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The map label for this gene is lepB [H]

Identifier: 220917433

GI number: 220917433

Start: 2583719

End: 2584738

Strand: Reverse

Name: lepB [H]

Synonym: A2cp1_2333

Alternate gene names: 220917433

Gene position: 2584738-2583719 (Counterclockwise)

Preceding gene: 220917434

Following gene: 220917432

Centisome position: 51.39

GC content: 76.96

Gene sequence:

>1020_bases
GTGGCGGACGCCGCCCGCCTGGCGCGCGCGCGCCGCGACGCGCTCCGCTTCGCGCGCGACGCCCGCCGGCTGGCCGCCCG
GCACCGCCGCGCCCTGGGCGACGCGCGCGGCGCGGTGGACGCGGCCGCCGCCGAGGTGACCGCCGCGGCGCGGGGCGGGG
AGCCGGACGCGCTCTCCGCCGCGCTCCGCAGGCTGGACGCGCTCTGGGAGGAGCACCTCGCGGCGCGGGTCAAGCCCTGG
TGGCGCGAGTACGCGGAGTCCATCGCGCTCGCGGTGGTGCTGGCGCTCCTGGTCCGCGCGTTCGTGCTCGACGCGTTCCG
GATCCCGTCCGGCTCGATGGTCCCGACGCTGGTGGTGGGCGACTACATCTTCGTCTCCAAGGTCGCCTACGCGGTGCGGC
TCCCGTTCACGCACCTCCGCCTGGTCGAGACCGGCGCGCCGCGGCGCGGCGACGTCATCGTGTTCGAGAACCCGCGCGAC
CCGAGCAGCGACTACGTGAAGCGGGTGGTGGGCGTCGCCGGCGACGTCATCGAGATCCGCGAGCAGGTGCTCTACGTCAA
CGGCGTGCCGCAGCCGCGCGCGGCCGCCGGCGAGTACGCCTACGCCGAGCGGAGCCCATCCACCGGGGAGCCGCTGGCGG
AGCGCTGCCGCCGCTACCGCGAGGCGCTCGCCAAGGGGCCCATCCTCCCGCCCCGGGGCGATCTCCCCGGCGACGCCGAG
TCGAGCTGGCAGGCGGCCGCCGCCGACGGGGTGGCGAGCTACGACGTGCTCCAGTGCCGGCGGGCGCGCCTCGCCTCGCG
CGAGGGGCCGTTCGAGGTGGTCCGCCCCGGGCACGTGTTCGTGATGGGCGACAACCGCGATCTCTCGGCCGACAGCCGGG
GGATGGGCGGGTGGCAGGTCCCCGTGGGCCACATCCGCGGCCGCGCCGCGCTGGTCTTCTGGAGCTGGGGGGACGGGGGC
CTGTGGCCGCGGGGCGCAGGAGGCCTCCGGCTCGACCGGCTTTTCAAACCCATCGACTAG

Upstream 100 bases:

>100_bases
AAGCAGAAGGAGGGCAAGAAGCGCATGAAGCAGGTGGGCTCGGTGGAGATCCCGCAGGAGGCGTTCCTCGCGGTCCTGAA
GGTGGAGGAGTAGCGCCGCC

Downstream 100 bases:

>100_bases
CGCTAGAAACACCCCCTGATGCCCAGCCTCTCCCCGTCCTCCCTGCCGCGCTCCGCGCGCGGGCAGATCACGTGGGTCAC
GGCCGCGATCCTCGCTGCGC

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 339; Mature: 338

Protein sequence:

>339_residues
MADAARLARARRDALRFARDARRLAARHRRALGDARGAVDAAAAEVTAAARGGEPDALSAALRRLDALWEEHLAARVKPW
WREYAESIALAVVLALLVRAFVLDAFRIPSGSMVPTLVVGDYIFVSKVAYAVRLPFTHLRLVETGAPRRGDVIVFENPRD
PSSDYVKRVVGVAGDVIEIREQVLYVNGVPQPRAAAGEYAYAERSPSTGEPLAERCRRYREALAKGPILPPRGDLPGDAE
SSWQAAAADGVASYDVLQCRRARLASREGPFEVVRPGHVFVMGDNRDLSADSRGMGGWQVPVGHIRGRAALVFWSWGDGG
LWPRGAGGLRLDRLFKPID

Sequences:

>Translated_339_residues
MADAARLARARRDALRFARDARRLAARHRRALGDARGAVDAAAAEVTAAARGGEPDALSAALRRLDALWEEHLAARVKPW
WREYAESIALAVVLALLVRAFVLDAFRIPSGSMVPTLVVGDYIFVSKVAYAVRLPFTHLRLVETGAPRRGDVIVFENPRD
PSSDYVKRVVGVAGDVIEIREQVLYVNGVPQPRAAAGEYAYAERSPSTGEPLAERCRRYREALAKGPILPPRGDLPGDAE
SSWQAAAADGVASYDVLQCRRARLASREGPFEVVRPGHVFVMGDNRDLSADSRGMGGWQVPVGHIRGRAALVFWSWGDGG
LWPRGAGGLRLDRLFKPID
>Mature_338_residues
ADAARLARARRDALRFARDARRLAARHRRALGDARGAVDAAAAEVTAAARGGEPDALSAALRRLDALWEEHLAARVKPWW
REYAESIALAVVLALLVRAFVLDAFRIPSGSMVPTLVVGDYIFVSKVAYAVRLPFTHLRLVETGAPRRGDVIVFENPRDP
SSDYVKRVVGVAGDVIEIREQVLYVNGVPQPRAAAGEYAYAERSPSTGEPLAERCRRYREALAKGPILPPRGDLPGDAES
SWQAAAADGVASYDVLQCRRARLASREGPFEVVRPGHVFVMGDNRDLSADSRGMGGWQVPVGHIRGRAALVFWSWGDGGL
WPRGAGGLRLDRLFKPID

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

Organism=Escherichia coli, GI1788921, Length=280, Percent_Identity=35.3571428571429, Blast_Score=137, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019757
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056
- InterPro:   IPR019533
- InterPro:   IPR019766 [H]

Pfam domain/function: PF00717 Peptidase_S24; PF10502 Peptidase_S26 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 36974; Mature: 36842

Theoretical pI: Translated: 10.18; Mature: 10.18

Prosite motif: PS00501 SPASE_I_1 ; PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
1.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MADAARLARARRDALRFARDARRLAARHRRALGDARGAVDAAAAEVTAAARGGEPDALSA
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ALRRLDALWEEHLAARVKPWWREYAESIALAVVLALLVRAFVLDAFRIPSGSMVPTLVVG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
DYIFVSKVAYAVRLPFTHLRLVETGAPRRGDVIVFENPRDPSSDYVKRVVGVAGDVIEIR
HHHHHHHHHHHHHCCHHHEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCHHHHHH
EQVLYVNGVPQPRAAAGEYAYAERSPSTGEPLAERCRRYREALAKGPILPPRGDLPGDAE
HHHEEECCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
SSWQAAAADGVASYDVLQCRRARLASREGPFEVVRPGHVFVMGDNRDLSADSRGMGGWQV
CCCHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCC
PVGHIRGRAALVFWSWGDGGLWPRGAGGLRLDRLFKPID
CHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHCCCCC
>Mature Secondary Structure 
ADAARLARARRDALRFARDARRLAARHRRALGDARGAVDAAAAEVTAAARGGEPDALSA
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHH
ALRRLDALWEEHLAARVKPWWREYAESIALAVVLALLVRAFVLDAFRIPSGSMVPTLVVG
HHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHH
DYIFVSKVAYAVRLPFTHLRLVETGAPRRGDVIVFENPRDPSSDYVKRVVGVAGDVIEIR
HHHHHHHHHHHHHCCHHHEEEECCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCHHHHHH
EQVLYVNGVPQPRAAAGEYAYAERSPSTGEPLAERCRRYREALAKGPILPPRGDLPGDAE
HHHEEECCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCCC
SSWQAAAADGVASYDVLQCRRARLASREGPFEVVRPGHVFVMGDNRDLSADSRGMGGWQV
CCCHHHHHCCCHHHHHHHHHHHHHHCCCCCEEEECCCEEEEEECCCCCCCCCCCCCCCCC
PVGHIRGRAALVFWSWGDGGLWPRGAGGLRLDRLFKPID
CHHHHCCCEEEEEEECCCCCCCCCCCCCCCHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 6311837; 9278503; 2202591; 1618816; 1546969; 8394311; 2551889; 9823901 [H]