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The map label for this gene is acsA [H]

Identifier: 220918635

GI number: 220918635

Start: 3960886

End: 3962784

Strand: Direct

Name: acsA [H]

Synonym: A2cp1_3543

Alternate gene names: 220918635

Gene position: 3960886-3962784 (Clockwise)

Preceding gene: 220918631

Following gene: 220918636

Centisome position: 78.76

GC content: 67.93

Gene sequence:

>1899_bases
ATGAGCTCGAAGAAGACGCAGCTGGAAGGTGAGGTCTTCTACCCCTCCGCCGAGGTGGCCACGCAGGCGCGCGTGCCGGA
CTGGGCCGCGCTGGCGAAGCGCGCCGACGAGGACCTGGAGGGCTTCTGGGCCGCGGAGGCCGAGGAGCTCGAGTGGTACC
GGAAGTGGGACAAGGTCCTCGACGCCTCCGAGAAGCCGTTCTACCGCTGGTTCAAGGGCGCGCAGACCAACATCGTCCAC
AACTGCCTGGACCGCCACCAGCGCACCTGGCGCAAGAACAAGCTCTCGCTGGTGTGGGTGGGCGAGAAGGGCGAGGTCCG
GACGTACTCGTATTTCGCGCTGAACCGCGACGTGTCCAAGTTCGCGAACGTCCTGAAGGCCATGGGCGTGAAGAAGGGCG
ACCGCGTCACCATCTACATGCCCCGCATCCCCGAGATCGTGATCGCCATGCTGGCGGCCGCGAAGATCGGCGCCATCCAC
TCGGTGGTGTACGGCGGGTTCTCGGTGGACGCGCTGCAGGGCCGCATCGAGGACTCGGAGTCGAAGGTCGTGATCACCGC
CGACGGCGGGTTCATGAACGGGAAGATCGTCGAGCTGAAGAAGACGGTGGACGACGCCGTCCGCCGCTGCCCGACGGTGG
AGACCGTGATCGTGGTCCAGCGCACCGCGCACGAGGTCCGCATGGAGGCGGGCCGCGACTACTGGTACCACGAACTGATG
AAGCTCCCCCTCGCCGCGGGCGTCTGCCCGACCGAGGTGATGGACTCCACCGACCCGCTCTACATCCTCTACACCTCCGG
CACCACCGGGAAGCCGAAGGGGCTCATCCACGGGCACGGCGGCTACCAGGTCGGCATCTACTCCACGCTCAAGTACGTCT
TCGACATCAAGGACGAGGACCGCTACTGGTGCGCGGCGGATCCGGGCTGGGTCACCGGCCACAGCTACATCGTGTACGGG
CCGCTGCTCATGGGCGCGACCACGTTCATGTACGAGGGCGCGCCGACCTACCCGTACCCGAACCGCTGGTGGTCGCTGGT
CGAGAAGTACGGCATCACCATCCTCTACACCGCGCCCACCGCCATCCGCGGCCTGATGCGCTTCGGCGAGTCGTGGCCGA
ACCGCCACGACCTCTCCACGCTCCGGCTGCTCGGCTCGGTGGGCGAGCCCATCAACCCCGAGGCGTGGAAGTGGTACCAC
CGCGTCATCGGCAAGGGCCGCTGCCCGGTGATGGACACGTGGTGGCAGACCGAGACCGGCATGTTCATGATCACGCCGGT
CCCGACGCTCCCGCTGAAGCCCGGCTCGGCGGCGAAGCCGTTCTTCGGCCAGCAGGTCTCGATCCTCGACGACAACGGCA
AGGCGGTCCCCGACGGCGAGGAGGGGTTCCTGGTGCTGGAGCGGCCCTGGCCGGCGATGGCCATGACCGTCTACAAGGAC
CCTGAACGGTTCGTGAAGACCTACTGGGAGAAGTACCCGGGCCGCTACATGGCCGGGGACGCCGCCAAGCGCGACGCCGA
CGGCTACTACTGGGTCATCGGCCGCACCGACGACGTCATCAAGGTCTCCGGCTACCGCCTCGGCACCGCCGAGATCGAGA
GCGCCCTGGTGTCGCACCCGGCCATCGCCGAGGCGGCGGTGATCGGGCTGCCGCACGAGGTGAAGGGGCAGGCCATCCAC
TGCTACTGCCTGCTGCGCCAGGGCTTCAAGCCGAGCCCCGAGCTGGAGGACGAGGTGAAGCAGCACGTGGCGCAGCACCT
CGGGCCCATCGTGCGGCCGGAGAAGGTGACGTTCGTGGACTCGCTGCCCAAGACGCGCTCCGGCAAGATCATGCGGCGCG
TGCTCAAGGCGCGCGCCCAGGGGCTCCCCGAGGGCGACGTCTCCACGCTGGAGGAGTGA

Upstream 100 bases:

>100_bases
TAATGTCGAGGGTCCGACTCGATCTCCGAAGCCCCCACGCCGCGCCGGGTCCCCCTCCCGGCGCGCGACGTCCGGCCCGA
CCGGCGAAAAGGAGCCCGTG

Downstream 100 bases:

>100_bases
TCGCCTCCTCCCCGCCCGCTCCCCACGCGAAAAGGGAACGGGCGGGGCGGCGCGCTTTCGGCGATACTCGCCGCCCGATG
CAGACCGACCTGCCCCTCTG

Product: acetate/CoA ligase

Products: NA

Alternate protein names: Acetate--CoA ligase; Acyl-activating enzyme [H]

Number of amino acids: Translated: 632; Mature: 631

Protein sequence:

>632_residues
MSSKKTQLEGEVFYPSAEVATQARVPDWAALAKRADEDLEGFWAAEAEELEWYRKWDKVLDASEKPFYRWFKGAQTNIVH
NCLDRHQRTWRKNKLSLVWVGEKGEVRTYSYFALNRDVSKFANVLKAMGVKKGDRVTIYMPRIPEIVIAMLAAAKIGAIH
SVVYGGFSVDALQGRIEDSESKVVITADGGFMNGKIVELKKTVDDAVRRCPTVETVIVVQRTAHEVRMEAGRDYWYHELM
KLPLAAGVCPTEVMDSTDPLYILYTSGTTGKPKGLIHGHGGYQVGIYSTLKYVFDIKDEDRYWCAADPGWVTGHSYIVYG
PLLMGATTFMYEGAPTYPYPNRWWSLVEKYGITILYTAPTAIRGLMRFGESWPNRHDLSTLRLLGSVGEPINPEAWKWYH
RVIGKGRCPVMDTWWQTETGMFMITPVPTLPLKPGSAAKPFFGQQVSILDDNGKAVPDGEEGFLVLERPWPAMAMTVYKD
PERFVKTYWEKYPGRYMAGDAAKRDADGYYWVIGRTDDVIKVSGYRLGTAEIESALVSHPAIAEAAVIGLPHEVKGQAIH
CYCLLRQGFKPSPELEDEVKQHVAQHLGPIVRPEKVTFVDSLPKTRSGKIMRRVLKARAQGLPEGDVSTLEE

Sequences:

>Translated_632_residues
MSSKKTQLEGEVFYPSAEVATQARVPDWAALAKRADEDLEGFWAAEAEELEWYRKWDKVLDASEKPFYRWFKGAQTNIVH
NCLDRHQRTWRKNKLSLVWVGEKGEVRTYSYFALNRDVSKFANVLKAMGVKKGDRVTIYMPRIPEIVIAMLAAAKIGAIH
SVVYGGFSVDALQGRIEDSESKVVITADGGFMNGKIVELKKTVDDAVRRCPTVETVIVVQRTAHEVRMEAGRDYWYHELM
KLPLAAGVCPTEVMDSTDPLYILYTSGTTGKPKGLIHGHGGYQVGIYSTLKYVFDIKDEDRYWCAADPGWVTGHSYIVYG
PLLMGATTFMYEGAPTYPYPNRWWSLVEKYGITILYTAPTAIRGLMRFGESWPNRHDLSTLRLLGSVGEPINPEAWKWYH
RVIGKGRCPVMDTWWQTETGMFMITPVPTLPLKPGSAAKPFFGQQVSILDDNGKAVPDGEEGFLVLERPWPAMAMTVYKD
PERFVKTYWEKYPGRYMAGDAAKRDADGYYWVIGRTDDVIKVSGYRLGTAEIESALVSHPAIAEAAVIGLPHEVKGQAIH
CYCLLRQGFKPSPELEDEVKQHVAQHLGPIVRPEKVTFVDSLPKTRSGKIMRRVLKARAQGLPEGDVSTLEE
>Mature_631_residues
SSKKTQLEGEVFYPSAEVATQARVPDWAALAKRADEDLEGFWAAEAEELEWYRKWDKVLDASEKPFYRWFKGAQTNIVHN
CLDRHQRTWRKNKLSLVWVGEKGEVRTYSYFALNRDVSKFANVLKAMGVKKGDRVTIYMPRIPEIVIAMLAAAKIGAIHS
VVYGGFSVDALQGRIEDSESKVVITADGGFMNGKIVELKKTVDDAVRRCPTVETVIVVQRTAHEVRMEAGRDYWYHELMK
LPLAAGVCPTEVMDSTDPLYILYTSGTTGKPKGLIHGHGGYQVGIYSTLKYVFDIKDEDRYWCAADPGWVTGHSYIVYGP
LLMGATTFMYEGAPTYPYPNRWWSLVEKYGITILYTAPTAIRGLMRFGESWPNRHDLSTLRLLGSVGEPINPEAWKWYHR
VIGKGRCPVMDTWWQTETGMFMITPVPTLPLKPGSAAKPFFGQQVSILDDNGKAVPDGEEGFLVLERPWPAMAMTVYKDP
ERFVKTYWEKYPGRYMAGDAAKRDADGYYWVIGRTDDVIKVSGYRLGTAEIESALVSHPAIAEAAVIGLPHEVKGQAIHC
YCLLRQGFKPSPELEDEVKQHVAQHLGPIVRPEKVTFVDSLPKTRSGKIMRRVLKARAQGLPEGDVSTLEE

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI8923896, Length=659, Percent_Identity=46.5857359635812, Blast_Score=586, Evalue=1e-167,
Organism=Homo sapiens, GI253970489, Length=672, Percent_Identity=45.8333333333333, Blast_Score=582, Evalue=1e-166,
Organism=Homo sapiens, GI28416953, Length=616, Percent_Identity=44.8051948051948, Blast_Score=520, Evalue=1e-147,
Organism=Homo sapiens, GI13375727, Length=607, Percent_Identity=37.8912685337727, Blast_Score=394, Evalue=1e-109,
Organism=Homo sapiens, GI122937307, Length=566, Percent_Identity=30.0353356890459, Blast_Score=235, Evalue=9e-62,
Organism=Homo sapiens, GI42544132, Length=529, Percent_Identity=29.3005671077505, Blast_Score=231, Evalue=2e-60,
Organism=Homo sapiens, GI38505220, Length=560, Percent_Identity=30.8928571428571, Blast_Score=225, Evalue=8e-59,
Organism=Homo sapiens, GI115511026, Length=538, Percent_Identity=28.0669144981413, Blast_Score=206, Evalue=4e-53,
Organism=Homo sapiens, GI31982927, Length=643, Percent_Identity=25.3499222395023, Blast_Score=194, Evalue=2e-49,
Organism=Homo sapiens, GI58082049, Length=547, Percent_Identity=28.5191956124314, Blast_Score=191, Evalue=1e-48,
Organism=Homo sapiens, GI157311624, Length=551, Percent_Identity=28.1306715063521, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI157311622, Length=551, Percent_Identity=28.1306715063521, Blast_Score=184, Evalue=2e-46,
Organism=Homo sapiens, GI195947378, Length=436, Percent_Identity=24.7706422018349, Blast_Score=123, Evalue=6e-28,
Organism=Homo sapiens, GI42544134, Length=345, Percent_Identity=26.3768115942029, Blast_Score=119, Evalue=6e-27,
Organism=Homo sapiens, GI187761345, Length=386, Percent_Identity=27.720207253886, Blast_Score=109, Evalue=7e-24,
Organism=Homo sapiens, GI187761343, Length=386, Percent_Identity=27.720207253886, Blast_Score=109, Evalue=7e-24,
Organism=Escherichia coli, GI1790505, Length=600, Percent_Identity=51.3333333333333, Blast_Score=618, Evalue=1e-178,
Organism=Escherichia coli, GI1786529, Length=620, Percent_Identity=39.6774193548387, Blast_Score=424, Evalue=1e-120,
Organism=Escherichia coli, GI221142682, Length=529, Percent_Identity=23.8185255198488, Blast_Score=137, Evalue=2e-33,
Organism=Escherichia coli, GI145693145, Length=537, Percent_Identity=24.9534450651769, Blast_Score=118, Evalue=9e-28,
Organism=Escherichia coli, GI1788107, Length=556, Percent_Identity=23.3812949640288, Blast_Score=108, Evalue=1e-24,
Organism=Escherichia coli, GI1786810, Length=531, Percent_Identity=22.0338983050847, Blast_Score=103, Evalue=3e-23,
Organism=Escherichia coli, GI1786801, Length=537, Percent_Identity=23.2774674115456, Blast_Score=84, Evalue=2e-17,
Organism=Caenorhabditis elegans, GI71982997, Length=650, Percent_Identity=42.3076923076923, Blast_Score=507, Evalue=1e-144,
Organism=Caenorhabditis elegans, GI71983001, Length=647, Percent_Identity=42.3493044822257, Blast_Score=506, Evalue=1e-143,
Organism=Caenorhabditis elegans, GI17569507, Length=622, Percent_Identity=22.9903536977492, Blast_Score=165, Evalue=8e-41,
Organism=Caenorhabditis elegans, GI17557194, Length=567, Percent_Identity=25.3968253968254, Blast_Score=126, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17559526, Length=579, Percent_Identity=24.006908462867, Blast_Score=116, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17538037, Length=560, Percent_Identity=25.7142857142857, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17531443, Length=554, Percent_Identity=21.4801444043321, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI17558820, Length=536, Percent_Identity=20.7089552238806, Blast_Score=86, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17560140, Length=540, Percent_Identity=22.2222222222222, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI115534440, Length=470, Percent_Identity=23.1914893617021, Blast_Score=82, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI71985884, Length=376, Percent_Identity=23.6702127659574, Blast_Score=74, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6319264, Length=630, Percent_Identity=43.6507936507937, Blast_Score=518, Evalue=1e-147,
Organism=Saccharomyces cerevisiae, GI6323182, Length=612, Percent_Identity=43.4640522875817, Blast_Score=507, Evalue=1e-144,
Organism=Saccharomyces cerevisiae, GI6319699, Length=499, Percent_Identity=25.0501002004008, Blast_Score=129, Evalue=2e-30,
Organism=Drosophila melanogaster, GI24667955, Length=653, Percent_Identity=44.104134762634, Blast_Score=551, Evalue=1e-157,
Organism=Drosophila melanogaster, GI62472339, Length=543, Percent_Identity=48.4346224677716, Blast_Score=519, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24667959, Length=510, Percent_Identity=48.0392156862745, Blast_Score=483, Evalue=1e-136,
Organism=Drosophila melanogaster, GI21355225, Length=617, Percent_Identity=35.6564019448946, Blast_Score=373, Evalue=1e-103,
Organism=Drosophila melanogaster, GI18859661, Length=608, Percent_Identity=26.6447368421053, Blast_Score=122, Evalue=8e-28,
Organism=Drosophila melanogaster, GI21355181, Length=525, Percent_Identity=24.7619047619048, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24656500, Length=369, Percent_Identity=24.1192411924119, Blast_Score=84, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24648260, Length=386, Percent_Identity=25.1295336787565, Blast_Score=84, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24581924, Length=357, Percent_Identity=24.3697478991597, Blast_Score=80, Evalue=3e-15,
Organism=Drosophila melanogaster, GI21356947, Length=355, Percent_Identity=24.2253521126761, Blast_Score=76, Evalue=9e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011904
- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: =6.2.1.1 [H]

Molecular weight: Translated: 71180; Mature: 71049

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSKKTQLEGEVFYPSAEVATQARVPDWAALAKRADEDLEGFWAAEAEELEWYRKWDKVL
CCCCCCCCCCEEECCCHHHHHHCCCCHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHH
DASEKPFYRWFKGAQTNIVHNCLDRHQRTWRKNKLSLVWVGEKGEVRTYSYFALNRDVSK
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEEEEECCCHHH
FANVLKAMGVKKGDRVTIYMPRIPEIVIAMLAAAKIGAIHSVVYGGFSVDALQGRIEDSE
HHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCC
SKVVITADGGFMNGKIVELKKTVDDAVRRCPTVETVIVVQRTAHEVRMEAGRDYWYHELM
CEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHCCCCHHHHHHH
KLPLAAGVCPTEVMDSTDPLYILYTSGTTGKPKGLIHGHGGYQVGIYSTLKYVFDIKDED
HHHHHCCCCCHHHHCCCCCEEEEEECCCCCCCCCEEECCCCEEEHHHHHEEEHEECCCCC
RYWCAADPGWVTGHSYIVYGPLLMGATTFMYEGAPTYPYPNRWWSLVEKYGITILYTAPT
CEEEECCCCEECCCCEEEECHHHHCCHHHEECCCCCCCCCHHHHHHHHHCCCEEEEECHH
AIRGLMRFGESWPNRHDLSTLRLLGSVGEPINPEAWKWYHRVIGKGRCPVMDTWWQTETG
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
MFMITPVPTLPLKPGSAAKPFFGQQVSILDDNGKAVPDGEEGFLVLERPWPAMAMTVYKD
EEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCEEEEEECC
PERFVKTYWEKYPGRYMAGDAAKRDADGYYWVIGRTDDVIKVSGYRLGTAEIESALVSHP
HHHHHHHHHHHCCCCEECCCCCCCCCCCEEEEEECCCCEEEECCEEECHHHHHHHHHCCC
AIAEAAVIGLPHEVKGQAIHCYCLLRQGFKPSPELEDEVKQHVAQHLGPIVRPEKVTFVD
CHHHHHEECCCHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEC
SLPKTRSGKIMRRVLKARAQGLPEGDVSTLEE
CCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCC
>Mature Secondary Structure 
SSKKTQLEGEVFYPSAEVATQARVPDWAALAKRADEDLEGFWAAEAEELEWYRKWDKVL
CCCCCCCCCEEECCCHHHHHHCCCCHHHHHHHHCCHHHHHHCCCCHHHHHHHHHHHHHH
DASEKPFYRWFKGAQTNIVHNCLDRHQRTWRKNKLSLVWVGEKGEVRTYSYFALNRDVSK
CCCCCCHHHHHCCCCHHHHHHHHHHHHHHHHHCCEEEEEECCCCCEEEEEEEEECCCHHH
FANVLKAMGVKKGDRVTIYMPRIPEIVIAMLAAAKIGAIHSVVYGGFSVDALQGRIEDSE
HHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCCCCC
SKVVITADGGFMNGKIVELKKTVDDAVRRCPTVETVIVVQRTAHEVRMEAGRDYWYHELM
CEEEEEECCCCCCCEEEEHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHCCCCHHHHHHH
KLPLAAGVCPTEVMDSTDPLYILYTSGTTGKPKGLIHGHGGYQVGIYSTLKYVFDIKDED
HHHHHCCCCCHHHHCCCCCEEEEEECCCCCCCCCEEECCCCEEEHHHHHEEEHEECCCCC
RYWCAADPGWVTGHSYIVYGPLLMGATTFMYEGAPTYPYPNRWWSLVEKYGITILYTAPT
CEEEECCCCEECCCCEEEECHHHHCCHHHEECCCCCCCCCHHHHHHHHHCCCEEEEECHH
AIRGLMRFGESWPNRHDLSTLRLLGSVGEPINPEAWKWYHRVIGKGRCPVMDTWWQTETG
HHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCC
MFMITPVPTLPLKPGSAAKPFFGQQVSILDDNGKAVPDGEEGFLVLERPWPAMAMTVYKD
EEEEECCCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCCCCCEEEEECCCCCEEEEEECC
PERFVKTYWEKYPGRYMAGDAAKRDADGYYWVIGRTDDVIKVSGYRLGTAEIESALVSHP
HHHHHHHHHHHCCCCEECCCCCCCCCCCEEEEEECCCCEEEECCEEECHHHHHHHHHCCC
AIAEAAVIGLPHEVKGQAIHCYCLLRQGFKPSPELEDEVKQHVAQHLGPIVRPEKVTFVD
CHHHHHEECCCHHHCCCEEEEEEEECCCCCCCCCHHHHHHHHHHHHCCCCCCCCEEEEEC
SLPKTRSGKIMRRVLKARAQGLPEGDVSTLEE
CCCCCCCCHHHHHHHHHHHCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA