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The map label for this gene is bcd [H]

Identifier: 220917381

GI number: 220917381

Start: 2532040

End: 2533182

Strand: Direct

Name: bcd [H]

Synonym: A2cp1_2281

Alternate gene names: 220917381

Gene position: 2532040-2533182 (Clockwise)

Preceding gene: 220917380

Following gene: 220917382

Centisome position: 50.35

GC content: 70.34

Gene sequence:

>1143_bases
ATGGACATCCAGCTCACCGAGGAGCAGCGCCAGGTCCGGGACCTCTGCCGGGAGTTCGCCGATCGCGAGCTCAAGCCGCA
CGCGCGGCGCTGGGACCGCGACCACGAGTTCCCCGCCGCCGCCGTGAAGCAGCTCGGCGAGATGGGGCTGATGGGCGTGG
CCGTGCCGGCGGAGTGGGGCGGCGCCGGGATGGACAACGTGTCGTACGCGCTCGCGATGGAGGAGATCTCGCGCGGCTGC
GCCGGCACCGGCGTCATCATGAGCGTGTCGAACTCGCTCTACTGCGACCCGGTGCTGAAGTACGGCAGCGACGCCCAGCG
CAAGGAGTTCCTCGAGCCGTACGCGCGCGGCGAGAAGCTCGGCTGCTTCGCGCTCACCGAGCCCATGAGCGGCTCGGACG
CGGCCGAGATGCGCACCGTGGCGGTCCGGCGCGGCGACGAGTACGTGCTCGACGGCACCAAGAACTTCATCACCAACGGG
CCGCAGGCCGACGCGGTGCTCGTGTTCGCCATGACCGACAAGGCGAAGCGGCACAAGGGCATCAGCGCCTTCCTGGTGCC
GACCGACGCGCGCGGGTTCAGCCGCGGCAAGCCGGACGACAAGGTGGGCATCCGGGCCTCCGGCTCCTGCTCCCTGTTCT
TCGAGGGCTGCGCCATCCCGGCCCGCCACCGGCTCGGCGAGGAGGGCGACGGGTTCAAGATCGCCATGGGCACGCTCGAC
GGCGGCCGGATCGGCATCGCCGGCCAGGCGCTCGGCATCGCGGTGGCGGCGTTCGAGGAGGCGGTGGCCTACGCCAAGGA
GCGCAAGGCGTTCGGCCAGCCCATCACCCAGTTCCAGGCCATCCAGTTCATGCTCGCCGACATGGCCACCGAGATCGACG
CGGCCCGGCTCCTGGTGCTGCGCGCCGCCTCCGCAAAGGACCGCGGCGTGCGCCACAGCGCCGAGAGCGCCATGGCGAAG
CTCTTCGCCTCCGAGATGAGCGAGCGCGTCACCTCGAAGGCGATCCAGATCCACGGCGGCTATGGGTACGTGAAGGAGTT
CGACGTGGAGCGCCACTGGCGCGACAGCCGCATCACCGAGATCTACGAGGGCACCAGCGAGATCCAGCGCCTCGTGATCT
CCGCCTCGGTGCTGAAGGGCTAG

Upstream 100 bases:

>100_bases
CGCGCGGCGCGCTGGAGCGGGCGTTGACGCACCGTTGACGCAGGGCGCGGTGGCCTGAGACGCTGCGCGCCGAGGCTGCA
CCTTCCAGAAAGGACGTTCC

Downstream 100 bases:

>100_bases
CCGCCGGCACCTCGACCGAGCGCTCCACCGGCGACCCCGCCCAGGGCGGCCCCGCGCCGGGCGGAGCCACACCCGGATCC
TGCATGGACTTCGAGCTCGA

Product: acyl-CoA dehydrogenase domain-containing protein

Products: NA

Alternate protein names: Butyryl-CoA dehydrogenase; SCAD [H]

Number of amino acids: Translated: 380; Mature: 380

Protein sequence:

>380_residues
MDIQLTEEQRQVRDLCREFADRELKPHARRWDRDHEFPAAAVKQLGEMGLMGVAVPAEWGGAGMDNVSYALAMEEISRGC
AGTGVIMSVSNSLYCDPVLKYGSDAQRKEFLEPYARGEKLGCFALTEPMSGSDAAEMRTVAVRRGDEYVLDGTKNFITNG
PQADAVLVFAMTDKAKRHKGISAFLVPTDARGFSRGKPDDKVGIRASGSCSLFFEGCAIPARHRLGEEGDGFKIAMGTLD
GGRIGIAGQALGIAVAAFEEAVAYAKERKAFGQPITQFQAIQFMLADMATEIDAARLLVLRAASAKDRGVRHSAESAMAK
LFASEMSERVTSKAIQIHGGYGYVKEFDVERHWRDSRITEIYEGTSEIQRLVISASVLKG

Sequences:

>Translated_380_residues
MDIQLTEEQRQVRDLCREFADRELKPHARRWDRDHEFPAAAVKQLGEMGLMGVAVPAEWGGAGMDNVSYALAMEEISRGC
AGTGVIMSVSNSLYCDPVLKYGSDAQRKEFLEPYARGEKLGCFALTEPMSGSDAAEMRTVAVRRGDEYVLDGTKNFITNG
PQADAVLVFAMTDKAKRHKGISAFLVPTDARGFSRGKPDDKVGIRASGSCSLFFEGCAIPARHRLGEEGDGFKIAMGTLD
GGRIGIAGQALGIAVAAFEEAVAYAKERKAFGQPITQFQAIQFMLADMATEIDAARLLVLRAASAKDRGVRHSAESAMAK
LFASEMSERVTSKAIQIHGGYGYVKEFDVERHWRDSRITEIYEGTSEIQRLVISASVLKG
>Mature_380_residues
MDIQLTEEQRQVRDLCREFADRELKPHARRWDRDHEFPAAAVKQLGEMGLMGVAVPAEWGGAGMDNVSYALAMEEISRGC
AGTGVIMSVSNSLYCDPVLKYGSDAQRKEFLEPYARGEKLGCFALTEPMSGSDAAEMRTVAVRRGDEYVLDGTKNFITNG
PQADAVLVFAMTDKAKRHKGISAFLVPTDARGFSRGKPDDKVGIRASGSCSLFFEGCAIPARHRLGEEGDGFKIAMGTLD
GGRIGIAGQALGIAVAAFEEAVAYAKERKAFGQPITQFQAIQFMLADMATEIDAARLLVLRAASAKDRGVRHSAESAMAK
LFASEMSERVTSKAIQIHGGYGYVKEFDVERHWRDSRITEIYEGTSEIQRLVISASVLKG

Specific function: Unknown

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4557233, Length=378, Percent_Identity=56.0846560846561, Blast_Score=424, Evalue=1e-119,
Organism=Homo sapiens, GI226958412, Length=373, Percent_Identity=39.142091152815, Blast_Score=277, Evalue=1e-74,
Organism=Homo sapiens, GI4501859, Length=373, Percent_Identity=38.0697050938338, Blast_Score=275, Evalue=4e-74,
Organism=Homo sapiens, GI7656849, Length=377, Percent_Identity=38.1962864721485, Blast_Score=268, Evalue=8e-72,
Organism=Homo sapiens, GI187960098, Length=377, Percent_Identity=36.604774535809, Blast_Score=260, Evalue=2e-69,
Organism=Homo sapiens, GI4557231, Length=377, Percent_Identity=36.604774535809, Blast_Score=259, Evalue=2e-69,
Organism=Homo sapiens, GI226958414, Length=333, Percent_Identity=39.3393393393393, Blast_Score=254, Evalue=8e-68,
Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=33.9522546419098, Blast_Score=224, Evalue=1e-58,
Organism=Homo sapiens, GI21361497, Length=361, Percent_Identity=37.1191135734072, Blast_Score=223, Evalue=2e-58,
Organism=Homo sapiens, GI4557235, Length=338, Percent_Identity=38.7573964497041, Blast_Score=221, Evalue=1e-57,
Organism=Homo sapiens, GI76496475, Length=338, Percent_Identity=38.7573964497041, Blast_Score=220, Evalue=2e-57,
Organism=Homo sapiens, GI4503943, Length=379, Percent_Identity=32.1899736147757, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI7669494, Length=365, Percent_Identity=32.3287671232877, Blast_Score=176, Evalue=3e-44,
Organism=Homo sapiens, GI48976061, Length=381, Percent_Identity=30.4461942257218, Blast_Score=139, Evalue=6e-33,
Organism=Homo sapiens, GI211971008, Length=381, Percent_Identity=30.4461942257218, Blast_Score=138, Evalue=7e-33,
Organism=Homo sapiens, GI38505218, Length=354, Percent_Identity=27.9661016949153, Blast_Score=123, Evalue=2e-28,
Organism=Escherichia coli, GI87081958, Length=382, Percent_Identity=32.4607329842932, Blast_Score=177, Evalue=1e-45,
Organism=Escherichia coli, GI1786223, Length=380, Percent_Identity=29.4736842105263, Blast_Score=170, Evalue=1e-43,
Organism=Escherichia coli, GI87082384, Length=270, Percent_Identity=30, Blast_Score=91, Evalue=1e-19,
Organism=Escherichia coli, GI87081702, Length=396, Percent_Identity=23.989898989899, Blast_Score=74, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17508101, Length=374, Percent_Identity=40.6417112299465, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17538396, Length=377, Percent_Identity=39.5225464190981, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI17569725, Length=382, Percent_Identity=38.7434554973822, Blast_Score=275, Evalue=2e-74,
Organism=Caenorhabditis elegans, GI17534899, Length=382, Percent_Identity=37.434554973822, Blast_Score=271, Evalue=3e-73,
Organism=Caenorhabditis elegans, GI17506239, Length=370, Percent_Identity=37.2972972972973, Blast_Score=270, Evalue=7e-73,
Organism=Caenorhabditis elegans, GI17570075, Length=381, Percent_Identity=36.4829396325459, Blast_Score=254, Evalue=6e-68,
Organism=Caenorhabditis elegans, GI17533517, Length=379, Percent_Identity=36.4116094986807, Blast_Score=249, Evalue=1e-66,
Organism=Caenorhabditis elegans, GI71990804, Length=293, Percent_Identity=41.9795221843003, Blast_Score=237, Evalue=9e-63,
Organism=Caenorhabditis elegans, GI71985184, Length=384, Percent_Identity=34.8958333333333, Blast_Score=223, Evalue=2e-58,
Organism=Caenorhabditis elegans, GI17551932, Length=354, Percent_Identity=34.180790960452, Blast_Score=206, Evalue=2e-53,
Organism=Caenorhabditis elegans, GI17505929, Length=359, Percent_Identity=33.7047353760446, Blast_Score=204, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI17534353, Length=376, Percent_Identity=31.9148936170213, Blast_Score=201, Evalue=7e-52,
Organism=Caenorhabditis elegans, GI71985192, Length=329, Percent_Identity=33.434650455927, Blast_Score=177, Evalue=1e-44,
Organism=Caenorhabditis elegans, GI71982178, Length=275, Percent_Identity=32.7272727272727, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI32563615, Length=231, Percent_Identity=35.4978354978355, Blast_Score=167, Evalue=6e-42,
Organism=Caenorhabditis elegans, GI17531909, Length=238, Percent_Identity=34.0336134453782, Blast_Score=138, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17562446, Length=336, Percent_Identity=30.6547619047619, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI17531913, Length=179, Percent_Identity=31.2849162011173, Blast_Score=92, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI86563383, Length=269, Percent_Identity=26.3940520446097, Blast_Score=66, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI86563381, Length=269, Percent_Identity=26.3940520446097, Blast_Score=66, Evalue=4e-11,
Organism=Drosophila melanogaster, GI21356377, Length=375, Percent_Identity=56, Blast_Score=445, Evalue=1e-125,
Organism=Drosophila melanogaster, GI24646207, Length=375, Percent_Identity=48.5333333333333, Blast_Score=362, Evalue=1e-100,
Organism=Drosophila melanogaster, GI24666513, Length=375, Percent_Identity=37.3333333333333, Blast_Score=280, Evalue=1e-75,
Organism=Drosophila melanogaster, GI24660351, Length=373, Percent_Identity=39.6782841823056, Blast_Score=271, Evalue=6e-73,
Organism=Drosophila melanogaster, GI21355753, Length=374, Percent_Identity=35.5614973262032, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI281363737, Length=385, Percent_Identity=34.8051948051948, Blast_Score=219, Evalue=3e-57,
Organism=Drosophila melanogaster, GI19920834, Length=381, Percent_Identity=30.1837270341207, Blast_Score=167, Evalue=9e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: =1.3.99.2 [H]

Molecular weight: Translated: 41407; Mature: 41407

Theoretical pI: Translated: 6.41; Mature: 6.41

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDIQLTEEQRQVRDLCREFADRELKPHARRWDRDHEFPAAAVKQLGEMGLMGVAVPAEWG
CCCEECHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCEEEECCCCCC
GAGMDNVSYALAMEEISRGCAGTGVIMSVSNSLYCDPVLKYGSDAQRKEFLEPYARGEKL
CCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEECHHHHCCCCHHHHHHHHHHHCCCCE
GCFALTEPMSGSDAAEMRTVAVRRGDEYVLDGTKNFITNGPQADAVLVFAMTDKAKRHKG
EEEEECCCCCCCCHHHHHHHHHHCCCEEEECCCHHHHCCCCCCCEEEEEEECCHHHHCCC
ISAFLVPTDARGFSRGKPDDKVGIRASGSCSLFFEGCAIPARHRLGEEGDGFKIAMGTLD
CEEEEEECCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCHHHHCCCCCCCEEEEEEECC
GGRIGIAGQALGIAVAAFEEAVAYAKERKAFGQPITQFQAIQFMLADMATEIDAARLLVL
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAASAKDRGVRHSAESAMAKLFASEMSERVTSKAIQIHGGYGYVKEFDVERHWRDSRITE
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHCCHHHHHCCHHHHH
IYEGTSEIQRLVISASVLKG
HHCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MDIQLTEEQRQVRDLCREFADRELKPHARRWDRDHEFPAAAVKQLGEMGLMGVAVPAEWG
CCCEECHHHHHHHHHHHHHHCCCCCCHHHHCCCCCCCHHHHHHHHHHCCCEEEECCCCCC
GAGMDNVSYALAMEEISRGCAGTGVIMSVSNSLYCDPVLKYGSDAQRKEFLEPYARGEKL
CCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCEECHHHHCCCCHHHHHHHHHHHCCCCE
GCFALTEPMSGSDAAEMRTVAVRRGDEYVLDGTKNFITNGPQADAVLVFAMTDKAKRHKG
EEEEECCCCCCCCHHHHHHHHHHCCCEEEECCCHHHHCCCCCCCEEEEEEECCHHHHCCC
ISAFLVPTDARGFSRGKPDDKVGIRASGSCSLFFEGCAIPARHRLGEEGDGFKIAMGTLD
CEEEEEECCCCCCCCCCCCCCCCEEECCCEEEEECCCCCCHHHHCCCCCCCEEEEEEECC
GGRIGIAGQALGIAVAAFEEAVAYAKERKAFGQPITQFQAIQFMLADMATEIDAARLLVL
CCEEEECCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
RAASAKDRGVRHSAESAMAKLFASEMSERVTSKAIQIHGGYGYVKEFDVERHWRDSRITE
HHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCHHHCCHHHHHCCHHHHH
IYEGTSEIQRLVISASVLKG
HHCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8655474; 11466286 [H]