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The map label for this gene is drrB [H]

Identifier: 220919136

GI number: 220919136

Start: 4530097

End: 4530900

Strand: Direct

Name: drrB [H]

Synonym: A2cp1_4056

Alternate gene names: 220919136

Gene position: 4530097-4530900 (Clockwise)

Preceding gene: 220919135

Following gene: 220919139

Centisome position: 90.07

GC content: 70.77

Gene sequence:

>804_bases
ATGAACGCGGTCCACGAGGCGCTCGCGATCCGCGCGCGGCCGCGGCCGGCCTCGGCGGCGTCGGCGGTGCTGACGCTGGC
GTGGCGGGCGATGCTGAAGATCAAGCACGTCCCCTTCCAGCTGTTCGACGTGACCGTCACGCCGATCATGTTCACCTTGC
TGTTCACGTTCATCTTCGGCGGCGCGCTGGCCGGCTCGCCGCGCCAGTACGTGCAGTACCTCGTGCCCGGCGTGCTGGTG
CAGACGGTGCTGTTCATCACCGTCTACACCGGCGTGGGGCTGAACTCGGACATCCGCAAGGGCCTGTACGACCGCTTCCG
GTCGCTGCCCATGTGGCAGCCGGCGCCGCTGCTCGGGGCGCTCGCGGGCGACGTGTTCCGCTACTCGGTGGCCGGGGCGG
TGATCCTGGTGGTCGGGTTCATCCTCGGCTTCCGGCCGCAGGGCGGGGCGCCGGGCGTCCTCGCCGCGATGGCGCTGGTG
CTGGTGTTCAGCTTCGCGCTCTCGTGGCTGTGGATCGTGGTGGGCATGCTGGTGCGCACGCCCGAGTCGGTCATGACCAC
GAGCTTCGTGTTCCTGATGCCGCTCACGTTCGCGAGCGACATCTTCGTCGGCCTGGGGACGATGCCCGGCTGGCTCCAGG
GCGTCGTCCGGCACAACCCGGTGACGCACCTCGCGAACGCGTCGCGCGACCTCATGCACGGCCGGCCGGCCGGCGCGGAC
GTGTCCTGGACGCTGCTCGCGTCGCTCGTGATCGTGGCCGCGGTGGCGCCGCTCGCGATGCGGCTCTACCGGAAGGAGCG
GTAG

Upstream 100 bases:

>100_bases
CGGTGGGCAACCCGAGCCTGGACGAGGTGTTCCTGGCGCTCACCGGCCGGCCGGCGGAGCGGGACGAGTCCGAGGGCGGC
GGCGAGAAGGAGGCGAGCCG

Downstream 100 bases:

>100_bases
CGCCCCCGCTCGGCCTCGACGGGCTCGGGGGGCGCGGGGGCCGGGGGCGCGCCTACCGCGCGATGGGCTTGTAGCGGAGG
CGCTTCGGCTTCGCGCCCTC

Product: ABC-2 type transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 267; Mature: 267

Protein sequence:

>267_residues
MNAVHEALAIRARPRPASAASAVLTLAWRAMLKIKHVPFQLFDVTVTPIMFTLLFTFIFGGALAGSPRQYVQYLVPGVLV
QTVLFITVYTGVGLNSDIRKGLYDRFRSLPMWQPAPLLGALAGDVFRYSVAGAVILVVGFILGFRPQGGAPGVLAAMALV
LVFSFALSWLWIVVGMLVRTPESVMTTSFVFLMPLTFASDIFVGLGTMPGWLQGVVRHNPVTHLANASRDLMHGRPAGAD
VSWTLLASLVIVAAVAPLAMRLYRKER

Sequences:

>Translated_267_residues
MNAVHEALAIRARPRPASAASAVLTLAWRAMLKIKHVPFQLFDVTVTPIMFTLLFTFIFGGALAGSPRQYVQYLVPGVLV
QTVLFITVYTGVGLNSDIRKGLYDRFRSLPMWQPAPLLGALAGDVFRYSVAGAVILVVGFILGFRPQGGAPGVLAAMALV
LVFSFALSWLWIVVGMLVRTPESVMTTSFVFLMPLTFASDIFVGLGTMPGWLQGVVRHNPVTHLANASRDLMHGRPAGAD
VSWTLLASLVIVAAVAPLAMRLYRKER
>Mature_267_residues
MNAVHEALAIRARPRPASAASAVLTLAWRAMLKIKHVPFQLFDVTVTPIMFTLLFTFIFGGALAGSPRQYVQYLVPGVLV
QTVLFITVYTGVGLNSDIRKGLYDRFRSLPMWQPAPLLGALAGDVFRYSVAGAVILVVGFILGFRPQGGAPGVLAAMALV
LVFSFALSWLWIVVGMLVRTPESVMTTSFVFLMPLTFASDIFVGLGTMPGWLQGVVRHNPVTHLANASRDLMHGRPAGAD
VSWTLLASLVIVAAVAPLAMRLYRKER

Specific function: Part of the ABC transporter complex drrAB involved in daunorubicin and doxorubicin resistance. Probably responsible for the translocation of the substrate across the membrane [H]

COG id: COG0842

COG function: function code V; ABC-type multidrug transport system, permease component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ABC transmembrane type-2 domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000412
- InterPro:   IPR013525 [H]

Pfam domain/function: PF01061 ABC2_membrane [H]

EC number: NA

Molecular weight: Translated: 28966; Mature: 28966

Theoretical pI: Translated: 11.37; Mature: 11.37

Prosite motif: PS51012 ABC_TM2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 1924314 [H]