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The map label for this gene is 220917258

Identifier: 220917258

GI number: 220917258

Start: 2395660

End: 2397042

Strand: Reverse

Name: 220917258

Synonym: A2cp1_2156

Alternate gene names: NA

Gene position: 2397042-2395660 (Counterclockwise)

Preceding gene: 220917264

Following gene: 220917257

Centisome position: 47.66

GC content: 75.78

Gene sequence:

>1383_bases
ATGACGTCCATCCGCTTCCTCGGCGCGGCCGGCACGGTGACGGGCTCACGGTTCCTGGTGGAGACCGGCTCGGTCCGGAT
CCTGGTCGACGCGGGCCTGTTCCAGGGCCACAAGGAGCTGCGCCTCCGCAACCGCGCCCCCTGGCCGGTCTCCCCCCGAG
ACCTGACGGCGGTGGTCCTGACGCACGCGCACGTGGACCACAGCGGGGCGCTGCCGCTGCTGGCGCGCCAGGGCTTCCGC
GGGCCGGTCCACTGCACCCCGGCCACCCGCGACCTGGCCGGCCTGCTCCTCCCCGACTCGGGGAGGCTCCAGGAAGAGGA
GGCCCGCTACGCGAACCGGAAGGGCTACTCGAAGCATGCGCCCGCCCTCCCGCTCTACACCGAGCAGGACGCGCAGGACG
TGCTGCCCCGGCTGGCGCCGCTCCGGTACGGCGAGCCCCGCCAGATCGCGCCCGGCGTGACCATCCGCTTCCACCGCGCC
GGGCACATCCTGGGCAGCGCGCTGGTGGAGCTGAGCGTCGGGGGCGCGCGCGGGGCGCGGATCCTGTTCAGCGGGGATCT
GGGCCGCTACGGCGCCCCCATCCTCTCGGACCCCGAGCCCGGCCCCGCCGCCGACGCGCTGGTGCTGGAGAGCACCTACG
CCGGCCGGCGCCACGAGGCGGCCTCGCCCGCCGCCGCGCTCGCGGCCGAGGTCCACGCCGTGGTCCGCTCCGGCGGCGCG
CTGGTGGTGCCGGCGTTCGCGGTGGGGCGCACGCAGGAGATCCTGTTCACGCTGCGTGAGCTGGAGGACCGCCGCGAGAT
CCCGGCCATCCCGGTGTTCGTGGACTCGCCCATGGCGGTGGACGCGACCCCGATCTACCTCGCGCACCGCGAGGATCACG
ACGACGAGACGGTCCGGCGCATCGCCGCCGGGGAGGAGCCGCTCCGGCCCGCGAAGCTGACGTTCTGCCGCAGCCCGGAC
CAGTCGAAGGCCATCAACGACGTGCGCGGCCCGTGCATCATCCTGTCGGCCTCGGGCATGGCCACCGGCGGGCGCGTGCT
CCACCACCTGGCGCGCCGGCTCCCCGACCCGCGCAACACGGTCCTGCTGGTGGGCTTCCAGGCCGGCGGCACCCGCGGCT
GGCGCCTGCAGAACGGCGCCGAGACGCTGCGCATCCACGGCGAGGACGTGCCGGTGAAGGCGCGCGTCGCGACGCTGGGC
GGGTTCTCGGCGCACGCCGACGAGGCGGAGATCCGGCGCTGGCTCGCCACGCTGCCGGCGCAGCCGCGCCGGACGTTCCT
GGTGCACGGCGAGCCCACCGCGCTCGCGGCGGCGAAGGCGCGCATGGACGAGCTGGGCTGGGCCGCGCTCGTCCCCTCGC
ACCTCGAGGAGGTCCGGCTGTGA

Upstream 100 bases:

>100_bases
CCGGCGCATGTCGTGAACGCTCCGTCTGCGGTCCCGTGGTGCCCACCGCGCGCGGGAGGGCCGCGCCGCGCGCGTCCAGG
GATTGTAGAATTCGCTCACG

Downstream 100 bases:

>100_bases
CGGCCGCGGACGGGGGGCGCACCGCGCTGGTGCTGTCCGGCGGCGGGGCCCGCGGCGCCTACGAGGCCGGCGTGGTCCGC
TACCTGCGCGAGGAGCTCGC

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 460; Mature: 459

Protein sequence:

>460_residues
MTSIRFLGAAGTVTGSRFLVETGSVRILVDAGLFQGHKELRLRNRAPWPVSPRDLTAVVLTHAHVDHSGALPLLARQGFR
GPVHCTPATRDLAGLLLPDSGRLQEEEARYANRKGYSKHAPALPLYTEQDAQDVLPRLAPLRYGEPRQIAPGVTIRFHRA
GHILGSALVELSVGGARGARILFSGDLGRYGAPILSDPEPGPAADALVLESTYAGRRHEAASPAAALAAEVHAVVRSGGA
LVVPAFAVGRTQEILFTLRELEDRREIPAIPVFVDSPMAVDATPIYLAHREDHDDETVRRIAAGEEPLRPAKLTFCRSPD
QSKAINDVRGPCIILSASGMATGGRVLHHLARRLPDPRNTVLLVGFQAGGTRGWRLQNGAETLRIHGEDVPVKARVATLG
GFSAHADEAEIRRWLATLPAQPRRTFLVHGEPTALAAAKARMDELGWAALVPSHLEEVRL

Sequences:

>Translated_460_residues
MTSIRFLGAAGTVTGSRFLVETGSVRILVDAGLFQGHKELRLRNRAPWPVSPRDLTAVVLTHAHVDHSGALPLLARQGFR
GPVHCTPATRDLAGLLLPDSGRLQEEEARYANRKGYSKHAPALPLYTEQDAQDVLPRLAPLRYGEPRQIAPGVTIRFHRA
GHILGSALVELSVGGARGARILFSGDLGRYGAPILSDPEPGPAADALVLESTYAGRRHEAASPAAALAAEVHAVVRSGGA
LVVPAFAVGRTQEILFTLRELEDRREIPAIPVFVDSPMAVDATPIYLAHREDHDDETVRRIAAGEEPLRPAKLTFCRSPD
QSKAINDVRGPCIILSASGMATGGRVLHHLARRLPDPRNTVLLVGFQAGGTRGWRLQNGAETLRIHGEDVPVKARVATLG
GFSAHADEAEIRRWLATLPAQPRRTFLVHGEPTALAAAKARMDELGWAALVPSHLEEVRL
>Mature_459_residues
TSIRFLGAAGTVTGSRFLVETGSVRILVDAGLFQGHKELRLRNRAPWPVSPRDLTAVVLTHAHVDHSGALPLLARQGFRG
PVHCTPATRDLAGLLLPDSGRLQEEEARYANRKGYSKHAPALPLYTEQDAQDVLPRLAPLRYGEPRQIAPGVTIRFHRAG
HILGSALVELSVGGARGARILFSGDLGRYGAPILSDPEPGPAADALVLESTYAGRRHEAASPAAALAAEVHAVVRSGGAL
VVPAFAVGRTQEILFTLRELEDRREIPAIPVFVDSPMAVDATPIYLAHREDHDDETVRRIAAGEEPLRPAKLTFCRSPDQ
SKAINDVRGPCIILSASGMATGGRVLHHLARRLPDPRNTVLLVGFQAGGTRGWRLQNGAETLRIHGEDVPVKARVATLGG
FSAHADEAEIRRWLATLPAQPRRTFLVHGEPTALAAAKARMDELGWAALVPSHLEEVRL

Specific function: Has endoribonuclease activity towards 23S and 16S rRNA (in vitro) [H]

COG id: COG1236

COG function: function code J; Predicted exonuclease of the beta-lactamase fold involved in RNA processing

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family [H]

Homologues:

Organism=Homo sapiens, GI7706427, Length=444, Percent_Identity=27.7027027027027, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI33300633, Length=467, Percent_Identity=25.2676659528908, Blast_Score=146, Evalue=3e-35,
Organism=Caenorhabditis elegans, GI32566029, Length=443, Percent_Identity=27.9909706546275, Blast_Score=152, Evalue=2e-37,
Organism=Caenorhabditis elegans, GI32564696, Length=465, Percent_Identity=26.0215053763441, Blast_Score=148, Evalue=6e-36,
Organism=Saccharomyces cerevisiae, GI6323307, Length=455, Percent_Identity=24.6153846153846, Blast_Score=126, Evalue=6e-30,
Organism=Drosophila melanogaster, GI24648013, Length=446, Percent_Identity=26.9058295964126, Blast_Score=156, Evalue=2e-38,
Organism=Drosophila melanogaster, GI21358523, Length=462, Percent_Identity=25.3246753246753, Blast_Score=146, Evalue=4e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022712
- InterPro:   IPR001279
- InterPro:   IPR011108 [H]

Pfam domain/function: PF10996 Beta-Casp; PF00753 Lactamase_B; PF07521 RMMBL [H]

EC number: NA

Molecular weight: Translated: 49550; Mature: 49419

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSIRFLGAAGTVTGSRFLVETGSVRILVDAGLFQGHKELRLRNRAPWPVSPRDLTAVVL
CCCEEEECCCCCCCCCEEEEECCCEEEEEECCCCCCCHHHHHCCCCCCCCCCCCEEEEEE
THAHVDHSGALPLLARQGFRGPVHCTPATRDLAGLLLPDSGRLQEEEARYANRKGYSKHA
EEEECCCCCCCHHHHHCCCCCCEECCCCCCCHHEEECCCCCCCCHHHHHHHHCCCCCCCC
PALPLYTEQDAQDVLPRLAPLRYGEPRQIAPGVTIRFHRAGHILGSALVELSVGGARGAR
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHEEECCCCCCEE
ILFSGDLGRYGAPILSDPEPGPAADALVLESTYAGRRHEAASPAAALAAEVHAVVRSGGA
EEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
LVVPAFAVGRTQEILFTLRELEDRREIPAIPVFVDSPMAVDATPIYLAHREDHDDETVRR
EEEEEHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEECCCEEEEEECCCCCHHHHHH
IAAGEEPLRPAKLTFCRSPDQSKAINDVRGPCIILSASGMATGGRVLHHLARRLPDPRNT
HHCCCCCCCCCEEEEECCCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCE
VLLVGFQAGGTRGWRLQNGAETLRIHGEDVPVKARVATLGGFSAHADEAEIRRWLATLPA
EEEEEEECCCCCCEEECCCCEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCC
QPRRTFLVHGEPTALAAAKARMDELGWAALVPSHLEEVRL
CCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHCC
>Mature Secondary Structure 
TSIRFLGAAGTVTGSRFLVETGSVRILVDAGLFQGHKELRLRNRAPWPVSPRDLTAVVL
CCEEEECCCCCCCCCEEEEECCCEEEEEECCCCCCCHHHHHCCCCCCCCCCCCEEEEEE
THAHVDHSGALPLLARQGFRGPVHCTPATRDLAGLLLPDSGRLQEEEARYANRKGYSKHA
EEEECCCCCCCHHHHHCCCCCCEECCCCCCCHHEEECCCCCCCCHHHHHHHHCCCCCCCC
PALPLYTEQDAQDVLPRLAPLRYGEPRQIAPGVTIRFHRAGHILGSALVELSVGGARGAR
CCCCCCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEEEECCHHHHHHHHHEEECCCCCCEE
ILFSGDLGRYGAPILSDPEPGPAADALVLESTYAGRRHEAASPAAALAAEVHAVVRSGGA
EEEECCCCCCCCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
LVVPAFAVGRTQEILFTLRELEDRREIPAIPVFVDSPMAVDATPIYLAHREDHDDETVRR
EEEEEHHCCCHHHHHHHHHHHHHHHCCCEEEEEECCCCEECCCEEEEEECCCCCHHHHHH
IAAGEEPLRPAKLTFCRSPDQSKAINDVRGPCIILSASGMATGGRVLHHLARRLPDPRNT
HHCCCCCCCCCEEEEECCCCHHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHCCCCCCE
VLLVGFQAGGTRGWRLQNGAETLRIHGEDVPVKARVATLGGFSAHADEAEIRRWLATLPA
EEEEEEECCCCCCEEECCCCEEEEECCCCCCEEEEEEEECCCCCCCCHHHHHHHHHHCCC
QPRRTFLVHGEPTALAAAKARMDELGWAALVPSHLEEVRL
CCCEEEEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA