTCCTAATGGCCTTAACCCAAAATATACTTTTGACACCTTTGTGGTCG
GAAACAGTAACCGGTTTGCCCATGCTGCTTCACTGGCGGTTGCTGAAGCCCCGGCCCGGGCCTATAATCCCCTCTTTATA
TATGGAGATGTTGGTCTGGGTAAAACTCATTTAATGCAGGCTATTGCCCATTTTATTCTGGATCATAATCCCGATAAAAA
AGTTGTCTATGTATCTTCAGAGACATTTACCAATGAACTTATAAATGCCATTAAGGATGATAGGACAGTTGAATTCAGAA
ATAAATACAGGAATATAGATATCCTCCTGGTTGACGATATCCAGTTTTTAGCCGGTAAAGAAAGGACCCAGGAAGAATTT
TTTCATACCTTCAATTCACTCCATGAAGCCAATAAACAGTTGATAATATCCAGTGACCGGCCCCCGAAAGAAATACCAAC
CCTGGAAGAGAGGCTGCGTTCCCGTTTTGAGTGGGGGTTGATTACCGATATTCAAAAACCAGATCTCGAGACCAGAATAG
CTATTTTAAGAAAAAAAGCAGACCTTGAGGACCTGGAGGTCCCCAATGAAGTAATTATCTATATCGCCAATAAAATTCAG
TCCAACATTAGAGAACTTGAGGGGGCATTAATTAAAGTTATCGCTTACTCTTCCCTGGTCAACAGGGAAATAGATATAGA
TCTGGCCCAGGAGGCCTTGAAAGACCTGGTGGCTAAAGATAATAATGCTCCTAAACAGATTACCATTGATCACATAAAAA
AGGTTGTCGCCGATTATTATAACCTGACAATAGAAGACATGGATTCAAAGAAAAGAACCCAGAATATAGCCTTCCCCAGG
CAGATAGCCATGTATCTTTCGAGGGAGTTAACCAGTTCTTCCTTACCCCAGATCGGGGAAAACTTTGGAGGAAGGGATCA
TACTACAGTTATCCATGCTCACAATAAGGTTACTAAAAAATATGAAGATGATCTTGACTTTAAGAAAATGATAGATAAGC
TGGTTGAAAAAATAAAAACAGGGACCCGTTAA

Upstream 100 bases:

>100_bases
AACCAATAAAGTTATTCACAAATTTGTGGATAAACTACTGGATTATCCCTTTATTTTGGGGATAACTTTTATTTTTCAGA
GGATTTAGGAGGGTAATTTA

Downstream 100 bases:

>100_bases
ACTACACAACTTCCAGTAAATTTAAATTTACAACTTACAGATTTAAATCCTGATGTAATAGATTTAGTATTAATACAATC
TGTTAATAAATTAAGGATAA

Product: chromosomal replication initiator protein DnaA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 463; Mature: 462

Protein sequence:

>463_residues
MSFSQDELNHIWQETLSKIKEKLSNPSFRTWFSDTEAHSLVNNQLIVKVPNDFIKDWLESRYLELIEEVIKNLTNSNWKI
VLMSPEELDELDNKDRARVETRDKVKSKNNKKNSNIEIPNGLNPKYTFDTFVVGNSNRFAHAASLAVAEAPARAYNPLFI
YGDVGLGKTHLMQAIAHFILDHNPDKKVVYVSSETFTNELINAIKDDRTVEFRNKYRNIDILLVDDIQFLAGKERTQEEF
FHTFNSLHEANKQLIISSDRPPKEIPTLEERLRSRFEWGLITDIQKPDLETRIAILRKKADLEDLEVPNEVIIYIANKIQ
SNIRELEGALIKVIAYSSLVNREIDIDLAQEALKDLVAKDNNAPKQITIDHIKKVVADYYNLTIEDMDSKKRTQNIAFPR
QIAMYLSRELTSSSLPQIGENFGGRDHTTVIHAHNKVTKKYEDDLDFKKMIDKLVEKIKTGTR

Sequences:

>Translated_463_residues
MSFSQDELNHIWQETLSKIKEKLSNPSFRTWFSDTEAHSLVNNQLIVKVPNDFIKDWLESRYLELIEEVIKNLTNSNWKI
VLMSPEELDELDNKDRARVETRDKVKSKNNKKNSNIEIPNGLNPKYTFDTFVVGNSNRFAHAASLAVAEAPARAYNPLFI
YGDVGLGKTHLMQAIAHFILDHNPDKKVVYVSSETFTNELINAIKDDRTVEFRNKYRNIDILLVDDIQFLAGKERTQEEF
FHTFNSLHEANKQLIISSDRPPKEIPTLEERLRSRFEWGLITDIQKPDLETRIAILRKKADLEDLEVPNEVIIYIANKIQ
SNIRELEGALIKVIAYSSLVNREIDIDLAQEALKDLVAKDNNAPKQITIDHIKKVVADYYNLTIEDMDSKKRTQNIAFPR
QIAMYLSRELTSSSLPQIGENFGGRDHTTVIHAHNKVTKKYEDDLDFKKMIDKLVEKIKTGTR
>Mature_462_residues
SFSQDELNHIWQETLSKIKEKLSNPSFRTWFSDTEAHSLVNNQLIVKVPNDFIKDWLESRYLELIEEVIKNLTNSNWKIV
LMSPEELDELDNKDRARVETRDKVKSKNNKKNSNIEIPNGLNPKYTFDTFVVGNSNRFAHAASLAVAEAPARAYNPLFIY
GDVGLGKTHLMQAIAHFILDHNPDKKVVYVSSETFTNELINAIKDDRTVEFRNKYRNIDILLVDDIQFLAGKERTQEEFF
HTFNSLHEANKQLIISSDRPPKEIPTLEERLRSRFEWGLITDIQKPDLETRIAILRKKADLEDLEVPNEVIIYIANKIQS
NIRELEGALIKVIAYSSLVNREIDIDLAQEALKDLVAKDNNAPKQITIDHIKKVVADYYNLTIEDMDSKKRTQNIAFPRQ
IAMYLSRELTSSSLPQIGENFGGRDHTTVIHAHNKVTKKYEDDLDFKKMIDKLVEKIKTGTR

Specific function: Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box):5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phosph

COG id: COG0593

COG function: function code L; ATPase involved in DNA replication initiation

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the dnaA family [H]

Homologues:

Organism=Escherichia coli, GI2367267, Length=467, Percent_Identity=42.6124197002141, Blast_Score=397, Evalue=1e-111,
Organism=Escherichia coli, GI226510964, Length=243, Percent_Identity=23.4567901234568, Blast_Score=72, Evalue=1e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR001957
- InterPro:   IPR020591
- InterPro:   IPR018312
- InterPro:   IPR013159
- InterPro:   IPR013317
- InterPro:   IPR010921 [H]

Pfam domain/function: PF00308 Bac_DnaA; PF08299 Bac_DnaA_C [H]

EC number: NA

Molecular weight: Translated: 53494; Mature: 53363

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS01008 DNAA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.1 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFSQDELNHIWQETLSKIKEKLSNPSFRTWFSDTEAHSLVNNQLIVKVPNDFIKDWLES
CCCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHCCCEEEECCHHHHHHHHHH
RYLELIEEVIKNLTNSNWKIVLMSPEELDELDNKDRARVETRDKVKSKNNKKNSNIEIPN
HHHHHHHHHHHHHCCCCCEEEEECHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEECCC
GLNPKYTFDTFVVGNSNRFAHAASLAVAEAPARAYNPLFIYGDVGLGKTHLMQAIAHFIL
CCCCCEEEEEEEEECCCCHHHHHHHHHHHCCHHHCCCEEEEECCCCCHHHHHHHHHHHHH
DHNPDKKVVYVSSETFTNELINAIKDDRTVEFRNKYRNIDILLVDDIQFLAGKERTQEEF
CCCCCCEEEEEECHHHHHHHHHHHCCCCEEHHHHHHCCEEEEEECCHHHHHCCCHHHHHH
FHTFNSLHEANKQLIISSDRPPKEIPTLEERLRSRFEWGLITDIQKPDLETRIAILRKKA
HHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHC
DLEDLEVPNEVIIYIANKIQSNIRELEGALIKVIAYSSLVNREIDIDLAQEALKDLVAKD
CCHHHCCCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
NNAPKQITIDHIKKVVADYYNLTIEDMDSKKRTQNIAFPRQIAMYLSRELTSSSLPQIGE
CCCCCEEEHHHHHHHHHHHHCCEEECCCCHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHH
NFGGRDHTTVIHAHNKVTKKYEDDLDFKKMIDKLVEKIKTGTR
HCCCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
SFSQDELNHIWQETLSKIKEKLSNPSFRTWFSDTEAHSLVNNQLIVKVPNDFIKDWLES
CCCHHHHHHHHHHHHHHHHHHHCCCCCEECCCCHHHHHHHCCCEEEECCHHHHHHHHHH
RYLELIEEVIKNLTNSNWKIVLMSPEELDELDNKDRARVETRDKVKSKNNKKNSNIEIPN
HHHHHHHHHHHHHCCCCCEEEEECHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCCEECCC
GLNPKYTFDTFVVGNSNRFAHAASLAVAEAPARAYNPLFIYGDVGLGKTHLMQAIAHFIL
CCCCCEEEEEEEEECCCCHHHHHHHHHHHCCHHHCCCEEEEECCCCCHHHHHHHHHHHHH
DHNPDKKVVYVSSETFTNELINAIKDDRTVEFRNKYRNIDILLVDDIQFLAGKERTQEEF
CCCCCCEEEEEECHHHHHHHHHHHCCCCEEHHHHHHCCEEEEEECCHHHHHCCCHHHHHH
FHTFNSLHEANKQLIISSDRPPKEIPTLEERLRSRFEWGLITDIQKPDLETRIAILRKKA
HHHHHHHHHCCCEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHC
DLEDLEVPNEVIIYIANKIQSNIRELEGALIKVIAYSSLVNREIDIDLAQEALKDLVAKD
CCHHHCCCCHHEEEEHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
NNAPKQITIDHIKKVVADYYNLTIEDMDSKKRTQNIAFPRQIAMYLSRELTSSSLPQIGE
CCCCCEEEHHHHHHHHHHHHCCEEECCCCHHHHHCCCCHHHHHHHHHHHHHHCCCHHHHH
NFGGRDHTTVIHAHNKVTKKYEDDLDFKKMIDKLVEKIKTGTR
HCCCCCCEEEEECCCHHHHHHHCCCCHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA