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The map label for this gene is hemF [H]

Identifier: 220917053

GI number: 220917053

Start: 2203490

End: 2204398

Strand: Reverse

Name: hemF [H]

Synonym: A2cp1_1949

Alternate gene names: 220917053

Gene position: 2204398-2203490 (Counterclockwise)

Preceding gene: 220917054

Following gene: 220917052

Centisome position: 43.83

GC content: 76.9

Gene sequence:

>909_bases
GTGCCCACGCCCGCGTCCCCCGAGCTGCTCGCCCGCCTGCGCGCGGGCATGGCCGAGACCGTCCGCGCGCTGCAGGAGGA
GATCTGCGCCGCGCTGGAGCGCGCCGACGGCGCCGCCCGCTTCGCCGCGGATCCCTGGGAGCGCCCCGGGGGCGGCGGCG
GCGAGAGCCGCGTGCTCCAGGACGGCGCGGTGCTGGAGAAGGCGGGCGTGAACGTGTCGGAGGTGCACGGGGAGCTGCCC
GACGCGCTCGCGCGCAAGGTGCAGGGCGAGGGCGGCGCGTTCACCGCGGCGGGGCTGTCGGTGGTGGTCCACCCGGCCAG
CCCGATGGCCCCCACCGCGCACATGAACGTGCGGCTGCTGAGCCGCGGCGGGGGCGCCTGGTTCGGCGGCGGCGCCGACC
TCACCCCCTACTACCTCTTCGAGGAGGACTGCCGGCACTTCCACGCCGTGCTGCGCGAGGCCTGCGAGCGCCACGCGCCC
GGCAGCTACGCGCGCCACAAGCGCGCCGCGGACGCGTACTTCTACCTGCGCCACCGCGGCGAGCACCGCGGGGTGGGCGG
GATCTTCTACGAGGACGCCGGGGACGACCTGGAGCGCGAGCTCGCGTTCGCGGGCGAGATGGGCCGGGCGTTCCTGCGGG
CCTACCTGCCCATCCTGGAGCGCCGCCGCGCGACCCCGTTCGGCGAGGCGGAGCGGCGCTGGCAGGAGATCCGGCGCGGG
CGCTACGTGGAGTTCAACCTGGTCTGGGACCGCGGCACCGTGTTCGGGCTGGAGACCTCCGGCCGCACCGAGTCGATCCT
GATGTCGCTGCCGCCGCGGGTGCGCTGGGTCTACGACCACCGGCCGGCGCCCGGCAGCCGCGAGGCGGCGCTCCTCGACG
TGCTGCGCGCGCCGCGCGAGTGGGCGTGA

Upstream 100 bases:

>100_bases
GCACCATGCACTCCTCGCGGCGCGCGACCGCCGCCAGCGCCTGAGCCGCGGCCCCGCGCGGGAGGTGCGGAGGCGCCGCG
CCGGCGGCAAGGGTTCCGCC

Downstream 100 bases:

>100_bases
GCGGCGCGGCCGGGCGCGTTAACCTCTCCCGCGTGCAGCTCGAGCTGGTCCCCTCGCCCGTCCCGGCGTTGCCGCCGGGC
ATGCGGCTGTGGCGCGCGCT

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 302; Mature: 301

Protein sequence:

>302_residues
MPTPASPELLARLRAGMAETVRALQEEICAALERADGAARFAADPWERPGGGGGESRVLQDGAVLEKAGVNVSEVHGELP
DALARKVQGEGGAFTAAGLSVVVHPASPMAPTAHMNVRLLSRGGGAWFGGGADLTPYYLFEEDCRHFHAVLREACERHAP
GSYARHKRAADAYFYLRHRGEHRGVGGIFYEDAGDDLERELAFAGEMGRAFLRAYLPILERRRATPFGEAERRWQEIRRG
RYVEFNLVWDRGTVFGLETSGRTESILMSLPPRVRWVYDHRPAPGSREAALLDVLRAPREWA

Sequences:

>Translated_302_residues
MPTPASPELLARLRAGMAETVRALQEEICAALERADGAARFAADPWERPGGGGGESRVLQDGAVLEKAGVNVSEVHGELP
DALARKVQGEGGAFTAAGLSVVVHPASPMAPTAHMNVRLLSRGGGAWFGGGADLTPYYLFEEDCRHFHAVLREACERHAP
GSYARHKRAADAYFYLRHRGEHRGVGGIFYEDAGDDLERELAFAGEMGRAFLRAYLPILERRRATPFGEAERRWQEIRRG
RYVEFNLVWDRGTVFGLETSGRTESILMSLPPRVRWVYDHRPAPGSREAALLDVLRAPREWA
>Mature_301_residues
PTPASPELLARLRAGMAETVRALQEEICAALERADGAARFAADPWERPGGGGGESRVLQDGAVLEKAGVNVSEVHGELPD
ALARKVQGEGGAFTAAGLSVVVHPASPMAPTAHMNVRLLSRGGGAWFGGGADLTPYYLFEEDCRHFHAVLREACERHAPG
SYARHKRAADAYFYLRHRGEHRGVGGIFYEDAGDDLERELAFAGEMGRAFLRAYLPILERRRATPFGEAERRWQEIRRGR
YVEFNLVWDRGTVFGLETSGRTESILMSLPPRVRWVYDHRPAPGSREAALLDVLRAPREWA

Specific function: Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III [H]

COG id: COG0408

COG function: function code H; Coproporphyrinogen III oxidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI41393599, Length=306, Percent_Identity=46.078431372549, Blast_Score=278, Evalue=4e-75,
Organism=Escherichia coli, GI1788777, Length=294, Percent_Identity=51.7006802721088, Blast_Score=290, Evalue=6e-80,
Organism=Saccharomyces cerevisiae, GI6320249, Length=329, Percent_Identity=46.2006079027356, Blast_Score=280, Evalue=2e-76,
Organism=Drosophila melanogaster, GI17864388, Length=320, Percent_Identity=44.6875, Blast_Score=274, Evalue=4e-74,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001260
- InterPro:   IPR018375 [H]

Pfam domain/function: PF01218 Coprogen_oxidas [H]

EC number: =1.3.3.3 [H]

Molecular weight: Translated: 33327; Mature: 33196

Theoretical pI: Translated: 7.07; Mature: 7.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPTPASPELLARLRAGMAETVRALQEEICAALERADGAARFAADPWERPGGGGGESRVLQ
CCCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCEEC
DGAVLEKAGVNVSEVHGELPDALARKVQGEGGAFTAAGLSVVVHPASPMAPTAHMNVRLL
CCCHHHHHCCCHHHHHCCCHHHHHHHHCCCCCEEEECCEEEEEECCCCCCCCCCCEEEEE
SRGGGAWFGGGADLTPYYLFEEDCRHFHAVLREACERHAPGSYARHKRAADAYFYLRHRG
ECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
EHRGVGGIFYEDAGDDLERELAFAGEMGRAFLRAYLPILERRRATPFGEAERRWQEIRRG
CCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
RYVEFNLVWDRGTVFGLETSGRTESILMSLPPRVRWVYDHRPAPGSREAALLDVLRAPRE
CEEEEEEEECCCEEEEEECCCCCHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCC
WA
CC
>Mature Secondary Structure 
PTPASPELLARLRAGMAETVRALQEEICAALERADGAARFAADPWERPGGGGGESRVLQ
CCCCCHHHHHHHHHCHHHHHHHHHHHHHHHHHHCCCCHHCCCCCCCCCCCCCCCCCEEC
DGAVLEKAGVNVSEVHGELPDALARKVQGEGGAFTAAGLSVVVHPASPMAPTAHMNVRLL
CCCHHHHHCCCHHHHHCCCHHHHHHHHCCCCCEEEECCEEEEEECCCCCCCCCCCEEEEE
SRGGGAWFGGGADLTPYYLFEEDCRHFHAVLREACERHAPGSYARHKRAADAYFYLRHRG
ECCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCC
EHRGVGGIFYEDAGDDLERELAFAGEMGRAFLRAYLPILERRRATPFGEAERRWQEIRRG
CCCCCCCEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHCC
RYVEFNLVWDRGTVFGLETSGRTESILMSLPPRVRWVYDHRPAPGSREAALLDVLRAPRE
CEEEEEEEECCCEEEEEECCCCCHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHCCCC
WA
CC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 14621292 [H]