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The map label for this gene is aqpZ [H]

Identifier: 220918833

GI number: 220918833

Start: 4162198

End: 4162935

Strand: Direct

Name: aqpZ [H]

Synonym: A2cp1_3745

Alternate gene names: 220918833

Gene position: 4162198-4162935 (Clockwise)

Preceding gene: 220918831

Following gene: 220918836

Centisome position: 82.76

GC content: 72.9

Gene sequence:

>738_bases
ATGCCCCTGGCACACCGGATGGCGGCGGAGGTCGTCGGCACGTTCTGGCTCGTCCTCGGCGGTTGCGGCAGCGCGGTCCT
CGCCGCCGCCGTCCCGGGGCTCGGGATCGGCTTCCACGGGGTGGCGCTCGCCTTCGGCCTGACCGTGCTCACGATGGCGT
ACGCCATCGGGCACGTGTCCGGATGTCACCTCAACCCCGCAGTGACGGTGGGGCTCACGGTCGCGCGCCGCTTCCCGGCG
GGCGAGGTCGGCCCGTACGTCGTCGCCCAGGTGATCGGTGCGATAGCCGGCGCGGGCGTCCTGTACCTCATCGCCTCCAG
CAAGGCGGGCTTCGACGTGTCTGCGGGCTTCGCCTCGAACGGCTTCGCCGAGCACTCGCCCGGCGGCTACGCCCTGGGCG
CGTGCTTCCTGACCGAGCTCGTGATGACGTTCGCGTTCCTGTTCGTGATCCTGGGCGCGACCGACGAGCGCGCGCCGAAG
GGCCTCGCCCCGATCGCGATCGGCCTGTGCCTCACGCTCATCCACCTCGTAAGCATCCCCGTGACCAACACCTCGGTGAA
CCCCGCCCGGTCCACCGGGCCGGCCCTGTTCGCGGGCGGCTGGGCGGTGGCGCAGCTCTGGATGTTCTGGATCGCGCCGA
TCGTGGGCGCGGCGCTGGCTGGCATCGTCTACCCGCTCGTCGCCGGCGGCCGCGCCGCGCACGGACGCGCGACGGCCACG
CACGCGAGCGCGACCTGA

Upstream 100 bases:

>100_bases
TCGCACCGCGCTCGGAGGCACTCGGATGAGCGTGCCTTCACCCCACACGCTTCGTGCTATCCCCGTCGCCGACGCGCACG
CGCGCGCGGAGGTCGCGATC

Downstream 100 bases:

>100_bases
GGCACCACCCGGGGGCCCGCTGTTCGCCGCCGGAGCCCCGCCCATGGCGAGGCTCCGGGCGGACGGCCGTCACCGTCTCA
GCGCGTCGCGGATCTCGCGG

Product: aquaporin Z

Products: H2O [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 245; Mature: 244

Protein sequence:

>245_residues
MPLAHRMAAEVVGTFWLVLGGCGSAVLAAAVPGLGIGFHGVALAFGLTVLTMAYAIGHVSGCHLNPAVTVGLTVARRFPA
GEVGPYVVAQVIGAIAGAGVLYLIASSKAGFDVSAGFASNGFAEHSPGGYALGACFLTELVMTFAFLFVILGATDERAPK
GLAPIAIGLCLTLIHLVSIPVTNTSVNPARSTGPALFAGGWAVAQLWMFWIAPIVGAALAGIVYPLVAGGRAAHGRATAT
HASAT

Sequences:

>Translated_245_residues
MPLAHRMAAEVVGTFWLVLGGCGSAVLAAAVPGLGIGFHGVALAFGLTVLTMAYAIGHVSGCHLNPAVTVGLTVARRFPA
GEVGPYVVAQVIGAIAGAGVLYLIASSKAGFDVSAGFASNGFAEHSPGGYALGACFLTELVMTFAFLFVILGATDERAPK
GLAPIAIGLCLTLIHLVSIPVTNTSVNPARSTGPALFAGGWAVAQLWMFWIAPIVGAALAGIVYPLVAGGRAAHGRATAT
HASAT
>Mature_244_residues
PLAHRMAAEVVGTFWLVLGGCGSAVLAAAVPGLGIGFHGVALAFGLTVLTMAYAIGHVSGCHLNPAVTVGLTVARRFPAG
EVGPYVVAQVIGAIAGAGVLYLIASSKAGFDVSAGFASNGFAEHSPGGYALGACFLTELVMTFAFLFVILGATDERAPKG
LAPIAIGLCLTLIHLVSIPVTNTSVNPARSTGPALFAGGWAVAQLWMFWIAPIVGAALAGIVYPLVAGGRAAHGRATATH
ASAT

Specific function: Channel that permits osmotically driven movement of water in both directions. It is involved in the osmoregulation and in the maintenance of cell turgor during volume expansion in rapidly growing cells. It mediates rapid entry or exit of water in response

COG id: COG0580

COG function: function code G; Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family)

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MIP/aquaporin (TC 1.A.8) family [H]

Homologues:

Organism=Homo sapiens, GI4502183, Length=219, Percent_Identity=40.6392694063927, Blast_Score=121, Evalue=6e-28,
Organism=Homo sapiens, GI4755125, Length=191, Percent_Identity=38.2198952879581, Blast_Score=121, Evalue=7e-28,
Organism=Homo sapiens, GI4502181, Length=191, Percent_Identity=38.2198952879581, Blast_Score=120, Evalue=9e-28,
Organism=Homo sapiens, GI37694062, Length=196, Percent_Identity=36.734693877551, Blast_Score=120, Evalue=1e-27,
Organism=Homo sapiens, GI4502179, Length=222, Percent_Identity=36.4864864864865, Blast_Score=113, Evalue=1e-25,
Organism=Homo sapiens, GI6912506, Length=221, Percent_Identity=32.579185520362, Blast_Score=101, Evalue=7e-22,
Organism=Homo sapiens, GI157266307, Length=244, Percent_Identity=31.9672131147541, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI4826645, Length=248, Percent_Identity=33.4677419354839, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI86792455, Length=187, Percent_Identity=32.620320855615, Blast_Score=83, Evalue=2e-16,
Organism=Homo sapiens, GI22538420, Length=270, Percent_Identity=27.037037037037, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI45446752, Length=201, Percent_Identity=28.8557213930348, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI297307120, Length=98, Percent_Identity=35.7142857142857, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI297307116, Length=121, Percent_Identity=33.8842975206612, Blast_Score=65, Evalue=5e-11,
Organism=Homo sapiens, GI297307118, Length=121, Percent_Identity=33.8842975206612, Blast_Score=65, Evalue=8e-11,
Organism=Homo sapiens, GI4502187, Length=241, Percent_Identity=26.9709543568465, Blast_Score=64, Evalue=9e-11,
Organism=Escherichia coli, GI1787101, Length=207, Percent_Identity=69.0821256038647, Blast_Score=277, Evalue=6e-76,
Organism=Escherichia coli, GI1790362, Length=256, Percent_Identity=30.078125, Blast_Score=75, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI71992966, Length=239, Percent_Identity=32.2175732217573, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71993722, Length=231, Percent_Identity=30.7359307359307, Blast_Score=82, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17558372, Length=196, Percent_Identity=31.1224489795918, Blast_Score=74, Evalue=7e-14,
Organism=Caenorhabditis elegans, GI71992961, Length=237, Percent_Identity=31.6455696202532, Blast_Score=69, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6321054, Length=211, Percent_Identity=30.3317535545024, Blast_Score=78, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24652747, Length=232, Percent_Identity=36.6379310344828, Blast_Score=133, Evalue=9e-32,
Organism=Drosophila melanogaster, GI45551084, Length=232, Percent_Identity=36.6379310344828, Blast_Score=133, Evalue=9e-32,
Organism=Drosophila melanogaster, GI24652751, Length=188, Percent_Identity=35.6382978723404, Blast_Score=87, Evalue=7e-18,
Organism=Drosophila melanogaster, GI19922038, Length=188, Percent_Identity=35.6382978723404, Blast_Score=87, Evalue=9e-18,
Organism=Drosophila melanogaster, GI17136672, Length=229, Percent_Identity=29.6943231441048, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI45550503, Length=228, Percent_Identity=29.3859649122807, Blast_Score=77, Evalue=9e-15,
Organism=Drosophila melanogaster, GI24762342, Length=196, Percent_Identity=31.6326530612245, Blast_Score=76, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24762344, Length=235, Percent_Identity=30.6382978723404, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24762346, Length=235, Percent_Identity=30.6382978723404, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI24762348, Length=235, Percent_Identity=30.6382978723404, Blast_Score=75, Evalue=3e-14,
Organism=Drosophila melanogaster, GI20130305, Length=235, Percent_Identity=30.6382978723404, Blast_Score=75, Evalue=3e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012269
- InterPro:   IPR000425
- InterPro:   IPR022357 [H]

Pfam domain/function: PF00230 MIP [H]

EC number: NA

Molecular weight: Translated: 24533; Mature: 24402

Theoretical pI: Translated: 8.35; Mature: 8.35

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00221 MIP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLAHRMAAEVVGTFWLVLGGCGSAVLAAAVPGLGIGFHGVALAFGLTVLTMAYAIGHVS
CCHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
GCHLNPAVTVGLTVARRFPAGEVGPYVVAQVIGAIAGAGVLYLIASSKAGFDVSAGFASN
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHEEEEECCCCCCCEECCCCCC
GFAEHSPGGYALGACFLTELVMTFAFLFVILGATDERAPKGLAPIAIGLCLTLIHLVSIP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
VTNTSVNPARSTGPALFAGGWAVAQLWMFWIAPIVGAALAGIVYPLVAGGRAAHGRATAT
CCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
HASAT
CCCCC
>Mature Secondary Structure 
PLAHRMAAEVVGTFWLVLGGCGSAVLAAAVPGLGIGFHGVALAFGLTVLTMAYAIGHVS
CHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
GCHLNPAVTVGLTVARRFPAGEVGPYVVAQVIGAIAGAGVLYLIASSKAGFDVSAGFASN
CCCCCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCHHEEEEECCCCCCCEECCCCCC
GFAEHSPGGYALGACFLTELVMTFAFLFVILGATDERAPKGLAPIAIGLCLTLIHLVSIP
CCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHCC
VTNTSVNPARSTGPALFAGGWAVAQLWMFWIAPIVGAALAGIVYPLVAGGRAAHGRATAT
CCCCCCCCCCCCCCCEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCC
HASAT
CCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: H2O [Periplasm] [C]

Specific reaction: H2O [Periplasm] = H2O [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]