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The map label for this gene is hisC [H]

Identifier: 220919332

GI number: 220919332

Start: 4734458

End: 4735501

Strand: Direct

Name: hisC [H]

Synonym: A2cp1_4253

Alternate gene names: 220919332

Gene position: 4734458-4735501 (Clockwise)

Preceding gene: 220919330

Following gene: 220919337

Centisome position: 94.14

GC content: 75.29

Gene sequence:

>1044_bases
GTGAACGCGTTCAAGCCCCACCTCGCCTCGGTCGCCGACTACCCGTACGCGAAGGTCGATGCGCGCCTGAAGCTCGACCA
GAACGAGAGCCCCGACGACCTCCCGCCCGACCTGAAGGCCCGCGCGCTGGAGCGCATCGCCGCCGCCGCCTGGAACCGCT
ACCCCGAGCTGCACGCCGAGGACGTGCGGGCGGCGCTGGCGCGACACGAGGGCTGGGACCCGCAGGGCGTGGTGCTCGCG
CCGGGCTCGAACCTGCTCGTGCTCGCGCTCACGCAGGCCGCGCGCACCGTCGTCGACACGGTGCCGGCGTTCCCCTACTA
CAAGGGCGGCAGCCTCGCGACCGGCACGCCGTGGCGCGGCATCCCGCTCGCGCCCGGGTTCGCGATCCCCATGGACGCGC
TGCTCGCCGCCATGGACGGCGCGGGCGGCGTGCTGTTCCTGCCCAACCCGCACGCGCCCACCGGGCAGCTCTTCGCGACC
GGCGACGTGGAGCGGCTCGCCGAGCGCGCCCGCCAGCAGGGCTGGGTGCTGGTGGTGGACGAGGCGTACCACGCGTTCGC
GGGCAGCGACGCCCGGCCGCTGGCGCGCGCGAACGACCACGTGGCGGTGCTGCGCACGTTCTCGAAGTCCTGGTGCCTGG
GCGGCGTCCGCGCCGGCTACCTGCTCGCGTCGCCGAAGGTGGCGGCGGTGGTCCGCGCCTGCCTGCCGCCGTTCTGCATC
CCGGTGCACACCGGCGCGATCCTGCAGACGGTGCTCGAGGCGCCCGGCTACGTGGGCGAGCTGGCGCAGCGGATCCAGGC
CGAGCGCGCCCGCGTGCTCGAGGCGCTCTCGACGCACCCGACCTGGCGCCCCTATCCCAGCGCCGCGAACTACGTCCTCG
TCCGCACGCCGGACGCGAAGGCGGCCTGGGACCACCTGCTCTCGCGCGGCATCCTGGTCCGCCGGCAGGACCACTACGCC
GGGCTGGAGGGCTGCATCCGCATCACCATCGGCACGCGCGCCGAGAACGACGCGCTGCTGGCGGCGGCGGCCGAGGCCCG
CTGA

Upstream 100 bases:

>100_bases
TCTCGCGGGGTTGCGCGCCGTCGTGTCGGGACTTCCCGACCCGCGCTCCGCCGGTCCCGACTGGGGGAGGTCTGCGCGTC
CGTGTGGTAGGTTCTCGCGC

Downstream 100 bases:

>100_bases
GGCCGGGGCCGCCGGCTCCGGCTCCGGCTCGACGCTGCGCGACCCGATCCGGCGGGCGCCCCGCCCGCGGCGCTCACCCG
GCGCGCCGCGGCACCACCGC

Product: class I and II aminotransferase

Products: NA

Alternate protein names: Imidazole acetol-phosphate transaminase [H]

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MNAFKPHLASVADYPYAKVDARLKLDQNESPDDLPPDLKARALERIAAAAWNRYPELHAEDVRAALARHEGWDPQGVVLA
PGSNLLVLALTQAARTVVDTVPAFPYYKGGSLATGTPWRGIPLAPGFAIPMDALLAAMDGAGGVLFLPNPHAPTGQLFAT
GDVERLAERARQQGWVLVVDEAYHAFAGSDARPLARANDHVAVLRTFSKSWCLGGVRAGYLLASPKVAAVVRACLPPFCI
PVHTGAILQTVLEAPGYVGELAQRIQAERARVLEALSTHPTWRPYPSAANYVLVRTPDAKAAWDHLLSRGILVRRQDHYA
GLEGCIRITIGTRAENDALLAAAAEAR

Sequences:

