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The map label for this gene is serS

Identifier: 220919077

GI number: 220919077

Start: 4445856

End: 4447163

Strand: Direct

Name: serS

Synonym: A2cp1_3994

Alternate gene names: 220919077

Gene position: 4445856-4447163 (Clockwise)

Preceding gene: 220919071

Following gene: 220919078

Centisome position: 88.4

GC content: 70.57

Gene sequence:

>1308_bases
ATGCTGGACCTCAAGGCCGTCGCCGCCGACTTCGAGAGCTTCGAGCGCCGCCTCGCCCGCCGGGGCGAGGGCGCGGTGCA
GGCGCTCGCGCCGGTGAAGCCGCTCGCCGCCCGCCGCCGTGAGCTGAACGTACTGCTGGAGAAGCAGAAGAAGGAACAGG
CGGACGCGAACGCGAACATTCGGCAACTGGCCCGCACCGACAAGGACGCGGTGGAGGGCGCCCGCGCCTCGCTGCGCGCG
CTCGGCGACGAGGTGAAGAAGACCGAGGCCGCGCTCGGCGAGGTCGAGGCGGAGCTCACCCGCCTGCTCATGCTGGTGCC
GAACCCGCCGAGCGACTCGGTGCCGGACGGCAAGGACGAGCACGACAACGTGGTGGTGAGGACCTGGGGCGAGAAGAAGG
CCTACGGGTTCACCCCGAAGCCGCACTGGGAGCTGGGCGAGGCGCTGGGCGTGCTGGAGTGGCAGCAGGCCGCGAAGCTG
TCCGGCTCGCGCTTCACCATCCTGAAGGGCGCGGCGGCGCGGCTGGAGCGCGCCATCGTCTCCTTCTTCATCGACGTCCA
CACCTCGCGCGGCTACACCGAGATCCTCCCGCCGTACCTCGTGACCGGCGAGACCATGACCGGCACCGGGCAGCTCCCGA
AGTTCGAGGAGGACCTGTTCAAGACCACGAACGAGCCGCCGATGTACCTCATCCCCACGGCGGAGGTCCCGGTCACGAAC
ATGCACCGGGACGAGATCTTCGAGGCGAACGCGATGCCGGTGTCGTACTGCGCGTTCAGCCCGTGCTTCCGCGCCGAGGC
CGGCTCGGCCGGCCGCGACACCCGCGGGATCATGCGCCAGCACCAGTTCCACAAGGTGGAGCTGGTGAAGCTCTCCAAGG
CGGAGGAGAGCGACGCCGAGCACGAGAAGATGCTCGACGACGCCTGCGAGGTGCTGCGCCGGCTCGGGCTGCACCACCGC
GTCTCGCTGCTCTGCACCGGCGACATGGGCTTCTCCTCGGCCAAGACCTACGACATCGAGGTGTGGTGCCCGGGCCAGGG
CGCCTACCGCGAGATCAGCTCGGTCTCGAACTGCGAGGACTTCCAGGCCCGCCGCATCCGCGTGCGCTACCGCGGCGAGA
ACGGCAAGCCGCGCCTCGCGCACACGCTGAACGGCTCGGGCGTGGCGGTGGGCCGCACCATCGTCGCGATCCTGGAGCAG
TGCCAGGAGGCGGACGGGACCGTGGTCATCCCCGAGCCGCTCCGCCCGTACATGGGGGGCCTCGAGCGGATCGCCGCCGA
GACGTTCCCGCGGGGCGTGGAGCGGTAG

Upstream 100 bases:

>100_bases
GCGAATCCCCGGGGTCACGCCTGCCAAGACCCCTTGCCCGTCCAGAGGTTAAAGACTAATCCTGCGGCCCGGATTCCAAC
CGATTCGAAGGGGTTGCCGC

Downstream 100 bases:

>100_bases
GTAGGCCGGGCCCCGAGGCCGGGCCCCTCGGGTCCCGCTCATCCCGAGCGTCCCTCGACTCCGGCCGTGCCCCAATCGTT
CCGCTCACTCCGAGCGTCCC

Product: seryl-tRNA synthetase

Products: NA

Alternate protein names: Serine--tRNA ligase; SerRS; Seryl-tRNA(Ser/Sec) synthetase

Number of amino acids: Translated: 435; Mature: 435

Protein sequence:

>435_residues
MLDLKAVAADFESFERRLARRGEGAVQALAPVKPLAARRRELNVLLEKQKKEQADANANIRQLARTDKDAVEGARASLRA
LGDEVKKTEAALGEVEAELTRLLMLVPNPPSDSVPDGKDEHDNVVVRTWGEKKAYGFTPKPHWELGEALGVLEWQQAAKL
SGSRFTILKGAAARLERAIVSFFIDVHTSRGYTEILPPYLVTGETMTGTGQLPKFEEDLFKTTNEPPMYLIPTAEVPVTN
MHRDEIFEANAMPVSYCAFSPCFRAEAGSAGRDTRGIMRQHQFHKVELVKLSKAEESDAEHEKMLDDACEVLRRLGLHHR
VSLLCTGDMGFSSAKTYDIEVWCPGQGAYREISSVSNCEDFQARRIRVRYRGENGKPRLAHTLNGSGVAVGRTIVAILEQ
CQEADGTVVIPEPLRPYMGGLERIAAETFPRGVER

Sequences:

>Translated_435_residues
MLDLKAVAADFESFERRLARRGEGAVQALAPVKPLAARRRELNVLLEKQKKEQADANANIRQLARTDKDAVEGARASLRA
LGDEVKKTEAALGEVEAELTRLLMLVPNPPSDSVPDGKDEHDNVVVRTWGEKKAYGFTPKPHWELGEALGVLEWQQAAKL
SGSRFTILKGAAARLERAIVSFFIDVHTSRGYTEILPPYLVTGETMTGTGQLPKFEEDLFKTTNEPPMYLIPTAEVPVTN
MHRDEIFEANAMPVSYCAFSPCFRAEAGSAGRDTRGIMRQHQFHKVELVKLSKAEESDAEHEKMLDDACEVLRRLGLHHR
VSLLCTGDMGFSSAKTYDIEVWCPGQGAYREISSVSNCEDFQARRIRVRYRGENGKPRLAHTLNGSGVAVGRTIVAILEQ
CQEADGTVVIPEPLRPYMGGLERIAAETFPRGVER
>Mature_435_residues
MLDLKAVAADFESFERRLARRGEGAVQALAPVKPLAARRRELNVLLEKQKKEQADANANIRQLARTDKDAVEGARASLRA
LGDEVKKTEAALGEVEAELTRLLMLVPNPPSDSVPDGKDEHDNVVVRTWGEKKAYGFTPKPHWELGEALGVLEWQQAAKL
SGSRFTILKGAAARLERAIVSFFIDVHTSRGYTEILPPYLVTGETMTGTGQLPKFEEDLFKTTNEPPMYLIPTAEVPVTN
MHRDEIFEANAMPVSYCAFSPCFRAEAGSAGRDTRGIMRQHQFHKVELVKLSKAEESDAEHEKMLDDACEVLRRLGLHHR
VSLLCTGDMGFSSAKTYDIEVWCPGQGAYREISSVSNCEDFQARRIRVRYRGENGKPRLAHTLNGSGVAVGRTIVAILEQ
CQEADGTVVIPEPLRPYMGGLERIAAETFPRGVER

Specific function: Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec)

COG id: COG0172

COG function: function code J; Seryl-tRNA synthetase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily

Homologues:

Organism=Homo sapiens, GI16306548, Length=402, Percent_Identity=34.5771144278607, Blast_Score=217, Evalue=1e-56,
Organism=Homo sapiens, GI8923421, Length=406, Percent_Identity=33.4975369458128, Blast_Score=209, Evalue=5e-54,
Organism=Homo sapiens, GI225579074, Length=348, Percent_Identity=34.7701149425287, Blast_Score=201, Evalue=1e-51,
Organism=Escherichia coli, GI1787120, Length=434, Percent_Identity=46.7741935483871, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17539260, Length=360, Percent_Identity=33.3333333333333, Blast_Score=197, Evalue=7e-51,
Organism=Caenorhabditis elegans, GI17542084, Length=341, Percent_Identity=31.0850439882698, Blast_Score=164, Evalue=1e-40,
Organism=Saccharomyces cerevisiae, GI6320226, Length=410, Percent_Identity=30.9756097560976, Blast_Score=197, Evalue=3e-51,
Organism=Saccharomyces cerevisiae, GI6321799, Length=370, Percent_Identity=31.3513513513514, Blast_Score=188, Evalue=2e-48,
Organism=Drosophila melanogaster, GI24581334, Length=357, Percent_Identity=35.0140056022409, Blast_Score=205, Evalue=4e-53,
Organism=Drosophila melanogaster, GI17737985, Length=372, Percent_Identity=31.989247311828, Blast_Score=151, Evalue=8e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SYS_ANAD2 (B8J8M9)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002494381.1
- ProteinModelPortal:   B8J8M9
- SMR:   B8J8M9
- GeneID:   7297333
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_3994
- HOGENOM:   HBG629391
- ProtClustDB:   PRK05431
- GO:   GO:0005737
- HAMAP:   MF_00176
- InterPro:   IPR002314
- InterPro:   IPR006195
- InterPro:   IPR002317
- InterPro:   IPR015866
- InterPro:   IPR010978
- Gene3D:   G3DSA:1.10.287.40
- PANTHER:   PTHR11778
- PIRSF:   PIRSF001529
- PRINTS:   PR00981
- TIGRFAMs:   TIGR00414

Pfam domain/function: PF02403 Seryl_tRNA_N; PF00587 tRNA-synt_2b; SSF46589 tRNA_binding_arm

EC number: =6.1.1.11

Molecular weight: Translated: 48253; Mature: 48253

Theoretical pI: Translated: 6.52; Mature: 6.52

Prosite motif: PS50862 AA_TRNA_LIGASE_II

Important sites: BINDING 287-287 BINDING 386-386

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDLKAVAADFESFERRLARRGEGAVQALAPVKPLAARRRELNVLLEKQKKEQADANANI
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
RQLARTDKDAVEGARASLRALGDEVKKTEAALGEVEAELTRLLMLVPNPPSDSVPDGKDE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCC
HDNVVVRTWGEKKAYGFTPKPHWELGEALGVLEWQQAAKLSGSRFTILKGAAARLERAIV
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHH
SFFIDVHTSRGYTEILPPYLVTGETMTGTGQLPKFEEDLFKTTNEPPMYLIPTAEVPVTN
HHHHHHHCCCCCHHHCCCEEEECCCCCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCC
MHRDEIFEANAMPVSYCAFSPCFRAEAGSAGRDTRGIMRQHQFHKVELVKLSKAEESDAE
CCHHHHHCCCCCCCHHHHCCCHHHCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCHH
HEKMLDDACEVLRRLGLHHRVSLLCTGDMGFSSAKTYDIEVWCPGQGAYREISSVSNCED
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEEEECCCCHHHHHHHHCCCHH
FQARRIRVRYRGENGKPRLAHTLNGSGVAVGRTIVAILEQCQEADGTVVIPEPLRPYMGG
HHCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHH
LERIAAETFPRGVER
HHHHHHHHCCCCCCC
>Mature Secondary Structure
MLDLKAVAADFESFERRLARRGEGAVQALAPVKPLAARRRELNVLLEKQKKEQADANANI
CCCHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHH
RQLARTDKDAVEGARASLRALGDEVKKTEAALGEVEAELTRLLMLVPNPPSDSVPDGKDE
HHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCCCC
HDNVVVRTWGEKKAYGFTPKPHWELGEALGVLEWQQAAKLSGSRFTILKGAAARLERAIV
CCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHHH
SFFIDVHTSRGYTEILPPYLVTGETMTGTGQLPKFEEDLFKTTNEPPMYLIPTAEVPVTN
HHHHHHHCCCCCHHHCCCEEEECCCCCCCCCCCCHHHHHHHCCCCCCEEEEECCCCCCCC
MHRDEIFEANAMPVSYCAFSPCFRAEAGSAGRDTRGIMRQHQFHKVELVKLSKAEESDAE
CCHHHHHCCCCCCCHHHHCCCHHHCCCCCCCCHHHHHHHHHHCCEEEEEEECCCCCCCHH
HEKMLDDACEVLRRLGLHHRVSLLCTGDMGFSSAKTYDIEVWCPGQGAYREISSVSNCED
HHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEEEEECCCCHHHHHHHHCCCHH
FQARRIRVRYRGENGKPRLAHTLNGSGVAVGRTIVAILEQCQEADGTVVIPEPLRPYMGG
HHCEEEEEEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCEEEECCCCCHHHHH
LERIAAETFPRGVER
HHHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA