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The map label for this gene is phr [H]

Identifier: 220918322

GI number: 220918322

Start: 3583912

End: 3585372

Strand: Reverse

Name: phr [H]

Synonym: A2cp1_3226

Alternate gene names: 220918322

Gene position: 3585372-3583912 (Counterclockwise)

Preceding gene: 220918323

Following gene: 220918321

Centisome position: 71.29

GC content: 78.17

Gene sequence:

>1461_bases
ATGCCCGTCCCCGCCGAGCGGATCCGCGCCCTGAACGCCGCGCCGCTCCGCCCGGAGCGGGCGGTGGTGCTCCACTGGAT
GACGAGCGCGCGGCGGACCCGCTCGAACCCCGCGCTCGAGCGGGCCGCGGAGCTGGGCCGGGAGCTGGGCCGGCCGGTGC
TGGTGGTGGAGCCGCTGCGGTGCGGGTACCCGCACGCGAGCGACCGGCTCCACGCGTTCCTGCTGGAGGGCATGCGCGAC
AACGCCGCGGCGCTCGCCGGACGGGCGCTGTACCACCCGTGGGTGGAGCGGCGCGCCGGGGAGGGGGACGGGCTGCTCGA
GGCGCTCGCGGCGAGGGCGTGCGCCGTGATCGCGGACGACTTCCCCACCGGCTTCCCCGCGCAGGCGATCCACGCCGCGG
CGGCGCGCCTCGACGTGCGCCTGGAGGCGGTGGACGCGAGCTGCGTGGTGCCGTTCCGCCTGGCTGGCAAGGACTTCCCC
ACCGCGCACGCCTACCGGCGGCACCTCCAGCGCACGCTGCCGACGTGGCTGGATCGCCTGCCGGCGGAGGACCCGCTGGC
GCGCGCGCCGCCGCCCTGGGGTGCGTCGGTGCCGGTGGAGATCCGGCGGCGCTGGCCGGCCGCCCGCGGCGCGGAGCTGG
ACCGCCCGGCCGCGCTCGCCGCGGGGCTGCCGATCGATCACGGGGTCCCGCCGGCCGGCCGCGGCGGGAGCGTGGCGGCC
CGGCGCCGGCTCGCGGCGTTCCTGCGCGAGGGGCTCGACGGCTACGCCGAGCGCCGCAACGCGCCGGACGAGCCGCGGGG
ATCGAGCGGGCTCTCGCCCTGGCTCCACTTCGGGCACGTCAGCAGCTTCGAGGTCCTGCGGGCGGTGCTGCGCCGGGAGG
GCTGGACCCCGCCCGCGGTCGCCACGCCGCCCAGGGGCGCCCGCGCCGGCTGGTGGGCGCTGTCCCCCTCCGCCGAGGCC
TTCCTCGATCAGCTCCTCACCTGGCGCGAGCTGGCCTTCGTCACCTGCGCGCACGTCCCGGAGCACCGCGCGTACGCGTC
GCTCCCGGCCTGGGCGCGCGCCACCCTGGCCCGGCACGCCGCCGACCCGCGGCCGGCGGTCTACGCGCGGGCGGCGCTGG
AGGCCGCCGAGACGCACGACCCGCTCTGGAACGCGGCGCAGCGCCAGCTCCTGCGAGAGGGCGTGGTGCACGGGTATCTC
CGGATGCTCTGGGGGAAGAAGATCCTGGAGTGGAGCGCGACGCCGGAGGAGGCGCACGCGACCCTGCTCGAGCTGAACGA
CCGCCACGCGCTGGACGGCCGCGACCCGAACTCGGTCGCGGGCATCGCCTGGTGCCTCGGCCGCTACGACCGGCCCTGGG
GGCCGGAGCGGCCGGTGTTCGGCACCGTCCGATACATGTCCTCCGCGAACACCGCCCGGAAGTGGCCGGTGCGCCGGTAC
CTGGAGCGCCACGGACCGTGA

Upstream 100 bases:

>100_bases
GCCACCACGTGCGCGCCCAGGGCCTCGAGTACCTCGCCGGCCAGGTGTACCTGGATCCCGATCCCAAGGAGCTCATGCTC
CGCAACCACGCGTGAGCCGC

Downstream 100 bases:

>100_bases
ACGCCGCGCGGCACCCCTCCCGACGGGAGTGGCGCGGGCCGGTCGCGGGGCGGAAGGATGCTCGGATGCACCCAGTCCAA
CGCACCGTGCTGGTGACCGG

Product: DNA photolyase FAD-binding

Products: NA

Alternate protein names: DNA photolyase; Photoreactivating enzyme [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MPVPAERIRALNAAPLRPERAVVLHWMTSARRTRSNPALERAAELGRELGRPVLVVEPLRCGYPHASDRLHAFLLEGMRD
NAAALAGRALYHPWVERRAGEGDGLLEALAARACAVIADDFPTGFPAQAIHAAAARLDVRLEAVDASCVVPFRLAGKDFP
TAHAYRRHLQRTLPTWLDRLPAEDPLARAPPPWGASVPVEIRRRWPAARGAELDRPAALAAGLPIDHGVPPAGRGGSVAA
RRRLAAFLREGLDGYAERRNAPDEPRGSSGLSPWLHFGHVSSFEVLRAVLRREGWTPPAVATPPRGARAGWWALSPSAEA
FLDQLLTWRELAFVTCAHVPEHRAYASLPAWARATLARHAADPRPAVYARAALEAAETHDPLWNAAQRQLLREGVVHGYL
RMLWGKKILEWSATPEEAHATLLELNDRHALDGRDPNSVAGIAWCLGRYDRPWGPERPVFGTVRYMSSANTARKWPVRRY
LERHGP

Sequences:

>Translated_486_residues
MPVPAERIRALNAAPLRPERAVVLHWMTSARRTRSNPALERAAELGRELGRPVLVVEPLRCGYPHASDRLHAFLLEGMRD
NAAALAGRALYHPWVERRAGEGDGLLEALAARACAVIADDFPTGFPAQAIHAAAARLDVRLEAVDASCVVPFRLAGKDFP
TAHAYRRHLQRTLPTWLDRLPAEDPLARAPPPWGASVPVEIRRRWPAARGAELDRPAALAAGLPIDHGVPPAGRGGSVAA
RRRLAAFLREGLDGYAERRNAPDEPRGSSGLSPWLHFGHVSSFEVLRAVLRREGWTPPAVATPPRGARAGWWALSPSAEA
FLDQLLTWRELAFVTCAHVPEHRAYASLPAWARATLARHAADPRPAVYARAALEAAETHDPLWNAAQRQLLREGVVHGYL
RMLWGKKILEWSATPEEAHATLLELNDRHALDGRDPNSVAGIAWCLGRYDRPWGPERPVFGTVRYMSSANTARKWPVRRY
LERHGP
>Mature_485_residues
PVPAERIRALNAAPLRPERAVVLHWMTSARRTRSNPALERAAELGRELGRPVLVVEPLRCGYPHASDRLHAFLLEGMRDN
AAALAGRALYHPWVERRAGEGDGLLEALAARACAVIADDFPTGFPAQAIHAAAARLDVRLEAVDASCVVPFRLAGKDFPT
AHAYRRHLQRTLPTWLDRLPAEDPLARAPPPWGASVPVEIRRRWPAARGAELDRPAALAAGLPIDHGVPPAGRGGSVAAR
RRLAAFLREGLDGYAERRNAPDEPRGSSGLSPWLHFGHVSSFEVLRAVLRREGWTPPAVATPPRGARAGWWALSPSAEAF
LDQLLTWRELAFVTCAHVPEHRAYASLPAWARATLARHAADPRPAVYARAALEAAETHDPLWNAAQRQLLREGVVHGYLR
MLWGKKILEWSATPEEAHATLLELNDRHALDGRDPNSVAGIAWCLGRYDRPWGPERPVFGTVRYMSSANTARKWPVRRYL
ERHGP

Specific function: Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ul

COG id: COG0415

COG function: function code L; Deoxyribodipyrimidine photolyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Contains 1 DNA photolyase domain [H]

Homologues:

Organism=Drosophila melanogaster, GI24586396, Length=487, Percent_Identity=32.6488706365503, Blast_Score=209, Evalue=3e-54,
Organism=Drosophila melanogaster, GI24586398, Length=487, Percent_Identity=32.6488706365503, Blast_Score=209, Evalue=4e-54,
Organism=Drosophila melanogaster, GI24586404, Length=151, Percent_Identity=45.6953642384106, Blast_Score=143, Evalue=3e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008148
- InterPro:   IPR006050
- InterPro:   IPR005101
- InterPro:   IPR014729 [H]

Pfam domain/function: PF00875 DNA_photolyase; PF03441 FAD_binding_7 [H]

EC number: =4.1.99.3 [H]

Molecular weight: Translated: 53630; Mature: 53498

Theoretical pI: Translated: 10.37; Mature: 10.37

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPVPAERIRALNAAPLRPERAVVLHWMTSARRTRSNPALERAAELGRELGRPVLVVEPLR
CCCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCHH
CGYPHASDRLHAFLLEGMRDNAAALAGRALYHPWVERRAGEGDGLLEALAARACAVIADD
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
FPTGFPAQAIHAAAARLDVRLEAVDASCVVPFRLAGKDFPTAHAYRRHLQRTLPTWLDRL
CCCCCCHHHHHHHHHHHHEEEEEECCCEEEEHEECCCCCCHHHHHHHHHHHHHHHHHHHC
PAEDPLARAPPPWGASVPVEIRRRWPAARGAELDRPAALAAGLPIDHGVPPAGRGGSVAA
CCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHH
RRRLAAFLREGLDGYAERRNAPDEPRGSSGLSPWLHFGHVSSFEVLRAVLRREGWTPPAV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCC
ATPPRGARAGWWALSPSAEAFLDQLLTWRELAFVTCAHVPEHRAYASLPAWARATLARHA
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHC
ADPRPAVYARAALEAAETHDPLWNAAQRQLLREGVVHGYLRMLWGKKILEWSATPEEAHA
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
TLLELNDRHALDGRDPNSVAGIAWCLGRYDRPWGPERPVFGTVRYMSSANTARKWPVRRY
HHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHCCHHHHH
LERHGP
HHHCCC
>Mature Secondary Structure 
PVPAERIRALNAAPLRPERAVVLHWMTSARRTRSNPALERAAELGRELGRPVLVVEPLR
CCCHHHHHHCCCCCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEECCHH
CGYPHASDRLHAFLLEGMRDNAAALAGRALYHPWVERRAGEGDGLLEALAARACAVIADD
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCC
FPTGFPAQAIHAAAARLDVRLEAVDASCVVPFRLAGKDFPTAHAYRRHLQRTLPTWLDRL
CCCCCCHHHHHHHHHHHHEEEEEECCCEEEEHEECCCCCCHHHHHHHHHHHHHHHHHHHC
PAEDPLARAPPPWGASVPVEIRRRWPAARGAELDRPAALAAGLPIDHGVPPAGRGGSVAA
CCCCCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCHHHHCCCCCCCCCCCCCCCCHHHH
RRRLAAFLREGLDGYAERRNAPDEPRGSSGLSPWLHFGHVSSFEVLRAVLRREGWTPPAV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHCCCCHHHHHHHHHHHCCCCCCCC
ATPPRGARAGWWALSPSAEAFLDQLLTWRELAFVTCAHVPEHRAYASLPAWARATLARHA
CCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHCCCHHHHHHHHHHC
ADPRPAVYARAALEAAETHDPLWNAAQRQLLREGVVHGYLRMLWGKKILEWSATPEEAHA
CCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHH
TLLELNDRHALDGRDPNSVAGIAWCLGRYDRPWGPERPVFGTVRYMSSANTARKWPVRRY
HHHHCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHCCCCHHCCHHHHH
LERHGP
HHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7813451; 9371463 [H]