>Translated_347_residues
MNAFKPHLASVADYPYAKVDARLKLDQNESPDDLPPDLKARALERIAAAAWNRYPELHAEDVRAALARHEGWDPQGVVLA
PGSNLLVLALTQAARTVVDTVPAFPYYKGGSLATGTPWRGIPLAPGFAIPMDALLAAMDGAGGVLFLPNPHAPTGQLFAT
GDVERLAERARQQGWVLVVDEAYHAFAGSDARPLARANDHVAVLRTFSKSWCLGGVRAGYLLASPKVAAVVRACLPPFCI
PVHTGAILQTVLEAPGYVGELAQRIQAERARVLEALSTHPTWRPYPSAANYVLVRTPDAKAAWDHLLSRGILVRRQDHYA
GLEGCIRITIGTRAENDALLAAAAEAR
>Mature_347_residues
MNAFKPHLASVADYPYAKVDARLKLDQNESPDDLPPDLKARALERIAAAAWNRYPELHAEDVRAALARHEGWDPQGVVLA
PGSNLLVLALTQAARTVVDTVPAFPYYKGGSLATGTPWRGIPLAPGFAIPMDALLAAMDGAGGVLFLPNPHAPTGQLFAT
GDVERLAERARQQGWVLVVDEAYHAFAGSDARPLARANDHVAVLRTFSKSWCLGGVRAGYLLASPKVAAVVRACLPPFCI
PVHTGAILQTVLEAPGYVGELAQRIQAERARVLEALSTHPTWRPYPSAANYVLVRTPDAKAAWDHLLSRGILVRRQDHYA
GLEGCIRITIGTRAENDALLAAAAEAR

Specific function: Histidine biosynthesis; seventh step. [C]

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily [H]

Homologues:

Organism=Escherichia coli, GI1788332, Length=328, Percent_Identity=29.5731707317073, Blast_Score=128, Evalue=4e-31,
Organism=Saccharomyces cerevisiae, GI6322075, Length=339, Percent_Identity=24.7787610619469, Blast_Score=86, Evalue=6e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.9 [H]

Molecular weight: Translated: 37296; Mature: 37296

Theoretical pI: Translated: 8.02; Mature: 8.02

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAFKPHLASVADYPYAKVDARLKLDQNESPDDLPPDLKARALERIAAAAWNRYPELHAE
CCCCCCHHHHHHCCCCCEECEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHH
DVRAALARHEGWDPQGVVLAPGSNLLVLALTQAARTVVDTVPAFPYYKGGSLATGTPWRG
HHHHHHHHCCCCCCCCEEECCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
IPLAPGFAIPMDALLAAMDGAGGVLFLPNPHAPTGQLFATGDVERLAERARQQGWVLVVD
CCCCCCCCCCHHHHHHHHCCCCCEEECCCCCCCCCCEEECCCHHHHHHHHHHCCCEEEEE
EAYHAFAGSDARPLARANDHVAVLRTFSKSWCLGGVRAGYLLASPKVAAVVRACLPPFCI
CCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHCCCCEE
PVHTGAILQTVLEAPGYVGELAQRIQAERARVLEALSTHPTWRPYPSAANYVLVRTPDAK
ECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHH
AAWDHLLSRGILVRRQDHYAGLEGCIRITIGTRAENDALLAAAAEAR
HHHHHHHHCCEEEEECCHHCCCCCEEEEEECCCCCCCEEEEECCCCC
>Mature Secondary Structure
MNAFKPHLASVADYPYAKVDARLKLDQNESPDDLPPDLKARALERIAAAAWNRYPELHAE
CCCCCCHHHHHHCCCCCEECEEEEECCCCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCHH
DVRAALARHEGWDPQGVVLAPGSNLLVLALTQAARTVVDTVPAFPYYKGGSLATGTPWRG
HHHHHHHHCCCCCCCCEEECCCCCEEEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCC
IPLAPGFAIPMDALLAAMDGAGGVLFLPNPHAPTGQLFATGDVERLAERARQQGWVLVVD
CCCCCCCCCCHHHHHHHHCCCCCEEECCCCCCCCCCEEECCCHHHHHHHHHHCCCEEEEE
EAYHAFAGSDARPLARANDHVAVLRTFSKSWCLGGVRAGYLLASPKVAAVVRACLPPFCI
CCHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEECCCHHHHHHHHHCCCCEE
PVHTGAILQTVLEAPGYVGELAQRIQAERARVLEALSTHPTWRPYPSAANYVLVRTPDAK
ECCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEECCCHH
AAWDHLLSRGILVRRQDHYAGLEGCIRITIGTRAENDALLAAAAEAR
HHHHHHHHCCEEEEECCHHCCCCCEEEEEECCCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10567266 [H]