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The map label for this gene is groEL [H]

Identifier: 220918823

GI number: 220918823

Start: 4151757

End: 4153400

Strand: Direct

Name: groEL [H]

Synonym: A2cp1_3735

Alternate gene names: 220918823

Gene position: 4151757-4153400 (Clockwise)

Preceding gene: 220918822

Following gene: 220918824

Centisome position: 82.55

GC content: 67.64

Gene sequence:

>1644_bases
ATGGCAGCCAAGGAAATCGTCTTCGACCAGAAGGCCCGCGACGCGATCCTCAAGGGCGTGAACACGCTCGCCGACGCGGT
GAAGGTGACCCTCGGGCCGAAGGGCCGGAACGTGGTCATCGAGAAGAGCTTCGGCTCCCCGACCATCACCAAGGACGGCG
TGACGGTCGCGAAGGAGATCGAGCTCGAGAACAAGTTCGAGAACATGGGCGCGCAGATGGTGAAGGAGGTCGCCTCCAAG
ACCTCCGACGTGGCCGGTGACGGCACCACCACCGCGACCGTGCTCGCCCAGGCCATCTACCGCGAGGGCTCGAAGCTCGT
CGCGGCCGGCCACAACCCGATGGACGTGAAGCGCGGCATCGACAAGGCCGTCGAGGCCATCGTGGGCGAGCTGAAGAAGC
TCTCCAAGCCGACGAAGGACCACAAGGAGATCGCCCAGGTCGGCATCATCTCCGCCAACGGCGACACCACCATCGGCAAC
ATCATCGCCGAGGCGATGGAGAAGGTCGGCAAGGAGGGCGTCATCACCGTCGAGGAGGCCAAGGGCCTCGAGACGACGCT
CGACGTGGTCGAGGGCATGCAGTTCGACCGCGGCTACCTCTCGCCGTACTTCGTGACCGACGCGGAGCGCATGGAGGCGG
TCCTCGAGGACGCCTACATCCTCATCAACGAGAAGAAGATCTCGAACATGAAGGACCTGCTCCCGCTGCTGGAGCAGATC
GCGCGCTCGGGCAAGCCGCTCATCATCGTGGCCGAGGAGGTCGAGGGTGAGGCGCTGGCGACGCTGGTCGTCAACAAGCT
GCGCGGCACGCTGCACGTCTGCGCGGTGAAGGCCCCGGGCTTCGGCGACCGCCGCAAGGCCATGCTGGAGGACATCGCGA
TCCTCACCGGCGGCCGCATGATCGCCGAGGAGCTCGGCCTCAAGCTCGAGCAGGTCACGCTGAAGGACCTCGGCCGCGCC
AAGCGCGTCACGGTGGACAAGGACAACACCACCATCGTCGACGGCGCCGGCAAGAAGGAGGACATCGAGGCCCGGGTGAA
GACCATCCGCGCGCAGATCGAGGAGACCACCTCCGACTACGACCGCGAGAAGCTCCAGGAGCGCCTCGCGAAGCTGGTGG
GCGGCGTGGCGGTCATCAACGTCGGCGCGGCCACCGAGACCGAGATGAAGGAGAAGAAGGCCCGCGTCGAGGACGCGCTC
CACGCGACCCGCGCGGCCGTCGAGGAGGGCATCGTCCCCGGCGGCGGCGTGGCGTACCTGCGCTGCGTGAAGGCGCTCGA
GGGCGTGAAGGTGAACGAGGGCGAGAAGGTCGGCCTCGACATCGTCCGCCGCGCCATCGAGGAGCCGCTCCGCCAGATCT
CCGGCAACGGCGGCTACGAGGGCTCGATCGTGGTGAACAAGGTGAAGGAGGCGAAGGAGGCCGCGTTCGGCTTCAACGCC
GCCACGGGCGAGTACGAGGACCTGGTGAAGGCCGGCGTCATCGACCCGACCAAGGTCTCGCGCTCCGCGCTGCAGAACGC
GGCGTCGGTCGCCTCGCTGATGCTCACCACCATGGCGATGGTCGCCGAGAAGCCGAAGGAGGAGGCTGCGGCCCCCGCCG
GCGGCGGCATGGGCGGCATGGGCGGGATGGGCGGCATGATGTAG

Upstream 100 bases:

>100_bases
CGACGGCGAGGAGCACCTGATCATGCGCGAGGAGGACATCCTCGGCGTGATCGAAGGCTAGCGCCCGCAGCCCCTCTCAC
GGAACACGGAGCTCAAAGAC

Downstream 100 bases:

>100_bases
GCCGTCCCGTCCTCCCGGACGGAACCGAGGGGTCGCCGGTGCGCCGGCGGCCCCTCTTCTTTTCGTGATGACGGCAGCTT
CGCTCAGCGTGTGGACGCCG

Product: chaperonin GroEL

Products: NA

Alternate protein names: GroEL protein 2; Protein Cpn60 2 [H]

Number of amino acids: Translated: 547; Mature: 546

Protein sequence:

>547_residues
MAAKEIVFDQKARDAILKGVNTLADAVKVTLGPKGRNVVIEKSFGSPTITKDGVTVAKEIELENKFENMGAQMVKEVASK
TSDVAGDGTTTATVLAQAIYREGSKLVAAGHNPMDVKRGIDKAVEAIVGELKKLSKPTKDHKEIAQVGIISANGDTTIGN
IIAEAMEKVGKEGVITVEEAKGLETTLDVVEGMQFDRGYLSPYFVTDAERMEAVLEDAYILINEKKISNMKDLLPLLEQI
ARSGKPLIIVAEEVEGEALATLVVNKLRGTLHVCAVKAPGFGDRRKAMLEDIAILTGGRMIAEELGLKLEQVTLKDLGRA
KRVTVDKDNTTIVDGAGKKEDIEARVKTIRAQIEETTSDYDREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDAL
HATRAAVEEGIVPGGGVAYLRCVKALEGVKVNEGEKVGLDIVRRAIEEPLRQISGNGGYEGSIVVNKVKEAKEAAFGFNA
ATGEYEDLVKAGVIDPTKVSRSALQNAASVASLMLTTMAMVAEKPKEEAAAPAGGGMGGMGGMGGMM

Sequences:

>Translated_547_residues
MAAKEIVFDQKARDAILKGVNTLADAVKVTLGPKGRNVVIEKSFGSPTITKDGVTVAKEIELENKFENMGAQMVKEVASK
TSDVAGDGTTTATVLAQAIYREGSKLVAAGHNPMDVKRGIDKAVEAIVGELKKLSKPTKDHKEIAQVGIISANGDTTIGN
IIAEAMEKVGKEGVITVEEAKGLETTLDVVEGMQFDRGYLSPYFVTDAERMEAVLEDAYILINEKKISNMKDLLPLLEQI
ARSGKPLIIVAEEVEGEALATLVVNKLRGTLHVCAVKAPGFGDRRKAMLEDIAILTGGRMIAEELGLKLEQVTLKDLGRA
KRVTVDKDNTTIVDGAGKKEDIEARVKTIRAQIEETTSDYDREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDAL
HATRAAVEEGIVPGGGVAYLRCVKALEGVKVNEGEKVGLDIVRRAIEEPLRQISGNGGYEGSIVVNKVKEAKEAAFGFNA
ATGEYEDLVKAGVIDPTKVSRSALQNAASVASLMLTTMAMVAEKPKEEAAAPAGGGMGGMGGMGGMM
>Mature_546_residues
AAKEIVFDQKARDAILKGVNTLADAVKVTLGPKGRNVVIEKSFGSPTITKDGVTVAKEIELENKFENMGAQMVKEVASKT
SDVAGDGTTTATVLAQAIYREGSKLVAAGHNPMDVKRGIDKAVEAIVGELKKLSKPTKDHKEIAQVGIISANGDTTIGNI
IAEAMEKVGKEGVITVEEAKGLETTLDVVEGMQFDRGYLSPYFVTDAERMEAVLEDAYILINEKKISNMKDLLPLLEQIA
RSGKPLIIVAEEVEGEALATLVVNKLRGTLHVCAVKAPGFGDRRKAMLEDIAILTGGRMIAEELGLKLEQVTLKDLGRAK
RVTVDKDNTTIVDGAGKKEDIEARVKTIRAQIEETTSDYDREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDALH
ATRAAVEEGIVPGGGVAYLRCVKALEGVKVNEGEKVGLDIVRRAIEEPLRQISGNGGYEGSIVVNKVKEAKEAAFGFNAA
TGEYEDLVKAGVIDPTKVSRSALQNAASVASLMLTTMAMVAEKPKEEAAAPAGGGMGGMGGMGGMM

Specific function: Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions [H]

COG id: COG0459

COG function: function code O; Chaperonin GroEL (HSP60 family)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chaperonin (HSP60) family [H]

Homologues:

Organism=Homo sapiens, GI41399285, Length=528, Percent_Identity=52.4621212121212, Blast_Score=540, Evalue=1e-153,
Organism=Homo sapiens, GI31542947, Length=528, Percent_Identity=52.4621212121212, Blast_Score=540, Evalue=1e-153,
Organism=Homo sapiens, GI38455427, Length=116, Percent_Identity=34.4827586206897, Blast_Score=67, Evalue=5e-11,
Organism=Escherichia coli, GI1790586, Length=531, Percent_Identity=67.4199623352166, Blast_Score=696, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17555558, Length=529, Percent_Identity=52.1739130434783, Blast_Score=544, Evalue=1e-155,
Organism=Caenorhabditis elegans, GI193210679, Length=211, Percent_Identity=50.7109004739336, Blast_Score=209, Evalue=4e-54,
Organism=Caenorhabditis elegans, GI17564182, Length=554, Percent_Identity=23.2851985559567, Blast_Score=69, Evalue=6e-12,
Organism=Saccharomyces cerevisiae, GI6323288, Length=520, Percent_Identity=54.6153846153846, Blast_Score=546, Evalue=1e-156,
Organism=Saccharomyces cerevisiae, GI6322524, Length=123, Percent_Identity=28.4552845528455, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24641193, Length=528, Percent_Identity=53.7878787878788, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI24641191, Length=528, Percent_Identity=53.7878787878788, Blast_Score=561, Evalue=1e-160,
Organism=Drosophila melanogaster, GI45550936, Length=528, Percent_Identity=50.9469696969697, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550132, Length=528, Percent_Identity=50.9469696969697, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI45550935, Length=528, Percent_Identity=50.9469696969697, Blast_Score=534, Evalue=1e-152,
Organism=Drosophila melanogaster, GI17864606, Length=554, Percent_Identity=43.1407942238267, Blast_Score=453, Evalue=1e-127,
Organism=Drosophila melanogaster, GI24584129, Length=527, Percent_Identity=36.2428842504744, Blast_Score=332, Evalue=5e-91,
Organism=Drosophila melanogaster, GI19921262, Length=527, Percent_Identity=36.2428842504744, Blast_Score=332, Evalue=5e-91,

Paralogues:

None

Copy number: 2180 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 360 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 15012 Molecules/Cell In: Growth Phase,

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018370
- InterPro:   IPR001844
- InterPro:   IPR002423 [H]

Pfam domain/function: PF00118 Cpn60_TCP1 [H]

EC number: NA

Molecular weight: Translated: 58112; Mature: 57981

Theoretical pI: Translated: 5.22; Mature: 5.22

Prosite motif: PS00296 CHAPERONINS_CPN60

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAKEIVFDQKARDAILKGVNTLADAVKVTLGPKGRNVVIEKSFGSPTITKDGVTVAKEI
CCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHH
ELENKFENMGAQMVKEVASKTSDVAGDGTTTATVLAQAIYREGSKLVAAGHNPMDVKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHH
DKAVEAIVGELKKLSKPTKDHKEIAQVGIISANGDTTIGNIIAEAMEKVGKEGVITVEEA
HHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCC
KGLETTLDVVEGMQFDRGYLSPYFVTDAERMEAVLEDAYILINEKKISNMKDLLPLLEQI
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHCCEEEEECHHHCCHHHHHHHHHHH
ARSGKPLIIVAEEVEGEALATLVVNKLRGTLHVCAVKAPGFGDRRKAMLEDIAILTGGRM
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
IAEELGLKLEQVTLKDLGRAKRVTVDKDNTTIVDGAGKKEDIEARVKTIRAQIEETTSDY
HHHHHCCCHHHHHHHHCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDALHATRAAVEEGIVPGGGVAYL
HHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RCVKALEGVKVNEGEKVGLDIVRRAIEEPLRQISGNGGYEGSIVVNKVKEAKEAAFGFNA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
ATGEYEDLVKAGVIDPTKVSRSALQNAASVASLMLTTMAMVAEKPKEEAAAPAGGGMGGM
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCC
GGMGGMM
CCCCCCC
>Mature Secondary Structure 
AAKEIVFDQKARDAILKGVNTLADAVKVTLGPKGRNVVIEKSFGSPTITKDGVTVAKEI
CCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCEEEEEECCCCCCCCCCCCHHHHHH
ELENKFENMGAQMVKEVASKTSDVAGDGTTTATVLAQAIYREGSKLVAAGHNPMDVKRGI
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCEEEECCCCCHHHHHHH
DKAVEAIVGELKKLSKPTKDHKEIAQVGIISANGDTTIGNIIAEAMEKVGKEGVITVEEA
HHHHHHHHHHHHHHCCCCHHHHHHHHHEEEECCCCCHHHHHHHHHHHHHCCCCEEEECCC
KGLETTLDVVEGMQFDRGYLSPYFVTDAERMEAVLEDAYILINEKKISNMKDLLPLLEQI
CCHHHHHHHHHCCCCCCCCCCCEEECCHHHHHHHHHCCEEEEECHHHCCHHHHHHHHHHH
ARSGKPLIIVAEEVEGEALATLVVNKLRGTLHVCAVKAPGFGDRRKAMLEDIAILTGGRM
HHCCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEECCCCCHHHHHHHHHHHHHCCCHH
IAEELGLKLEQVTLKDLGRAKRVTVDKDNTTIVDGAGKKEDIEARVKTIRAQIEETTSDY
HHHHHCCCHHHHHHHHCCCCCEEEEECCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHH
DREKLQERLAKLVGGVAVINVGAATETEMKEKKARVEDALHATRAAVEEGIVPGGGVAYL
HHHHHHHHHHHHHCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHH
RCVKALEGVKVNEGEKVGLDIVRRAIEEPLRQISGNGGYEGSIVVNKVKEAKEAAFGFNA
HHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCC
ATGEYEDLVKAGVIDPTKVSRSALQNAASVASLMLTTMAMVAEKPKEEAAAPAGGGMGGM
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCC
GGMGGMM
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA