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The map label for this gene is tmk [H]

Identifier: 220917316

GI number: 220917316

Start: 2459240

End: 2459899

Strand: Direct

Name: tmk [H]

Synonym: A2cp1_2216

Alternate gene names: 220917316

Gene position: 2459240-2459899 (Clockwise)

Preceding gene: 220917315

Following gene: 220917317

Centisome position: 48.9

GC content: 77.27

Gene sequence:

>660_bases
GTGAGCGCGGCGGGGGGCGGCGGACGCGGACGTCCGGCCGCTCGCGGCCGCTTCGTCGTCCTCGAGGGGCTCGACGGCGC
CGGGACCACCACGCAGGCGCGGCTGCTCGGCGAGCGGCTCCGCGCGGACGGCCGCACCGCCCACGTCACCGCCGAGCCGT
CCGGGGGGCCGGTGGGCGCGCTCGTTCGCCAGGTGCTGACGCGCCGCGTGACCGGCGTCGCGGGCGCGGACTTCGACCCG
CACGCGCTCGCGCTGCTGTTCGCGGCGGATCGCCGCGATCACCGGGCCGTCGAGATCGACCCGAAGCTGGCCGCGGGGAT
CGACGTCGTCTCCGACCGCTACACGCTGTCGTCGCTCGCCTACCAGGGCGCGGCGCTCGGGGAGATGGAGTGGGTCCGCC
AGGTGAACGGGGCGGCGGGCCCGCCGGACGCGACGCTGTTCCTCCGGGTGCGGCCCGAGGTCGCGCTGCGGCGCCGGCGC
GCCGCGTCGCTCGACCGCGAGATCTACGAGGTGGGCGCGTTCCAGCGGAAGGTGGCCGCCGAGTACGATCGCGCCATCGC
GCTGTTGCGCCAGGCGGGCGAGAGCGTGATCGAGATCGACGGTGAGCGCCCGGTGGAGGCCGTGGCCGCCGCGGTGTGGG
CGGCCGTCTCGACCCTGTAG

Upstream 100 bases:

>100_bases
TCGCCGTCCGCTCCTTCCTGCGCGCTCGCCGCCTCATGCGCGAGGAGGACGCGCTGTACGCGCGGTTCCGCGCGCTGCGC
GAGACGCTGAGGCTGGATCC

Downstream 100 bases:

>100_bases
CCGGCTGGCGTCCGCGCGCGGGACGGGTTACGGGAGGGGGCGATGCCCCGCACGCCCACCGCCGCCCTCGTCGTCGTCGG
CAACGAGGTCCTCTCCGCCA

Product: dTMP kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 219; Mature: 218

Protein sequence:

>219_residues
MSAAGGGGRGRPAARGRFVVLEGLDGAGTTTQARLLGERLRADGRTAHVTAEPSGGPVGALVRQVLTRRVTGVAGADFDP
HALALLFAADRRDHRAVEIDPKLAAGIDVVSDRYTLSSLAYQGAALGEMEWVRQVNGAAGPPDATLFLRVRPEVALRRRR
AASLDREIYEVGAFQRKVAAEYDRAIALLRQAGESVIEIDGERPVEAVAAAVWAAVSTL

Sequences:

>Translated_219_residues
MSAAGGGGRGRPAARGRFVVLEGLDGAGTTTQARLLGERLRADGRTAHVTAEPSGGPVGALVRQVLTRRVTGVAGADFDP
HALALLFAADRRDHRAVEIDPKLAAGIDVVSDRYTLSSLAYQGAALGEMEWVRQVNGAAGPPDATLFLRVRPEVALRRRR
AASLDREIYEVGAFQRKVAAEYDRAIALLRQAGESVIEIDGERPVEAVAAAVWAAVSTL
>Mature_218_residues
SAAGGGGRGRPAARGRFVVLEGLDGAGTTTQARLLGERLRADGRTAHVTAEPSGGPVGALVRQVLTRRVTGVAGADFDPH
ALALLFAADRRDHRAVEIDPKLAAGIDVVSDRYTLSSLAYQGAALGEMEWVRQVNGAAGPPDATLFLRVRPEVALRRRRA
ASLDREIYEVGAFQRKVAAEYDRAIALLRQAGESVIEIDGERPVEAVAAAVWAAVSTL

Specific function: Phosphorylation Of Dtmp To Form Dtdp In Both De Novo And Salvage Pathways Of Dttp Synthesis. [C]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Homo sapiens, GI42544174, Length=198, Percent_Identity=31.8181818181818, Blast_Score=87, Evalue=9e-18,
Organism=Homo sapiens, GI259013537, Length=113, Percent_Identity=37.1681415929204, Blast_Score=65, Evalue=4e-11,
Organism=Escherichia coli, GI1787340, Length=209, Percent_Identity=34.4497607655502, Blast_Score=80, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17535647, Length=176, Percent_Identity=36.3636363636364, Blast_Score=94, Evalue=7e-20,
Organism=Saccharomyces cerevisiae, GI6322517, Length=207, Percent_Identity=28.0193236714976, Blast_Score=77, Evalue=2e-15,
Organism=Drosophila melanogaster, GI28573735, Length=199, Percent_Identity=28.643216080402, Blast_Score=81, Evalue=5e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23144; Mature: 23012

Theoretical pI: Translated: 9.59; Mature: 9.59

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
0.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAAGGGGRGRPAARGRFVVLEGLDGAGTTTQARLLGERLRADGRTAHVTAEPSGGPVGA
CCCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHH
LVRQVLTRRVTGVAGADFDPHALALLFAADRRDHRAVEIDPKLAAGIDVVSDRYTLSSLA
HHHHHHHHHHHCCCCCCCCHHHEEEEEHHCCCCCCEEEECCHHHHCCHHHCCCHHHHHHH
YQGAALGEMEWVRQVNGAAGPPDATLFLRVRPEVALRRRRAASLDREIYEVGAFQRKVAA
HCCCCHHHHHHHHHHCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYDRAIALLRQAGESVIEIDGERPVEAVAAAVWAAVSTL
HHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SAAGGGGRGRPAARGRFVVLEGLDGAGTTTQARLLGERLRADGRTAHVTAEPSGGPVGA
CCCCCCCCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHCCCCCEEEEEECCCCCCHHH
LVRQVLTRRVTGVAGADFDPHALALLFAADRRDHRAVEIDPKLAAGIDVVSDRYTLSSLA
HHHHHHHHHHHCCCCCCCCHHHEEEEEHHCCCCCCEEEECCHHHHCCHHHCCCHHHHHHH
YQGAALGEMEWVRQVNGAAGPPDATLFLRVRPEVALRRRRAASLDREIYEVGAFQRKVAA
HCCCCHHHHHHHHHHCCCCCCCCCEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EYDRAIALLRQAGESVIEIDGERPVEAVAAAVWAAVSTL
HHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11792869 [H]