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The map label for this gene is mprA [H]

Identifier: 220917453

GI number: 220917453

Start: 2607439

End: 2607801

Strand: Direct

Name: mprA [H]

Synonym: A2cp1_2353

Alternate gene names: 220917453

Gene position: 2607439-2607801 (Clockwise)

Preceding gene: 220917452

Following gene: 220917472

Centisome position: 51.84

GC content: 77.13

Gene sequence:

>363_bases
GTGCCCACGCCCCGCGTCCTGCTCGTCGACGACGACGCCGCCATCTGCGAGTTCCTCGCCACGCTGCTCGACCTGGAGGG
GCTCGCGCCGCGCGTCGCGCCGGGTGCGCAGGAGGCGCTCGGCGCGCTGGCCGACGCGGACGCGGTGCTCCTCGACGTGG
CCATGCCGGGGATGGACGGGCTGGAGCTGTGTCGGCGCATGCGCGCGGCCGGCTTCGGCGGGCCGATCCTGGTCGTCTCG
GCGCGGCCCGGCCCGGACCTGCCGCGCAAGGCGGTCGAGGCGGGCGCGAGCGGCTTCGTCCGCAAGCCGTTCGACAACGC
CGAGCTGATCGCCTGCCTGCGCGGCCTGCTCGCCGCCGCCTGA

Upstream 100 bases:

>100_bases
AGGACGGCGCGCCCGCCCCGGCGCACCTGAAGCCGCGCTCGCTCCGGGTGGAGTGCAGCGAGGGCAGGCTGGACGCCCCG
CTGGCGCAGAGGTGACGCGC

Downstream 100 bases:

>100_bases
GCCGCGCGCGTCACGGCTCGCGGTCGGGCGGCCCTGCGCGACCGCGGTCGTCCTGCTCCGCCTCCGCGGCCCGGTCCGCC
CGGTGCCGGCGCTCGGACTC

Product: response regulator receiver protein

Products: NA

Alternate protein names: Mycobacterial persistence regulator A [H]

Number of amino acids: Translated: 120; Mature: 119

Protein sequence:

>120_residues
MPTPRVLLVDDDAAICEFLATLLDLEGLAPRVAPGAQEALGALADADAVLLDVAMPGMDGLELCRRMRAAGFGGPILVVS
ARPGPDLPRKAVEAGASGFVRKPFDNAELIACLRGLLAAA

Sequences:

>Translated_120_residues
MPTPRVLLVDDDAAICEFLATLLDLEGLAPRVAPGAQEALGALADADAVLLDVAMPGMDGLELCRRMRAAGFGGPILVVS
ARPGPDLPRKAVEAGASGFVRKPFDNAELIACLRGLLAAA
>Mature_119_residues
PTPRVLLVDDDAAICEFLATLLDLEGLAPRVAPGAQEALGALADADAVLLDVAMPGMDGLELCRRMRAAGFGGPILVVSA
RPGPDLPRKAVEAGASGFVRKPFDNAELIACLRGLLAAA

Specific function: Member of the two-component regulatory system mprB/mprA which contributes to maintaining a balance among several systems involved in stress resistance and is required for establishment and maintenance of persistent infection in the host. Functions as a tr

COG id: COG0745

COG function: function code TK; Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=34.5794392523364, Blast_Score=65, Evalue=2e-12,
Organism=Escherichia coli, GI1789809, Length=116, Percent_Identity=33.6206896551724, Blast_Score=64, Evalue=4e-12,
Organism=Escherichia coli, GI1786784, Length=115, Percent_Identity=32.1739130434783, Blast_Score=60, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 12320; Mature: 12188

Theoretical pI: Translated: 4.34; Mature: 4.34

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTPRVLLVDDDAAICEFLATLLDLEGLAPRVAPGAQEALGALADADAVLLDVAMPGMDG
CCCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCH
LELCRRMRAAGFGGPILVVSARPGPDLPRKAVEAGASGFVRKPFDNAELIACLRGLLAAA
HHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
PTPRVLLVDDDAAICEFLATLLDLEGLAPRVAPGAQEALGALADADAVLLDVAMPGMDG
CCCCEEEEECCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHCCCHHHHHHHCCCCCH
LELCRRMRAAGFGGPILVVSARPGPDLPRKAVEAGASGFVRKPFDNAELIACLRGLLAAA
HHHHHHHHHCCCCCCEEEEECCCCCCCCHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA