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The map label for this gene is glcD [H]

Identifier: 220917103

GI number: 220917103

Start: 2253727

End: 2255115

Strand: Direct

Name: glcD [H]

Synonym: A2cp1_2000

Alternate gene names: 220917103

Gene position: 2253727-2255115 (Clockwise)

Preceding gene: 220917102

Following gene: 220917104

Centisome position: 44.81

GC content: 73.87

Gene sequence:

>1389_bases
ATGACCGCCGCCCGCGACGCCGCGCTGCGCGAGCTCGAGGCCGCGTTCCCGCGCGAGCGGCTGGTGCGCGATCCCGGGCG
GCTGGAGGCCTACGGGCGGGACGAGTCCGACCTGGGCGCGCGGCCGCCGGACGCGGCGGTGCTGGTGGAGTCCGCCGAGG
AGATCCGCGCGATCTTCGCCATCGCGAGCCGGCACCGCGTGCCGGTGATCCCGGTCGCGGCGCGCAGCGGCAAGTCCGGC
GGCGTGCTGGCGCTGCACGGCGGGATCGCCGTCTCGCTCGAGCGCATGAACCGGATCCTGGAGATCTCGCCGGAGGACCT
GGTGGCGCGGGTGCAGCCGGCGGTGGTGACCGGCGTGCTCCAGGCCGAGGTGGAGCGGCACGGGCTGTTCTACCCGCCCG
ACCCGAACTCGCTGGAGATGTGCACCATCGGCGGGAACGTGGCGGAGAACGCCGGCGGCCCGCGCGCGCTGAAGTACGGC
GTCACCCGCGAGTACGTGCTGGGCCTCACCGCCGTGCTCCCCACCGGCGAGATCCTGCGGCTGGGCAAGCGCAGCATCAA
GGGCGTGGCCGGCTACGACCTCACCGCGCTGCTGGTGGGCAGCGAGGGGACGCTCGGGATCGTGACCGAGGCGACGCTGA
AGCTGCTGCCCCGCCCGCGCCACGTGGCCACCGCGCTGGTGGTGTTCGCCTCGGTGGCGGAGGCGGCGCGCGCGGTGAAC
GAGGTGCTGCAGGGCGGCATCCTGCCCCGCTGCCTGGAGCTGCTCGACGACGTCTCGCTGGCCGCCGCCGCGAAGACCTC
GCCCTACCGCTTCCCGCCCGGCGCCGGCGCGGCGCTGCTGGTGGAGACCGACGGCAACGACGAGGAGCAGGTGTTCGCCG
AGATCGTGCGGCTGGCCGAGAAGGTCCAGGTGCACGCGCAGGGCGACGTGATCGTGGCGCAGAACGAGGCGCAGCGGCGC
GACGTGTGGGAGACGCGCCGTTACCTGTCGGTGAACCTGAAGGCGCTGCACCCGCTGAAGCTCTCCGAGGACGTCGCGGT
CCCGCGCTCGAGGATCCCGGAGATGATCGCGCGGGCCAAGGCGGTGGGCGGACGGCTCGGGCTCACCGTCGCGACCTACG
GCCACGCCGGCGACGGGAACCTGCACTGCAACGTCCTGTTCGACCGGCCCGAGGAGCGCCCGAAGGTGGACGAGGCGGTG
GCGGCCATCCTGCGCGACGCGGTGGACCTGGGGGGCACCATCACCGGCGAGCATGGCGTCGGCGTCGCCAAGCGCGACTT
CCTCGAGTACGAGCAGGGCGCCGAGGTGGTCGCGCTGGAGCGCCGGCTCAAGGCCGCGTTCGACCCGCTCGGCATCCTGA
ACCCGGGGAAGATCTTCCCGGAGCGCTGA

Upstream 100 bases:

>100_bases
TCCCGCCGCGGATGAGCGCGGACGAGGTCGCGCGCGTGGTCGTGTTCGCGGCGCTGGACGCGCCCGACGCCATCACCGGC
GCCAACCTGGAGGTGTACGG

Downstream 100 bases:

>100_bases
CGCCATCGAGGCACGGTCGGTGCGGGCCATGCGCCGGCGATCGCGCCGCGCCGCGTGCCCCTTGGAGTCGCCGGGAGCGA
GGCCCGTCGGGGTTGACCCC

Product: FAD linked oxidase domain-containing protein

Products: 2-oxo acid; H2O2

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 461

Protein sequence:

>462_residues
MTAARDAALRELEAAFPRERLVRDPGRLEAYGRDESDLGARPPDAAVLVESAEEIRAIFAIASRHRVPVIPVAARSGKSG
GVLALHGGIAVSLERMNRILEISPEDLVARVQPAVVTGVLQAEVERHGLFYPPDPNSLEMCTIGGNVAENAGGPRALKYG
VTREYVLGLTAVLPTGEILRLGKRSIKGVAGYDLTALLVGSEGTLGIVTEATLKLLPRPRHVATALVVFASVAEAARAVN
EVLQGGILPRCLELLDDVSLAAAAKTSPYRFPPGAGAALLVETDGNDEEQVFAEIVRLAEKVQVHAQGDVIVAQNEAQRR
DVWETRRYLSVNLKALHPLKLSEDVAVPRSRIPEMIARAKAVGGRLGLTVATYGHAGDGNLHCNVLFDRPEERPKVDEAV
AAILRDAVDLGGTITGEHGVGVAKRDFLEYEQGAEVVALERRLKAAFDPLGILNPGKIFPER

Sequences:

>Translated_462_residues
MTAARDAALRELEAAFPRERLVRDPGRLEAYGRDESDLGARPPDAAVLVESAEEIRAIFAIASRHRVPVIPVAARSGKSG
GVLALHGGIAVSLERMNRILEISPEDLVARVQPAVVTGVLQAEVERHGLFYPPDPNSLEMCTIGGNVAENAGGPRALKYG
VTREYVLGLTAVLPTGEILRLGKRSIKGVAGYDLTALLVGSEGTLGIVTEATLKLLPRPRHVATALVVFASVAEAARAVN
EVLQGGILPRCLELLDDVSLAAAAKTSPYRFPPGAGAALLVETDGNDEEQVFAEIVRLAEKVQVHAQGDVIVAQNEAQRR
DVWETRRYLSVNLKALHPLKLSEDVAVPRSRIPEMIARAKAVGGRLGLTVATYGHAGDGNLHCNVLFDRPEERPKVDEAV
AAILRDAVDLGGTITGEHGVGVAKRDFLEYEQGAEVVALERRLKAAFDPLGILNPGKIFPER
>Mature_461_residues
TAARDAALRELEAAFPRERLVRDPGRLEAYGRDESDLGARPPDAAVLVESAEEIRAIFAIASRHRVPVIPVAARSGKSGG
VLALHGGIAVSLERMNRILEISPEDLVARVQPAVVTGVLQAEVERHGLFYPPDPNSLEMCTIGGNVAENAGGPRALKYGV
TREYVLGLTAVLPTGEILRLGKRSIKGVAGYDLTALLVGSEGTLGIVTEATLKLLPRPRHVATALVVFASVAEAARAVNE
VLQGGILPRCLELLDDVSLAAAAKTSPYRFPPGAGAALLVETDGNDEEQVFAEIVRLAEKVQVHAQGDVIVAQNEAQRRD
VWETRRYLSVNLKALHPLKLSEDVAVPRSRIPEMIARAKAVGGRLGLTVATYGHAGDGNLHCNVLFDRPEERPKVDEAVA
AILRDAVDLGGTITGEHGVGVAKRDFLEYEQGAEVVALERRLKAAFDPLGILNPGKIFPER

Specific function: Unknown

COG id: COG0277

COG function: function code C; FAD/FMN-containing dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 FAD-binding PCMH-type domain [H]

Homologues:

Organism=Homo sapiens, GI37595756, Length=439, Percent_Identity=37.5854214123007, Blast_Score=265, Evalue=9e-71,
Organism=Homo sapiens, GI37595754, Length=464, Percent_Identity=35.9913793103448, Blast_Score=256, Evalue=3e-68,
Organism=Homo sapiens, GI119964728, Length=433, Percent_Identity=30.9468822170901, Blast_Score=167, Evalue=3e-41,
Organism=Homo sapiens, GI4501993, Length=235, Percent_Identity=26.3829787234043, Blast_Score=100, Evalue=2e-21,
Organism=Escherichia coli, GI1789351, Length=420, Percent_Identity=38.8095238095238, Blast_Score=261, Evalue=9e-71,
Organism=Escherichia coli, GI1787977, Length=497, Percent_Identity=29.7786720321932, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI48994907, Length=506, Percent_Identity=22.7272727272727, Blast_Score=96, Evalue=7e-21,
Organism=Escherichia coli, GI48994914, Length=125, Percent_Identity=43.2, Blast_Score=85, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI71992373, Length=439, Percent_Identity=32.5740318906606, Blast_Score=226, Evalue=1e-59,
Organism=Caenorhabditis elegans, GI71992381, Length=439, Percent_Identity=31.8906605922551, Blast_Score=213, Evalue=2e-55,
Organism=Caenorhabditis elegans, GI71992392, Length=383, Percent_Identity=33.420365535248, Blast_Score=198, Evalue=5e-51,
Organism=Caenorhabditis elegans, GI17534361, Length=434, Percent_Identity=29.4930875576037, Blast_Score=180, Evalue=1e-45,
Organism=Caenorhabditis elegans, GI17556096, Length=221, Percent_Identity=28.9592760180996, Blast_Score=98, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6320027, Length=455, Percent_Identity=32.0879120879121, Blast_Score=213, Evalue=5e-56,
Organism=Saccharomyces cerevisiae, GI6320023, Length=438, Percent_Identity=27.3972602739726, Blast_Score=163, Evalue=5e-41,
Organism=Saccharomyces cerevisiae, GI6320764, Length=461, Percent_Identity=25.3796095444685, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI18921117, Length=425, Percent_Identity=29.8823529411765, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24639277, Length=425, Percent_Identity=29.8823529411765, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24639275, Length=425, Percent_Identity=29.8823529411765, Blast_Score=176, Evalue=3e-44,
Organism=Drosophila melanogaster, GI24653753, Length=289, Percent_Identity=25.2595155709343, Blast_Score=89, Evalue=5e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016166
- InterPro:   IPR016167
- InterPro:   IPR016164
- InterPro:   IPR016168
- InterPro:   IPR004113
- InterPro:   IPR004490
- InterPro:   IPR006094
- InterPro:   IPR016171 [H]

Pfam domain/function: PF02913 FAD-oxidase_C; PF01565 FAD_binding_4 [H]

EC number: 1.1.3.15

Molecular weight: Translated: 49401; Mature: 49270

Theoretical pI: Translated: 6.09; Mature: 6.09

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.5 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
0.7 %Met     (Mature Protein)
1.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAARDAALRELEAAFPRERLVRDPGRLEAYGRDESDLGARPPDAAVLVESAEEIRAIFA
CCCHHHHHHHHHHHHCCHHHHHCCCCCEEECCCCCCCCCCCCCCHHEEHHHHHHHHHHHH
IASRHRVPVIPVAARSGKSGGVLALHGGIAVSLERMNRILEISPEDLVARVQPAVVTGVL
HHHCCCCCEEEEECCCCCCCCEEEEECCEEEEHHHHHHHHCCCHHHHHHHHCHHHHHHHH
QAEVERHGLFYPPDPNSLEMCTIGGNVAENAGGPRALKYGVTREYVLGLTAVLPTGEILR
HHHHHHCCCCCCCCCCCEEEEEECCCHHCCCCCCCEEEECCCHHHHHHHHHHCCCHHHHH
LGKRSIKGVAGYDLTALLVGSEGTLGIVTEATLKLLPRPRHVATALVVFASVAEAARAVN
HHHHHCCCCCCCCEEEEEECCCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
EVLQGGILPRCLELLDDVSLAAAAKTSPYRFPPGAGAALLVETDGNDEEQVFAEIVRLAE
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
KVQVHAQGDVIVAQNEAQRRDVWETRRYLSVNLKALHPLKLSEDVAVPRSRIPEMIARAK
HHEEEECCCEEEECCCHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
AVGGRLGLTVATYGHAGDGNLHCNVLFDRPEERPKVDEAVAAILRDAVDLGGTITGEHGV
HCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCC
GVAKRDFLEYEQGAEVVALERRLKAAFDPLGILNPGKIFPER
CHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
TAARDAALRELEAAFPRERLVRDPGRLEAYGRDESDLGARPPDAAVLVESAEEIRAIFA
CCHHHHHHHHHHHHCCHHHHHCCCCCEEECCCCCCCCCCCCCCHHEEHHHHHHHHHHHH
IASRHRVPVIPVAARSGKSGGVLALHGGIAVSLERMNRILEISPEDLVARVQPAVVTGVL
HHHCCCCCEEEEECCCCCCCCEEEEECCEEEEHHHHHHHHCCCHHHHHHHHCHHHHHHHH
QAEVERHGLFYPPDPNSLEMCTIGGNVAENAGGPRALKYGVTREYVLGLTAVLPTGEILR
HHHHHHCCCCCCCCCCCEEEEEECCCHHCCCCCCCEEEECCCHHHHHHHHHHCCCHHHHH
LGKRSIKGVAGYDLTALLVGSEGTLGIVTEATLKLLPRPRHVATALVVFASVAEAARAVN
HHHHHCCCCCCCCEEEEEECCCCCEEEEEHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHH
EVLQGGILPRCLELLDDVSLAAAAKTSPYRFPPGAGAALLVETDGNDEEQVFAEIVRLAE
HHHHCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEECCCCCHHHHHHHHHHHHH
KVQVHAQGDVIVAQNEAQRRDVWETRRYLSVNLKALHPLKLSEDVAVPRSRIPEMIARAK
HHEEEECCCEEEECCCHHHHHHHHHHHHEEEEEEEECCCCCCCCCCCCHHHHHHHHHHHH
AVGGRLGLTVATYGHAGDGNLHCNVLFDRPEERPKVDEAVAAILRDAVDLGGTITGEHGV
HCCCCEEEEEEECCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHHHCCCEEECCCCC
GVAKRDFLEYEQGAEVVALERRLKAAFDPLGILNPGKIFPER
CHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: (S)-2-hydroxy acid; O2

Specific reaction: (S)-2-hydroxy acid + O2 = 2-oxo acid + H2O2

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8969504; 9384377 [H]