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The map label for this gene is macA [H]

Identifier: 220919386

GI number: 220919386

Start: 4798879

End: 4800255

Strand: Direct

Name: macA [H]

Synonym: A2cp1_4307

Alternate gene names: 220919386

Gene position: 4798879-4800255 (Clockwise)

Preceding gene: 220919385

Following gene: 220919387

Centisome position: 95.42

GC content: 73.64

Gene sequence:

>1377_bases
ATGGCCACGCAGAACCCGCTCCCGATGCCCTCCCCCGACCACGCTGCCCCGGCCCCGGACGCCCCGGTGCTCGCCGCCCT
CCCGCCGCAGCCGCGCATGAGCTGGGGCAAGCGGATCGTCGCCGGCCTGTTCGTGGTGGCGGTGGTCGCCATCACCGTCT
CCGCGCTCCGCCCGAAGCCGCCGCCGCCCATCGGCATCCAGGCGGTGGCGGCGAAGCGCGGGCCCATCACCCGCCTCGTC
ACCGCCGCCGGCAAGCTGCAGGCGGCCACCGAGGTGAAGCTCTCCGCGAACGTCTCGGGCGACCTGCTCGAGCTCGACGC
GCACGAGGGCGACCTGGTGAAGAAGGGCCAGGTGCTGGGAAAGGTGGACTCGCGGCGCTACAGCGCGCAGGTGGCGCAGC
AGACCGCGGCGCGCGCCAGCGCCGCCGCCGACGTCGAGCTGGAGAAGGTGAAGGTCGCGCAGCTCGAGCAGGAGCTGGCC
CGGGTGGAGCGCCTGGTGAAGACCGGCAACGCGAGCGCGGCCGAGCTCGACACCGCCCGCTCCAACCTCGGGGCCGAGCG
GGCCCGCCAGCAGGCGGCGGTCGAGCGGGTGGCCCAGGCCGAGGCGGCGCTCAGCGAGGCGCGCCACGCGCTCTCGCTCA
CCACGCTCGCCTCGCCCATCGACGGCGTCATCACCAAGCGCCAGAAGACCGCGGGCGAGCGCGTGCGGGGCTCGGACCTC
TCCGAGGACGTGGTGCTCATCATCTCCACGCTCTCCAAGATGGAGGCGAAGATCGAGGTGGGCGAGCACGAGGTCGTCTA
CGTGAAGGAGGGCGACACCGCCGAGGTCGAGATCGACGCCTTCCCGGACCAGAAGTTCCCGGCGACCGTCGTGGAGGTGG
CGCGCAACGCCACCGTGAAGAACCAGGGCACCGAGGGCGAGGTGACCACGTTCTTCGTGCGGCTCGCGCTCGACCACCCG
GTGCAGAACGCGCTCCCCGGCATGAGCGCGCAGGCGTCGATCGCCACCGACACGCGCGACAGCGCGGTGGTGGTGCCGAT
CCAGGCCGTGACCGTCCGGCCCGAGCGCGAGCTGACCGGCGCCGGCCCCGCGCCGGAGGGCCCGCCCGCCCCGGCACAGG
GCGCCGGCCAGAAGAAGGCCAAGCGCGACCCGCTGCGCAAGGTGGTGTTCGTGATCGAGGACGGGGTGGCGAAGATCCGC
CCGGTCGAGACGGGCCTCGCCAGCGACACCGAGCTCGAGATCACCTCCGGCCTGAAGGAGGGCGAGAAGGTGGTGGAGGG
CCCGTACCGCGTGCTCTCGCGCGAGCTCGCCGACGGCAAGCGCGTCAACGAGGAGCCGCTGGGCGGCAAGCCGGGCGCCG
GCGGGAAGAAGGGCTAG

Upstream 100 bases:

>100_bases
TCTCAAGCTGACGCAGGCGGAGCTCTCGCTCCTCGAGTCCCGCATCGATCACGCCGTGGCGGTCGCCGACCTGGCGCGCG
CCGCGGGAGGAACGCTCTAG

Downstream 100 bases:

>100_bases
CCGTGGCCGAGCCGCTCATCGTCGTCGAGGAGCTTCACCGGCACTACGTGGTGGGCGGCGAGACCGTGCGCGCGCTCGAC
GGCGTGTCGTTCACCATCGA

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 458; Mature: 457

Protein sequence:

>458_residues
MATQNPLPMPSPDHAAPAPDAPVLAALPPQPRMSWGKRIVAGLFVVAVVAITVSALRPKPPPPIGIQAVAAKRGPITRLV
TAAGKLQAATEVKLSANVSGDLLELDAHEGDLVKKGQVLGKVDSRRYSAQVAQQTAARASAAADVELEKVKVAQLEQELA
RVERLVKTGNASAAELDTARSNLGAERARQQAAVERVAQAEAALSEARHALSLTTLASPIDGVITKRQKTAGERVRGSDL
SEDVVLIISTLSKMEAKIEVGEHEVVYVKEGDTAEVEIDAFPDQKFPATVVEVARNATVKNQGTEGEVTTFFVRLALDHP
VQNALPGMSAQASIATDTRDSAVVVPIQAVTVRPERELTGAGPAPEGPPAPAQGAGQKKAKRDPLRKVVFVIEDGVAKIR
PVETGLASDTELEITSGLKEGEKVVEGPYRVLSRELADGKRVNEEPLGGKPGAGGKKG

Sequences:

>Translated_458_residues
MATQNPLPMPSPDHAAPAPDAPVLAALPPQPRMSWGKRIVAGLFVVAVVAITVSALRPKPPPPIGIQAVAAKRGPITRLV
TAAGKLQAATEVKLSANVSGDLLELDAHEGDLVKKGQVLGKVDSRRYSAQVAQQTAARASAAADVELEKVKVAQLEQELA
RVERLVKTGNASAAELDTARSNLGAERARQQAAVERVAQAEAALSEARHALSLTTLASPIDGVITKRQKTAGERVRGSDL
SEDVVLIISTLSKMEAKIEVGEHEVVYVKEGDTAEVEIDAFPDQKFPATVVEVARNATVKNQGTEGEVTTFFVRLALDHP
VQNALPGMSAQASIATDTRDSAVVVPIQAVTVRPERELTGAGPAPEGPPAPAQGAGQKKAKRDPLRKVVFVIEDGVAKIR
PVETGLASDTELEITSGLKEGEKVVEGPYRVLSRELADGKRVNEEPLGGKPGAGGKKG
>Mature_457_residues
ATQNPLPMPSPDHAAPAPDAPVLAALPPQPRMSWGKRIVAGLFVVAVVAITVSALRPKPPPPIGIQAVAAKRGPITRLVT
AAGKLQAATEVKLSANVSGDLLELDAHEGDLVKKGQVLGKVDSRRYSAQVAQQTAARASAAADVELEKVKVAQLEQELAR
VERLVKTGNASAAELDTARSNLGAERARQQAAVERVAQAEAALSEARHALSLTTLASPIDGVITKRQKTAGERVRGSDLS
EDVVLIISTLSKMEAKIEVGEHEVVYVKEGDTAEVEIDAFPDQKFPATVVEVARNATVKNQGTEGEVTTFFVRLALDHPV
QNALPGMSAQASIATDTRDSAVVVPIQAVTVRPERELTGAGPAPEGPPAPAQGAGQKKAKRDPLRKVVFVIEDGVAKIRP
VETGLASDTELEITSGLKEGEKVVEGPYRVLSRELADGKRVNEEPLGGKPGAGGKKG

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=403, Percent_Identity=25.0620347394541, Blast_Score=96, Evalue=4e-21,
Organism=Escherichia coli, GI87082036, Length=309, Percent_Identity=24.2718446601942, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 48039; Mature: 47908

Theoretical pI: Translated: 7.11; Mature: 7.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATQNPLPMPSPDHAAPAPDAPVLAALPPQPRMSWGKRIVAGLFVVAVVAITVSALRPKP
CCCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PPPIGIQAVAAKRGPITRLVTAAGKLQAATEVKLSANVSGDLLELDAHEGDLVKKGQVLG
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHEEEEECCCCCCEEEECCCCCCHHHCCHHHH
KVDSRRYSAQVAQQTAARASAAADVELEKVKVAQLEQELARVERLVKTGNASAAELDTAR
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SNLGAERARQQAAVERVAQAEAALSEARHALSLTTLASPIDGVITKRQKTAGERVRGSDL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
SEDVVLIISTLSKMEAKIEVGEHEVVYVKEGDTAEVEIDAFPDQKFPATVVEVARNATVK
CCHHHHHHHHHHHHHHHEEECCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHCCCCC
NQGTEGEVTTFFVRLALDHPVQNALPGMSAQASIATDTRDSAVVVPIQAVTVRPERELTG
CCCCCCCHHEEEEEHHHCCCHHHHCCCCCCCCEEECCCCCCEEEEEEEEEEECCCCCCCC
AGPAPEGPPAPAQGAGQKKAKRDPLRKVVFVIEDGVAKIRPVETGLASDTELEITSGLKE
CCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHEECCCCCEEECCCCCCCCCCCHHHHCCHH
GEKVVEGPYRVLSRELADGKRVNEEPLGGKPGAGGKKG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
ATQNPLPMPSPDHAAPAPDAPVLAALPPQPRMSWGKRIVAGLFVVAVVAITVSALRPKP
CCCCCCCCCCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCC
PPPIGIQAVAAKRGPITRLVTAAGKLQAATEVKLSANVSGDLLELDAHEGDLVKKGQVLG
CCCCCEEEEECCCCCHHHHHHHHHHHHHHHEEEEECCCCCCEEEECCCCCCHHHCCHHHH
KVDSRRYSAQVAQQTAARASAAADVELEKVKVAQLEQELARVERLVKTGNASAAELDTAR
HHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHH
SNLGAERARQQAAVERVAQAEAALSEARHALSLTTLASPIDGVITKRQKTAGERVRGSDL
HHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCC
SEDVVLIISTLSKMEAKIEVGEHEVVYVKEGDTAEVEIDAFPDQKFPATVVEVARNATVK
CCHHHHHHHHHHHHHHHEEECCEEEEEEECCCCEEEEEECCCCCCCCHHHHHHHHCCCCC
NQGTEGEVTTFFVRLALDHPVQNALPGMSAQASIATDTRDSAVVVPIQAVTVRPERELTG
CCCCCCCHHEEEEEHHHCCCHHHHCCCCCCCCEEECCCCCCEEEEEEEEEEECCCCCCCC
AGPAPEGPPAPAQGAGQKKAKRDPLRKVVFVIEDGVAKIRPVETGLASDTELEITSGLKE
CCCCCCCCCCCCCCCCCCHHHHCHHHHHHHHEECCCCCEEECCCCCCCCCCCHHHHCCHH
GEKVVEGPYRVLSRELADGKRVNEEPLGGKPGAGGKKG
HHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]