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The map label for this gene is rnc [H]

Identifier: 220917396

GI number: 220917396

Start: 2545079

End: 2546230

Strand: Reverse

Name: rnc [H]

Synonym: A2cp1_2296

Alternate gene names: 220917396

Gene position: 2546230-2545079 (Counterclockwise)

Preceding gene: 220917397

Following gene: 220917395

Centisome position: 50.63

GC content: 78.82

Gene sequence:

>1152_bases
ATGGGCGAGGATCGAGGACCAGCGCAGGAGCCCGCGGGCGCGCCGCCGGAGCCGGACCCGGCGCTCGACCCGGTGGGCGC
GCTGGAGGCGCGGCTCGGCATCGCGGTCACCGACCGCCAGGCCGCCCTGGCCGCGCTCACGCACAAGTCCTACGTGAACG
AGCACCGCGAGGACGGGCTGCAGGACAACGAGCGGCTCGAGTTCCTGGGGGACGCGGTCATCGACCTGGCCGTGTCGCAC
CGGCTCATGGAGCGCTTCCCCTCGGCGCGCGAGGGCGACCTCTCCAAGATGCGCGCCGCGGTGGTGGACGAGCAGGGGCT
CGCCGGGATGGCCCGCGCGCTCGACCTCGGGACGCTGCTCCGCCTCGGGCGCGGCGAGGAGCTGACCGGCGGCCGGCAGA
AGTCGTCGCTGCTCGCCGACGCGATGGAGGCGGTGATCGCCGCCGTGTACCAGGGGCAGGGGCTCCCGGCGGTGCTCTGC
TTCGTGGACCGCTTCCTCGGCGAGGCGTTCGCGCGCGCGGCGGCCGGCACCCTGGACCGCGACTTCAAGACCCAGCTCCA
GGAGCTCTCGCAGAGCCGGCTGCGCGCCACCCCGCGGTACCGCGTGGTCGCCGAGCACGGCCCGGACCACTCGAAGACGT
TCGAGGTCGAGACCGACCTGCGCGGCGAGGTGCTGGGGCGCGGCGCCGGACGGTCGAAGAAGGACGCGGAGCAGGCGGCG
GCGCGGCTCGCGCTGGATGCGCTCGGGCGACGCCTCGCGGTGGAGGCAGGACACGGCGGGGCGGAGCCCACGGCCACGGT
CCCCGCGGCCGCACCGCGGGCCGAGGTCACCGAGGCGCCGGCCGCCGCACCGGCGCCGGACGAGGCGCTCACGGCAGCCC
CGGCGCCGCTCGCGCCCCCGGAGGCGATCGCCGCCGAGCCGGGACCGGAGGACCGCCGCCCCGACCGCGCGCCGGCCGGG
GTGGTCGAGGACCCGGCGGCGACCGCGCACCCGCCGCACGCCCCGGCGCCCCGGCGCCGCCGCGCGGCCCCGTCCGGCGG
CCGGAAGGCCGCCGCCCCGGCGCGCACCCGCAAGGCTGCGCCGAAGCGGAAGACGGCGACCGGGAAGGGCGCCGCCAAGG
GAGCCCGCAAGGGGACGCGCCCCCGGCGCTGA

Upstream 100 bases:

>100_bases
GGACGCGGTGGCCGAGCGGATCGCGGCGCGGAGCGCCGACCCGTACCAGCTCGCGGAAGAGCTGGCTGCGCTGCTGCGGG
CCTGAGCGGGAGAGCGGACG

Downstream 100 bases:

>100_bases
GGGGCGCCGTCTTTCCATTTGCCGGGGCTCCCACCCGCGACTAGCATCCCGCGGCATGACGCGCTCCTCCCTTCTGGTGA
TTTCACTGTTCGTGTCGCTG

Product: Ribonuclease III

Products: NA

Alternate protein names: Ribonuclease III; RNase III [H]

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MGEDRGPAQEPAGAPPEPDPALDPVGALEARLGIAVTDRQAALAALTHKSYVNEHREDGLQDNERLEFLGDAVIDLAVSH
RLMERFPSAREGDLSKMRAAVVDEQGLAGMARALDLGTLLRLGRGEELTGGRQKSSLLADAMEAVIAAVYQGQGLPAVLC
FVDRFLGEAFARAAAGTLDRDFKTQLQELSQSRLRATPRYRVVAEHGPDHSKTFEVETDLRGEVLGRGAGRSKKDAEQAA
ARLALDALGRRLAVEAGHGGAEPTATVPAAAPRAEVTEAPAAAPAPDEALTAAPAPLAPPEAIAAEPGPEDRRPDRAPAG
VVEDPAATAHPPHAPAPRRRRAAPSGGRKAAAPARTRKAAPKRKTATGKGAAKGARKGTRPRR

Sequences:

>Translated_383_residues
MGEDRGPAQEPAGAPPEPDPALDPVGALEARLGIAVTDRQAALAALTHKSYVNEHREDGLQDNERLEFLGDAVIDLAVSH
RLMERFPSAREGDLSKMRAAVVDEQGLAGMARALDLGTLLRLGRGEELTGGRQKSSLLADAMEAVIAAVYQGQGLPAVLC
FVDRFLGEAFARAAAGTLDRDFKTQLQELSQSRLRATPRYRVVAEHGPDHSKTFEVETDLRGEVLGRGAGRSKKDAEQAA
ARLALDALGRRLAVEAGHGGAEPTATVPAAAPRAEVTEAPAAAPAPDEALTAAPAPLAPPEAIAAEPGPEDRRPDRAPAG
VVEDPAATAHPPHAPAPRRRRAAPSGGRKAAAPARTRKAAPKRKTATGKGAAKGARKGTRPRR
>Mature_382_residues
GEDRGPAQEPAGAPPEPDPALDPVGALEARLGIAVTDRQAALAALTHKSYVNEHREDGLQDNERLEFLGDAVIDLAVSHR
LMERFPSAREGDLSKMRAAVVDEQGLAGMARALDLGTLLRLGRGEELTGGRQKSSLLADAMEAVIAAVYQGQGLPAVLCF
VDRFLGEAFARAAAGTLDRDFKTQLQELSQSRLRATPRYRVVAEHGPDHSKTFEVETDLRGEVLGRGAGRSKKDAEQAAA
RLALDALGRRLAVEAGHGGAEPTATVPAAAPRAEVTEAPAAAPAPDEALTAAPAPLAPPEAIAAEPGPEDRRPDRAPAGV
VEDPAATAHPPHAPAPRRRRAAPSGGRKAAAPARTRKAAPKRKTATGKGAAKGARKGTRPRR

Specific function: Digests double-stranded RNA. Involved in the processing of ribosomal RNA precursors and of some mRNAs [H]

COG id: COG0571

COG function: function code K; dsRNA-specific ribonuclease

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RNase III domain [H]

Homologues:

Organism=Homo sapiens, GI155030236, Length=239, Percent_Identity=28.8702928870293, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI155030234, Length=239, Percent_Identity=28.8702928870293, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1788920, Length=212, Percent_Identity=35.377358490566, Blast_Score=121, Evalue=6e-29,
Organism=Caenorhabditis elegans, GI193202651, Length=240, Percent_Identity=29.5833333333333, Blast_Score=83, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17506883, Length=240, Percent_Identity=29.5833333333333, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17137682, Length=224, Percent_Identity=28.5714285714286, Blast_Score=69, Evalue=5e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001159
- InterPro:   IPR014720
- InterPro:   IPR000999
- InterPro:   IPR011907 [H]

Pfam domain/function: PF00035 dsrm; PF00636 Ribonuclease_3 [H]

EC number: =3.1.26.3 [H]

Molecular weight: Translated: 40051; Mature: 39920

Theoretical pI: Translated: 9.47; Mature: 9.47

Prosite motif: PS50137 DS_RBD ; PS00517 RNASE_3_1 ; PS50142 RNASE_3_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGEDRGPAQEPAGAPPEPDPALDPVGALEARLGIAVTDRQAALAALTHKSYVNEHREDGL
CCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCEEECCHHHHHHHHHHHHHHHHHHHCCC
QDNERLEFLGDAVIDLAVSHRLMERFPSAREGDLSKMRAAVVDEQGLAGMARALDLGTLL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RLGRGEELTGGRQKSSLLADAMEAVIAAVYQGQGLPAVLCFVDRFLGEAFARAAAGTLDR
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
DFKTQLQELSQSRLRATPRYRVVAEHGPDHSKTFEVETDLRGEVLGRGAGRSKKDAEQAA
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCCCHHHHCCCCCCCHHHHHHHH
ARLALDALGRRLAVEAGHGGAEPTATVPAAAPRAEVTEAPAAAPAPDEALTAAPAPLAPP
HHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHCCCCCCCCC
EAIAAEPGPEDRRPDRAPAGVVEDPAATAHPPHAPAPRRRRAAPSGGRKAAAPARTRKAA
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHCC
PKRKTATGKGAAKGARKGTRPRR
CCCCCCCCCCHHHHHHCCCCCCC
>Mature Secondary Structure 
GEDRGPAQEPAGAPPEPDPALDPVGALEARLGIAVTDRQAALAALTHKSYVNEHREDGL
CCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHCEEECCHHHHHHHHHHHHHHHHHHHCCC
QDNERLEFLGDAVIDLAVSHRLMERFPSAREGDLSKMRAAVVDEQGLAGMARALDLGTLL
CCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHH
RLGRGEELTGGRQKSSLLADAMEAVIAAVYQGQGLPAVLCFVDRFLGEAFARAAAGTLDR
HHCCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCH
DFKTQLQELSQSRLRATPRYRVVAEHGPDHSKTFEVETDLRGEVLGRGAGRSKKDAEQAA
HHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCEEEECCCCCHHHHCCCCCCCHHHHHHHH
ARLALDALGRRLAVEAGHGGAEPTATVPAAAPRAEVTEAPAAAPAPDEALTAAPAPLAPP
HHHHHHHHHHHEEEECCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCHHHHCCCCCCCCC
EAIAAEPGPEDRRPDRAPAGVVEDPAATAHPPHAPAPRRRRAAPSGGRKAAAPARTRKAA
HHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHCCCCCCCCCCCCCHHHHHCC
PKRKTATGKGAAKGARKGTRPRR
CCCCCCCCCCHHHHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA