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The map label for this gene is czcD [H]

Identifier: 220917295

GI number: 220917295

Start: 2436327

End: 2437355

Strand: Direct

Name: czcD [H]

Synonym: A2cp1_2195

Alternate gene names: 220917295

Gene position: 2436327-2437355 (Clockwise)

Preceding gene: 220917292

Following gene: 220917296

Centisome position: 48.44

GC content: 73.37

Gene sequence:

>1029_bases
ATGTCGCACGGCCACCCGCACGTCCACGGAGCGCACGAGCCCCCGGCCACGGCCGGGACAGGAGGGGCGCGGGACTGGTC
CGGCGAGCGCCGCGGCGCGTGCGGCCTCCACCACGCCGAGCACGAGCGGGCGCACCAGCACGGCGCGCACGGGGCGGGCG
CGAGCCTGCGCCGCCTGGGGATCTCGCTCGCGCTCACGGCCGCGATCATGGTCGCCGAGGCGGTGGGCGGCTGGCTGTCG
GGCTCGCTGGCGCTCGTCTCCGACGCGGGCCACATGCTCACCGACGCGGGCGCGCTGGGGCTCGCGCTCGTCGCGGCCTG
GCTCTCCACCCGGCCTGCGGACGACAAGCGCACCTTCGGCTACCGCCGCGCCGAGGTGCTCGGGGCGCAGCTCAACGTGG
GCGCGCTGGTGGTGCTCTCGGGCTGGATCGCCTGGGAGGCGGTCCAGCGCCTGCGCGATCCGGGCCCGCCCATCCGGCTC
GAGCTCATGGCGTTCGTGGCCGGCATCGGCCTCGCGGCGAACCTGGCCATCCTCTGGTTCCTGCACGGTGAGCACTCGCT
CAACGCGCGCTCGGCGTTCCTGCACGTCCTCTCCGACACCATCTCCTCGGTGGCCATCCTCGCCGGCGCGGTGGTGATGG
GCATCCGGCCGGACCTCCGCTGGATCGACCCGGTGCTCTCGCTCGCCATCGCGCTCCTCATCCTCTGGGGCGCGGTGCGG
CTCATCCTCGAGATCACCGACATCCTGATGGAGAGCGTGCCCGCGCACCTCGACGCGGGGGCGATCGGCTCGCAGATGGA
GTGCTGCCCGGGCGTGGTCGCGGTGCACGACCTGCACATCTGGACCATCTCGAGCGGCATGCTCTCTCTCTCCGCGCACC
TCGTGGTGGAGCCGGGGAGCGTGGGCCGCAACGACGAGATCCTCACGGCGGTGAAGCGCGACCTGCGCCACCGGTACGGG
ATCGACCACACCACGCTGCAGATCGAGTCGGCCGAGTACGCGCACGTCGACGACGTGCACCGGCACTGA

Upstream 100 bases:

>100_bases
GCCGCGCCCGCGTGCGATGCGGCGGGGCCTTGCCGTGCCGCCCGCGCGTGCGCGTCCATGGAGCATGGCGTAGACTGCAC
GGCCCGGAGGTTCAAGCGGA

Downstream 100 bases:

>100_bases
TCCCGCCCCGGCCGCCGAGTCGCGCTCCGATCCCTGCACCGCGCGCCCGCGCCCGCCGGCGCCGTCATAACGGACGGTTG
TTCGCTTGACCGGACAGACG

Product: cation diffusion facilitator family transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MSHGHPHVHGAHEPPATAGTGGARDWSGERRGACGLHHAEHERAHQHGAHGAGASLRRLGISLALTAAIMVAEAVGGWLS
GSLALVSDAGHMLTDAGALGLALVAAWLSTRPADDKRTFGYRRAEVLGAQLNVGALVVLSGWIAWEAVQRLRDPGPPIRL
ELMAFVAGIGLAANLAILWFLHGEHSLNARSAFLHVLSDTISSVAILAGAVVMGIRPDLRWIDPVLSLAIALLILWGAVR
LILEITDILMESVPAHLDAGAIGSQMECCPGVVAVHDLHIWTISSGMLSLSAHLVVEPGSVGRNDEILTAVKRDLRHRYG
IDHTTLQIESAEYAHVDDVHRH

Sequences:

>Translated_342_residues
MSHGHPHVHGAHEPPATAGTGGARDWSGERRGACGLHHAEHERAHQHGAHGAGASLRRLGISLALTAAIMVAEAVGGWLS
GSLALVSDAGHMLTDAGALGLALVAAWLSTRPADDKRTFGYRRAEVLGAQLNVGALVVLSGWIAWEAVQRLRDPGPPIRL
ELMAFVAGIGLAANLAILWFLHGEHSLNARSAFLHVLSDTISSVAILAGAVVMGIRPDLRWIDPVLSLAIALLILWGAVR
LILEITDILMESVPAHLDAGAIGSQMECCPGVVAVHDLHIWTISSGMLSLSAHLVVEPGSVGRNDEILTAVKRDLRHRYG
IDHTTLQIESAEYAHVDDVHRH
>Mature_341_residues
SHGHPHVHGAHEPPATAGTGGARDWSGERRGACGLHHAEHERAHQHGAHGAGASLRRLGISLALTAAIMVAEAVGGWLSG
SLALVSDAGHMLTDAGALGLALVAAWLSTRPADDKRTFGYRRAEVLGAQLNVGALVVLSGWIAWEAVQRLRDPGPPIRLE
LMAFVAGIGLAANLAILWFLHGEHSLNARSAFLHVLSDTISSVAILAGAVVMGIRPDLRWIDPVLSLAIALLILWGAVRL
ILEITDILMESVPAHLDAGAIGSQMECCPGVVAVHDLHIWTISSGMLSLSAHLVVEPGSVGRNDEILTAVKRDLRHRYGI
DHTTLQIESAEYAHVDDVHRH

Specific function: Involved in divalent cation and potassium homeostasis in the cell. Catalyzes the active efflux of zinc, cadmium and cobalt, in exchange for potassium and H(+) ions [H]

COG id: COG1230

COG function: function code P; Co/Zn/Cd efflux system component

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily [H]

Homologues:

Organism=Homo sapiens, GI21359890, Length=301, Percent_Identity=32.2259136212625, Blast_Score=170, Evalue=2e-42,
Organism=Homo sapiens, GI52352805, Length=307, Percent_Identity=28.6644951140065, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI64762489, Length=308, Percent_Identity=30.1948051948052, Blast_Score=149, Evalue=4e-36,
Organism=Homo sapiens, GI289803013, Length=299, Percent_Identity=30.4347826086957, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI289803009, Length=299, Percent_Identity=30.4347826086957, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI289803007, Length=299, Percent_Identity=30.4347826086957, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI289803003, Length=299, Percent_Identity=30.4347826086957, Blast_Score=147, Evalue=1e-35,
Organism=Homo sapiens, GI21361112, Length=302, Percent_Identity=30.1324503311258, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI14210520, Length=218, Percent_Identity=25.6880733944954, Blast_Score=94, Evalue=2e-19,
Organism=Homo sapiens, GI52351208, Length=197, Percent_Identity=28.4263959390863, Blast_Score=77, Evalue=2e-14,
Organism=Escherichia coli, GI1786966, Length=292, Percent_Identity=39.041095890411, Blast_Score=139, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI193210990, Length=351, Percent_Identity=28.2051282051282, Blast_Score=166, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17555794, Length=333, Percent_Identity=29.7297297297297, Blast_Score=139, Evalue=2e-33,
Organism=Caenorhabditis elegans, GI17555796, Length=288, Percent_Identity=30.5555555555556, Blast_Score=135, Evalue=2e-32,
Organism=Caenorhabditis elegans, GI32564488, Length=307, Percent_Identity=28.0130293159609, Blast_Score=91, Evalue=8e-19,
Organism=Saccharomyces cerevisiae, GI6324892, Length=149, Percent_Identity=30.8724832214765, Blast_Score=78, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323899, Length=146, Percent_Identity=36.986301369863, Blast_Score=76, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320411, Length=198, Percent_Identity=28.7878787878788, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24583858, Length=321, Percent_Identity=24.6105919003115, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24585900, Length=167, Percent_Identity=29.3413173652695, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24585898, Length=167, Percent_Identity=29.3413173652695, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24585896, Length=167, Percent_Identity=29.3413173652695, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI19921672, Length=167, Percent_Identity=29.3413173652695, Blast_Score=96, Evalue=4e-20,
Organism=Drosophila melanogaster, GI24584409, Length=139, Percent_Identity=35.9712230215827, Blast_Score=93, Evalue=3e-19,
Organism=Drosophila melanogaster, GI28574430, Length=136, Percent_Identity=36.0294117647059, Blast_Score=90, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24656728, Length=134, Percent_Identity=36.5671641791045, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656724, Length=134, Percent_Identity=36.5671641791045, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656720, Length=134, Percent_Identity=36.5671641791045, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24656715, Length=134, Percent_Identity=36.5671641791045, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI21357035, Length=134, Percent_Identity=36.5671641791045, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24645863, Length=105, Percent_Identity=36.1904761904762, Blast_Score=66, Evalue=4e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002524 [H]

Pfam domain/function: PF01545 Cation_efflux [H]

EC number: NA

Molecular weight: Translated: 36298; Mature: 36167

Theoretical pI: Translated: 6.72; Mature: 6.72

Prosite motif: PS01319 RBFA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHGHPHVHGAHEPPATAGTGGARDWSGERRGACGLHHAEHERAHQHGAHGAGASLRRLG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHH
ISLALTAAIMVAEAVGGWLSGSLALVSDAGHMLTDAGALGLALVAAWLSTRPADDKRTFG
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHC
YRRAEVLGAQLNVGALVVLSGWIAWEAVQRLRDPGPPIRLELMAFVAGIGLAANLAILWF
HHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEEEEE
LHGEHSLNARSAFLHVLSDTISSVAILAGAVVMGIRPDLRWIDPVLSLAIALLILWGAVR
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LILEITDILMESVPAHLDAGAIGSQMECCPGVVAVHDLHIWTISSGMLSLSAHLVVEPGS
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCHHEEEEEEEECCCC
VGRNDEILTAVKRDLRHRYGIDHTTLQIESAEYAHVDDVHRH
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCC
>Mature Secondary Structure 
SHGHPHVHGAHEPPATAGTGGARDWSGERRGACGLHHAEHERAHQHGAHGAGASLRRLG
CCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCCCCHHHHHHH
ISLALTAAIMVAEAVGGWLSGSLALVSDAGHMLTDAGALGLALVAAWLSTRPADDKRTFG
HHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHC
YRRAEVLGAQLNVGALVVLSGWIAWEAVQRLRDPGPPIRLELMAFVAGIGLAANLAILWF
HHHHHHHCCCCCCCEEEEHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHEEEEEE
LHGEHSLNARSAFLHVLSDTISSVAILAGAVVMGIRPDLRWIDPVLSLAIALLILWGAVR
ECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHH
LILEITDILMESVPAHLDAGAIGSQMECCPGVVAVHDLHIWTISSGMLSLSAHLVVEPGS
HHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCEEEEEEEEEEECCCHHEEEEEEEECCCC
VGRNDEILTAVKRDLRHRYGIDHTTLQIESAEYAHVDDVHRH
CCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9308178; 9384377; 9099864 [H]