Click here to switch to the map view.

The map label for this gene is sbm [H]

Identifier: 220917201

GI number: 220917201

Start: 2339902

End: 2340324

Strand: Direct

Name: sbm [H]

Synonym: A2cp1_2098

Alternate gene names: 220917201

Gene position: 2339902-2340324 (Clockwise)

Preceding gene: 220917200

Following gene: 220917202

Centisome position: 46.53

GC content: 70.45

Gene sequence:

>423_bases
ATGAGCCCCGCCACCGAGCGCCCCCTCCGCATCCTCGTCGCCAAGCCCGGCCTGGACGGCCACGATCGCGGCGCCAAGAT
CATCGCCCGCGCGCTGCGCGACGGCGGCTTCGAGGTCATCTACACCGGCCTGCACCAGACGCCGGAGATGATCGTGGCCG
CCGCCGTCCAGGAGGACGTGGACGCGATCGGCCTCTCGATCATGTCGGGCGCCCACATGACGCTGTTCCCGGCGGTGATC
GAGCTGCTGAGGGAGAAGGGCGCCGTGGACATCGTGGTGTTCGGCGGCGGGATCATCCCGCAGGACGACGTTCCCCGCCT
GAAGGAGAAGGGGACCGCCGAGGTGTTCCTGCCCGGCTCCTCCACCCAGGCGATCATCGAGTGGATCCGCGCGAACATCC
GTCCGCGTGCCGCGGCCGCCTAG

Upstream 100 bases:

>100_bases
TCCTGGAGCTGACGAGCACGACCGGCGCGGGGGAGCACCCGGGCCGTGAGCTGGATCCCGAAGCGCCGGATCTCATCGCC
CTCTTGGAGAAGCCGACCAC

Downstream 100 bases:

>100_bases
GCGCGAGCCGACCCTCGCCCCTCCCCGCGAGGCCCGCACCGGGCGCCGGGCGTCTGCCCGGCCGCCCGCCGGCGCGCGGG
GTCGCACGCGTTCGGCAGTG

Product: cobalamin B12-binding domain-containing protein

Products: succinyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 140; Mature: 139

Protein sequence:

>140_residues
MSPATERPLRILVAKPGLDGHDRGAKIIARALRDGGFEVIYTGLHQTPEMIVAAAVQEDVDAIGLSIMSGAHMTLFPAVI
ELLREKGAVDIVVFGGGIIPQDDVPRLKEKGTAEVFLPGSSTQAIIEWIRANIRPRAAAA

Sequences:

>Translated_140_residues
MSPATERPLRILVAKPGLDGHDRGAKIIARALRDGGFEVIYTGLHQTPEMIVAAAVQEDVDAIGLSIMSGAHMTLFPAVI
ELLREKGAVDIVVFGGGIIPQDDVPRLKEKGTAEVFLPGSSTQAIIEWIRANIRPRAAAA
>Mature_139_residues
SPATERPLRILVAKPGLDGHDRGAKIIARALRDGGFEVIYTGLHQTPEMIVAAAVQEDVDAIGLSIMSGAHMTLFPAVIE
LLREKGAVDIVVFGGGIIPQDDVPRLKEKGTAEVFLPGSSTQAIIEWIRANIRPRAAAA

Specific function: Unknown

COG id: COG2185

COG function: function code I; Methylmalonyl-CoA mutase, C-terminal domain/subunit (cobalamin-binding)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 B12-binding domain [H]

Homologues:

Organism=Homo sapiens, GI156105689, Length=114, Percent_Identity=48.2456140350877, Blast_Score=98, Evalue=2e-21,
Organism=Escherichia coli, GI1789284, Length=114, Percent_Identity=47.3684210526316, Blast_Score=104, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI25144500, Length=131, Percent_Identity=44.2748091603053, Blast_Score=97, Evalue=2e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006159
- InterPro:   IPR016176
- InterPro:   IPR014348
- InterPro:   IPR006158
- InterPro:   IPR006099
- InterPro:   IPR006098 [H]

Pfam domain/function: PF02310 B12-binding; PF01642 MM_CoA_mutase [H]

EC number: 5.4.99.2

Molecular weight: Translated: 14903; Mature: 14771

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSPATERPLRILVAKPGLDGHDRGAKIIARALRDGGFEVIYTGLHQTPEMIVAAAVQEDV
CCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHH
DAIGLSIMSGAHMTLFPAVIELLREKGAVDIVVFGGGIIPQDDVPRLKEKGTAEVFLPGS
HHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHCCCEEEEECCC
STQAIIEWIRANIRPRAAAA
CHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
SPATERPLRILVAKPGLDGHDRGAKIIARALRDGGFEVIYTGLHQTPEMIVAAAVQEDV
CCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHH
DAIGLSIMSGAHMTLFPAVIELLREKGAVDIVVFGGGIIPQDDVPRLKEKGTAEVFLPGS
HHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHCCCEEEEECCC
STQAIIEWIRANIRPRAAAA
CHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (R)-methylmalonyl-CoA

Specific reaction: (R)-methylmalonyl-CoA = succinyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1355087; 9278503 [H]