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The map label for this gene is atoC [H]

Identifier: 220917327

GI number: 220917327

Start: 2468340

End: 2470166

Strand: Reverse

Name: atoC [H]

Synonym: A2cp1_2227

Alternate gene names: 220917327

Gene position: 2470166-2468340 (Counterclockwise)

Preceding gene: 220917328

Following gene: 220917326

Centisome position: 49.12

GC content: 71.21

Gene sequence:

>1827_bases
GTGGCCACGCTCATCGTGAGAGGACCGGACGGCTCCGAGCGCGAGGTCGCGCTGGTGAAGCGCATCACCAGCGTGGGCCG
TGATCCGGAGAACGACGTGCCGGTGGAGGACCCGGCGCTGCCCGCCACCGCGCTGCACATCCACTTCGACGGGAAGGACT
ACAACGCCGCCGCCCACGACCGCTCCGACATGACGGTGAACGGGAAGCGGCGGGGCGCCTGGCGCCTGGGGCCGGGCGAC
CGGATCCGGGTGGCGGGCACCGAGCTCACCTTCGAGGCCGTGGCGCGCACGCCGCTGCCGTCGGCCCGGCCCATCGCCGG
CCAGCGGCTGCAGGCGCTCGAGACGCTGGTGCGCTTCTCCGAGCGGCTCCTCGGGGCGACCGACCTGAACCGGCTGCTCG
ACGAACTGATGGACGCGCTGCTCGAGGTCACCCACGCCGACAAGGGGTTCCTGATCCTGCTCGAGGACGGGGAGATGAGC
GTCCGCGCCGCGCGCAACGTGGCCCGCGAGACCATCGAGGGCGCGGTCGAGCGGGTCTCCGACTCGATCATCCGGCGCGT
GGTGGAGACCCGCCGCGCGCTGGTGGTGGCCGACGCGCTGCACGACTCGGAGTGGTCGGGCTCGACGTCGGTGGTGAACC
TGAAGCTCTGCTCGGTGATGTGCGCCCCGCTCATGCAGAAGGGCGAGGTCTTCGGCGTCATCTACCTCGGCAACGACAAC
GTGGTCTCGCTGTTCGACGAGCGCGCCCTCGAGCTGCTCGCGCCGTTCGCCGCGCAGGCGTCGCTGCTGGTGCAGAACGC
CATGCTGCTCGACTCGCTGCGCCGCGAGAACCTCTCCCTCAAGGAGGCGGTGGCGTCGCGGCAGTACGGCGACCTCATCG
GCGCCGGCGCCTCGATGCGCGAGGTCTACCGGCGCATCGACAAGGTGGCCGGGACCGACATCTCGGTGCTGGTGTCCGGC
GAGACCGGCACCGGCAAGGAGGTGGTGGCCCGCGAGATCCACCGGCGCTCCACGCGCGCCACCGGGCCGTTCGTGGCGGT
GAACTGCGGCGCCATCCCGGAGGCGCTGCTCGAGTCCGAGCTGTTCGGCCACGTGAAGGGCGCGTTCACCGGGGCGGTGG
CCACCCGCATCGGCAAGTTCCAGGCGGCCCACGGCGGCACGCTGTTCCTCGACGAGATCGGCGACATGCCGCTCGCGCTG
CAGGTGAAGATCCTGCGGGCGCTGCAGGATCGCGCCGTCACCAAGGTGGGCGACAACCGCCCGGAGGCGGTGGACCTGCG
GGTGGTGGCCGCCACGAACCGCGTGCTCGAGGACGAGATCCGCAAGGGCACGTTCCGCGAGGACCTGTACTACCGGCTGA
ACGTGGTCGCCATCCACCTGCCCCCGCTCCGCGATCGCGGCGAGGACGTGGTGGTCATCGGCAAGTACTTCCTGCAGAAG
TACGCGAAGGAGTTCGGCGCGCGCGTGCGCGGGTTCACCCCCGGCGCGCTCGTGGCCATGCGCAAGTACGCGTGGCCGGG
CAACATCCGCGAGCTCGAGAACCGGGTGAAGAAGGCGGTGGTGCTGGCCGACCGCGCGCTGGTCTCGGCGGAGGACCTCG
ATCTCCGCCCGGAGATCCTCGAGCCCATCCTCCCGCTCGCCCAGGCGAAGGAGGAGTTCCAGAAGCGGTACATCAACGAG
GTGCTGGAGCGGAACGCCGGGAACCGCACCAAGACCGCGAAGGACCTGGGCGTGGACCCGCGCACCGTGTTCCGCCACCT
CGAGAAGCTCGAGGCCGAGCGGCGCGGCCAGGTCCTGCCGCCCGACGACGAGGAGACCGAGGCGTGA

Upstream 100 bases:

>100_bases
GCCCATCGCCACTTCGTCCCCATCGTCGAGACGGAGATGGGGCCGGGCGGCGAGCCGGCCGGCGCGTCGCTGAAGCTCGA
GTGGAGGTACTAGGGGACCC

Downstream 100 bases:

>100_bases
ACCGTCCCCTCCTGCCCGCGGCCCTGGGCGCGCTCGCGCTCGCGCTGGCCGGCTGCCCGCTCCCGCAGCCGCTCCCCGAC
TACCCCAAGGGCGGCACCAT

Product: Fis Family transcriptional regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 608; Mature: 607

Protein sequence:

>608_residues
MATLIVRGPDGSEREVALVKRITSVGRDPENDVPVEDPALPATALHIHFDGKDYNAAAHDRSDMTVNGKRRGAWRLGPGD
RIRVAGTELTFEAVARTPLPSARPIAGQRLQALETLVRFSERLLGATDLNRLLDELMDALLEVTHADKGFLILLEDGEMS
VRAARNVARETIEGAVERVSDSIIRRVVETRRALVVADALHDSEWSGSTSVVNLKLCSVMCAPLMQKGEVFGVIYLGNDN
VVSLFDERALELLAPFAAQASLLVQNAMLLDSLRRENLSLKEAVASRQYGDLIGAGASMREVYRRIDKVAGTDISVLVSG
ETGTGKEVVAREIHRRSTRATGPFVAVNCGAIPEALLESELFGHVKGAFTGAVATRIGKFQAAHGGTLFLDEIGDMPLAL
QVKILRALQDRAVTKVGDNRPEAVDLRVVAATNRVLEDEIRKGTFREDLYYRLNVVAIHLPPLRDRGEDVVVIGKYFLQK
YAKEFGARVRGFTPGALVAMRKYAWPGNIRELENRVKKAVVLADRALVSAEDLDLRPEILEPILPLAQAKEEFQKRYINE
VLERNAGNRTKTAKDLGVDPRTVFRHLEKLEAERRGQVLPPDDEETEA

Sequences:

>Translated_608_residues
MATLIVRGPDGSEREVALVKRITSVGRDPENDVPVEDPALPATALHIHFDGKDYNAAAHDRSDMTVNGKRRGAWRLGPGD
RIRVAGTELTFEAVARTPLPSARPIAGQRLQALETLVRFSERLLGATDLNRLLDELMDALLEVTHADKGFLILLEDGEMS
VRAARNVARETIEGAVERVSDSIIRRVVETRRALVVADALHDSEWSGSTSVVNLKLCSVMCAPLMQKGEVFGVIYLGNDN
VVSLFDERALELLAPFAAQASLLVQNAMLLDSLRRENLSLKEAVASRQYGDLIGAGASMREVYRRIDKVAGTDISVLVSG
ETGTGKEVVAREIHRRSTRATGPFVAVNCGAIPEALLESELFGHVKGAFTGAVATRIGKFQAAHGGTLFLDEIGDMPLAL
QVKILRALQDRAVTKVGDNRPEAVDLRVVAATNRVLEDEIRKGTFREDLYYRLNVVAIHLPPLRDRGEDVVVIGKYFLQK
YAKEFGARVRGFTPGALVAMRKYAWPGNIRELENRVKKAVVLADRALVSAEDLDLRPEILEPILPLAQAKEEFQKRYINE
VLERNAGNRTKTAKDLGVDPRTVFRHLEKLEAERRGQVLPPDDEETEA
>Mature_607_residues
ATLIVRGPDGSEREVALVKRITSVGRDPENDVPVEDPALPATALHIHFDGKDYNAAAHDRSDMTVNGKRRGAWRLGPGDR
IRVAGTELTFEAVARTPLPSARPIAGQRLQALETLVRFSERLLGATDLNRLLDELMDALLEVTHADKGFLILLEDGEMSV
RAARNVARETIEGAVERVSDSIIRRVVETRRALVVADALHDSEWSGSTSVVNLKLCSVMCAPLMQKGEVFGVIYLGNDNV
VSLFDERALELLAPFAAQASLLVQNAMLLDSLRRENLSLKEAVASRQYGDLIGAGASMREVYRRIDKVAGTDISVLVSGE
TGTGKEVVAREIHRRSTRATGPFVAVNCGAIPEALLESELFGHVKGAFTGAVATRIGKFQAAHGGTLFLDEIGDMPLALQ
VKILRALQDRAVTKVGDNRPEAVDLRVVAATNRVLEDEIRKGTFREDLYYRLNVVAIHLPPLRDRGEDVVVIGKYFLQKY
AKEFGARVRGFTPGALVAMRKYAWPGNIRELENRVKKAVVLADRALVSAEDLDLRPEILEPILPLAQAKEEFQKRYINEV
LERNAGNRTKTAKDLGVDPRTVFRHLEKLEAERRGQVLPPDDEETEA

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=353, Percent_Identity=45.3257790368272, Blast_Score=306, Evalue=3e-84,
Organism=Escherichia coli, GI1790437, Length=312, Percent_Identity=47.1153846153846, Blast_Score=279, Evalue=3e-76,
Organism=Escherichia coli, GI87082117, Length=399, Percent_Identity=41.1027568922306, Blast_Score=271, Evalue=1e-73,
Organism=Escherichia coli, GI1790299, Length=385, Percent_Identity=38.961038961039, Blast_Score=264, Evalue=2e-71,
Organism=Escherichia coli, GI1789233, Length=319, Percent_Identity=45.4545454545455, Blast_Score=262, Evalue=4e-71,
Organism=Escherichia coli, GI1788905, Length=284, Percent_Identity=44.7183098591549, Blast_Score=257, Evalue=1e-69,
Organism=Escherichia coli, GI87082152, Length=325, Percent_Identity=44.3076923076923, Blast_Score=257, Evalue=2e-69,
Organism=Escherichia coli, GI1789087, Length=318, Percent_Identity=42.1383647798742, Blast_Score=253, Evalue=3e-68,
Organism=Escherichia coli, GI1786524, Length=318, Percent_Identity=40.8805031446541, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI87081872, Length=235, Percent_Identity=43.8297872340426, Blast_Score=199, Evalue=4e-52,
Organism=Escherichia coli, GI1787583, Length=304, Percent_Identity=36.8421052631579, Blast_Score=193, Evalue=2e-50,
Organism=Escherichia coli, GI1789828, Length=267, Percent_Identity=35.5805243445693, Blast_Score=143, Evalue=4e-35,
Organism=Escherichia coli, GI87081858, Length=293, Percent_Identity=28.6689419795222, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 66954; Mature: 66822

Theoretical pI: Translated: 6.54; Mature: 6.54

Prosite motif: PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATLIVRGPDGSEREVALVKRITSVGRDPENDVPVEDPALPATALHIHFDGKDYNAAAHD
CCEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCC
RSDMTVNGKRRGAWRLGPGDRIRVAGTELTFEAVARTPLPSARPIAGQRLQALETLVRFS
CCCCEECCCCCCCEECCCCCEEEEECCCEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
ERLLGATDLNRLLDELMDALLEVTHADKGFLILLEDGEMSVRAARNVARETIEGAVERVS
HHHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
DSIIRRVVETRRALVVADALHDSEWSGSTSVVNLKLCSVMCAPLMQKGEVFGVIYLGNDN
HHHHHHHHHHHHHEEEHHHHCCCCCCCCCCEEEHHHHHHHHHHHHCCCCEEEEEEECCCC
VVSLFDERALELLAPFAAQASLLVQNAMLLDSLRRENLSLKEAVASRQYGDLIGAGASMR
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHH
EVYRRIDKVAGTDISVLVSGETGTGKEVVAREIHRRSTRATGPFVAVNCGAIPEALLESE
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHH
LFGHVKGAFTGAVATRIGKFQAAHGGTLFLDEIGDMPLALQVKILRALQDRAVTKVGDNR
HHHHHHHHHHHHHHHHHHHHEECCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
PEAVDLRVVAATNRVLEDEIRKGTFREDLYYRLNVVAIHLPPLRDRGEDVVVIGKYFLQK
CCEEEEEEEEHHHHHHHHHHHCCCCHHHHEEEEEEEEEECCCCCCCCCCEEEEHHHHHHH
YAKEFGARVRGFTPGALVAMRKYAWPGNIRELENRVKKAVVLADRALVSAEDLDLRPEIL
HHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
EPILPLAQAKEEFQKRYINEVLERNAGNRTKTAKDLGVDPRTVFRHLEKLEAERRGQVLP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCC
PDDEETEA
CCCCCCCC
>Mature Secondary Structure 
ATLIVRGPDGSEREVALVKRITSVGRDPENDVPVEDPALPATALHIHFDGKDYNAAAHD
CEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEEEEEECCCCCCCCCCC
RSDMTVNGKRRGAWRLGPGDRIRVAGTELTFEAVARTPLPSARPIAGQRLQALETLVRFS
CCCCEECCCCCCCEECCCCCEEEEECCCEEHHHHHCCCCCCCCCCHHHHHHHHHHHHHHH
ERLLGATDLNRLLDELMDALLEVTHADKGFLILLEDGEMSVRAARNVARETIEGAVERVS
HHHHCHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCHHHHHHHHHHHHHHHHHHHHHH
DSIIRRVVETRRALVVADALHDSEWSGSTSVVNLKLCSVMCAPLMQKGEVFGVIYLGNDN
HHHHHHHHHHHHHEEEHHHHCCCCCCCCCCEEEHHHHHHHHHHHHCCCCEEEEEEECCCC
VVSLFDERALELLAPFAAQASLLVQNAMLLDSLRRENLSLKEAVASRQYGDLIGAGASMR
EEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHCCCHHHH
EVYRRIDKVAGTDISVLVSGETGTGKEVVAREIHRRSTRATGPFVAVNCGAIPEALLESE
HHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHH
LFGHVKGAFTGAVATRIGKFQAAHGGTLFLDEIGDMPLALQVKILRALQDRAVTKVGDNR
HHHHHHHHHHHHHHHHHHHHEECCCCEEEEHHHCCCCHHHHHHHHHHHHHHHHHHCCCCC
PEAVDLRVVAATNRVLEDEIRKGTFREDLYYRLNVVAIHLPPLRDRGEDVVVIGKYFLQK
CCEEEEEEEEHHHHHHHHHHHCCCCHHHHEEEEEEEEEECCCCCCCCCCEEEEHHHHHHH
YAKEFGARVRGFTPGALVAMRKYAWPGNIRELENRVKKAVVLADRALVSAEDLDLRPEIL
HHHHHCCCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHH
EPILPLAQAKEEFQKRYINEVLERNAGNRTKTAKDLGVDPRTVFRHLEKLEAERRGQVLP
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCHHHHHHHHHHHHHHHCCCCCC
PDDEETEA
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]