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The map label for this gene is pcm

Identifier: 220917311

GI number: 220917311

Start: 2455054

End: 2455683

Strand: Direct

Name: pcm

Synonym: A2cp1_2211

Alternate gene names: 220917311

Gene position: 2455054-2455683 (Clockwise)

Preceding gene: 220917310

Following gene: 220917312

Centisome position: 48.81

GC content: 75.87

Gene sequence:

>630_bases
GTGAGCACGGAGCTCGCCGCCTGGCTCGGCCACATGGGCATCCGCGACCGGCGCGTCCTCGACGCGATCGCGGCGCTCGA
CCGCGCGCGCTTCGTGTCCCGCGACCTCTCGGCCGAGGCCTACGCCGATCGGCCGCTCCCCATCGGCTTCGGCCAGACCA
TCTCGCAGCCGTACGTGGTGGCGTTCATGACCGAGGCGCTCGAGCTCGAGGGCGGCGAGCGCGTGCTGGAGGTCGGCACC
GGCTCCGGTTACCAGACCGCGCTGCTGGCGCGGCTCGCCGGCGAGGTGTGGTCGGTCGAGATCGTCCCCGGGCTGGCGGC
GCGGGCGCGTGCGCTGCTGCTCGAGGAGCTCGGCCTCGCGAACGTCCACCTGCGCGAGGGCGACGGCGCGCTGGGGTGGC
CGGAGGCGGCGCCGTTCGAGCGCATCCTCGTCACCGCCGCCGCGCCGCGCGTCCCGCCGGCGCTCCGGGCGCAGCTCGCG
CCGGGCGGACGGATGGTGCTGCCGGTGGGTGAGGCGGAGTCGGAGCAGGTGCTCCGCGTGGTCGAGCGCGGCGCGGACGG
GATCGAGGAGAGCGAGGACGTCCTCCCCGTCCGCTTCGTCCCGCTCACGCACCTCCCGCCTGCGGTATGA

Upstream 100 bases:

>100_bases
AGGTGGGCTAGCGCCGCGGCCGCCCCCGGCGGGCTCGCCCCGGCGGACGGCGGCGGCGCGCCACCTCGCGGGCGCGGCGC
GGGAGTGCCTAGCATCGGGC

Downstream 100 bases:

>100_bases
TCCCCGCGCATGATCGTCTGCCCCGTGTGCGACCACCCCCAGGCGCTCGGCTCCGAGTGCGAGGTCTGCGGCAAGCGCCT
CGCTCTCCACGGCGTGCCGG

Product: protein-L-isoaspartate O-methyltransferase

Products: NA

Alternate protein names: L-isoaspartyl protein carboxyl methyltransferase; Protein L-isoaspartyl methyltransferase; Protein-beta-aspartate methyltransferase; PIMT

Number of amino acids: Translated: 209; Mature: 208

Protein sequence:

>209_residues
MSTELAAWLGHMGIRDRRVLDAIAALDRARFVSRDLSAEAYADRPLPIGFGQTISQPYVVAFMTEALELEGGERVLEVGT
GSGYQTALLARLAGEVWSVEIVPGLAARARALLLEELGLANVHLREGDGALGWPEAAPFERILVTAAAPRVPPALRAQLA
PGGRMVLPVGEAESEQVLRVVERGADGIEESEDVLPVRFVPLTHLPPAV

Sequences:

>Translated_209_residues
MSTELAAWLGHMGIRDRRVLDAIAALDRARFVSRDLSAEAYADRPLPIGFGQTISQPYVVAFMTEALELEGGERVLEVGT
GSGYQTALLARLAGEVWSVEIVPGLAARARALLLEELGLANVHLREGDGALGWPEAAPFERILVTAAAPRVPPALRAQLA
PGGRMVLPVGEAESEQVLRVVERGADGIEESEDVLPVRFVPLTHLPPAV
>Mature_208_residues
STELAAWLGHMGIRDRRVLDAIAALDRARFVSRDLSAEAYADRPLPIGFGQTISQPYVVAFMTEALELEGGERVLEVGTG
SGYQTALLARLAGEVWSVEIVPGLAARARALLLEELGLANVHLREGDGALGWPEAAPFERILVTAAAPRVPPALRAQLAP
GGRMVLPVGEAESEQVLRVVERGADGIEESEDVLPVRFVPLTHLPPAV

Specific function: Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins

COG id: COG2518

COG function: function code O; Protein-L-isoaspartate carboxylmethyltransferase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. L- isoaspartyl/D-aspartyl protein methyltransferase family

Homologues:

Organism=Homo sapiens, GI226530908, Length=199, Percent_Identity=37.6884422110553, Blast_Score=114, Evalue=7e-26,
Organism=Escherichia coli, GI1789100, Length=190, Percent_Identity=53.6842105263158, Blast_Score=170, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI71983477, Length=196, Percent_Identity=37.2448979591837, Blast_Score=105, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI193207222, Length=194, Percent_Identity=36.0824742268041, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17981723, Length=201, Percent_Identity=36.81592039801, Blast_Score=107, Evalue=5e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PIMT_ANAD2 (B8J9E3)

Other databases:

- EMBL:   CP001359
- RefSeq:   YP_002492615.1
- ProteinModelPortal:   B8J9E3
- SMR:   B8J9E3
- GeneID:   7297221
- GenomeReviews:   CP001359_GR
- KEGG:   acp:A2cp1_2211
- HOGENOM:   HBG699907
- ProtClustDB:   CLSK945842
- GO:   GO:0005737
- HAMAP:   MF_00090
- InterPro:   IPR000682
- PANTHER:   PTHR11579
- TIGRFAMs:   TIGR00080

Pfam domain/function: PF01135 PCMT

EC number: =2.1.1.77

Molecular weight: Translated: 22341; Mature: 22210

Theoretical pI: Translated: 4.55; Mature: 4.55

Prosite motif: PS01279 PCMT

Important sites: ACT_SITE 55-55

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
1.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTELAAWLGHMGIRDRRVLDAIAALDRARFVSRDLSAEAYADRPLPIGFGQTISQPYVV
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCE
AFMTEALELEGGERVLEVGTGSGYQTALLARLAGEVWSVEIVPGLAARARALLLEELGLA
EHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCC
NVHLREGDGALGWPEAAPFERILVTAAAPRVPPALRAQLAPGGRMVLPVGEAESEQVLRV
EEEEECCCCCCCCCCCCCHHHHEEECCCCCCCHHHHHEECCCCEEEEECCCCCHHHHHHH
VERGADGIEESEDVLPVRFVPLTHLPPAV
HHHCCCCCCCCCCCCEEEEECCCCCCCCC
>Mature Secondary Structure 
STELAAWLGHMGIRDRRVLDAIAALDRARFVSRDLSAEAYADRPLPIGFGQTISQPYVV
CCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCCCCCCCCE
AFMTEALELEGGERVLEVGTGSGYQTALLARLAGEVWSVEIVPGLAARARALLLEELGLA
EHHHHHHHCCCCCEEEEECCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCC
NVHLREGDGALGWPEAAPFERILVTAAAPRVPPALRAQLAPGGRMVLPVGEAESEQVLRV
EEEEECCCCCCCCCCCCCHHHHEEECCCCCCCHHHHHEECCCCEEEEECCCCCHHHHHHH
VERGADGIEESEDVLPVRFVPLTHLPPAV
HHHCCCCCCCCCCCCEEEEECCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA