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The map label for this gene is adhA [H]

Identifier: 220917629

GI number: 220917629

Start: 2798948

End: 2799931

Strand: Direct

Name: adhA [H]

Synonym: A2cp1_2529

Alternate gene names: 220917629

Gene position: 2798948-2799931 (Clockwise)

Preceding gene: 220917620

Following gene: 220917630

Centisome position: 55.65

GC content: 78.35

Gene sequence:

>984_bases
ATGCGCGCCATGGTCCTCGCCCGCCCGGGCGCCCCGCTCGCCCCGGCGGAGCTCCCCGATCCCGTCCCCGGACCCGGCGA
GCTGCGGCTGCGGGTGGGCGCCTGCGGCGTGTGCCGCACCGACCTGCACGTCGCCGACGGGGAGCTGCCGGACCCGAAGC
TGCCGCTGGTGCTCGGCCACGAGATCGTCGGGCGGGTGGATCGGGTCGGGGCCGGGGTGACCCGCTTCCGGCCCGGCGAT
CGGGTGGGGATCCCGTGGCTGGGCTGGACGTGCGGCCGGTGCGCGGCCTGCCGGAGCGGCCGGGAGAACCTGTGCAGCGC
GGCGCGGTTCACCGGCTACCACCGCGACGGCGGCTACGCCGAGCTGGCCGTCGCGGACGCGCGCTACGCGTTCGCCATCC
CCGGGGACTACGAGGACGCCGACGCGGCGCCGCTGCTCTGCGCCGGCCTCATCGGCCACCGCGCCTGGGCGCCGGTCCGC
GGCGCCCAGCGACTCGGCCTCTACGGCTTCGGGGCCGCGGCGCACCTGGTGGTGCAGCTCGCCCGGCACGCGGGGCAGCG
CGTGTTCGCGTTCACCCGGCCCGGGGACGCCGAGGCGCAGGCGTTCGCGCTGCAGCTCGGGGCCGAGTGGGCCGGCGCCT
CGGGCGAGGTGCCGCCCGAGCCGCTCGACGCCGCCATCCTGTTCGCGCCGGTGGGCGCGCTCGTGCCCATCGCGCTCCGC
GACGTGGTGCCGGGCGGCACCGTGGTCTGCGCTGGCATCCACATGAGCGACATCCCCTCGTTCCCGTACGCGCTGCTGTG
GGGCGAGCGGACCCTCCGCTCGATCGCGAACCTCACCCGCGCCGACGGCGACGCGCTGCTCGCGCTCGCGCCCGAGGTCC
CGCTCCGCACCGAGGTCGTCCCGTACCCGCTGGAGCGCGCCAACGACGCGCTCGCCGACCTCCGCGCCGGCCGGCTGCGC
GGGGCGGCGGTGCTGGTGCCGTGA

Upstream 100 bases:

>100_bases
GGACCCGGGGCCGGGTTGCACGCAGCGTCCGTCGCCCCGCCGCCGAGGGCCCCCGCCCCGCCCGCTTGACCCGCTCCCCG
GCGCCGTGTTCCGTCGAGCC

Downstream 100 bases:

>100_bases
GCGGCCGCATTCACGGTCGGTGACGGCGTTCGCGAGGTTCTCGCTCCGGGTTCGACGGGGCTCACCCTGAGCGGCGCGCC
CCCCGGAGCCGGTCGCGCGC

Product: zinc-binding alcohol dehydrogenase family protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 327; Mature: 327

Protein sequence:

>327_residues
MRAMVLARPGAPLAPAELPDPVPGPGELRLRVGACGVCRTDLHVADGELPDPKLPLVLGHEIVGRVDRVGAGVTRFRPGD
RVGIPWLGWTCGRCAACRSGRENLCSAARFTGYHRDGGYAELAVADARYAFAIPGDYEDADAAPLLCAGLIGHRAWAPVR
GAQRLGLYGFGAAAHLVVQLARHAGQRVFAFTRPGDAEAQAFALQLGAEWAGASGEVPPEPLDAAILFAPVGALVPIALR
DVVPGGTVVCAGIHMSDIPSFPYALLWGERTLRSIANLTRADGDALLALAPEVPLRTEVVPYPLERANDALADLRAGRLR
GAAVLVP

Sequences:

>Translated_327_residues
MRAMVLARPGAPLAPAELPDPVPGPGELRLRVGACGVCRTDLHVADGELPDPKLPLVLGHEIVGRVDRVGAGVTRFRPGD
RVGIPWLGWTCGRCAACRSGRENLCSAARFTGYHRDGGYAELAVADARYAFAIPGDYEDADAAPLLCAGLIGHRAWAPVR
GAQRLGLYGFGAAAHLVVQLARHAGQRVFAFTRPGDAEAQAFALQLGAEWAGASGEVPPEPLDAAILFAPVGALVPIALR
DVVPGGTVVCAGIHMSDIPSFPYALLWGERTLRSIANLTRADGDALLALAPEVPLRTEVVPYPLERANDALADLRAGRLR
GAAVLVP
>Mature_327_residues
MRAMVLARPGAPLAPAELPDPVPGPGELRLRVGACGVCRTDLHVADGELPDPKLPLVLGHEIVGRVDRVGAGVTRFRPGD
RVGIPWLGWTCGRCAACRSGRENLCSAARFTGYHRDGGYAELAVADARYAFAIPGDYEDADAAPLLCAGLIGHRAWAPVR
GAQRLGLYGFGAAAHLVVQLARHAGQRVFAFTRPGDAEAQAFALQLGAEWAGASGEVPPEPLDAAILFAPVGALVPIALR
DVVPGGTVVCAGIHMSDIPSFPYALLWGERTLRSIANLTRADGDALLALAPEVPLRTEVVPYPLERANDALADLRAGRLR
GAAVLVP

Specific function: Preferred Specificity Is Towards 1-Propanol. [C]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=104, Percent_Identity=41.3461538461538, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI71743840, Length=111, Percent_Identity=39.6396396396396, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI262073058, Length=111, Percent_Identity=39.6396396396396, Blast_Score=82, Evalue=5e-16,
Organism=Homo sapiens, GI34577061, Length=104, Percent_Identity=40.3846153846154, Blast_Score=80, Evalue=2e-15,
Organism=Homo sapiens, GI4501929, Length=104, Percent_Identity=40.3846153846154, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI71565154, Length=110, Percent_Identity=38.1818181818182, Blast_Score=77, Evalue=3e-14,
Organism=Homo sapiens, GI4501939, Length=104, Percent_Identity=36.5384615384615, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI156523966, Length=104, Percent_Identity=36.5384615384615, Blast_Score=75, Evalue=1e-13,
Organism=Homo sapiens, GI71565152, Length=104, Percent_Identity=35.5769230769231, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI156627571, Length=145, Percent_Identity=32.4137931034483, Blast_Score=66, Evalue=5e-11,
Organism=Escherichia coli, GI87081918, Length=320, Percent_Identity=32.8125, Blast_Score=130, Evalue=8e-32,
Organism=Escherichia coli, GI1787863, Length=222, Percent_Identity=31.981981981982, Blast_Score=108, Evalue=7e-25,
Organism=Escherichia coli, GI1786518, Length=209, Percent_Identity=35.8851674641148, Blast_Score=106, Evalue=2e-24,
Organism=Escherichia coli, GI87082401, Length=317, Percent_Identity=28.7066246056782, Blast_Score=105, Evalue=5e-24,
Organism=Escherichia coli, GI226510992, Length=148, Percent_Identity=34.4594594594595, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1790045, Length=195, Percent_Identity=30.7692307692308, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1786552, Length=250, Percent_Identity=32.8, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788407, Length=237, Percent_Identity=26.5822784810127, Blast_Score=75, Evalue=7e-15,
Organism=Escherichia coli, GI1788073, Length=266, Percent_Identity=28.1954887218045, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1786825, Length=110, Percent_Identity=32.7272727272727, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI87082125, Length=183, Percent_Identity=26.775956284153, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17562582, Length=337, Percent_Identity=29.3768545994065, Blast_Score=107, Evalue=9e-24,
Organism=Caenorhabditis elegans, GI71988145, Length=193, Percent_Identity=33.160621761658, Blast_Score=105, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17562584, Length=329, Percent_Identity=27.0516717325228, Blast_Score=101, Evalue=4e-22,
Organism=Caenorhabditis elegans, GI17562876, Length=243, Percent_Identity=29.2181069958848, Blast_Score=79, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=217, Percent_Identity=30.4147465437788, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI25146526, Length=119, Percent_Identity=36.9747899159664, Blast_Score=75, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI71997431, Length=121, Percent_Identity=36.3636363636364, Blast_Score=70, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17565904, Length=84, Percent_Identity=41.6666666666667, Blast_Score=65, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323961, Length=210, Percent_Identity=37.6190476190476, Blast_Score=125, Evalue=1e-29,
Organism=Saccharomyces cerevisiae, GI6323729, Length=220, Percent_Identity=35, Blast_Score=122, Evalue=1e-28,
Organism=Saccharomyces cerevisiae, GI6324486, Length=202, Percent_Identity=35.6435643564356, Blast_Score=115, Evalue=9e-27,
Organism=Saccharomyces cerevisiae, GI6319621, Length=220, Percent_Identity=34.5454545454545, Blast_Score=115, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323980, Length=334, Percent_Identity=26.6467065868263, Blast_Score=86, Evalue=1e-17,
Organism=Saccharomyces cerevisiae, GI6319949, Length=334, Percent_Identity=27.5449101796407, Blast_Score=84, Evalue=4e-17,
Organism=Saccharomyces cerevisiae, GI6320033, Length=100, Percent_Identity=40, Blast_Score=77, Evalue=5e-15,
Organism=Saccharomyces cerevisiae, GI6319258, Length=163, Percent_Identity=31.2883435582822, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319257, Length=178, Percent_Identity=31.4606741573034, Blast_Score=69, Evalue=7e-13,
Organism=Drosophila melanogaster, GI17737895, Length=110, Percent_Identity=38.1818181818182, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR014187
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: =1.1.1.1 [H]

Molecular weight: Translated: 34276; Mature: 34276

Theoretical pI: Translated: 6.85; Mature: 6.85

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
2.4 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRAMVLARPGAPLAPAELPDPVPGPGELRLRVGACGVCRTDLHVADGELPDPKLPLVLGH
CCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEECCCEECCCCCCCCCCCEEECH
EIVGRVDRVGAGVTRFRPGDRVGIPWLGWTCGRCAACRSGRENLCSAARFTGYHRDGGYA
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCEE
ELAVADARYAFAIPGDYEDADAAPLLCAGLIGHRAWAPVRGAQRLGLYGFGAAAHLVVQL
EEEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCEEECCHHHHHHHHH
ARHAGQRVFAFTRPGDAEAQAFALQLGAEWAGASGEVPPEPLDAAILFAPVGALVPIALR
HHHCCCEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHH
DVVPGGTVVCAGIHMSDIPSFPYALLWGERTLRSIANLTRADGDALLALAPEVPLRTEVV
HCCCCCEEEEECCCHHCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
PYPLERANDALADLRAGRLRGAAVLVP
CCCHHHHHHHHHHHHHCCCCCEEEECC
>Mature Secondary Structure
MRAMVLARPGAPLAPAELPDPVPGPGELRLRVGACGVCRTDLHVADGELPDPKLPLVLGH
CCEEEEECCCCCCCCCCCCCCCCCCCCEEEEECCCCEEECCCEECCCCCCCCCCCEEECH
EIVGRVDRVGAGVTRFRPGDRVGIPWLGWTCGRCAACRSGRENLCSAARFTGYHRDGGYA
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCEE
ELAVADARYAFAIPGDYEDADAAPLLCAGLIGHRAWAPVRGAQRLGLYGFGAAAHLVVQL
EEEEECCEEEEECCCCCCCCCCHHHHHHHHHHHHCCCCCCCHHHCCEEECCHHHHHHHHH
ARHAGQRVFAFTRPGDAEAQAFALQLGAEWAGASGEVPPEPLDAAILFAPVGALVPIALR
HHHCCCEEEEEECCCCCCHHEEEEEECCCCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHH
DVVPGGTVVCAGIHMSDIPSFPYALLWGERTLRSIANLTRADGDALLALAPEVPLRTEVV
HCCCCCEEEEECCCHHCCCCCCEEEEHHHHHHHHHHHHHCCCCCEEEEECCCCCCCCCCC
PYPLERANDALADLRAGRLRGAAVLVP
CCCHHHHHHHHHHHHHCCCCCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]