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The map label for this gene is tmk [H]

Identifier: 220918549

GI number: 220918549

Start: 3859256

End: 3860959

Strand: Reverse

Name: tmk [H]

Synonym: A2cp1_3457

Alternate gene names: 220918549

Gene position: 3860959-3859256 (Counterclockwise)

Preceding gene: 220918550

Following gene: 220918548

Centisome position: 76.77

GC content: 81.75

Gene sequence:

>1704_bases
ATGCTCGTGTCCTTCGAAGGCATCGACGGCAGCGGCAAGACCGCGCTCTCCAACCTGGTCTGCGAGCGCCTCCGCGGCGC
GGGGCGCGAGGTCGTCCACGCGCGCGAGCGCGGGGTCCTCGCCACCGCCGCGGCGCGCCGGGTGCGCGAGCTGACGCGCG
ACCCGCGCCTGCTCGAGCTCTCGCCGCGCGCCGAGCTGTTCCTGAACCTGGCCCGCGAGGCGCAGCAGCTCGAGGAGGTG
GTGCGGCCGGCGCTGGCGCGCGGGGCGCTCTGCGTCGCCGACCGGAGCCTCCACTCGATCCTGGCGCTGGCCATCGCCGG
CCGCGGCCTCCCGCGCGCCGAGGTCGAGGCGGCGGTGCGCGCCGCCTCGGGCGGCACCTGGCCGGACCTCGCCGTCCTGG
TGGACGTGGATCCCGACCTGGCGCGGCTGCGCAAGCGCGTCGGGAAGATCCTGGAGGGCCGCGCCGACGAGCCGGGATCG
AGGAAGGGCCTCGCCGGGCACGGCCTCCAGGTCCGGATCCGCGAGCACCTCGCCGCCGAGGCCGCCGCGGCGCCGGAGGC
CTGGCTCCGGGTCGCGAACGAGGGGAGGTCGCTCGAGGCGCTCGCCGACCTGGTCGCGGAGGCGATCGCCGCGCGCGTGG
ACGGCCGCGCCCCGCGCCGGCCCCGCGCCGCGCCGCCCACCGCGCGCCCCCGGGCGCACGCGGCCGCGCAGGCGGAGGCC
GGCGGGCTGGCGGAGCGGTTCGAGGCGGCGCTCGACGCGCTCGCGGCGCGGGAGCCCGCGCTCGCGGCCCACCTGCTGGC
GGGCATCCCCGGCCGCGCCGCCCACGCGCGGCGGGTGGCGCTCGCCGCCCGGTGCCCGGCCGTGGTTGCGCGCGCGCTCG
AGGGCCTGTCCGACCCGGAGTCGCACGCGCTGAGGTGGGCGCTGGCCGGGCGGGTCCCGGCCGACGTGGCGGCCGGCCTG
GGCGCCGACGCGTCGTCCGAGGCGATGCGCCTGCGGGCGGCGCTCCTGGCGCGCGCGCCGGGGCCCGCGGTGGCCGGCCT
GGTCGCGGCGGATGGATCGGAGGCGTGGGCGCTCCGCGCCGAGGCGCTGGAGCGGGGGGGGCTGGAGGGCGTGCTGCGCG
GGCTGGCCGGGCTCGGCTCGGAGCGCGCGTGGGCGCTCCGCGCGGAGGGCGTCGGGCAGGGGCTGTGGGACGCGGTGGGG
CGCGGCCTGGCCGGCGTGGACGGCGCGCGCGCCGACGCGATGCGCGCCGCGCTCGCCGCCCACGATGGCCTCGCCGCGCT
GCGCGGGACGGTCGGGGTGGAGAGTGGCCCCGCCCGCGCGCTCCGCGAGCGGCTGTTCCCGCTCGCGCCGAAGCGCGTGC
TCCGCACGCTGGCGGGCAACGCGGCGCCGTGGACCTGGCCGCTGCGCGAGCGCGCGCTCGCCGCGACCAAGGAGGCGCTC
GACGCGGTGGACGGGATGGATCACCCGCGCGCCTGGGCGCTGCGGGCCGAGGGCGTCGCGCGCTGGCCCGCCACCGCGGT
GTCGTCGCTCCGGCACCTCGCCGCGACCGCGCGCGGCCGGGAGATCGTCGCGGCCGCGCTGCGGGCCGCGCCGGCGAGCC
TGCCGGTGCTGCGGAACGCGCACGCGGCGCTCGCGCTGGCGGCGCACGCGGCGGGCCCGGCCCCGCTCCCGCCGGCGGCG
GTGGAGGCCTCATGCACCCCTTGA

Upstream 100 bases:

>100_bases
TGGCTCGTCGCGCTCGTCACCGCGCGGGCCCAGCCGTACAGCAAGCTCGCCGAGGCGTTCTCGCGCGCCGCGCCGGCGCG
CACGCGCAGGGCCTGACCCC

Downstream 100 bases:

>100_bases
CCCCGATCAGCGGGATCGACCTGCACACGCTGCCGCTCGGCACGGTGCTCCCGCGCATCGGCGCGGCGCTGGCGGTGGGC
GTGGCGCTCGGGGTCCGGCC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 567; Mature: 567

Protein sequence:

>567_residues
MLVSFEGIDGSGKTALSNLVCERLRGAGREVVHARERGVLATAAARRVRELTRDPRLLELSPRAELFLNLAREAQQLEEV
VRPALARGALCVADRSLHSILALAIAGRGLPRAEVEAAVRAASGGTWPDLAVLVDVDPDLARLRKRVGKILEGRADEPGS
RKGLAGHGLQVRIREHLAAEAAAAPEAWLRVANEGRSLEALADLVAEAIAARVDGRAPRRPRAAPPTARPRAHAAAQAEA
GGLAERFEAALDALAAREPALAAHLLAGIPGRAAHARRVALAARCPAVVARALEGLSDPESHALRWALAGRVPADVAAGL
GADASSEAMRLRAALLARAPGPAVAGLVAADGSEAWALRAEALERGGLEGVLRGLAGLGSERAWALRAEGVGQGLWDAVG
RGLAGVDGARADAMRAALAAHDGLAALRGTVGVESGPARALRERLFPLAPKRVLRTLAGNAAPWTWPLRERALAATKEAL
DAVDGMDHPRAWALRAEGVARWPATAVSSLRHLAATARGREIVAAALRAAPASLPVLRNAHAALALAAHAAGPAPLPPAA
VEASCTP

Sequences:

>Translated_567_residues
MLVSFEGIDGSGKTALSNLVCERLRGAGREVVHARERGVLATAAARRVRELTRDPRLLELSPRAELFLNLAREAQQLEEV
VRPALARGALCVADRSLHSILALAIAGRGLPRAEVEAAVRAASGGTWPDLAVLVDVDPDLARLRKRVGKILEGRADEPGS
RKGLAGHGLQVRIREHLAAEAAAAPEAWLRVANEGRSLEALADLVAEAIAARVDGRAPRRPRAAPPTARPRAHAAAQAEA
GGLAERFEAALDALAAREPALAAHLLAGIPGRAAHARRVALAARCPAVVARALEGLSDPESHALRWALAGRVPADVAAGL
GADASSEAMRLRAALLARAPGPAVAGLVAADGSEAWALRAEALERGGLEGVLRGLAGLGSERAWALRAEGVGQGLWDAVG
RGLAGVDGARADAMRAALAAHDGLAALRGTVGVESGPARALRERLFPLAPKRVLRTLAGNAAPWTWPLRERALAATKEAL
DAVDGMDHPRAWALRAEGVARWPATAVSSLRHLAATARGREIVAAALRAAPASLPVLRNAHAALALAAHAAGPAPLPPAA
VEASCTP
>Mature_567_residues
MLVSFEGIDGSGKTALSNLVCERLRGAGREVVHARERGVLATAAARRVRELTRDPRLLELSPRAELFLNLAREAQQLEEV
VRPALARGALCVADRSLHSILALAIAGRGLPRAEVEAAVRAASGGTWPDLAVLVDVDPDLARLRKRVGKILEGRADEPGS
RKGLAGHGLQVRIREHLAAEAAAAPEAWLRVANEGRSLEALADLVAEAIAARVDGRAPRRPRAAPPTARPRAHAAAQAEA
GGLAERFEAALDALAAREPALAAHLLAGIPGRAAHARRVALAARCPAVVARALEGLSDPESHALRWALAGRVPADVAAGL
GADASSEAMRLRAALLARAPGPAVAGLVAADGSEAWALRAEALERGGLEGVLRGLAGLGSERAWALRAEGVGQGLWDAVG
RGLAGVDGARADAMRAALAAHDGLAALRGTVGVESGPARALRERLFPLAPKRVLRTLAGNAAPWTWPLRERALAATKEAL
DAVDGMDHPRAWALRAEGVARWPATAVSSLRHLAATARGREIVAAALRAAPASLPVLRNAHAALALAAHAAGPAPLPPAA
VEASCTP

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=149, Percent_Identity=32.8859060402685, Blast_Score=69, Evalue=9e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 58559; Mature: 58559

Theoretical pI: Translated: 11.33; Mature: 11.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVSFEGIDGSGKTALSNLVCERLRGAGREVVHARERGVLATAAARRVRELTRDPRLLEL
CEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEE
SPRAELFLNLAREAQQLEEVVRPALARGALCVADRSLHSILALAIAGRGLPRAEVEAAVR
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AASGGTWPDLAVLVDVDPDLARLRKRVGKILEGRADEPGSRKGLAGHGLQVRIREHLAAE
HCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHHHHHHHHH
AAAAPEAWLRVANEGRSLEALADLVAEAIAARVDGRAPRRPRAAPPTARPRAHAAAQAEA
HHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHC
GGLAERFEAALDALAAREPALAAHLLAGIPGRAAHARRVALAARCPAVVARALEGLSDPE
CCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
SHALRWALAGRVPADVAAGLGADASSEAMRLRAALLARAPGPAVAGLVAADGSEAWALRA
HHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHEEEEECCCCCHHHHHH
EALERGGLEGVLRGLAGLGSERAWALRAEGVGQGLWDAVGRGLAGVDGARADAMRAALAA
HHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHH
HDGLAALRGTVGVESGPARALRERLFPLAPKRVLRTLAGNAAPWTWPLRERALAATKEAL
HCCHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
DAVDGMDHPRAWALRAEGVARWPATAVSSLRHLAATARGREIVAAALRAAPASLPVLRNA
HHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHH
HAALALAAHAAGPAPLPPAAVEASCTP
HHHHHHHHHCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MLVSFEGIDGSGKTALSNLVCERLRGAGREVVHARERGVLATAAARRVRELTRDPRLLEL
CEEEECCCCCCCHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEEE
SPRAELFLNLAREAQQLEEVVRPALARGALCVADRSLHSILALAIAGRGLPRAEVEAAVR
CCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHH
AASGGTWPDLAVLVDVDPDLARLRKRVGKILEGRADEPGSRKGLAGHGLQVRIREHLAAE
HCCCCCCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEEHHHHHHHHH
AAAAPEAWLRVANEGRSLEALADLVAEAIAARVDGRAPRRPRAAPPTARPRAHAAAQAEA
HHCCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCHHHHHHHHC
GGLAERFEAALDALAAREPALAAHLLAGIPGRAAHARRVALAARCPAVVARALEGLSDPE
CCHHHHHHHHHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCH
SHALRWALAGRVPADVAAGLGADASSEAMRLRAALLARAPGPAVAGLVAADGSEAWALRA
HHHHHHHHCCCCCHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHEEEEECCCCCHHHHHH
EALERGGLEGVLRGLAGLGSERAWALRAEGVGQGLWDAVGRGLAGVDGARADAMRAALAA
HHHHCCCHHHHHHHHHHCCCCCEEEEECCCCCCHHHHHHCCCCCCCCCHHHHHHHHHHHH
HDGLAALRGTVGVESGPARALRERLFPLAPKRVLRTLAGNAAPWTWPLRERALAATKEAL
HCCHHHHHHHCCCCCCHHHHHHHHHCCCCHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHH
DAVDGMDHPRAWALRAEGVARWPATAVSSLRHLAATARGREIVAAALRAAPASLPVLRNA
HHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHCCHHHHHHHHHHCCCCCCHHHHH
HAALALAAHAAGPAPLPPAAVEASCTP
HHHHHHHHHCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA