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The map label for this gene is thrC [H]

Identifier: 220917314

GI number: 220917314

Start: 2457494

End: 2458852

Strand: Direct

Name: thrC [H]

Synonym: A2cp1_2214

Alternate gene names: 220917314

Gene position: 2457494-2458852 (Clockwise)

Preceding gene: 220917313

Following gene: 220917315

Centisome position: 48.86

GC content: 72.92

Gene sequence:

>1359_bases
ATGGCCGCGCCCGCGTTCTCGTCCTGGTTCCGCTGCGCGGACGGTTGCGACTTCCGCGCCGAGCTCACCGAGGTGGTCTA
CGAGTGCCCGCGCTGCGGCGGGCTGCTCGAGGTCGAGCACGACCGCGCCGCGCTCGCGACCCGGAGCGCCGCCGAGTGGA
AGGCGCTGTTCGACGGGCGCTTCAAGCTGGGCGCCTGGCCGTACGGCTCGGGGGTATGGGGCAAGAAGGAGTGGGTCTAC
CCCGGCATCGCCGACGCCAACGTCGTCTCGATGTTCGAGGGCGGCAGCCCGCTGCTCCGCATCGATCGCTACGCCCGCGA
ACTCGGCCTCGACGACGTGTGGCTGAAGGAGTGCGGGGTCACGCACACCGGGTCGTTCAAGGACCTGGGCATGACCGTGC
TCGTCTCCGCGGTGAAGGAGATGCGGGCCCGCGGCGCCGCCGTGCGCGCGGTCGCCTGCGCCTCCACCGGCGACACCTCG
GCCGCGCTCTCCGCCTACTGCGCCGCCGCCGGCATCCCCAGCGTGGTGCTGCTGCCGCGCGGCAAGATCTCCACCGCGCA
GCTCGTCCAGCCCATCTCGAACGGCGCGCTGGTGCTCGAGCTCGACACCGACTTCGACGGCTGCATGCAGGTGGTGAAGC
AGCTCAGCCGCACCAAGGACATCTACCTCGCGAACTCGATGAACTCGCTGCGCATCGAGGGGCAGAAGACCGCCTCCATC
GAGATCGCGCAGCAGCTCGGCTGGACCTCGCCGGACTGGATCGTGATCCCGGGCGGCAACCTGGGGAACGCGAGCGCGGT
CGGGAAGGGCTTCCTGCTCATGAAGGAGCTGGGCGTGGTGGACCGGCTCCCGCGCCTGGTGGTCGCGCAGGCGGAGCACG
CGAACCCGCTCTGGCGGGCCACCACCGGCGCCGGGGTGAAGCCCACCGCCGCGGTCGAGGTCGCGCCGCTCGCCGCCCGG
AAGACGCTCGCCTCCGCCATCCAGATCGGCGCCCCGGTGTCGGCGCGCCGCGCGCTGCGCGCGCTGGAGGCGCTCGACGG
CGTGGTCGAGCAGGCCAGCGAGCAGGAGCTCGCCGACGCGGCCGCGCGCGCGGACCGGGCCGGCATGTTCACCTGTCCGC
ACACCGGCGTGGCGCTCGCCGCGCTCGAGAAGCTCGCCGCGCGCGGGGTGGTGAAGCGGGGCGAGCGGGTGGTGGTGATC
TCCACCGCGCACGGCCTCAAGTTCTCGGACTTCAAGGTCGGCTACCACGACCAGACCTTGCCCGGGATCCGCGCCGGGCT
GCGCAATCCGGCCGTCCAGCTCCCCGCCACGCTCGGCGCGGTCCAGGACGCGATTGCCGGCCGCTTCGGGCGAGGGTAG

Upstream 100 bases:

>100_bases
GCAGCGTCCGCATCGCGCTCATCGTGGACGAGCCGCGCGTGCAGCTCGCCGCCGAGCGGATCGAGAAGTTCCTCAAGAAG
GGCCCGGGCGGGCGGTAGCG

Downstream 100 bases:

>100_bases
AACGCGGCCCATGAGCACCCCCACGCCCACCCATCCCGGCGCCGAGACCGGCGCGCTCCGCGCCGAGCACGACGCGCTCG
CGAAGCGACTCGAGGTGCGC

Product: threonine synthase

Products: NA

Alternate protein names: TS [H]

Number of amino acids: Translated: 452; Mature: 451

Protein sequence:

>452_residues
MAAPAFSSWFRCADGCDFRAELTEVVYECPRCGGLLEVEHDRAALATRSAAEWKALFDGRFKLGAWPYGSGVWGKKEWVY
PGIADANVVSMFEGGSPLLRIDRYARELGLDDVWLKECGVTHTGSFKDLGMTVLVSAVKEMRARGAAVRAVACASTGDTS
AALSAYCAAAGIPSVVLLPRGKISTAQLVQPISNGALVLELDTDFDGCMQVVKQLSRTKDIYLANSMNSLRIEGQKTASI
EIAQQLGWTSPDWIVIPGGNLGNASAVGKGFLLMKELGVVDRLPRLVVAQAEHANPLWRATTGAGVKPTAAVEVAPLAAR
KTLASAIQIGAPVSARRALRALEALDGVVEQASEQELADAAARADRAGMFTCPHTGVALAALEKLAARGVVKRGERVVVI
STAHGLKFSDFKVGYHDQTLPGIRAGLRNPAVQLPATLGAVQDAIAGRFGRG

Sequences:

>Translated_452_residues
MAAPAFSSWFRCADGCDFRAELTEVVYECPRCGGLLEVEHDRAALATRSAAEWKALFDGRFKLGAWPYGSGVWGKKEWVY
PGIADANVVSMFEGGSPLLRIDRYARELGLDDVWLKECGVTHTGSFKDLGMTVLVSAVKEMRARGAAVRAVACASTGDTS
AALSAYCAAAGIPSVVLLPRGKISTAQLVQPISNGALVLELDTDFDGCMQVVKQLSRTKDIYLANSMNSLRIEGQKTASI
EIAQQLGWTSPDWIVIPGGNLGNASAVGKGFLLMKELGVVDRLPRLVVAQAEHANPLWRATTGAGVKPTAAVEVAPLAAR
KTLASAIQIGAPVSARRALRALEALDGVVEQASEQELADAAARADRAGMFTCPHTGVALAALEKLAARGVVKRGERVVVI
STAHGLKFSDFKVGYHDQTLPGIRAGLRNPAVQLPATLGAVQDAIAGRFGRG
>Mature_451_residues
AAPAFSSWFRCADGCDFRAELTEVVYECPRCGGLLEVEHDRAALATRSAAEWKALFDGRFKLGAWPYGSGVWGKKEWVYP
GIADANVVSMFEGGSPLLRIDRYARELGLDDVWLKECGVTHTGSFKDLGMTVLVSAVKEMRARGAAVRAVACASTGDTSA
ALSAYCAAAGIPSVVLLPRGKISTAQLVQPISNGALVLELDTDFDGCMQVVKQLSRTKDIYLANSMNSLRIEGQKTASIE
IAQQLGWTSPDWIVIPGGNLGNASAVGKGFLLMKELGVVDRLPRLVVAQAEHANPLWRATTGAGVKPTAAVEVAPLAARK
TLASAIQIGAPVSARRALRALEALDGVVEQASEQELADAAARADRAGMFTCPHTGVALAALEKLAARGVVKRGERVVVIS
TAHGLKFSDFKVGYHDQTLPGIRAGLRNPAVQLPATLGAVQDAIAGRFGRG

Specific function: Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine [H]

COG id: COG0498

COG function: function code E; Threonine synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the threonine synthase family [H]

Homologues:

Organism=Escherichia coli, GI1786185, Length=316, Percent_Identity=26.5822784810127, Blast_Score=71, Evalue=1e-13,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001926
- InterPro:   IPR000634
- InterPro:   IPR004450 [H]

Pfam domain/function: PF00291 PALP [H]

EC number: =4.2.3.1 [H]

Molecular weight: Translated: 47762; Mature: 47631

Theoretical pI: Translated: 8.48; Mature: 8.48

Prosite motif: PS00165 DEHYDRATASE_SER_THR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAAPAFSSWFRCADGCDFRAELTEVVYECPRCGGLLEVEHDRAALATRSAAEWKALFDGR
CCCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHCCHHHHHHHHCCC
FKLGAWPYGSGVWGKKEWVYPGIADANVVSMFEGGSPLLRIDRYARELGLDDVWLKECGV
EEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHHCCC
THTGSFKDLGMTVLVSAVKEMRARGAAVRAVACASTGDTSAALSAYCAAAGIPSVVLLPR
CCCCCHHHHHHHHHHHHHHHHHHCCHHEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECC
GKISTAQLVQPISNGALVLELDTDFDGCMQVVKQLSRTKDIYLANSMNSLRIEGQKTASI
CCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCEEECCCCCHHH
EIAQQLGWTSPDWIVIPGGNLGNASAVGKGFLLMKELGVVDRLPRLVVAQAEHANPLWRA
HHHHHCCCCCCCEEEECCCCCCCHHHHCCHHHHHHHHCHHHHCCHHHHHCCCCCCCCEEE
TTGAGVKPTAAVEVAPLAARKTLASAIQIGAPVSARRALRALEALDGVVEQASEQELADA
CCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARADRAGMFTCPHTGVALAALEKLAARGVVKRGERVVVISTAHGLKFSDFKVGYHDQTL
HHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEECCEECCCCCCCC
PGIRAGLRNPAVQLPATLGAVQDAIAGRFGRG
HHHHHHHCCCCEECCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
AAPAFSSWFRCADGCDFRAELTEVVYECPRCGGLLEVEHDRAALATRSAAEWKALFDGR
CCCCHHHHHHHCCCCCHHHHHHHHHHHCCCCCCEEEECCCHHHHHHCCHHHHHHHHCCC
FKLGAWPYGSGVWGKKEWVYPGIADANVVSMFEGGSPLLRIDRYARELGLDDVWLKECGV
EEECCCCCCCCCCCCCCCCCCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCHHHHHHCCC
THTGSFKDLGMTVLVSAVKEMRARGAAVRAVACASTGDTSAALSAYCAAAGIPSVVLLPR
CCCCCHHHHHHHHHHHHHHHHHHCCHHEEEEEECCCCCCHHHHHHHHHHCCCCEEEEECC
GKISTAQLVQPISNGALVLELDTDFDGCMQVVKQLSRTKDIYLANSMNSLRIEGQKTASI
CCCCHHHHHHHCCCCEEEEEECCCHHHHHHHHHHHHCCCCEEEECCCCCEEECCCCCHHH
EIAQQLGWTSPDWIVIPGGNLGNASAVGKGFLLMKELGVVDRLPRLVVAQAEHANPLWRA
HHHHHCCCCCCCEEEECCCCCCCHHHHCCHHHHHHHHCHHHHCCHHHHHCCCCCCCCEEE
TTGAGVKPTAAVEVAPLAARKTLASAIQIGAPVSARRALRALEALDGVVEQASEQELADA
CCCCCCCCCCEEEECHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
AARADRAGMFTCPHTGVALAALEKLAARGVVKRGERVVVISTAHGLKFSDFKVGYHDQTL
HHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHCCCEEEEEEECCCCEECCEECCCCCCCC
PGIRAGLRNPAVQLPATLGAVQDAIAGRFGRG
HHHHHHHCCCCEECCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8688087 [H]