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The map label for this gene is glpK [H]

Identifier: 220918700

GI number: 220918700

Start: 4028279

End: 4029757

Strand: Reverse

Name: glpK [H]

Synonym: A2cp1_3608

Alternate gene names: 220918700

Gene position: 4029757-4028279 (Counterclockwise)

Preceding gene: 220918701

Following gene: 220918697

Centisome position: 80.13

GC content: 73.43

Gene sequence:

>1479_bases
GTGGCCAGCTACGTCCTCGCCATCGACCAGGGCACCACCGGCACCACCGTGCTGGTCCTCGACCGGCGCCTCTCGCCGCG
CGCGCGCGTGAACCAGGAGTTCCGGCAGATCTTCCCGAAGCCGGGCTGGGTCGAGCACGATCTCGAGGACATCTGGGGCT
CGACCGTGTCCACCGTGCAGCGTGCGCTCCGCGAGGCGGGGATCCGCGGCTCCGACGTCGCCGCGGTGGGCATCACCAAC
CAGCGCGAGACCACGGCGCTGTGGGAGCGCCGCTCCTCGCGCCCGGTGGCGCACGCCATCGTCTGGCAGGATCGCCGCAC
CACCGACGCGTGCGCGCAGCTGCGCTCCGCCGGGCACGAGCCGCTGGTGCGCGAGCGGACCGGTCTGGTGCTCGATCCGT
ACTTCTCCGCCACGAAGCTGCGGTGGCTGCTCGACAACACCAAGGGCGCGCGGCAGAAGGCCGAGGCCGGCGCGCTGGCG
TTCGGGACCATCGACAGCTTCCTGGTGTGGCGGCTCACCGGCGGCGCGGCGCACGTCACCGACGTCTCGAACGCGAGCCG
CACCCTGCTCATGGACCTGCGGGAGCGGCGCTGGGATCGCGAGCTCCTGGACCTGTTCGGCGTCCCGCCCAACGTGCTCC
CGGAGATCCGCGCGTCGTCGGAGGTGTACGGCACCACCCGCGGGGTGAAGGTGCTCCCGGACGGCATCCCGGTGGCGGGC
ATGGCCGGCGACCAGCAGGCGGCGCTGTTCGGCCAGGCCTGCTTCCGGCCGGGCGAGGCGAAGTGCACCTACGGCACCGG
CGCGTTCCTGCTCCAGAACGTCGGGCCGGAGCCGGTGATGTCGTCGCGCGGCCTGCTCACCACCGTCGCGTGGACGGTCG
GGGGCGAGACGGCGTACGCGCTGGAGGGCTCCTCGTTCATCGCCGGCGCCGCGGTGCAGTGGCTCCGCGACGGGCTGGGG
CTCATCGCGCGCGCGCCCGATGTGGAGGCGCTCGCGAAGCAGGTGAAGTCCACCGGCGAGCTGGTGTTCGTGCCGGCGCT
GGCGGGGCTGGGCGCGCCGCACTGGCGGCCGGAGGCGCGCGGGCTCATCGCGGGCATCGACCGCGGCACCACCGCGGCGC
ACCTGGCGCGCGCCACGCTCGAGGGGATCGCCTTCCTCATCCACGACCTCGCCGAGGCGATGCGCGCCGAGGCGGGCAAG
CCGTTCCCGGTCTTCAAGGTGGACGGCGGCGCCTCCCAGAACGACCTGCTCATGCAGTTCCAGGCTGACCTGCTCGAGGT
GCCGGTGGAGCGGCCGCGCATGATCGAGACCACCGCGCTCGGCGCCGCGTTCCTGGCCGGCCTGGCGGTGGGCTTCTGGA
AGGACCGCGAGGAGATCCGCCGCGCCTGGCAGGTGGGGAAGCGCTTCGAGCCGAAGATGAAGCCGGTCGAGCGAGAGCAG
CACGTGGCGAAGTGGCGGAAGGCGGTCCAGGGGGCGTAG

Upstream 100 bases:

>100_bases
CGGCCGCCGCCGCCACCCCGGCACGGCGCCGCGCCGCCCCAGGGCGGCGGGCGGGACGAAGGCGAAGGCCCGCGCCGGGC
GCCGGCGCAGGGGGTGAACC

Downstream 100 bases:

>100_bases
CCGCCCCGCGGGCAGCGCCACCGGAGGTGACGCCAAGGGACCCGCGCAGCAGGGGTGGGGCCCCGACGGCTCTGCCGGCG
GGGCGGGGCGGCACGCCCCG

Product: glycerol kinase

Products: NA

Alternate protein names: ATP:glycerol 3-phosphotransferase; Glycerokinase; GK [H]

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MASYVLAIDQGTTGTTVLVLDRRLSPRARVNQEFRQIFPKPGWVEHDLEDIWGSTVSTVQRALREAGIRGSDVAAVGITN
QRETTALWERRSSRPVAHAIVWQDRRTTDACAQLRSAGHEPLVRERTGLVLDPYFSATKLRWLLDNTKGARQKAEAGALA
FGTIDSFLVWRLTGGAAHVTDVSNASRTLLMDLRERRWDRELLDLFGVPPNVLPEIRASSEVYGTTRGVKVLPDGIPVAG
MAGDQQAALFGQACFRPGEAKCTYGTGAFLLQNVGPEPVMSSRGLLTTVAWTVGGETAYALEGSSFIAGAAVQWLRDGLG
LIARAPDVEALAKQVKSTGELVFVPALAGLGAPHWRPEARGLIAGIDRGTTAAHLARATLEGIAFLIHDLAEAMRAEAGK
PFPVFKVDGGASQNDLLMQFQADLLEVPVERPRMIETTALGAAFLAGLAVGFWKDREEIRRAWQVGKRFEPKMKPVEREQ
HVAKWRKAVQGA

Sequences:

>Translated_492_residues
MASYVLAIDQGTTGTTVLVLDRRLSPRARVNQEFRQIFPKPGWVEHDLEDIWGSTVSTVQRALREAGIRGSDVAAVGITN
QRETTALWERRSSRPVAHAIVWQDRRTTDACAQLRSAGHEPLVRERTGLVLDPYFSATKLRWLLDNTKGARQKAEAGALA
FGTIDSFLVWRLTGGAAHVTDVSNASRTLLMDLRERRWDRELLDLFGVPPNVLPEIRASSEVYGTTRGVKVLPDGIPVAG
MAGDQQAALFGQACFRPGEAKCTYGTGAFLLQNVGPEPVMSSRGLLTTVAWTVGGETAYALEGSSFIAGAAVQWLRDGLG
LIARAPDVEALAKQVKSTGELVFVPALAGLGAPHWRPEARGLIAGIDRGTTAAHLARATLEGIAFLIHDLAEAMRAEAGK
PFPVFKVDGGASQNDLLMQFQADLLEVPVERPRMIETTALGAAFLAGLAVGFWKDREEIRRAWQVGKRFEPKMKPVEREQ
HVAKWRKAVQGA
>Mature_491_residues
ASYVLAIDQGTTGTTVLVLDRRLSPRARVNQEFRQIFPKPGWVEHDLEDIWGSTVSTVQRALREAGIRGSDVAAVGITNQ
RETTALWERRSSRPVAHAIVWQDRRTTDACAQLRSAGHEPLVRERTGLVLDPYFSATKLRWLLDNTKGARQKAEAGALAF
GTIDSFLVWRLTGGAAHVTDVSNASRTLLMDLRERRWDRELLDLFGVPPNVLPEIRASSEVYGTTRGVKVLPDGIPVAGM
AGDQQAALFGQACFRPGEAKCTYGTGAFLLQNVGPEPVMSSRGLLTTVAWTVGGETAYALEGSSFIAGAAVQWLRDGLGL
IARAPDVEALAKQVKSTGELVFVPALAGLGAPHWRPEARGLIAGIDRGTTAAHLARATLEGIAFLIHDLAEAMRAEAGKP
FPVFKVDGGASQNDLLMQFQADLLEVPVERPRMIETTALGAAFLAGLAVGFWKDREEIRRAWQVGKRFEPKMKPVEREQH
VAKWRKAVQGA

Specific function: Key enzyme in the regulation of glycerol uptake and metabolism [H]

COG id: COG0554

COG function: function code C; Glycerol kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FGGY kinase family [H]

Homologues:

Organism=Homo sapiens, GI189409120, Length=496, Percent_Identity=43.5483870967742, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI4504007, Length=496, Percent_Identity=43.5483870967742, Blast_Score=414, Evalue=1e-115,
Organism=Homo sapiens, GI42794763, Length=500, Percent_Identity=43.6, Blast_Score=412, Evalue=1e-115,
Organism=Homo sapiens, GI41393575, Length=496, Percent_Identity=43.75, Blast_Score=410, Evalue=1e-114,
Organism=Homo sapiens, GI88196792, Length=503, Percent_Identity=31.8091451292247, Blast_Score=288, Evalue=6e-78,
Organism=Escherichia coli, GI1790361, Length=489, Percent_Identity=49.6932515337423, Blast_Score=510, Evalue=1e-146,
Organism=Escherichia coli, GI1790005, Length=475, Percent_Identity=25.2631578947368, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1789987, Length=443, Percent_Identity=28.2167042889391, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1787789, Length=478, Percent_Identity=26.9874476987448, Blast_Score=93, Evalue=4e-20,
Organism=Escherichia coli, GI1789138, Length=471, Percent_Identity=23.1422505307856, Blast_Score=89, Evalue=6e-19,
Organism=Escherichia coli, GI1789168, Length=500, Percent_Identity=25, Blast_Score=87, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI17535599, Length=495, Percent_Identity=38.5858585858586, Blast_Score=345, Evalue=3e-95,
Organism=Caenorhabditis elegans, GI71986140, Length=520, Percent_Identity=25, Blast_Score=166, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI71986147, Length=257, Percent_Identity=31.9066147859922, Blast_Score=122, Evalue=3e-28,
Organism=Saccharomyces cerevisiae, GI6321755, Length=544, Percent_Identity=37.5, Blast_Score=317, Evalue=4e-87,
Organism=Drosophila melanogaster, GI17864214, Length=504, Percent_Identity=41.2698412698413, Blast_Score=377, Evalue=1e-105,
Organism=Drosophila melanogaster, GI24655555, Length=467, Percent_Identity=40.0428265524625, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24655560, Length=467, Percent_Identity=40.0428265524625, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24655570, Length=467, Percent_Identity=40.0428265524625, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24655574, Length=467, Percent_Identity=40.0428265524625, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24655565, Length=467, Percent_Identity=40.0428265524625, Blast_Score=361, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24654573, Length=443, Percent_Identity=43.3408577878104, Blast_Score=360, Evalue=1e-99,
Organism=Drosophila melanogaster, GI19922058, Length=499, Percent_Identity=32.4649298597194, Blast_Score=271, Evalue=9e-73,
Organism=Drosophila melanogaster, GI24652871, Length=488, Percent_Identity=32.172131147541, Blast_Score=259, Evalue=3e-69,
Organism=Drosophila melanogaster, GI21357867, Length=522, Percent_Identity=29.8850574712644, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI24656367, Length=510, Percent_Identity=30, Blast_Score=223, Evalue=2e-58,
Organism=Drosophila melanogaster, GI24656372, Length=370, Percent_Identity=31.8918918918919, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI45552909, Length=317, Percent_Identity=27.7602523659306, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: 2,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000577
- InterPro:   IPR018485
- InterPro:   IPR018483
- InterPro:   IPR018484
- InterPro:   IPR005999 [H]

Pfam domain/function: PF02782 FGGY_C; PF00370 FGGY_N [H]

EC number: =2.7.1.30 [H]

Molecular weight: Translated: 53566; Mature: 53435

Theoretical pI: Translated: 9.40; Mature: 9.40

Prosite motif: PS00933 FGGY_KINASES_1 ; PS00445 FGGY_KINASES_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASYVLAIDQGTTGTTVLVLDRRLSPRARVNQEFRQIFPKPGWVEHDLEDIWGSTVSTVQ
CCCEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCHHHHHHH
RALREAGIRGSDVAAVGITNQRETTALWERRSSRPVAHAIVWQDRRTTDACAQLRSAGHE
HHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHCCCC
PLVRERTGLVLDPYFSATKLRWLLDNTKGARQKAEAGALAFGTIDSFLVWRLTGGAAHVT
CHHHHCCCCEECCCCCHHHHHHHHCCCCCHHHHHHCCCEEEHHHHHEEEEEEECCCEEEE
DVSNASRTLLMDLRERRWDRELLDLFGVPPNVLPEIRASSEVYGTTRGVKVLPDGIPVAG
ECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHCCCCCCEECCCCCCCCC
MAGDQQAALFGQACFRPGEAKCTYGTGAFLLQNVGPEPVMSSRGLLTTVAWTVGGETAYA
CCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHCCCCCCCCCCCCCEEEEEEEECCCEEEE
LEGSSFIAGAAVQWLRDGLGLIARAPDVEALAKQVKSTGELVFVPALAGLGAPHWRPEAR
ECCCCHHHHHHHHHHHHCHHHEECCCCHHHHHHHHHCCCCEEEEECHHCCCCCCCCCCCC
GLIAGIDRGTTAAHLARATLEGIAFLIHDLAEAMRAEAGKPFPVFKVDGGASQNDLLMQF
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHH
QADLLEVPVERPRMIETTALGAAFLAGLAVGFWKDREEIRRAWQVGKRFEPKMKPVEREQ
HHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHH
HVAKWRKAVQGA
HHHHHHHHHCCC
>Mature Secondary Structure 
ASYVLAIDQGTTGTTVLVLDRRLSPRARVNQEFRQIFPKPGWVEHDLEDIWGSTVSTVQ
CCEEEEEECCCCCCEEEEEECCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHCHHHHHHH
RALREAGIRGSDVAAVGITNQRETTALWERRSSRPVAHAIVWQDRRTTDACAQLRSAGHE
HHHHHCCCCCCCEEEEECCCCCHHHHHHHHCCCCCCEEEEEECCCCCHHHHHHHHHCCCC
PLVRERTGLVLDPYFSATKLRWLLDNTKGARQKAEAGALAFGTIDSFLVWRLTGGAAHVT
CHHHHCCCCEECCCCCHHHHHHHHCCCCCHHHHHHCCCEEEHHHHHEEEEEEECCCEEEE
DVSNASRTLLMDLRERRWDRELLDLFGVPPNVLPEIRASSEVYGTTRGVKVLPDGIPVAG
ECCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHCCCCHHHCCCCCCEECCCCCCCCC
MAGDQQAALFGQACFRPGEAKCTYGTGAFLLQNVGPEPVMSSRGLLTTVAWTVGGETAYA
CCCCHHHHHHHHHHCCCCCCEEECCCHHHHHHCCCCCCCCCCCCCEEEEEEEECCCEEEE
LEGSSFIAGAAVQWLRDGLGLIARAPDVEALAKQVKSTGELVFVPALAGLGAPHWRPEAR
ECCCCHHHHHHHHHHHHCHHHEECCCCHHHHHHHHHCCCCEEEEECHHCCCCCCCCCCCC
GLIAGIDRGTTAAHLARATLEGIAFLIHDLAEAMRAEAGKPFPVFKVDGGASQNDLLMQF
CEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEECCCCCCCHHHHHH
QADLLEVPVERPRMIETTALGAAFLAGLAVGFWKDREEIRRAWQVGKRFEPKMKPVEREQ
HHHHHHCCCCCCCEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCHHHHH
HVAKWRKAVQGA
HHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA