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The map label for this gene is trpA [H]

Identifier: 220919280

GI number: 220919280

Start: 4687197

End: 4688054

Strand: Direct

Name: trpA [H]

Synonym: A2cp1_4201

Alternate gene names: 220919280

Gene position: 4687197-4688054 (Clockwise)

Preceding gene: 220919279

Following gene: 220919283

Centisome position: 93.2

GC content: 78.32

Gene sequence:

>858_bases
GTGAGCCCGCGCCCCGCCCGCAAGCCCCGCGCCGCCGCCGCGCCCGTCGCGGCCGAGCGCCCCGACCGCATCTCGGCCGC
GTTCGAGCGCTGCCGCGCCGAGCGCCGGGCCGCGCTCGTCACCTACGTGATGGGCGGCGACCCCGACCTCGCCACCGCGC
GGGACATGGCGCTCGCCTGCGTGGAGGGCGGCGCCGACCTCGTCGAGCTTGGGGTGCCGTTCTCGGATCCCATCGCCGAC
GGCCCCACCATCCAGGCCGCCGCGCAGCGCGCGCTCGGCGCTGGCACCACGCTCGAGGACGTGCTCGGGATCGCCGCCGC
GGTCCGCGCGCGCTCGCAGGTCCCCATCGCGCTCATGGGCTACCTCAACCCCATGCTGGCGGGCGGGGTCGAGCGGCTCG
TGCGCGGCTGCGCCGACGCCGGCGTGGACGCGCTCATCATCCCCGACCTGCTGCCCGAGGAGGCCGAGGTGCTCGCCCCG
GCGTCGGCCGAGGCCGGCGTGAAGCTGGTCTACCTGCTCGCGCCCACCTCGAACCCGGCCCGCGTCGAGGCCGCGGCCCG
GGCCGCCACCGGCTTCCTCTACTTCGTGTCGGTGACCGGCGTGACCGGGGCGCGCCACGCGGTGGCCGAGGAGATCGCGC
CGCTCGTGTCCGCGGTGCGGGCCCGGACCGACCTGCCGGTGGTCATCGGCTTCGGCGTGGCCTCGCCCGAGCAGGCGCGC
GCGCTCGGCCCGCTCGCCGACGGCGTGGTGGTCGGGAGCGCGATCGTGAAGCGGATCGCCGAGGGCGGCTCGCGGCGCGC
TCGCGCCGAGCGGGTCACGCGGTTCGTGCGATCGCTGGGGCGCGCGCTGCGGCGCTGA

Upstream 100 bases:

>100_bases
CGCGGCGCAGCCGCGCCCGCCCGGCACGGCCGGCGCGGCCGAAGGGCAAGGCGAAGGCCGAGGCGAGGCCGCGCGCCGCG
GCGCGGAAGGGAGGCCGCCG

Downstream 100 bases:

>100_bases
TCGGGCGCTACGCCAGCCCGCCCGCCGGGTGGATGACCTGCACGGCGCCGTCGGCCCGGCGCATGTGCGGGTGGGAGATC
CAGCGGCACCGCGGGCAGAA

Product: tryptophan synthase subunit alpha

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 285; Mature: 284

Protein sequence:

>285_residues
MSPRPARKPRAAAAPVAAERPDRISAAFERCRAERRAALVTYVMGGDPDLATARDMALACVEGGADLVELGVPFSDPIAD
GPTIQAAAQRALGAGTTLEDVLGIAAAVRARSQVPIALMGYLNPMLAGGVERLVRGCADAGVDALIIPDLLPEEAEVLAP
ASAEAGVKLVYLLAPTSNPARVEAAARAATGFLYFVSVTGVTGARHAVAEEIAPLVSAVRARTDLPVVIGFGVASPEQAR
ALGPLADGVVVGSAIVKRIAEGGSRRARAERVTRFVRSLGRALRR

Sequences:

>Translated_285_residues
MSPRPARKPRAAAAPVAAERPDRISAAFERCRAERRAALVTYVMGGDPDLATARDMALACVEGGADLVELGVPFSDPIAD
GPTIQAAAQRALGAGTTLEDVLGIAAAVRARSQVPIALMGYLNPMLAGGVERLVRGCADAGVDALIIPDLLPEEAEVLAP
ASAEAGVKLVYLLAPTSNPARVEAAARAATGFLYFVSVTGVTGARHAVAEEIAPLVSAVRARTDLPVVIGFGVASPEQAR
ALGPLADGVVVGSAIVKRIAEGGSRRARAERVTRFVRSLGRALRR
>Mature_284_residues
SPRPARKPRAAAAPVAAERPDRISAAFERCRAERRAALVTYVMGGDPDLATARDMALACVEGGADLVELGVPFSDPIADG
PTIQAAAQRALGAGTTLEDVLGIAAAVRARSQVPIALMGYLNPMLAGGVERLVRGCADAGVDALIIPDLLPEEAEVLAPA
SAEAGVKLVYLLAPTSNPARVEAAARAATGFLYFVSVTGVTGARHAVAEEIAPLVSAVRARTDLPVVIGFGVASPEQARA
LGPLADGVVVGSAIVKRIAEGGSRRARAERVTRFVRSLGRALRR

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Escherichia coli, GI1787514, Length=242, Percent_Identity=31.8181818181818, Blast_Score=130, Evalue=8e-32,
Organism=Saccharomyces cerevisiae, GI6321412, Length=237, Percent_Identity=41.3502109704641, Blast_Score=180, Evalue=2e-46,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 29351; Mature: 29220

Theoretical pI: Translated: 9.27; Mature: 9.27

Prosite motif: PS00167 TRP_SYNTHASE_ALPHA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPRPARKPRAAAAPVAAERPDRISAAFERCRAERRAALVTYVMGGDPDLATARDMALAC
CCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHH
VEGGADLVELGVPFSDPIADGPTIQAAAQRALGAGTTLEDVLGIAAAVRARSQVPIALMG
HHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHH
YLNPMLAGGVERLVRGCADAGVDALIIPDLLPEEAEVLAPASAEAGVKLVYLLAPTSNPA
HHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHCCCCCCCCCEEEEEEEECCCCCH
RVEAAARAATGFLYFVSVTGVTGARHAVAEEIAPLVSAVRARTDLPVVIGFGVASPEQAR
HHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
ALGPLADGVVVGSAIVKRIAEGGSRRARAERVTRFVRSLGRALRR
HHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SPRPARKPRAAAAPVAAERPDRISAAFERCRAERRAALVTYVMGGDPDLATARDMALAC
CCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHH
VEGGADLVELGVPFSDPIADGPTIQAAAQRALGAGTTLEDVLGIAAAVRARSQVPIALMG
HHCCCCEEEECCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCHHHH
YLNPMLAGGVERLVRGCADAGVDALIIPDLLPEEAEVLAPASAEAGVKLVYLLAPTSNPA
HHHHHHHHHHHHHHHHHHHCCCCEEECCCCCCCHHHHCCCCCCCCCEEEEEEEECCCCCH
RVEAAARAATGFLYFVSVTGVTGARHAVAEEIAPLVSAVRARTDLPVVIGFGVASPEQAR
HHHHHHHHHHHEEEEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCEEEECCCCCHHHHH
ALGPLADGVVVGSAIVKRIAEGGSRRARAERVTRFVRSLGRALRR
HHCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA