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The map label for this gene is mco [H]

Identifier: 220918463

GI number: 220918463

Start: 3746055

End: 3747674

Strand: Reverse

Name: mco [H]

Synonym: A2cp1_3367

Alternate gene names: 220918463

Gene position: 3747674-3746055 (Counterclockwise)

Preceding gene: 220918470

Following gene: 220918462

Centisome position: 74.52

GC content: 72.04

Gene sequence:

>1620_bases
ATGCGCGGGAAGCCGATCGGCAGGCGGCAGTTCCTGGTGCGCACGACGGCAGCGGTCGCGGGTGCGGCGACGGCGCGCGG
TGCGCTCGCACGGATGATGCGCGGGGGCGGGGGAGGCGGGGGTACGACCACCGTGACGGATCCGCCGGTCAGCGGGCCGC
TGAGAGCGCTCCCCGTCGCGACGCCGGTCTCCGGGTCGCCGGGCGGCATGCTCCACTACCGGCTGGAGGCGTGCCAGGCG
CCGGTCGCGATCGACGGGGCGAGCGCGAACGCGATGGTGTACCGGGACCTCGGCGCGCCGCTGGACGGCCGCTTCGTGGC
GCCGGTGCTCCGGGCCGAGCCCGGCCCCGGCCAGCGCATCCGCCTCGAGTTCACGAACGGCCTCCCGGCCGACCCGGCGC
TGAACCTGCTCGGCCACGAGCGCCATCCCACCAACGTGCACGTGCACGGGCTGCACGTGTCCCCCGGGGCGGACGCGATG
ACGGGCCTGCCGGCGGACGACGTGCACCTCCGCATCGAGGGCGGCGGGCAGGGCCTCACCTACGACTACGACCTCGCGAT
GCAGCGGCCGGGCTCGATCGCGCTCTACCATCCGCACCTCCACGGCTCCGTGGCGGAGCAGATGTGGAACGGGCTGGTGG
GCGCGATCGACGTCTCCGACGGCGAGATCACCGCGCTCGATCCGTACCCGGCGACGCTCCTCGTGCTCAAGGACGTCACG
GTCTCGAACGGCGCCCCCGCGCCCTACACGATGCTCTCCGAGTACATGCGGGGCAGGGAAGGCAACGTCGTCACCGTCAA
CGGCCAGGTGAACCCGTACCTCGCCGTCACCGCGGGCGAGGTGCGACGGCTGCGCATCCTCAACGTGAGCAACGCCCGCT
TCTACCGCCTCTCGCTCCAGGGCCACCCGTTCCACGTGGTGGGCGCGGACGGTGGGCTCCTCGATCGGCCCACCGCGGCG
CGGTCCGAGCTCCTGATGGCGCCGGGCGAGCGCGTGGACCTGCTCGTGCCGTTCGGGACCGCCGACAAGGGCGACTACAA
GCTGCTCGCGCTGCCGTACGCCCGGCACGGGAACATGGCGAGCGCGCAGGTGACGCTGCTCACGGTCCGGATCGCGAGCC
GGACGCGCGCCGCCCAGGCGCTCCCCGCCGCGGTGGCCCCGGGGACGACGAGGCTCTCCGACGATCCGGCGCTGGCGCGG
CCGAGGTTCGCGCTCAGCATGGGGCAGGGGCGGGGCTACATCAACGGCATCACCTTCGAGCAGCTCGCGGACGGCTCCAT
CCGCAGCTGCGAGCATCACTCGATGGTCGGCGACGACGAGATCTGGGAGGTCGTGAACGAGAGCGGCATGGACCACCCGT
GGCACCAGCACGTGAACGACGCCCAGGTCCTCTCGATCAGCGGCGGCGACGCGAGCATCGCGAGGTACGCGGCGCTGTAC
ACGAGCGCTCCCGCGTGGAAGGACACGATCATCATCCCGAAGTGGGGCAGCGCGACCTTCCGCATGCCGATCCGCGACCA
CGGCGGGATGACCATGTTCCACTGCCACATCCTCGAGCACGAGGACATCGGGATGATGGGAATGTGGCACCTCATGGACG
ACGGGATGGGCGGGATGTGA

Upstream 100 bases:

>100_bases
GCGCCCGAGCGTTTCGCCGCATTCCCCGGCTGTGTGGTTGTCCGCGGAACGGTGCGTGGCTCTCCTGCACGTGGACCCCC
CGACATCGAAAGGGATCACC

Downstream 100 bases:

>100_bases
GCGGCCGCTCCCGCGCCGGACGCCGCTGCCATGGGGCGTCGGCCCGTCCGCCGCGCGTCGATCCCCGAGTCGCCTCCGAA
GGGGGAACTCGTCGCCGCGC

Product: multicopper oxidase type 2

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 539; Mature: 539

Protein sequence:

>539_residues
MRGKPIGRRQFLVRTTAAVAGAATARGALARMMRGGGGGGGTTTVTDPPVSGPLRALPVATPVSGSPGGMLHYRLEACQA
PVAIDGASANAMVYRDLGAPLDGRFVAPVLRAEPGPGQRIRLEFTNGLPADPALNLLGHERHPTNVHVHGLHVSPGADAM
TGLPADDVHLRIEGGGQGLTYDYDLAMQRPGSIALYHPHLHGSVAEQMWNGLVGAIDVSDGEITALDPYPATLLVLKDVT
VSNGAPAPYTMLSEYMRGREGNVVTVNGQVNPYLAVTAGEVRRLRILNVSNARFYRLSLQGHPFHVVGADGGLLDRPTAA
RSELLMAPGERVDLLVPFGTADKGDYKLLALPYARHGNMASAQVTLLTVRIASRTRAAQALPAAVAPGTTRLSDDPALAR
PRFALSMGQGRGYINGITFEQLADGSIRSCEHHSMVGDDEIWEVVNESGMDHPWHQHVNDAQVLSISGGDASIARYAALY
TSAPAWKDTIIIPKWGSATFRMPIRDHGGMTMFHCHILEHEDIGMMGMWHLMDDGMGGM

Sequences:

>Translated_539_residues
MRGKPIGRRQFLVRTTAAVAGAATARGALARMMRGGGGGGGTTTVTDPPVSGPLRALPVATPVSGSPGGMLHYRLEACQA
PVAIDGASANAMVYRDLGAPLDGRFVAPVLRAEPGPGQRIRLEFTNGLPADPALNLLGHERHPTNVHVHGLHVSPGADAM
TGLPADDVHLRIEGGGQGLTYDYDLAMQRPGSIALYHPHLHGSVAEQMWNGLVGAIDVSDGEITALDPYPATLLVLKDVT
VSNGAPAPYTMLSEYMRGREGNVVTVNGQVNPYLAVTAGEVRRLRILNVSNARFYRLSLQGHPFHVVGADGGLLDRPTAA
RSELLMAPGERVDLLVPFGTADKGDYKLLALPYARHGNMASAQVTLLTVRIASRTRAAQALPAAVAPGTTRLSDDPALAR
PRFALSMGQGRGYINGITFEQLADGSIRSCEHHSMVGDDEIWEVVNESGMDHPWHQHVNDAQVLSISGGDASIARYAALY
TSAPAWKDTIIIPKWGSATFRMPIRDHGGMTMFHCHILEHEDIGMMGMWHLMDDGMGGM
>Mature_539_residues
MRGKPIGRRQFLVRTTAAVAGAATARGALARMMRGGGGGGGTTTVTDPPVSGPLRALPVATPVSGSPGGMLHYRLEACQA
PVAIDGASANAMVYRDLGAPLDGRFVAPVLRAEPGPGQRIRLEFTNGLPADPALNLLGHERHPTNVHVHGLHVSPGADAM
TGLPADDVHLRIEGGGQGLTYDYDLAMQRPGSIALYHPHLHGSVAEQMWNGLVGAIDVSDGEITALDPYPATLLVLKDVT
VSNGAPAPYTMLSEYMRGREGNVVTVNGQVNPYLAVTAGEVRRLRILNVSNARFYRLSLQGHPFHVVGADGGLLDRPTAA
RSELLMAPGERVDLLVPFGTADKGDYKLLALPYARHGNMASAQVTLLTVRIASRTRAAQALPAAVAPGTTRLSDDPALAR
PRFALSMGQGRGYINGITFEQLADGSIRSCEHHSMVGDDEIWEVVNESGMDHPWHQHVNDAQVLSISGGDASIARYAALY
TSAPAWKDTIIIPKWGSATFRMPIRDHGGMTMFHCHILEHEDIGMMGMWHLMDDGMGGM

Specific function: May be involved in copper homeostasis and oxidative stress response [H]

COG id: COG2132

COG function: function code Q; Putative multicopper oxidases

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the multicopper oxidase family [H]

Homologues:

Organism=Escherichia coli, GI1786314, Length=447, Percent_Identity=26.6219239373602, Blast_Score=88, Evalue=1e-18,
Organism=Escherichia coli, GI1789394, Length=463, Percent_Identity=24.4060475161987, Blast_Score=80, Evalue=3e-16,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011706
- InterPro:   IPR011707
- InterPro:   IPR002355
- InterPro:   IPR008972 [H]

Pfam domain/function: PF07731 Cu-oxidase_2; PF07732 Cu-oxidase_3 [H]

EC number: NA

Molecular weight: Translated: 57373; Mature: 57373

Theoretical pI: Translated: 6.95; Mature: 6.95

Prosite motif: PS00080 MULTICOPPER_OXIDASE2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGKPIGRRQFLVRTTAAVAGAATARGALARMMRGGGGGGGTTTVTDPPVSGPLRALPVA
CCCCCCCCCEEEEEEHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEE
TPVSGSPGGMLHYRLEACQAPVAIDGASANAMVYRDLGAPLDGRFVAPVLRAEPGPGQRI
CCCCCCCCCEEEEEEHHHCCCEEEECCCCCEEEEEECCCCCCCCEECHHHHCCCCCCCEE
RLEFTNGLPADPALNLLGHERHPTNVHVHGLHVSPGADAMTGLPADDVHLRIEGGGQGLT
EEEECCCCCCCCHHHHHCCCCCCCEEEEEEEEECCCCCHHCCCCCCCEEEEEECCCCCCE
YDYDLAMQRPGSIALYHPHLHGSVAEQMWNGLVGAIDVSDGEITALDPYPATLLVLKDVT
EEEEEEECCCCCEEEECCCCCCHHHHHHHCCCEEEEECCCCCEEEECCCCEEEEEEEEEE
VSNGAPAPYTMLSEYMRGREGNVVTVNGQVNPYLAVTAGEVRRLRILNVSNARFYRLSLQ
ECCCCCCCHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCEEEEEEEEECCCEEEEEEEC
GHPFHVVGADGGLLDRPTAARSELLMAPGERVDLLVPFGTADKGDYKLLALPYARHGNMA
CCCEEEEECCCCCCCCCCHHHHHEEECCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCC
SAQVTLLTVRIASRTRAAQALPAAVAPGTTRLSDDPALARPRFALSMGQGRGYINGITFE
CEEEEEEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEECCEEHH
QLADGSIRSCEHHSMVGDDEIWEVVNESGMDHPWHQHVNDAQVLSISGGDASIARYAALY
HHCCCCCCCCHHCCCCCCHHHHHHHHHCCCCCCHHHCCCCCEEEEEECCCHHHHHHHHHH
TSAPAWKDTIIIPKWGSATFRMPIRDHGGMTMFHCHILEHEDIGMMGMWHLMDDGMGGM
CCCCCCCCEEEEECCCCCEEEEEECCCCCEEEEEEEEEECCCCCCEEEEEECCCCCCCC
>Mature Secondary Structure
MRGKPIGRRQFLVRTTAAVAGAATARGALARMMRGGGGGGGTTTVTDPPVSGPLRALPVA
CCCCCCCCCEEEEEEHHHHHCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEE
TPVSGSPGGMLHYRLEACQAPVAIDGASANAMVYRDLGAPLDGRFVAPVLRAEPGPGQRI
CCCCCCCCCEEEEEEHHHCCCEEEECCCCCEEEEEECCCCCCCCEECHHHHCCCCCCCEE
RLEFTNGLPADPALNLLGHERHPTNVHVHGLHVSPGADAMTGLPADDVHLRIEGGGQGLT
EEEECCCCCCCCHHHHHCCCCCCCEEEEEEEEECCCCCHHCCCCCCCEEEEEECCCCCCE
YDYDLAMQRPGSIALYHPHLHGSVAEQMWNGLVGAIDVSDGEITALDPYPATLLVLKDVT
EEEEEEECCCCCEEEECCCCCCHHHHHHHCCCEEEEECCCCCEEEECCCCEEEEEEEEEE
VSNGAPAPYTMLSEYMRGREGNVVTVNGQVNPYLAVTAGEVRRLRILNVSNARFYRLSLQ
ECCCCCCCHHHHHHHHCCCCCCEEEECCCCCCEEEEECCCEEEEEEEEECCCEEEEEEEC
GHPFHVVGADGGLLDRPTAARSELLMAPGERVDLLVPFGTADKGDYKLLALPYARHGNMA
CCCEEEEECCCCCCCCCCHHHHHEEECCCCCEEEEEECCCCCCCCEEEEEEEECCCCCCC
SAQVTLLTVRIASRTRAAQALPAAVAPGTTRLSDDPALARPRFALSMGQGRGYINGITFE
CEEEEEEEEEEHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEECCCCCEECCEEHH
QLADGSIRSCEHHSMVGDDEIWEVVNESGMDHPWHQHVNDAQVLSISGGDASIARYAALY
HHCCCCCCCCHHCCCCCCHHHHHHHHHCCCCCCHHHCCCCCEEEEEECCCHHHHHHHHHH
TSAPAWKDTIIIPKWGSATFRMPIRDHGGMTMFHCHILEHEDIGMMGMWHLMDDGMGGM
CCCCCCCCEEEEECCCCCEEEEEECCCCCEEEEEEEEEECCCCCCEEEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA