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The map label for this gene is nhaK [H]

Identifier: 220918457

GI number: 220918457

Start: 3739987

End: 3741618

Strand: Reverse

Name: nhaK [H]

Synonym: A2cp1_3361

Alternate gene names: 220918457

Gene position: 3741618-3739987 (Counterclockwise)

Preceding gene: 220918461

Following gene: 220918456

Centisome position: 74.4

GC content: 77.02

Gene sequence:

>1632_bases
ATGCTCGTCTTCGAGATCATCATCGGCCTGCTCCTCGCCGGCGCGGCCCTCACCGCCCTGTCCCGGCGGATCGGGACGCC
GTACCCGGCGCTGGTGGCGCTCGCAGGCGCGGCGCTCGCGCTCGTGCCGGGCACGCCGACGCTGGTCCTCGAGCCGGACC
TTGCGCTGACGCTGTTCGTCGCGCCGGTGCTGCTCGACGCGGCCTACGACGCGTCCCAGCGCGACCTGCGGGCGAGCTGG
CGCACCGTGGCCGGCCTTGCGGTCGGCGCGGTCGCGCTGACGGTGGTGGTGGTGGCGGTGGTCGCCCGCGCGCTCGTGCC
CGGCATGCCCTGGGCGGTGGCGGTGGCGCTCGGCGCCATCGTGGCGCCCCCGGACGCGGCGGCCGCGACCGCGGTGCTCG
GGCAGCTCCGCCCGCCGCACCGCCTCATGGTGATCCTCGAGGGCGAGAGCCTGTTCAACGACGCCAGCGCGCTCCTCGTC
TACCGCCTGGCGGTGGGCGCGGCGGTGGCGGGCGCGCTCTCGCCGCTCGAGGCGCTGCCGCTGCTGCTGGTCGCGACGGT
GGGGAGCGTGGCGCTCGGGTACGCGCTCGCCCGCGTGATCCCGCCGCTCATCGCGCGCATCGAGGACGTGCCCATCGCCG
TGGTGGTCCAGTTCTGCGGGACGTTCGCGGTCTGGATGCTCGCCGAGCGGCTCCACCTCTCGGGCATCCTCACCGTCGTC
GTCTTCGCCATGGCGAGCGCCCAGCGCGCCGCGGGGCAGATGGCCGCGCGCGTCCGCATCCCGTCGTATGCCGTCTGGGG
ATTCGCGGTCTTCGTGCTGAACGTCCTCGCGTTCATCCTGGTCGGCTTCCAGCTGAAGGCGATCCTGGGGCGGATCGACG
CGGCCACGCTCCTCCGGTACGCCGGCGTGGCGGGGGCGGTGGGCCTCGCCGCCATCGTGGCGCGCATCGCGTGGGTGTCC
GCCACGGCCGCCGTGAGTCGGCTGCGCTGCCGCCCAGCGTGCGACGGGGCGCCGGAGCGGCCGGACGCGATCGGGCTCTC
GCCGCGCGGCGCCGCGGTGGTCGGCTGGTGCGGCATGCGCGGCATCGTGACGCTCGCCGCGGCGCTGGCGTTGCCCACCG
GCGGCCGGGGCGCGCCGGCGTTCCCGCACCGGGACCTGGTCGTGTTCACCGCGTTCGCGGTGGTGCTCGGGACGCTGGTC
CTGCAGGGGATGACGCTCCGCCCCCTGCTGCGCGCGCTGCGGCTCGAGGGAGATCGCTCGGTCGATCGGGAGGTCCGGCT
CGCGCGCGTCGAGACGCTGCGCGCCGGCCTGTCGGCGACCGACGGCGCGGCGGGTGACGAGCTCTCGCGCGTGCTGCGGC
ACCGCTACGAGGTGATGCTCCGCGGCGCCGAGGCGGAGCTGCGCGGCGGGGCCGCGGAGGCGCCCGCGGGCGAGGCCGAC
GGTGGGCCGCCGCGCACCCAGGGCGCCGCCGTGGCGCGCCGGGCGGTGGAGGCGGAGCGCGGGCGGCTCCTGTCGCTGCG
CGCCGAGGGTACGATCGGGGACGCGGCGTTCCAGCGCGTCGAGGAGGAGCTGGATCTCGAGGAGCTGGGCCTGCGGCGGC
TGGCCCGCGACGAGGCGCCGGAGGCCTCGTGA

Upstream 100 bases:

>100_bases
TTCGGGAAATCTTCACGGCACGGCGGGAGCGACTCGCGACAGAATGGTGGCGGAGGACGTGCCCGCCGCGGGTGGCCGGC
ATCGGGGGCGTCCGGCCCGA

Downstream 100 bases:

>100_bases
CCCGGCACGGCCCCATCCTGCGCGTCGAGCGGCTGTGCAAGGCCTACGGCGCGACTCCGGCCGTGGACGGGATCACGTTC
CACGTCGCGCCCGGCGAGAT

Product: sodium/hydrogen exchanger

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 543; Mature: 543

Protein sequence:

>543_residues
MLVFEIIIGLLLAGAALTALSRRIGTPYPALVALAGAALALVPGTPTLVLEPDLALTLFVAPVLLDAAYDASQRDLRASW
RTVAGLAVGAVALTVVVVAVVARALVPGMPWAVAVALGAIVAPPDAAAATAVLGQLRPPHRLMVILEGESLFNDASALLV
YRLAVGAAVAGALSPLEALPLLLVATVGSVALGYALARVIPPLIARIEDVPIAVVVQFCGTFAVWMLAERLHLSGILTVV
VFAMASAQRAAGQMAARVRIPSYAVWGFAVFVLNVLAFILVGFQLKAILGRIDAATLLRYAGVAGAVGLAAIVARIAWVS
ATAAVSRLRCRPACDGAPERPDAIGLSPRGAAVVGWCGMRGIVTLAAALALPTGGRGAPAFPHRDLVVFTAFAVVLGTLV
LQGMTLRPLLRALRLEGDRSVDREVRLARVETLRAGLSATDGAAGDELSRVLRHRYEVMLRGAEAELRGGAAEAPAGEAD
GGPPRTQGAAVARRAVEAERGRLLSLRAEGTIGDAAFQRVEEELDLEELGLRRLARDEAPEAS

Sequences:

>Translated_543_residues
MLVFEIIIGLLLAGAALTALSRRIGTPYPALVALAGAALALVPGTPTLVLEPDLALTLFVAPVLLDAAYDASQRDLRASW
RTVAGLAVGAVALTVVVVAVVARALVPGMPWAVAVALGAIVAPPDAAAATAVLGQLRPPHRLMVILEGESLFNDASALLV
YRLAVGAAVAGALSPLEALPLLLVATVGSVALGYALARVIPPLIARIEDVPIAVVVQFCGTFAVWMLAERLHLSGILTVV
VFAMASAQRAAGQMAARVRIPSYAVWGFAVFVLNVLAFILVGFQLKAILGRIDAATLLRYAGVAGAVGLAAIVARIAWVS
ATAAVSRLRCRPACDGAPERPDAIGLSPRGAAVVGWCGMRGIVTLAAALALPTGGRGAPAFPHRDLVVFTAFAVVLGTLV
LQGMTLRPLLRALRLEGDRSVDREVRLARVETLRAGLSATDGAAGDELSRVLRHRYEVMLRGAEAELRGGAAEAPAGEAD
GGPPRTQGAAVARRAVEAERGRLLSLRAEGTIGDAAFQRVEEELDLEELGLRRLARDEAPEAS
>Mature_543_residues
MLVFEIIIGLLLAGAALTALSRRIGTPYPALVALAGAALALVPGTPTLVLEPDLALTLFVAPVLLDAAYDASQRDLRASW
RTVAGLAVGAVALTVVVVAVVARALVPGMPWAVAVALGAIVAPPDAAAATAVLGQLRPPHRLMVILEGESLFNDASALLV
YRLAVGAAVAGALSPLEALPLLLVATVGSVALGYALARVIPPLIARIEDVPIAVVVQFCGTFAVWMLAERLHLSGILTVV
VFAMASAQRAAGQMAARVRIPSYAVWGFAVFVLNVLAFILVGFQLKAILGRIDAATLLRYAGVAGAVGLAAIVARIAWVS
ATAAVSRLRCRPACDGAPERPDAIGLSPRGAAVVGWCGMRGIVTLAAALALPTGGRGAPAFPHRDLVVFTAFAVVLGTLV
LQGMTLRPLLRALRLEGDRSVDREVRLARVETLRAGLSATDGAAGDELSRVLRHRYEVMLRGAEAELRGGAAEAPAGEAD
GGPPRTQGAAVARRAVEAERGRLLSLRAEGTIGDAAFQRVEEELDLEELGLRRLARDEAPEAS

Specific function: Transporter involved in the efflux of sodium, potassium, lithium and rubidium [H]

COG id: COG0025

COG function: function code P; NhaP-type Na+/H+ and K+/H+ antiporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. Nhak (TC 2.A.36.3.2) subfamily [H]

Homologues:

Organism=Homo sapiens, GI15529998, Length=493, Percent_Identity=20.2839756592292, Blast_Score=79, Evalue=1e-14,
Organism=Escherichia coli, GI1790501, Length=523, Percent_Identity=26.1950286806883, Blast_Score=125, Evalue=5e-30,
Organism=Caenorhabditis elegans, GI25150332, Length=502, Percent_Identity=19.9203187250996, Blast_Score=71, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR018422
- InterPro:   IPR018417
- InterPro:   IPR004705 [H]

Pfam domain/function: PF00999 Na_H_Exchanger [H]

EC number: NA

Molecular weight: Translated: 56183; Mature: 56183

Theoretical pI: Translated: 8.91; Mature: 8.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLVFEIIIGLLLAGAALTALSRRIGTPYPALVALAGAALALVPGTPTLVLEPDLALTLFV
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCEEEECCCHHHHHHH
APVLLDAAYDASQRDLRASWRTVAGLAVGAVALTVVVVAVVARALVPGMPWAVAVALGAI
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VAPPDAAAATAVLGQLRPPHRLMVILEGESLFNDASALLVYRLAVGAAVAGALSPLEALP
CCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLVATVGSVALGYALARVIPPLIARIEDVPIAVVVQFCGTFAVWMLAERLHLSGILTVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFAMASAQRAAGQMAARVRIPSYAVWGFAVFVLNVLAFILVGFQLKAILGRIDAATLLRY
HHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGVAGAVGLAAIVARIAWVSATAAVSRLRCRPACDGAPERPDAIGLSPRGAAVVGWCGMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHH
GIVTLAAALALPTGGRGAPAFPHRDLVVFTAFAVVLGTLVLQGMTLRPLLRALRLEGDRS
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
VDREVRLARVETLRAGLSATDGAAGDELSRVLRHRYEVMLRGAEAELRGGAAEAPAGEAD
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCC
GGPPRTQGAAVARRAVEAERGRLLSLRAEGTIGDAAFQRVEEELDLEELGLRRLARDEAP
CCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCC
EAS
CCC
>Mature Secondary Structure
MLVFEIIIGLLLAGAALTALSRRIGTPYPALVALAGAALALVPGTPTLVLEPDLALTLFV
CHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHEEECCCCEEEECCCHHHHHHH
APVLLDAAYDASQRDLRASWRTVAGLAVGAVALTVVVVAVVARALVPGMPWAVAVALGAI
HHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHH
VAPPDAAAATAVLGQLRPPHRLMVILEGESLFNDASALLVYRLAVGAAVAGALSPLEALP
CCCCCHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LLLVATVGSVALGYALARVIPPLIARIEDVPIAVVVQFCGTFAVWMLAERLHLSGILTVV
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VFAMASAQRAAGQMAARVRIPSYAVWGFAVFVLNVLAFILVGFQLKAILGRIDAATLLRY
HHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AGVAGAVGLAAIVARIAWVSATAAVSRLRCRPACDGAPERPDAIGLSPRGAAVVGWCGMR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCEEEEHHHHH
GIVTLAAALALPTGGRGAPAFPHRDLVVFTAFAVVLGTLVLQGMTLRPLLRALRLEGDRS
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCC
VDREVRLARVETLRAGLSATDGAAGDELSRVLRHRYEVMLRGAEAELRGGAAEAPAGEAD
HHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHCCCHHHHCCCCCCCCCCCCC
GGPPRTQGAAVARRAVEAERGRLLSLRAEGTIGDAAFQRVEEELDLEELGLRRLARDEAP
CCCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHCCHHHHHHHHHHHCCCC
EAS
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA