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The map label for this gene is ywnE [H]

Identifier: 220919477

GI number: 220919477

Start: 4894202

End: 4895596

Strand: Direct

Name: ywnE [H]

Synonym: A2cp1_4398

Alternate gene names: 220919477

Gene position: 4894202-4895596 (Clockwise)

Preceding gene: 220919476

Following gene: 220919478

Centisome position: 97.31

GC content: 76.06

Gene sequence:

>1395_bases
GTGCTGGTCGTCGCGACGGGCCTGTCGCTGGTCGCGACCGGCCACGCCGTGCTGCACAAGCGCGACGTCCGCGCGGCGCT
GGGGTGGGTGGGGCTCATCTGGCTCGCGCCCATCGCCGGCGCGCTCGCGTACCTGCTGTTCGGCGTGAACCGCATCCGCC
GCCGGGCGCAGGCCATCGGCCTGCCCGGCGTGCGGAGCCGCGACGAGGACCGGCCGCCGCCCCCGCAGCTCCCGTCCGGC
GCCGCGCACCTCGCGCCGCTGGTGGCGCTCGCCGACGCGGTGGTGCGCCGCCCGCTCGTCGCCGGGAACGCCTTCACGTT
GCTGCCGGGCGGCGGCGTCGCCTACCCGGCCATGCTCGAGGCCATCGACGCGGCCCGGCGCTCGGTCACGTTCTGCACGT
ACATCTTCGACGCGGGGCTGGCCGGCGACGCGTTCGCCGACGCGCTGGCCCGCGCGCACGCGCGCGGCGTGAAGGTGCGC
GTGCTCGTGGACGCCATCGGCGTCCGCTACGGCTGGCCGCCCATCCACCAGCGCCTGCGCCGCCTGGGCGTGCGCACCGA
GCTGTTCCTGCCGCGCCTCACCCCGGCCTGGCTGCCGTTCGTGAACCTGCGCAACCACCGCAAGATCCTGGTGGTGGACG
GCCGGCTCGGCTTCACCGGCGGGATGAACGTGCGCGACGGGTTCCTGCCCCGGCCCGGCGGCCCGCCGCCGTTCATGGAC
CTGCAGGTGCGCATCGAGGGCCCGGTGGTGTCGCACCTCCAGTCGGCGTTCGCCGAGGACTGGCTGTTCACGACGGGCGA
GCCGCTGGAGGGCAACGCGTTCTTCCCGCCGCTCGCCGCCGCCGGGCCGGTGCTGGCGCGCGGCGTGGCCGACGGGCCGG
ACGAGGACTTCGAGGCCATCCGCTGGCTGCTGCTCGGCGCGCTCTCGGTGGCGCGCCGGCGGGTGCGCGTCGTCACGCCC
TACTTCCTGCCCGACCCGCCGCTCATCACGGCGCTCAACGTGGCGGCCATGCGCGGGGTCGAGGTGGACGTGGTGCTGCC
GGAGCGCGGGAACCTGCCGCTGGTGCAGTGGGCGCAGGCCGCGCAGCTCTGGCAGGTGCTGGACCGCGGCTGCCGGGTGT
GGTGCTCGCCGCCGCCGTTCGACCACACCAAGGCCATGGTGGTGGACGGGGCGTGGTCGCTCGTCGGCTCGGCGAACTGG
GATCCGCGCAGCCTGCGCCTCAACTTCGAGCTGGACGTGGAGGCCTGGGACCCCGAGCTGGCGGCGCGGGTGGACCGGCT
GGTGGAGGAACGGCTCGCGGCGGCGCGGCCGCTCACGCTCGCCGACGTGGACCGGCGCCCGCTGCCGGTGAAGCTGCGCG
ACGGCGTGGCGCGGCTGCTCTCGCCGTACCTGTGA

Upstream 100 bases:

>100_bases
CCGGGCCGGGCCGGGCGGCCGGCACGCCATCCCGCACCTCGACGGCCCGTCCGTTCGATGCTTCACTGATCCGGTGTTCC
GGGACGCGTGGAGCGCCGCC

Downstream 100 bases:

>100_bases
CCGCCGCGGCCGCCGGCGCCCGACCGGCGAGCGGTGCTCACGCGATTCACCCACTGTCAAGCGGGGCGGAAGCGACCGGG
GAGGATCGGGGCGGGCGCGC

Product: phospholipase D/Transphosphatidylase

Products: NA

Alternate protein names: CL synthase 2 [H]

Number of amino acids: Translated: 464; Mature: 464

Protein sequence:

>464_residues
MLVVATGLSLVATGHAVLHKRDVRAALGWVGLIWLAPIAGALAYLLFGVNRIRRRAQAIGLPGVRSRDEDRPPPPQLPSG
AAHLAPLVALADAVVRRPLVAGNAFTLLPGGGVAYPAMLEAIDAARRSVTFCTYIFDAGLAGDAFADALARAHARGVKVR
VLVDAIGVRYGWPPIHQRLRRLGVRTELFLPRLTPAWLPFVNLRNHRKILVVDGRLGFTGGMNVRDGFLPRPGGPPPFMD
LQVRIEGPVVSHLQSAFAEDWLFTTGEPLEGNAFFPPLAAAGPVLARGVADGPDEDFEAIRWLLLGALSVARRRVRVVTP
YFLPDPPLITALNVAAMRGVEVDVVLPERGNLPLVQWAQAAQLWQVLDRGCRVWCSPPPFDHTKAMVVDGAWSLVGSANW
DPRSLRLNFELDVEAWDPELAARVDRLVEERLAAARPLTLADVDRRPLPVKLRDGVARLLSPYL

Sequences:

>Translated_464_residues
MLVVATGLSLVATGHAVLHKRDVRAALGWVGLIWLAPIAGALAYLLFGVNRIRRRAQAIGLPGVRSRDEDRPPPPQLPSG
AAHLAPLVALADAVVRRPLVAGNAFTLLPGGGVAYPAMLEAIDAARRSVTFCTYIFDAGLAGDAFADALARAHARGVKVR
VLVDAIGVRYGWPPIHQRLRRLGVRTELFLPRLTPAWLPFVNLRNHRKILVVDGRLGFTGGMNVRDGFLPRPGGPPPFMD
LQVRIEGPVVSHLQSAFAEDWLFTTGEPLEGNAFFPPLAAAGPVLARGVADGPDEDFEAIRWLLLGALSVARRRVRVVTP
YFLPDPPLITALNVAAMRGVEVDVVLPERGNLPLVQWAQAAQLWQVLDRGCRVWCSPPPFDHTKAMVVDGAWSLVGSANW
DPRSLRLNFELDVEAWDPELAARVDRLVEERLAAARPLTLADVDRRPLPVKLRDGVARLLSPYL
>Mature_464_residues
MLVVATGLSLVATGHAVLHKRDVRAALGWVGLIWLAPIAGALAYLLFGVNRIRRRAQAIGLPGVRSRDEDRPPPPQLPSG
AAHLAPLVALADAVVRRPLVAGNAFTLLPGGGVAYPAMLEAIDAARRSVTFCTYIFDAGLAGDAFADALARAHARGVKVR
VLVDAIGVRYGWPPIHQRLRRLGVRTELFLPRLTPAWLPFVNLRNHRKILVVDGRLGFTGGMNVRDGFLPRPGGPPPFMD
LQVRIEGPVVSHLQSAFAEDWLFTTGEPLEGNAFFPPLAAAGPVLARGVADGPDEDFEAIRWLLLGALSVARRRVRVVTP
YFLPDPPLITALNVAAMRGVEVDVVLPERGNLPLVQWAQAAQLWQVLDRGCRVWCSPPPFDHTKAMVVDGAWSLVGSANW
DPRSLRLNFELDVEAWDPELAARVDRLVEERLAAARPLTLADVDRRPLPVKLRDGVARLLSPYL

Specific function: Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol [H]

COG id: COG1502

COG function: function code I; Phosphatidylserine/phosphatidylglycerophosphate/cardiolipin synthases and related enzymes

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PLD phosphodiesterase domains [H]

Homologues:

Organism=Escherichia coli, GI1787502, Length=451, Percent_Identity=30.3769401330377, Blast_Score=181, Evalue=9e-47,
Organism=Escherichia coli, GI1787007, Length=337, Percent_Identity=29.9703264094956, Blast_Score=108, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022924
- InterPro:   IPR015679
- InterPro:   IPR001736 [H]

Pfam domain/function: PF00614 PLDc [H]

EC number: 2.7.8.-

Molecular weight: Translated: 50523; Mature: 50523

Theoretical pI: Translated: 10.28; Mature: 10.28

Prosite motif: PS50035 PLD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVVATGLSLVATGHAVLHKRDVRAALGWVGLIWLAPIAGALAYLLFGVNRIRRRAQAIG
CEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPGVRSRDEDRPPPPQLPSGAAHLAPLVALADAVVRRPLVAGNAFTLLPGGGVAYPAMLE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEECCCEEEEECCCCCHHHHHHH
AIDAARRSVTFCTYIFDAGLAGDAFADALARAHARGVKVRVLVDAIGVRYGWPPIHQRLR
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEEHHHCCCCCHHHHHHHH
RLGVRTELFLPRLTPAWLPFVNLRNHRKILVVDGRLGFTGGMNVRDGFLPRPGGPPPFMD
HHCCCHHHHCCCCCHHHCCHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEE
LQVRIEGPVVSHLQSAFAEDWLFTTGEPLEGNAFFPPLAAAGPVLARGVADGPDEDFEAI
EEEEECCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCHHHCCHHHHCCCCCCCCHHHHHH
RWLLLGALSVARRRVRVVTPYFLPDPPLITALNVAAMRGVEVDVVLPERGNLPLVQWAQA
HHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHH
AQLWQVLDRGCRVWCSPPPFDHTKAMVVDGAWSLVGSANWDPRSLRLNFELDVEAWDPEL
HHHHHHHHHCCEEECCCCCCCCCCEEEEECCHHHCCCCCCCCCEEEEEEEEECCCCCHHH
AARVDRLVEERLAAARPLTLADVDRRPLPVKLRDGVARLLSPYL
HHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHCCCC
>Mature Secondary Structure
MLVVATGLSLVATGHAVLHKRDVRAALGWVGLIWLAPIAGALAYLLFGVNRIRRRAQAIG
CEEEEECCHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
LPGVRSRDEDRPPPPQLPSGAAHLAPLVALADAVVRRPLVAGNAFTLLPGGGVAYPAMLE
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCEECCCEEEEECCCCCHHHHHHH
AIDAARRSVTFCTYIFDAGLAGDAFADALARAHARGVKVRVLVDAIGVRYGWPPIHQRLR
HHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCEEEEEEEHHHCCCCCHHHHHHHH
RLGVRTELFLPRLTPAWLPFVNLRNHRKILVVDGRLGFTGGMNVRDGFLPRPGGPPPFMD
HHCCCHHHHCCCCCHHHCCHHCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCCCEE
LQVRIEGPVVSHLQSAFAEDWLFTTGEPLEGNAFFPPLAAAGPVLARGVADGPDEDFEAI
EEEEECCHHHHHHHHHHHHCCCEECCCCCCCCCCCCCHHHCCHHHHCCCCCCCCHHHHHH
RWLLLGALSVARRRVRVVTPYFLPDPPLITALNVAAMRGVEVDVVLPERGNLPLVQWAQA
HHHHHHHHHHHHHHEEEEECCCCCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHH
AQLWQVLDRGCRVWCSPPPFDHTKAMVVDGAWSLVGSANWDPRSLRLNFELDVEAWDPEL
HHHHHHHHHCCEEECCCCCCCCCCEEEEECCHHHCCCCCCCCCEEEEEEEEECCCCCHHH
AARVDRLVEERLAAARPLTLADVDRRPLPVKLRDGVARLLSPYL
HHHHHHHHHHHHHHCCCCEEECCCCCCCCCHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Transferring phosphorus-containing groups [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9150240; 9384377 [H]