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The map label for this gene is ubiE [H]

Identifier: 220917169

GI number: 220917169

Start: 2307409

End: 2308014

Strand: Reverse

Name: ubiE [H]

Synonym: A2cp1_2066

Alternate gene names: 220917169

Gene position: 2308014-2307409 (Counterclockwise)

Preceding gene: 220917170

Following gene: 220917168

Centisome position: 45.89

GC content: 79.7

Gene sequence:

>606_bases
GTGCGCGGCCTCGAGCAGATCCCCTGGCTGTACGACCTCGGCCTCTCGCTCGCCGAGCGCGGGCTGGTGGGGCGCTGGCG
GCGGTGGCTCGCCGGCGGGGCCCGCGGCCGGACGCTCGACCTCGGCACCGGGACCGGCCGCAACCTGCCGCTCGCGCCGG
GCGGCGTGCGCATCCTGGCGCTCGATCCCCACCCGCAGAACCTGGCCCGCGCACGGCGGCGGGGCCCGGGCGTGCCCATG
GTCCGGGCGCGGGCCGAGGCGCTGCCGTTCCGGGACGGGGCGTTCGACACGGTGCTCTGTGCGCTCGTGCTGTGCAGCGT
GGAGGACCCGCCGCGCGCCCTCGCCGAGCTGCGGCGCGTGCTCCGGCCCGGCGGCGACCTGCGCGCCATGGAGCACGTCC
GCCCGGCCGGCCTGGCGGGCCGGATCCACGACCTCCTCCAGCCGGCCTGGACGCGGCTCACCGGCGGCTGCCACCCGAAC
CGCGACACCGAGCGGGCCATCGCCCAGGCCGGCTTCGAGCTCGTCCCGGCCAGCCGTGAGGCCCGCGGCAACCTGCGCCG
GCTCGAGGCGCGCGCGCCCCTGTCGCGCGGGCCCGACTCCCGGTAA

Upstream 100 bases:

>100_bases
ACACCTCGAGGAGCTCGGCACGCACCAGGAGCTGATCGCGCGCGACGGCCGCTACGCCCACCTCTTCCACCTGCAGGCGC
AGGGCTACCTGGACTGACGC

Downstream 100 bases:

>100_bases
CGTCGTCGCGTGCGCCCCGTCCGACGCCTCCGCGCGCTGCGCGCCCTCGCCGCGGCGTTGCTCGCCGCGTGCGCGGCGCC
GGCCACCGCGGACGAGGCGC

Product: type 11 methyltransferase

Products: S-Adenosyl-L-Homocysteine; @OCTA02.txt*2- Polyprenyl-3-Methyl-6-Methoxy-1,4-Benzoquinol!; Menaquinol. [C]

Alternate protein names: NA

Number of amino acids: Translated: 201; Mature: 201

Protein sequence:

>201_residues
MRGLEQIPWLYDLGLSLAERGLVGRWRRWLAGGARGRTLDLGTGTGRNLPLAPGGVRILALDPHPQNLARARRRGPGVPM
VRARAEALPFRDGAFDTVLCALVLCSVEDPPRALAELRRVLRPGGDLRAMEHVRPAGLAGRIHDLLQPAWTRLTGGCHPN
RDTERAIAQAGFELVPASREARGNLRRLEARAPLSRGPDSR

Sequences:

>Translated_201_residues
MRGLEQIPWLYDLGLSLAERGLVGRWRRWLAGGARGRTLDLGTGTGRNLPLAPGGVRILALDPHPQNLARARRRGPGVPM
VRARAEALPFRDGAFDTVLCALVLCSVEDPPRALAELRRVLRPGGDLRAMEHVRPAGLAGRIHDLLQPAWTRLTGGCHPN
RDTERAIAQAGFELVPASREARGNLRRLEARAPLSRGPDSR
>Mature_201_residues
MRGLEQIPWLYDLGLSLAERGLVGRWRRWLAGGARGRTLDLGTGTGRNLPLAPGGVRILALDPHPQNLARARRRGPGVPM
VRARAEALPFRDGAFDTVLCALVLCSVEDPPRALAELRRVLRPGGDLRAMEHVRPAGLAGRIHDLLQPAWTRLTGGCHPN
RDTERAIAQAGFELVPASREARGNLRRLEARAPLSRGPDSR

Specific function: Methyltransferase required for the conversion of dimethylmenaquinone (DMKH2) to menaquinone (MKH2) [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the methyltransferase superfamily. UbiE family [H]

Homologues:

Organism=Homo sapiens, GI164663805, Length=159, Percent_Identity=36.4779874213836, Blast_Score=95, Evalue=3e-20,
Organism=Homo sapiens, GI89145417, Length=195, Percent_Identity=30.7692307692308, Blast_Score=93, Evalue=1e-19,
Organism=Escherichia coli, GI48994983, Length=207, Percent_Identity=31.4009661835749, Blast_Score=68, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004033 [H]

Pfam domain/function: PF01209 Ubie_methyltran [H]

EC number: 2.1.1.- [C]

Molecular weight: Translated: 21964; Mature: 21964

Theoretical pI: Translated: 12.01; Mature: 12.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
3.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRGLEQIPWLYDLGLSLAERGLVGRWRRWLAGGARGRTLDLGTGTGRNLPLAPGGVRILA
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCEEEEE
LDPHPQNLARARRRGPGVPMVRARAEALPFRDGAFDTVLCALVLCSVEDPPRALAELRRV
ECCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
LRPGGDLRAMEHVRPAGLAGRIHDLLQPAWTRLTGGCHPNRDTERAIAQAGFELVPASRE
HCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHH
ARGNLRRLEARAPLSRGPDSR
HHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MRGLEQIPWLYDLGLSLAERGLVGRWRRWLAGGARGRTLDLGTGTGRNLPLAPGGVRILA
CCCHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCCCCEEEEE
LDPHPQNLARARRRGPGVPMVRARAEALPFRDGAFDTVLCALVLCSVEDPPRALAELRRV
ECCCHHHHHHHHHCCCCCCHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCHHHHHHHHHH
LRPGGDLRAMEHVRPAGLAGRIHDLLQPAWTRLTGGCHPNRDTERAIAQAGFELVPASRE
HCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHCCCCCCCCCHH
ARGNLRRLEARAPLSRGPDSR
HHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: S-Adenosyl-L-Methionine; 2-Polyprenyl-6- Methoxy-1,4-Benzoquinol; Demethylmenaquinol [C]

Specific reaction: S-Adenosyl-L-Methionine + @OCTA02.txt*2-Polyprenyl-6- Methoxy-1,4-Benzoquinol! = S-Adenosyl-L-Homocysteine + 2- Polyprenyl-3-Methyl-6-Methoxy -1,4-Benzoquinol S-Adenosyl-L-Methionine + Demethylmenaquinol = S-Adenosyl-L-Homocysteine + Menaquinol. [C]

General reaction: Transferring one-carbon groups; Methyltransferases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA