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The map label for this gene is rcsC [H]

Identifier: 220918471

GI number: 220918471

Start: 3757399

End: 3759027

Strand: Reverse

Name: rcsC [H]

Synonym: A2cp1_3376

Alternate gene names: 220918471

Gene position: 3759027-3757399 (Counterclockwise)

Preceding gene: 220918473

Following gene: 220918470

Centisome position: 74.74

GC content: 75.69

Gene sequence:

>1629_bases
ATGTCGTCCCCGAGCCGAGAGCCTGCTTCGCACCGCCGCGCGTCCGCCGCCGAGCTGTTCCAGCGGCTGTGGGACGAGGT
GGCGGACCTCGTCGGCTCGGCGGCGACCGCCGCGCTGCTGCGGCGGGCGCTGAAGCGTGCAGCGGAGAAGCAGCCGGAGC
TGGCCGCGGTCGTCCTGAGGCGCGAGGGGCTCGGATACGCGTGGGTGCTCCCCGGCGCGTGGCACGACCCCGCGCGGCGC
GAGGCCGTCGAGCAGCTGCGGCGGCTGGTGCGCGAGGATCTCCACCCGTCGTTCCGTGAGCTCGCCGGACTCGTGATCGC
GCGCCGGCTCGCGCGGGCGCCGGAGCTGGTCGAGGCGGGCCCCGCGGCGAGGAGGCAGGGTGACGGAGCCCACGCCGTGA
CCCCGCCCCCCACGGCCTCGGTCCTCGCCGACCTCGCGCACGCGCTCGAGGCCGGTCAGGACGCGGAGGCGCGCGTCCGG
CGCGCGCTCGCTGCCCTCCGCCGCCTCGTACCCCACGATCGGTGCGCGCTCGTGAACGCCACGGCGGCGGCCGCGCCCCG
GCTCCTGCTCGAGCCGCCGCTGCCCGAGCCCGAGCGCCGTCGCCTGGAGACCAGGGCGGAGGCGCTGCTCGCGTCGCTCT
TCGACCACGCCCCCGGCGCGCTCCCGCCGATCCCCGCCGGGCCGGCGTCGCACCTCGCGGTGCCGCTCGTCGCGCTGGAC
GCGCTCGCCGGCGTCCTCCTGGTCGAGCGCGACGACGCCGCGTACGGTGAACAGGATCTCCAGTTGCTCTCGGTGGTCGC
CTCGCTGCTCGGCGCCTACCTCGCGTCCCTCCGGCTGCACGACGAGGAGCGCCGGGTCGCGCAGGAGCTCCGTGACGCGA
TCGGCAGGCGGACCCACTTCCTGAGCATGCTCTCGCACGAGCTCCGGAACCCGCTCGGCTCCATCGGCAACGCGCTGCAC
CTGCTCGACCGCGTGGCGCCAGGCAGCGAGCGCGCAGCGAGCGCGCGCGCCATCATGGGCCGGCAGTTCGGTCACCTGAC
GAGGCTCGTGAACGATCTGCTCGACGCGACCCGCCTCGCGAGCGGCAAGGTGCAGGTCCGCCGCGCGCGAATGGATCTCG
CCGAGGTCGTTTGCCGGACCGTGGATGACCACAGATCCCTGTTCGTCCGCGGCGGCGCCGGTCTCGACCTGCGGGTCGCC
GACGGGCCGCTGTGGGTGGACGGCGACGCCGTCCGGCTCGCGCAGGTGATCGGCAACCTGCTCTCCAACGCGGCCAAGTT
CGCGGGCCCCGACGGAAAGACCGAGGTGTCGGTCGCGCGCGAGGAGCCGGGGATTGCGGTCGTGCGCGTCCGCGACGACG
GGGTCGGGATCGCGCCGGAGGTCCGCTCCCGGCTCTTCGAGCCGTTCGCCCAGGGGGCCGACACGCTGGATCGCAATCGA
GCGGGGCTCGGGCTCGGGCTCGCGCTCGCGAAGGGGCTGGTGGACCTCCACGGGGGCACGATCGCCGCCCGCGGCGACGA
CGGGAGCCGCGGCACCGAGCTCGTCGTCACGCTCCCGCTCCTGCCGGAGACGCACGCAGCGGCGGCGCCTGCGTCCGGAG
AGAAGGCGGATCGAGCGACCGCTCCCTGA

Upstream 100 bases:

>100_bases
CTCGGCGAACCGCCCGGCTTCTTGGGGCAGCCCGCGCGGCTGCGGACCGAGGTGGTAGCGTGACCGCCCACGACGCGAGC
TTCACCCGGAGTGCCGCGGC

Downstream 100 bases:

>100_bases
GCGGGGAAAGGTCCCGCAGGTGCGCAGCCGCCTGCTGCGCAATGCCCCACCCCCCGATGTCGGCGCCCGGATCCGGCCGC
GGCGGGCGTACGTTGATGCG

Product: GAF sensor signal transduction histidine kinase

Products: NA

Alternate protein names: Capsular synthesis regulator component C [H]

Number of amino acids: Translated: 542; Mature: 541

Protein sequence:

>542_residues
MSSPSREPASHRRASAAELFQRLWDEVADLVGSAATAALLRRALKRAAEKQPELAAVVLRREGLGYAWVLPGAWHDPARR
EAVEQLRRLVREDLHPSFRELAGLVIARRLARAPELVEAGPAARRQGDGAHAVTPPPTASVLADLAHALEAGQDAEARVR
RALAALRRLVPHDRCALVNATAAAAPRLLLEPPLPEPERRRLETRAEALLASLFDHAPGALPPIPAGPASHLAVPLVALD
ALAGVLLVERDDAAYGEQDLQLLSVVASLLGAYLASLRLHDEERRVAQELRDAIGRRTHFLSMLSHELRNPLGSIGNALH
LLDRVAPGSERAASARAIMGRQFGHLTRLVNDLLDATRLASGKVQVRRARMDLAEVVCRTVDDHRSLFVRGGAGLDLRVA
DGPLWVDGDAVRLAQVIGNLLSNAAKFAGPDGKTEVSVAREEPGIAVVRVRDDGVGIAPEVRSRLFEPFAQGADTLDRNR
AGLGLGLALAKGLVDLHGGTIAARGDDGSRGTELVVTLPLLPETHAAAAPASGEKADRATAP

Sequences:

>Translated_542_residues
MSSPSREPASHRRASAAELFQRLWDEVADLVGSAATAALLRRALKRAAEKQPELAAVVLRREGLGYAWVLPGAWHDPARR
EAVEQLRRLVREDLHPSFRELAGLVIARRLARAPELVEAGPAARRQGDGAHAVTPPPTASVLADLAHALEAGQDAEARVR
RALAALRRLVPHDRCALVNATAAAAPRLLLEPPLPEPERRRLETRAEALLASLFDHAPGALPPIPAGPASHLAVPLVALD
ALAGVLLVERDDAAYGEQDLQLLSVVASLLGAYLASLRLHDEERRVAQELRDAIGRRTHFLSMLSHELRNPLGSIGNALH
LLDRVAPGSERAASARAIMGRQFGHLTRLVNDLLDATRLASGKVQVRRARMDLAEVVCRTVDDHRSLFVRGGAGLDLRVA
DGPLWVDGDAVRLAQVIGNLLSNAAKFAGPDGKTEVSVAREEPGIAVVRVRDDGVGIAPEVRSRLFEPFAQGADTLDRNR
AGLGLGLALAKGLVDLHGGTIAARGDDGSRGTELVVTLPLLPETHAAAAPASGEKADRATAP
>Mature_541_residues
SSPSREPASHRRASAAELFQRLWDEVADLVGSAATAALLRRALKRAAEKQPELAAVVLRREGLGYAWVLPGAWHDPARRE
AVEQLRRLVREDLHPSFRELAGLVIARRLARAPELVEAGPAARRQGDGAHAVTPPPTASVLADLAHALEAGQDAEARVRR
ALAALRRLVPHDRCALVNATAAAAPRLLLEPPLPEPERRRLETRAEALLASLFDHAPGALPPIPAGPASHLAVPLVALDA
LAGVLLVERDDAAYGEQDLQLLSVVASLLGAYLASLRLHDEERRVAQELRDAIGRRTHFLSMLSHELRNPLGSIGNALHL
LDRVAPGSERAASARAIMGRQFGHLTRLVNDLLDATRLASGKVQVRRARMDLAEVVCRTVDDHRSLFVRGGAGLDLRVAD
GPLWVDGDAVRLAQVIGNLLSNAAKFAGPDGKTEVSVAREEPGIAVVRVRDDGVGIAPEVRSRLFEPFAQGADTLDRNRA
GLGLGLALAKGLVDLHGGTIAARGDDGSRGTELVVTLPLLPETHAAAAPASGEKADRATAP

Specific function: Member of the two-component regulatory system RcsC/RcsB involved in the regulation of the expression of genes involved in colanic acid capsule synthesis. Together with RcsF, RcsC probably functions as a membrane-associated protein kinase that phosphorylat

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI145693157, Length=247, Percent_Identity=34.0080971659919, Blast_Score=121, Evalue=1e-28,
Organism=Escherichia coli, GI1789149, Length=266, Percent_Identity=31.9548872180451, Blast_Score=97, Evalue=3e-21,
Organism=Escherichia coli, GI1786912, Length=307, Percent_Identity=31.2703583061889, Blast_Score=90, Evalue=3e-19,
Organism=Escherichia coli, GI1786783, Length=239, Percent_Identity=28.8702928870293, Blast_Score=89, Evalue=7e-19,
Organism=Escherichia coli, GI1788713, Length=243, Percent_Identity=26.7489711934156, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1790436, Length=273, Percent_Identity=28.5714285714286, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI48994928, Length=264, Percent_Identity=27.6515151515151, Blast_Score=80, Evalue=4e-16,
Organism=Escherichia coli, GI1790346, Length=221, Percent_Identity=29.8642533936652, Blast_Score=79, Evalue=8e-16,
Organism=Escherichia coli, GI1788393, Length=248, Percent_Identity=28.6290322580645, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI87081816, Length=256, Percent_Identity=30.859375, Blast_Score=72, Evalue=7e-14,
Organism=Escherichia coli, GI1787894, Length=231, Percent_Identity=26.4069264069264, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1786600, Length=226, Percent_Identity=27.8761061946903, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1789808, Length=239, Percent_Identity=27.1966527196653, Blast_Score=69, Evalue=7e-13,
Organism=Escherichia coli, GI1790300, Length=278, Percent_Identity=27.6978417266187, Blast_Score=64, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR011006
- InterPro:   IPR000014
- InterPro:   IPR004358
- InterPro:   IPR019017
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02518 HATPase_c; PF00512 HisKA; PF09456 RcsC; PF00072 Response_reg [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 57716; Mature: 57584

Theoretical pI: Translated: 8.33; Mature: 8.33

Prosite motif: PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.7 %Met     (Translated Protein)
1.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
0.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSPSREPASHRRASAAELFQRLWDEVADLVGSAATAALLRRALKRAAEKQPELAAVVLR
CCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
REGLGYAWVLPGAWHDPARREAVEQLRRLVREDLHPSFRELAGLVIARRLARAPELVEAG
HCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHCC
PAARRQGDGAHAVTPPPTASVLADLAHALEAGQDAEARVRRALAALRRLVPHDRCALVNA
CHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHEEC
TAAAAPRLLLEPPLPEPERRRLETRAEALLASLFDHAPGALPPIPAGPASHLAVPLVALD
HHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
ALAGVLLVERDDAAYGEQDLQLLSVVASLLGAYLASLRLHDEERRVAQELRDAIGRRTHF
HHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LSMLSHELRNPLGSIGNALHLLDRVAPGSERAASARAIMGRQFGHLTRLVNDLLDATRLA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGKVQVRRARMDLAEVVCRTVDDHRSLFVRGGAGLDLRVADGPLWVDGDAVRLAQVIGNL
CCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECCCCEEECCHHHHHHHHHHHH
LSNAAKFAGPDGKTEVSVAREEPGIAVVRVRDDGVGIAPEVRSRLFEPFAQGADTLDRNR
HHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHCCC
AGLGLGLALAKGLVDLHGGTIAARGDDGSRGTELVVTLPLLPETHAAAAPASGEKADRAT
CCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCCCCHHCCCCCCCCCCCCCC
AP
CC
>Mature Secondary Structure 
SSPSREPASHRRASAAELFQRLWDEVADLVGSAATAALLRRALKRAAEKQPELAAVVLR
CCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHH
REGLGYAWVLPGAWHDPARREAVEQLRRLVREDLHPSFRELAGLVIARRLARAPELVEAG
HCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCHHHHCC
PAARRQGDGAHAVTPPPTASVLADLAHALEAGQDAEARVRRALAALRRLVPHDRCALVNA
CHHHCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCHHHHEEC
TAAAAPRLLLEPPLPEPERRRLETRAEALLASLFDHAPGALPPIPAGPASHLAVPLVALD
HHHHCCCCEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHH
ALAGVLLVERDDAAYGEQDLQLLSVVASLLGAYLASLRLHDEERRVAQELRDAIGRRTHF
HHHHHHEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHH
LSMLSHELRNPLGSIGNALHLLDRVAPGSERAASARAIMGRQFGHLTRLVNDLLDATRLA
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
SGKVQVRRARMDLAEVVCRTVDDHRSLFVRGGAGLDLRVADGPLWVDGDAVRLAQVIGNL
CCHHHHHHHHHHHHHHHHHHHHHHHEEEEECCCCCEEEECCCCEEECCHHHHHHHHHHHH
LSNAAKFAGPDGKTEVSVAREEPGIAVVRVRDDGVGIAPEVRSRLFEPFAQGADTLDRNR
HHHHHHHCCCCCCCEEEEEECCCCEEEEEEECCCCCCCHHHHHHHHHHHHCCCHHHHCCC
AGLGLGLALAKGLVDLHGGTIAARGDDGSRGTELVVTLPLLPETHAAAAPASGEKADRAT
CCCHHHHHHHHHHHHHCCCEEEECCCCCCCCCEEEEEECCCCCCHHCCCCCCCCCCCCCC
AP
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2404948; 8366025; 9097040; 9278503; 11758943; 11309126; 13129944 [H]