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The map label for this gene is gltA [H]

Identifier: 220918897

GI number: 220918897

Start: 4234049

End: 4235380

Strand: Direct

Name: gltA [H]

Synonym: A2cp1_3811

Alternate gene names: 220918897

Gene position: 4234049-4235380 (Clockwise)

Preceding gene: 220918896

Following gene: 220918900

Centisome position: 84.19

GC content: 65.77

Gene sequence:

>1332_bases
ATGGCTGAGTCCACGCTGAAGCAGGTGCTGAAGCAGAAGATCGAGGCGTTCCGCCCGCGGATTCAGAAGCTGAACAAGGA
GTTCGGCGAGGTGGTGATCGACAAGGTCAACATCGGCCAGGCGATCGGCGGCGCCCGCGACGTCCGCTGCCTCGTGACCG
ACATCTCGTACCTCGACCCGCAGGAAGGCATCCGCTTCCGCGGCAAGACCATCCCCGAGACCTTCGAGGCGCTCAAGGCG
CACGTGGTCCCGGGCGGCGAGATGCCGACCGTGGAGAGCTTCTTCTACTTCCTGCTCACGGGCGAGATCCCGACGAAGGA
GCAGGCGCAGGAGGTGTTCGCGGAGTTCAAGAAGCGCGAGGCGCTCCCGCAGTACGTCATCGACGTGCTCCGCGCGATGC
CGCGCGACTCGCACCCGATGGCGATGTTCTCGGCCGGCATCGTCACGATGCAGCGCGAGTCGGTGTTCGCGAAGCGCTAC
GGCGAGGGCAACCTCAAGAAGACGGACATGTGGGACCCGATGTACGAGGACGCGATGACGCTCGTCGCGCGCCTCCCGGT
GCTCGCCGCGTACATCTACCGGATGAAGTACAAGGGTGACACGCACATCGCGTCGGACGCGAGCCTCGATCTCGGCGGCA
ACTTCGCCAAGATGATCGGGCAGGTGAAGCCGTACGACGACGTGGCCCGCATGTACTTCATCCTGCACTCGGATCACGAG
TCGGGGAACGTCTCGGCCCACACCTCGCACCTGGTCGCGTCGGCGCTCTCCGACGCGTACTACTCCTACTCGGCCGGCAT
CAACGGCCTCGCCGGCCCGCTGCACGGCCTCGCGAACCAGGAGGTGCTCGGCTGGATCCAGCAGACGATGAAGAAGCTGA
ACAACCAGGTGCCCTCGAAGGAGCAGCTGAAGCAGTTCCTCTGGGACACGCTGAACTCGGGCCAGGTGATCCCGGGCTAC
GGCCACGCGGTGCTCCGCAAGACCGACCCCCGCTACACGGCGCAGAACGAGTTCGCGAAGAAGCACCTGCCGAACGACCC
GCTCTTCCAGCTCGTGAACATGATCTACGAGGTGGCGCCGGGCGTCCTCACCGAGCACGGCAAGACCAAGAACCCGTGGC
CGAACGTGGACGCGCACTCGGGCGTGATCCAGTGGTACTACGGCGTCCGCGAGTGGGACTTCTACACGGTCCTCTTCGGC
GTCGGCCGCGCGCTCGGCGTGCTCGCCAACCTCGTGTGGGACCGCGGCCTCGGCTACGCCATCGAGCGGCCGAAGTCGGT
CACCACCGAGATGCTGGAGAAGTGGGCGCACGAGGGCGGCCGGAAGATCTAG

Upstream 100 bases:

>100_bases
TTCCCGTTTGCGCCGTCCCCTCGCCCGCGAGTAGGATTCGGGCCCTCGCGTTACGAAATCCCAAGCAACTCAAACCTTCA
GACAGTTGGCCGGAGTGACC

Downstream 100 bases:

>100_bases
GCCCGCGCCCCGCAGCAGCCTGAAGACACCGAAGGCCGCCCGCGAGGGCGGCCTTCTCCGTTTCCGGATGTCGGAGGCGG
CGCGCGCGCTCGCGCCCGGG

Product: type I citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 443; Mature: 442

Protein sequence:

>443_residues
MAESTLKQVLKQKIEAFRPRIQKLNKEFGEVVIDKVNIGQAIGGARDVRCLVTDISYLDPQEGIRFRGKTIPETFEALKA
HVVPGGEMPTVESFFYFLLTGEIPTKEQAQEVFAEFKKREALPQYVIDVLRAMPRDSHPMAMFSAGIVTMQRESVFAKRY
GEGNLKKTDMWDPMYEDAMTLVARLPVLAAYIYRMKYKGDTHIASDASLDLGGNFAKMIGQVKPYDDVARMYFILHSDHE
SGNVSAHTSHLVASALSDAYYSYSAGINGLAGPLHGLANQEVLGWIQQTMKKLNNQVPSKEQLKQFLWDTLNSGQVIPGY
GHAVLRKTDPRYTAQNEFAKKHLPNDPLFQLVNMIYEVAPGVLTEHGKTKNPWPNVDAHSGVIQWYYGVREWDFYTVLFG
VGRALGVLANLVWDRGLGYAIERPKSVTTEMLEKWAHEGGRKI

Sequences:

>Translated_443_residues
MAESTLKQVLKQKIEAFRPRIQKLNKEFGEVVIDKVNIGQAIGGARDVRCLVTDISYLDPQEGIRFRGKTIPETFEALKA
HVVPGGEMPTVESFFYFLLTGEIPTKEQAQEVFAEFKKREALPQYVIDVLRAMPRDSHPMAMFSAGIVTMQRESVFAKRY
GEGNLKKTDMWDPMYEDAMTLVARLPVLAAYIYRMKYKGDTHIASDASLDLGGNFAKMIGQVKPYDDVARMYFILHSDHE
SGNVSAHTSHLVASALSDAYYSYSAGINGLAGPLHGLANQEVLGWIQQTMKKLNNQVPSKEQLKQFLWDTLNSGQVIPGY
GHAVLRKTDPRYTAQNEFAKKHLPNDPLFQLVNMIYEVAPGVLTEHGKTKNPWPNVDAHSGVIQWYYGVREWDFYTVLFG
VGRALGVLANLVWDRGLGYAIERPKSVTTEMLEKWAHEGGRKI
>Mature_442_residues
AESTLKQVLKQKIEAFRPRIQKLNKEFGEVVIDKVNIGQAIGGARDVRCLVTDISYLDPQEGIRFRGKTIPETFEALKAH
VVPGGEMPTVESFFYFLLTGEIPTKEQAQEVFAEFKKREALPQYVIDVLRAMPRDSHPMAMFSAGIVTMQRESVFAKRYG
EGNLKKTDMWDPMYEDAMTLVARLPVLAAYIYRMKYKGDTHIASDASLDLGGNFAKMIGQVKPYDDVARMYFILHSDHES
GNVSAHTSHLVASALSDAYYSYSAGINGLAGPLHGLANQEVLGWIQQTMKKLNNQVPSKEQLKQFLWDTLNSGQVIPGYG
HAVLRKTDPRYTAQNEFAKKHLPNDPLFQLVNMIYEVAPGVLTEHGKTKNPWPNVDAHSGVIQWYYGVREWDFYTVLFGV
GRALGVLANLVWDRGLGYAIERPKSVTTEMLEKWAHEGGRKI

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=436, Percent_Identity=51.605504587156, Blast_Score=461, Evalue=1e-130,
Organism=Escherichia coli, GI1786939, Length=398, Percent_Identity=26.6331658291457, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1786527, Length=327, Percent_Identity=24.7706422018349, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17555174, Length=436, Percent_Identity=49.5412844036697, Blast_Score=436, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6324328, Length=430, Percent_Identity=52.7906976744186, Blast_Score=457, Evalue=1e-129,
Organism=Saccharomyces cerevisiae, GI6319850, Length=434, Percent_Identity=50, Blast_Score=432, Evalue=1e-122,
Organism=Saccharomyces cerevisiae, GI6325257, Length=451, Percent_Identity=41.9068736141907, Blast_Score=344, Evalue=2e-95,
Organism=Drosophila melanogaster, GI24640126, Length=432, Percent_Identity=54.6296296296296, Blast_Score=478, Evalue=1e-135,
Organism=Drosophila melanogaster, GI24640124, Length=432, Percent_Identity=54.6296296296296, Blast_Score=477, Evalue=1e-135,
Organism=Drosophila melanogaster, GI21356863, Length=438, Percent_Identity=45.2054794520548, Blast_Score=381, Evalue=1e-106,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 49880; Mature: 49749

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAESTLKQVLKQKIEAFRPRIQKLNKEFGEVVIDKVNIGQAIGGARDVRCLVTDISYLDP
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
QEGIRFRGKTIPETFEALKAHVVPGGEMPTVESFFYFLLTGEIPTKEQAQEVFAEFKKRE
HHCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ALPQYVIDVLRAMPRDSHPMAMFSAGIVTMQRESVFAKRYGEGNLKKTDMWDPMYEDAMT
CCHHHHHHHHHHCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
LVARLPVLAAYIYRMKYKGDTHIASDASLDLGGNFAKMIGQVKPYDDVARMYFILHSDHE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCC
SGNVSAHTSHLVASALSDAYYSYSAGINGLAGPLHGLANQEVLGWIQQTMKKLNNQVPSK
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCH
EQLKQFLWDTLNSGQVIPGYGHAVLRKTDPRYTAQNEFAKKHLPNDPLFQLVNMIYEVAP
HHHHHHHHHHCCCCCCCCCCCCHHEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCC
GVLTEHGKTKNPWPNVDAHSGVIQWYYGVREWDFYTVLFGVGRALGVLANLVWDRGLGYA
CHHHCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IERPKSVTTEMLEKWAHEGGRKI
HCCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
AESTLKQVLKQKIEAFRPRIQKLNKEFGEVVIDKVNIGQAIGGARDVRCLVTDISYLDP
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCC
QEGIRFRGKTIPETFEALKAHVVPGGEMPTVESFFYFLLTGEIPTKEQAQEVFAEFKKRE
HHCCCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHH
ALPQYVIDVLRAMPRDSHPMAMFSAGIVTMQRESVFAKRYGEGNLKKTDMWDPMYEDAMT
CCHHHHHHHHHHCCCCCCCHHHHHHCHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHH
LVARLPVLAAYIYRMKYKGDTHIASDASLDLGGNFAKMIGQVKPYDDVARMYFILHSDHE
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCC
SGNVSAHTSHLVASALSDAYYSYSAGINGLAGPLHGLANQEVLGWIQQTMKKLNNQVPSK
CCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHCCCHHHHHHHHHHHHHHHCCCCCH
EQLKQFLWDTLNSGQVIPGYGHAVLRKTDPRYTAQNEFAKKHLPNDPLFQLVNMIYEVAP
HHHHHHHHHHCCCCCCCCCCCCHHEECCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHCC
GVLTEHGKTKNPWPNVDAHSGVIQWYYGVREWDFYTVLFGVGRALGVLANLVWDRGLGYA
CHHHCCCCCCCCCCCCCCCCCHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHH
IERPKSVTTEMLEKWAHEGGRKI
HCCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7522844; 12948626 [H]